L-arginine and superoxide dismutase prevent or reverse cerebral hypoperfusion after fluid-percussion traumatic brain injury

Journal of Neurotrauma

Volumn 14, Issue 4, 1997, Pages 223-233

  Dewitt, Douglas S ^a   Smith, Thomas G ^a   Deyo, Donald J ^a   Miller, Kimberly R ^a   Uchida, Tatsuo ^a   Prough, Donald S ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

cerebral circulation; free radicals; head trauma; ischemia; L arginine; laser Doppler; nitric oxide

Indexed keywords

ARGININE; DEXTRO ARGININE; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; PERCUSSION; RAT;

EID: 0031008736     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1997.14.223     Document Type: Article

References (50)

1. ARMSTEAD, W.M. and KURTH, C.D. (1994). Different cerebral hemodynamic responses following fluid percussion brain injury in the newborn and juvenile pig. J. Neurotrauma 11, 487-497.
2. BECKMAN, J.S. (1991). The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J. Dev. Physiol. 15, 53-59.
3. BECKMAN, J.S., CONGER, K.A., CHEN, J., TAN, M.J., and HALSEY, J.H. (1991). Nitric oxide helps regulate cerebral blood flow. J. Cereb. Blood Flow Metab. 11, S629.
4. BECKMAN, J.S., CHEN, J., CROW, J.P., and YE, Y.Z. (1994). Reactions of nitric oxide, Superoxide and peroxynitrite with Superoxide dismutase in neurodegeneration. Prog. Brain Res. 103, 371-380.
5. BONVENTO, G., SEYLAZ, J., and LACOMBE, P. (1994). Widespread attenuation of the cerebrovascular reactivity to hypercapnia following inhibition of nitric oxide synthase in the conscious rat. J. Cereb. Blood Flow Metab. 14, 699-703.
6. BOUMA, G.J., MUIZELAAR, J.P., CHOI, S.C., NEWLON, P.G., and YOUNG, H.F. (1991). Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia. J. Neurosurg. 75, 685-693.
7. BOUMA, G.J., MUIZELAAR, J.P., STRINGER, W.A., CHOI, S.C., FATOUROS, P., and YOUNG, H.F. (1992). Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using Xenon-enhanced computerized tomography. J. Neurosurg. 77, 360-368.
8. BREDT, D.S. and SNYDER, S.H. (1990). Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. USA 87, 682-685.
9. CROW, J.P. and BECKMAN, J.S. (1995). Reactions between nitric oxide, Superoxide and peroxynitrite: Footprints of peroxynitrites in vivo. Adv. Pharmacol. 34, 17-43.
10. DEWITT, D.S., JENKINS, L.W., WEI, E.P., LUTZ, H., BECKER, D.P., and KONTOS, H.A. (1986). Effects of fluid percussion brain injury on regional cerebral blood flow and pial arteriolar diameter. J. Neurosurg. 64, 787-794.
11. DEWITT, D.S., KONG, D.L., LYETH, B.G., et al. (1988). Experimental traumatic brain injury elevates prostaglandin E2 and thromboxane B2 levels in rats. J. Neurotrauma 5, 331-341.
12. DEWITT, D.S., PROUGH, D.S., COLONNA, D.M., DEAL, D.D., and VINES, S.M. (1992). Effects of nitric oxide synthase inhibitors on cerebral blood flow and autoregulation in rats. Anesthesiology 77(suppl 3A), A689(Abstract).
13. DIXON, C.E., LYETH, B.G., POVLISHOCK, J.T., et al. (1987). A fluid percussion model of experimental brain injury in the rat. J. Neurosurg. 67, 110-119.
14. FABIAN, R.H., DEWITT, D.S., and KENT, T.A. (1995). In vivo detection of Superoxide anion production by the brain using a cytochrome c electrode. J. Cereb. Blood Flow Metab. 15, 242-247.
15. FARACI, F.M. (1991). Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation. Am. J. Physiol. 261, H1038-H1042.
16. FURCHGOTT, R.F. and ZAWADZKI, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288, 373-376.
17. GRAHAM, D.I., ADAMS, J.H., and DOYLE, D. (1978). Ischaemic brain damage in fatal non-missile head injuries. J. Neurol. Sci. 39, 213-234.
18. HABERL, R.L., HEIZER, M.L., MARMAROU, A., and ELLIS, E.F. (1989). Laser-Doppler assessment of brain microcirculation: effect of systemic alterations. Am. J. Physiol. 256, H1247-H1254.
19. IGNARRO, L.J., BUGA, G.M., WOOD, K.S., BYRNS, R.E., and CHAUDHURI, G. (1987). Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84, 9265-9269.
20. KONTOS, H.A. (1989). Oxygen radicals in CNS damage. Chem. Biol. Interact. 72, 229-255.
21. KONTOS, H.A. and WEI, E.P. (1992). Endothelium-dependent responses after experimental brain injury. J. Neurotrauma 9, 349-354.
22. KOZNIEWSKA, E., OSEKA, M., and STYS, T. (1992). Effects of endothelium-derived nitric oxide on cerebral circulation during normoxia and hypoxia in the rat. J. Cereb. Blood Flow Metab. 12, 311-317.
23. LANGFITT, T.W. and OBRIST, W.D. (1981). Cerebral blood flow and metabolism after intracranial trauma. Prog. Neurol. Surg. 10, 14-48.
24. LASSEN, N.A. (1966). The luxury perfusion syndrome and its possible relation to acute metabolic acidosis localized within the brain. Lancet 2, 113-115.
25. MCINTOSH, T.K., HAYES, R.L., DEWITT, D.S., AGURA, V., and FADEN, A.I. (1987). Endogenous opioids may mediate secondary damage after experimental brain injury. Am. J. Physiol. 253, E565-E574.
26. MILLER, J.D. (1990). Assessing patients with head injury. Br. J. Surg. 77, 241-242.
27. MORIKAWA, E., HUANG, Z., and MOSKOWITZ, M.A. (1992a). L-arginine decreases infarct size called by middle cerebral arterial occlusion in SHR. Am. J. Physiol. 12, 380-389.
28. MORIKAWA, E., ROSENBLATT, S., and MOSKOWITZ, M.A. (1992b). L-arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischaemia. Br. J. Pharmacol. 107, 905-907.
29. MORIKAWA, E., MOSKOWITZ, M.A., HUANG, Z., YOSHIDA, T., IRIKURA, K., and DALKARA, T. (1994). L-Arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke 25, 429-435.
30. MORITA, K., IHNKEN, K., BUCKBERG, G.D., SHERMAN, M.P., and IGNARRO, L.J. (1996). Pulmonary vasoconstriction due to impaired nitric oxide production after cardiopulmonary bypass. Ann. Thorac. Surg. 61, 1775-1780.
31. MUIR, J.K., BOERSCHEL, M., and ELLIS, E.F. (1992). Continuous monitoring of posttraumatic cerebral blood flow using laser-Doppler flowmetry. J. Neurotrauma 9, 355-362.
32. MUIR, J.K., TYNAN, M., CALDWELL, R., and ELLIS, E.F. (1995). Superoxide dismutase improves posttraumatic cortical blood flow in rats. J. Neurotrauma 12, 179-188.
33. MUIZELAAR, J.P., MARMAROU, A., YOUNG, H.F., et al. (1993). Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated Superoxide dismutase: a phase II trial. J. Neurosurg. 78, 375-382.
34. OBRIST, W.D., LANGFITT, T.W., JAGGI, J.L., CRUZ, J., and GENNARELLI, T.A. (1984). Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. J. Neurosurg. 61, 241-253.
35. 125I-labeled bovine Superoxide dismutase (SOD) in the rat. Pharmacol. Toxicol. 62, 95-100.
36. PELLIGRINO, D.A., KOENIG, H.M., and ALBRECHT, R.F. (1993). Nitric oxide synthesis and regional cerebral blood flow responses to hypercapnia and hypoxia in the rat. J. Cereb. Blood Flow Metab. 13, 80-87.
37. PRADO, R., WATSON, B.D., ZHAO, W., et al. (1996). L-arginine does not improve cortical perfusion or histopathological outcome in spontaneously hypertensive rats subjected to distal middle cerebral artery photothrombotic occlusion. J. Cereb. Blood Flow Metab. 16, 612-622.
38. REYES, A.A., KARL, I.E., and KLAHR, S. (1994). Role of arginine in health and renal disease. Am. J. Physiol. 267, F331-D346.
39. RUBANYI, G.M. and VANHOUTTE, P.M. (1986). Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am. J. Physiol. 250, H822-H827.
40. SZABO, C., CSAKI, C., BENYO, Z., REIVICH, M., and KOVACH, A.G.B. (1995). Effect of Superoxide dismutase on hemorrhagic hypotension and retransfusion-evoked middle cerebral artery endothelial dysfunction. Circ. Shock. 44, 104-110.
41. TANAKA, K., GOTOH, F., GOMI, S., et al. (1991). Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat. Neurosci. Lett. 127, 129-132.
42. TOFTS, P.S. and KERMODE, A.G. (1991). Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn. Reson. Med. 17, 357-367.
43. G-nitro-L-arginine on cerebral blood flow response to changes in carbon dioxide tension. J. Cereb. Blood Flow Metab. 12, 947-953.
44. WEI, E.P., KONTOS, H.A., DIETRICH, W.D., POVLISHOCK, J.T., and ELLIS, E.F. (1981). Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats. Circ. Res. 48, 95-103.
45. YAMAKAMI, I. and MCINTOSH, T.K. (1989). Effects of traumatic brain injury on regional cerebral blood flow in rats as measured with radiolabeled microspheres. J. Cereb. Blood Flow Metab. 9, 117-124.
46. YAMAKAMI, I. and MCINTOSH, T.K. (1991). Alterations in regional cerebral blood flow following brain injury in the rat. J. Cereb. Blood Flow Metab. 11, 655-660.
47. YOUNG, B., RUNGE, J.W., WAXMAN, K.S., et al. (1996). Effects of pegorgotein on neurologic outcome of patients with severe head injury - a multicenter, randomized controlled trial. JAMA 276, 538-543.
48. YUAN, X.Q., PROUGH, D.S., SMITH, T.L., and DEWITT, D.S. (1988). The effects of traumatic brain injury on regional cerebral blood flow in rats. J. Neurotrauma 5, 289-301.
49. YUAN, X.Q., WADE, C.E., PROUGH, D.S., and DEWITT, D.S. (1989). Systemic hemodynamic and organ blood flow response to traumatic brain injury in rats. J. Neurotrauma 6, 211.
50. ZHANG, Z.G., CHOPP, M., BAILEY, F., and MALINSKI, T. (1995). Nitric oxide changes in the rat brain after transient middle cerebral artery occlusion. J. Neurol. Sci. 128, 22-27.