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Volumn 23, Issue 1, 2005, Pages 79-88

HIF-1α-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart

Author keywords

Erythropoietin; Erythropoietin receptor; Heat stress; Heme oxygenase 1; Hypoxia inducible factor 1 ; Vascular endothelial growth factor

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; VASCULOTROPIN; HIF1A PROTEIN, RAT; VASCULOTROPIN A;

EID: 33645795743     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00279.2004     Document Type: Article
Times cited : (112)

References (58)
  • 1
    • 0037040343 scopus 로고    scopus 로고
    • Mitochondrial PKC-ε and MAPK form signaling modules in the murine heart: Enhanced mitochondrial PKC-ε-MAPK interactions and differential MAPK activation in PKC-ε-induced cardio-protection
    • Baines CP, Zhang J, Wang GW, Zheng YT, Xiu JX, Cardwell EM, Bolli R, and Ping P. Mitochondrial PKC-ε and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKC-ε-MAPK interactions and differential MAPK activation in PKC-ε-induced cardio-protection. Circ Res 90: 390-397, 2002.
    • (2002) Circ Res , vol.90 , pp. 390-397
    • Baines, C.P.1    Zhang, J.2    Wang, G.W.3    Zheng, Y.T.4    Xiu, J.X.5    Cardwell, E.M.6    Bolli, R.7    Ping, P.8
  • 2
    • 0038163900 scopus 로고    scopus 로고
    • Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
    • Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, Lu H, Zweier JL, and Semenza GL. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation 108: 79-85, 2003.
    • (2003) Circulation , vol.108 , pp. 79-85
    • Cai, Z.1    Manalo, D.J.2    Wei, G.3    Rodriguez, E.R.4    Fox-Talbot, K.5    Lu, H.6    Zweier, J.L.7    Semenza, G.L.8
  • 3
    • 2442587705 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury
    • Cai Z and Semenza GL. Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury. Circulation 109: 2050-2053, 2004.
    • (2004) Circulation , vol.109 , pp. 2050-2053
    • Cai, Z.1    Semenza, G.L.2
  • 5
    • 0142154635 scopus 로고    scopus 로고
    • Oxygen-dependent and -independent regulation of HIF-1α
    • Chun YS, Kim MS, and Park JW. Oxygen-dependent and -independent regulation of HIF-1α. J Korean Med Sci 17: 581-588, 2002.
    • (2002) J Korean Med Sci , vol.17 , pp. 581-588
    • Chun, Y.S.1    Kim, M.S.2    Park, J.W.3
  • 6
    • 0011743689 scopus 로고    scopus 로고
    • Heat acclimation improves cardiac contractility and ischemic tolerance. Is acclimation memorized?
    • Cohen O, Stern M, and Horowitz M. Heat acclimation improves cardiac contractility and ischemic tolerance. Is acclimation memorized? (Abstract.) J Mol Cell Cardiol 33: A22, 2001.
    • (2001) (Abstract.) J Mol Cell Cardiol , vol.33
    • Cohen, O.1    Stern, M.2    Horowitz, M.3
  • 8
    • 0033027778 scopus 로고    scopus 로고
    • Does low thyroid hormone level switch on heat acclimation-induced changes in cardiac mechanical performance?
    • Eynan M, Palmon A, Hasin Y, and Horowitz M. Does low thyroid hormone level switch on heat acclimation-induced changes in cardiac mechanical performance? Am J Physiol Regul Integr Comp Physiol 276: R550-R558, 1999.
    • (1999) Am J Physiol Regul Integr Comp Physiol , vol.276
    • Eynan, M.1    Palmon, A.2    Hasin, Y.3    Horowitz, M.4
  • 10
    • 2442693041 scopus 로고    scopus 로고
    • Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression
    • Fandrey J. Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression. Am J Physiol Regul Integr Comp Physiol 286: R977-R988, 2004.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286
    • Fandrey, J.1
  • 11
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2
    • Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, and Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2. Cancer Res 59: 3915-3918, 1999.
    • (1999) Cancer Res , vol.59 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3    Pak, B.4    Ferreira, G.5    Semenza, G.L.6
  • 12
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, and Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277: 38205-38211, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 13
    • 0033380593 scopus 로고    scopus 로고
    • Heat acclimation alters endothelial nitric oxide activity in the splanchnic vascular bed
    • Hadad W and Horowitz M. Heat acclimation alters endothelial nitric oxide activity in the splanchnic vascular bed. J Therm Biol 24: 403-408, 1999.
    • (1999) J Therm Biol , vol.24 , pp. 403-408
    • Hadad, W.1    Horowitz, M.2
  • 14
    • 0035991511 scopus 로고    scopus 로고
    • Recombinant human interleukin (IL)-1β-mediated regulation of hypoxia-inducible factor-1α (HIF-1α) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism
    • Haddad JJ. Recombinant human interleukin (IL)-1β-mediated regulation of hypoxia-inducible factor-1α (HIF-1α) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism. Eur Cytokine Netw 13: 250-260, 2002.
    • (2002) Eur Cytokine Netw , vol.13 , pp. 250-260
    • Haddad, J.J.1
  • 15
    • 0017103109 scopus 로고
    • Acclimatization of rats to mild heat: Body water distribution and adaptability of submaxillary salivary gland
    • Horowitz M. Acclimatization of rats to mild heat: body water distribution and adaptability of submaxillary salivary gland. Pflügers Arch 366: 173-176, 1976.
    • (1976) Pflügers Arch , vol.366 , pp. 173-176
    • Horowitz, M.1
  • 16
    • 0036180660 scopus 로고    scopus 로고
    • From molecular and cellular to integrative heat defense during exposure to chronic heat
    • Horowitz M. From molecular and cellular to integrative heat defense during exposure to chronic heat. Comp Biochem Physiol A 131: 475-483, 2002.
    • (2002) Comp Biochem Physiol A , vol.131 , pp. 475-483
    • Horowitz, M.1
  • 17
    • 0345731130 scopus 로고    scopus 로고
    • Matching the heart to heat-induced circulatory load: Heat-acclimatory responses
    • Horowitz M. Matching the heart to heat-induced circulatory load: heat-acclimatory responses. News Physiol Sci 18: 215-221, 2003.
    • (2003) News Physiol Sci , vol.18 , pp. 215-221
    • Horowitz, M.1
  • 18
    • 0027408319 scopus 로고
    • Central and peripheral contributions to control of heart rate during heat acclimation
    • Horowitz M and Meiri U. Central and peripheral contributions to control of heart rate during heat acclimation. Pflügers Arch 422: 386-392, 1993.
    • (1993) Pflügers Arch , vol.422 , pp. 386-392
    • Horowitz, M.1    Meiri, U.2
  • 19
    • 0020686272 scopus 로고
    • Interrelationships between heat acclimation and salivary cooling mechanism in conscious rats
    • Horowitz M, Argov D, and Mizrahi R. Interrelationships between heat acclimation and salivary cooling mechanism in conscious rats. Comp Biochem Physiol A 74: 945-949, 1983.
    • (1983) Comp Biochem Physiol A , vol.74 , pp. 945-949
    • Horowitz, M.1    Argov, D.2    Mizrahi, R.3
  • 20
    • 4644309905 scopus 로고    scopus 로고
    • Stress related genomic responses during the course of heat acclimation and its association with ischemic/reperfusion cross-tolerance
    • Horowitz M, Eli-Berchoer L, Wapinski I, Friedman N, and Kodesh E. Stress related genomic responses during the course of heat acclimation and its association with ischemic/reperfusion cross-tolerance. J Appl Physiol 97: 1496-1507, 2004.
    • (2004) J Appl Physiol , vol.97 , pp. 1496-1507
    • Horowitz, M.1    Eli-Berchoer, L.2    Wapinski, I.3    Friedman, N.4    Kodesh, E.5
  • 22
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang BH, Rue E, Wang GL, Roe R, and Semenza GL. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271: 17771-17778, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 23
    • 1642453685 scopus 로고    scopus 로고
    • Nitric oxide induces hypoxiainducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
    • Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, and Hirota K. Nitric oxide induces hypoxiainducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem 279: 2550-2558, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 2550-2558
    • Kasuno, K.1    Takabuchi, S.2    Fukuda, K.3    Kizaka-Kondoh, S.4    Yodoi, J.5    Adachi, T.6    Semenza, G.L.7    Hirota, K.8
  • 24
    • 0037088576 scopus 로고    scopus 로고
    • Heat induction of the unphosphorylated form of hypoxia-inducible factor-1α is dependent on heat shock protein-90 activity
    • Katschinski DM, Le L, Heinrich D, Wagner KF, Hofer T, Schindler SG, and Wenger RH. Heat induction of the unphosphorylated form of hypoxia-inducible factor-1α is dependent on heat shock protein-90 activity. J Biol Chem 277: 9262-9267, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 9262-9267
    • Katschinski, D.M.1    Le, L.2    Heinrich, D.3    Wagner, K.F.4    Hofer, T.5    Schindler, S.G.6    Wenger, R.H.7
  • 25
    • 0033975850 scopus 로고    scopus 로고
    • Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
    • Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, Esumi H. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 95: 189-197, 2000.
    • (2000) Blood , vol.95 , pp. 189-197
    • Kimura, H.1    Weisz, A.2    Kurashima, Y.3    Hashimoto, K.4    Ogura, T.5    D'Acquisto, F.6    Addeo, R.7    Makuuchi, M.8    Esumi, H.9
  • 26
    • 0344874751 scopus 로고    scopus 로고
    • Cell typespecific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
    • Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, and Semenza GL. Cell typespecific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 93: 1074-1078, 2003.
    • (2003) Circ Res , vol.93 , pp. 1074-1078
    • Kelly, B.D.1    Hackett, S.F.2    Hirota, K.3    Oshima, Y.4    Cai, Z.5    Berg-Dixon, S.6    Rowan, A.7    Yan, Z.8    Campochiaro, P.A.9    Semenza, G.L.10
  • 27
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 28
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC, and Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21: 3995-4004, 2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 29
    • 0027228264 scopus 로고
    • Heat acclimation improves cardiac mechanics and metabolic performance during ischemia and reperfusion
    • Levi E, Vivi A, Hasin Y, Tassini M, Navon G, and Horowitz M. Heat acclimation improves cardiac mechanics and metabolic performance during ischemia and reperfusion. J Appl Physiol 75: 833-839, 1993.
    • (1993) J Appl Physiol , vol.75 , pp. 833-839
    • Levi, E.1    Vivi, A.2    Hasin, Y.3    Tassini, M.4    Navon, G.5    Horowitz, M.6
  • 30
    • 0033043766 scopus 로고    scopus 로고
    • Heat acclimation increases basal HSP72 level and alters its production dynamics during heat stress
    • Maloyan A, Palmon A, and Horowitz M. Heat acclimation increases basal HSP72 level and alters its production dynamics during heat stress. Am J Physiol Regul Integr Comp Physiol 276: R1506-R1515, 1999.
    • (1999) Am J Physiol Regul Integr Comp Physiol , vol.276
    • Maloyan, A.1    Palmon, A.2    Horowitz, M.3
  • 32
    • 0035985916 scopus 로고    scopus 로고
    • β-Adrenergic signaling and thyroid hormones affect HSP72 expression during heat acclimation
    • Maloyan A and Horowitz M. β-Adrenergic signaling and thyroid hormones affect HSP72 expression during heat acclimation. J Appl Physiol 93: 107-115, 2002.
    • (2002) J Appl Physiol , vol.93 , pp. 107-115
    • Maloyan, A.1    Horowitz, M.2
  • 33
    • 0042469448 scopus 로고    scopus 로고
    • Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases
    • Metzen E, Zhou J, Jelkmann W, Fandrey J, Brune B. Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases. Mol Biol Cell 14: 3470-3481, 2003.
    • (2003) Mol Biol Cell , vol.14 , pp. 3470-3481
    • Metzen, E.1    Zhou, J.2    Jelkmann, W.3    Fandrey, J.4    Brune, B.5
  • 34
    • 0035983247 scopus 로고    scopus 로고
    • Heme oxygenase-1: The "emerging molecule" has arrived
    • Morse D and Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am J Respir Cell Mol Biol 27: 8-16, 2002.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 8-16
    • Morse, D.1    Choi, A.M.2
  • 36
    • 0037073695 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible factor-1 by transcriptional and translational mechanisms
    • Page EL, Robitaille GA, Pouysse'gur J, and Richard DE. Induction of hypoxia-inducible factor-1 by transcriptional and translational mechanisms. J Biol Chem 277: 48403-48409, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 48403-48409
    • Page, E.L.1    Robitaille, G.A.2    Pouysse'gur, J.3    Richard, D.E.4
  • 37
    • 0033673457 scopus 로고    scopus 로고
    • Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: Redox-dependent effect of nitrogen oxides
    • Palmer LA, Gaston B, and Johns RA. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol Pharmacol 58: 1197-1203, 2000.
    • (2000) Mol Pharmacol , vol.58 , pp. 1197-1203
    • Palmer, L.A.1    Gaston, B.2    Johns, R.A.3
  • 38
    • 0038788826 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1α): Role of cytoplasmic trapping of HIF-2α
    • Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, and Johnson RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1α): role of cytoplasmic trapping of HIF-2α. Mol Cell Biol 23: 4959-4971, 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 4959-4971
    • Park, S.K.1    Dadak, A.M.2    Haase, V.H.3    Fontana, L.4    Giaccia, A.J.5    Johnson, R.S.6
  • 39
    • 3142533071 scopus 로고    scopus 로고
    • Changes in gene expression associated with acclimation to constant temperatures and fluctuating daily temperatures in an annual killifish Austrofundulus limnaeus
    • Podrabsky JE and Somero GN. Changes in gene expression associated with acclimation to constant temperatures and fluctuating daily temperatures in an annual killifish Austrofundulus limnaeus. J Exp Biol 207: 2237-2254, 2004.
    • (2004) J Exp Biol , vol.207 , pp. 2237-2254
    • Podrabsky, J.E.1    Somero, G.N.2
  • 40
    • 0036018452 scopus 로고    scopus 로고
    • Climate variations and the physiological basis of temperature-dependent biogeography: Systemic to molecular hierarchy of thermal tolerance in animals
    • Portner HO. Climate variations and the physiological basis of temperature-dependent biogeography: systemic to molecular hierarchy of thermal tolerance in animals. Comp Biochem Physiol A 132: 739-761, 2002.
    • (2002) Comp Biochem Physiol A , vol.132 , pp. 739-761
    • Portner, H.O.1
  • 41
    • 0030937718 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit
    • Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, and Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit. J Biol Chem 272: 11205-11214, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 11205-11214
    • Pugh, C.W.1    O'Rourke, J.F.2    Nagao, M.3    Gleadle, J.M.4    Ratcliffe, P.J.5
  • 42
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells
    • Richard DE, Berra E, and Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells. J Biol Chem 275: 26765-26771, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 43
    • 0001564716 scopus 로고    scopus 로고
    • Thermoregulatory responses to acute exercise-heat stress and heat acclimation
    • Bethesda, MD: Am Physiol Soc, sect. 4
    • Sawka MN, Wenger CB, and Pandolf KB. Thermoregulatory responses to acute exercise-heat stress and heat acclimation. In: Handbook of Physiology. Environmental Physiology. Bethesda, MD: Am Physiol Soc, 1996, sect. 4, vol. I, p. 157-187.
    • (1996) Handbook of Physiology. Environmental Physiology , vol.1 , pp. 157-187
    • Sawka, M.N.1    Wenger, C.B.2    Pandolf, K.B.3
  • 44
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology 19: 176-182, 2004.
    • (2004) Physiology , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 45
    • 3042829493 scopus 로고    scopus 로고
    • Hypoxic stress tolerance of the blind subterranean mole rat: Expression of erythropoietin and hypoxia-inducible factor 1α
    • Shams I, Avivi A, and Nevo E. Hypoxic stress tolerance of the blind subterranean mole rat: expression of erythropoietin and hypoxia-inducible factor 1α. Proc Natl Acad Sci USA 101: 9698-9703, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9698-9703
    • Shams, I.1    Avivi, A.2    Nevo, E.3
  • 50
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, and Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 277: 27975-27981, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van Obberghen, E.5
  • 51
    • 0036320934 scopus 로고    scopus 로고
    • 2- regulated gene expression
    • 2- regulated gene expression. FASEB J 16: 1152-1162, 2002.
    • (2002) FASEB J , vol.16 , pp. 1152-1162
    • Wenger, R.H.1
  • 52
    • 6344225691 scopus 로고    scopus 로고
    • Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury
    • Wright GL, Hanlon P, Amin K, Steenbergen C, Murphy E, and Arcasoy MO. Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury. FASEB J 18: 1031-1033, 2004.
    • (2004) FASEB J , vol.18 , pp. 1031-1033
    • Wright, G.L.1    Hanlon, P.2    Amin, K.3    Steenbergen, C.4    Murphy, E.5    Arcasoy, M.O.6
  • 54
    • 0032169214 scopus 로고    scopus 로고
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1/ARNT
    • Zelzer E, Levy Y, Kahana C, Shilo B, Rubinstein M, and Cohen B. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1/ARNT. EMBO J 17: 5085-5094, 1998.
    • (1998) EMBO J , vol.17 , pp. 5085-5094
    • Zelzer, E.1    Levy, Y.2    Kahana, C.3    Shilo, B.4    Rubinstein, M.5    Cohen, B.6
  • 56
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, and Semenza GL. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541-1545, 2000.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 58
    • 1842691021 scopus 로고    scopus 로고
    • PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1α from pVHL-independent degradation
    • Zhou J, Schmid T, Frank R, and Brune B. PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1α from pVHL-independent degradation. J Biol Chem 279: 13506-13513, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 13506-13513
    • Zhou, J.1    Schmid, T.2    Frank, R.3    Brune, B.4


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