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Volumn 305, Issue 12, 2013, Pages

Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice

Author keywords

20 hydroxyeicosatetraenoic acid; Autoregulation; Canonical transient receptor potential; Cerebral blood flow; Largeconductance Ca2+ activated K channels; Potassium channels

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; 20 HYDROXYICOSATETRAENOIC ACID; ANGIOTENSIN II; CALCIUM ION; CYTOCHROME P450; HET 0016; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; OXYGENASE INHIBITOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; UNCLASSIFIED DRUG;

EID: 84890381078     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00377.2013     Document Type: Article
Times cited : (83)

References (70)
  • 1
    • 84868214516 scopus 로고    scopus 로고
    • An elevation in physical coupling of type 1 inositol 1,4,5- trisphosphate (IP3) receptors to transient receptor potential 3 (TRPC3) channels constricts mesenteric arteries in genetic hypertension
    • Adebiyi A, Thomas-Gatewood CM, Leo MD, Kidd MW, Neeb ZP, Jaggar JH. An elevation in physical coupling of type 1 inositol 1,4,5- trisphosphate (IP3) receptors to transient receptor potential 3 (TRPC3) channels constricts mesenteric arteries in genetic hypertension. Hypertension 60: 1213-1219, 2012.
    • (2012) Hypertension , vol.60 , pp. 1213-1219
    • Adebiyi, A.1    Thomas-Gatewood, C.M.2    Leo, M.D.3    Kidd, M.W.4    Neeb, Z.P.5    Jaggar, J.H.6
  • 3
    • 77953022076 scopus 로고    scopus 로고
    • Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility
    • Adebiyi A, Zhao G, Narayanan D, Thomas-Gatewood CM, Bannister JP, Jaggar JH. Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility. Circ Res 106: 1603-1612.
    • Circ Res , vol.106 , pp. 1603-1612
    • Adebiyi, A.1    Zhao, G.2    Narayanan, D.3    Thomas-Gatewood, C.M.4    Bannister, J.P.5    Jaggar, J.H.6
  • 4
    • 33746589056 scopus 로고    scopus 로고
    • Kv2 channels oppose myogenic constriction of rat cerebral arteries
    • Amberg GC, Santana LF. Kv2 channels oppose myogenic constriction of rat cerebral arteries. Am J Physiol Cell Physiol 291: C348-C356, 2006.
    • (2006) Am J Physiol Cell Physiol , vol.291
    • Amberg, G.C.1    Santana, L.F.2
  • 6
    • 84868156163 scopus 로고    scopus 로고
    • Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2_ events, and IKCa channels, reducing arteriolar tone
    • Bagher P, Beleznai T, Kansui Y, Mitchell R, Garland CJ, Dora KA. Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2_ events, and IKCa channels, reducing arteriolar tone. Proc Natl Acad Sci USA 109: 18174-18179, 2012.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 18174-18179
    • Bagher, P.1    Beleznai, T.2    Kansui, Y.3    Mitchell, R.4    Garland, C.J.5    Dora, K.A.6
  • 8
    • 44349103219 scopus 로고    scopus 로고
    • Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow
    • Brayden JE, Earley S, Nelson MT, Reading S. Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow. Clin Exp Pharmacol Physiol 35: 1116-1120, 2008.
    • (2008) Clin Exp Pharmacol Physiol , vol.35 , pp. 1116-1120
    • Brayden, J.E.1    Earley, S.2    Nelson, M.T.3    Reading, S.4
  • 9
    • 0026575435 scopus 로고
    • Regulation of arterial tone by activation of calcium-dependent potassium channels
    • Brayden JE, Nelson MT. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science 256: 532-535, 1992.
    • (1992) Science , vol.256 , pp. 532-535
    • Brayden, J.E.1    Nelson, M.T.2
  • 11
    • 79960883495 scopus 로고    scopus 로고
    • Alzheimer-like' pathology in a murine model of arterial hypertension
    • Carnevale D, Lembo G. 'Alzheimer-like' pathology in a murine model of arterial hypertension. Biochem Soc Trans 39: 939-944, 2011.
    • (2011) Biochem Soc Trans , vol.39 , pp. 939-944
    • Carnevale, D.1    Lembo, G.2
  • 13
    • 84865822723 scopus 로고    scopus 로고
    • Hypertension induces brain beta-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature
    • Carnevale D, Mascio G, D'Andrea I, Fardella V, Bell RD, Branchi I, Pallante F, Zlokovic B, Yan SS, Lembo G. Hypertension induces brain beta-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension 60: 188-197, 2012.
    • (2012) Hypertension , vol.60 , pp. 188-197
    • Carnevale, D.1    Mascio, G.2    D'Andrea, I.3    Fardella, V.4    Bell, R.D.5    Branchi, I.6    Pallante, F.7    Zlokovic, B.8    Yan, S.S.9    Lembo, G.10
  • 15
    • 57349115247 scopus 로고    scopus 로고
    • Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats
    • Dunn KM, Renic M, Flasch AK, Harder DR, Falck J, Roman RJ. Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 295: H2455-H2465, 2008.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Dunn, K.M.1    Renic, M.2    Flasch, A.K.3    Harder, D.R.4    Falck, J.5    Roman, R.J.6
  • 16
    • 77954926657 scopus 로고    scopus 로고
    • Transient receptor potential channels and vascular function
    • Earley S, Brayden JE. Transient receptor potential channels and vascular function. Clin Sci (Lond) 119: 19-36, 2010.
    • (2010) Clin Sci (Lond) , vol.119 , pp. 19-36
    • Earley, S.1    Brayden, J.E.2
  • 17
    • 7244239194 scopus 로고    scopus 로고
    • Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries
    • Earley S, Waldron BJ, Brayden JE. Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Circ Res 95: 922-929, 2004.
    • (2004) Circ Res , vol.95 , pp. 922-929
    • Earley, S.1    Waldron, B.J.2    Brayden, J.E.3
  • 18
    • 0025097985 scopus 로고
    • Regulation of large cerebral arteries and cerebral microvascular pressure
    • Faraci FM, Heistad DD. Regulation of large cerebral arteries and cerebral microvascular pressure. Circ Res 66: 8-17, 1990.
    • (1990) Circ Res , vol.66 , pp. 8-17
    • Faraci, F.M.1    Heistad, D.D.2
  • 20
    • 84878970264 scopus 로고    scopus 로고
    • Caveolin and caveolae in age associated cardiovascular disease
    • Fridolfsson HN, Patel HH. Caveolin and caveolae in age associated cardiovascular disease. Journal of geriatric cardiology 10: 66-74, 2013.
    • (2013) Journal of Geriatric Cardiology , vol.10 , pp. 66-74
    • Fridolfsson, H.N.1    Patel, H.H.2
  • 22
    • 38149009487 scopus 로고    scopus 로고
    • Role of 20-HETE in the hypoxia-induced activation of Ca2_-activated K_ channel currents in rat cerebral arterial muscle cells
    • Gebremedhin D, Yamaura K, Harder DR. Role of 20-HETE in the hypoxia-induced activation of Ca2_-activated K_ channel currents in rat cerebral arterial muscle cells. Am J Physiol Heart Circ Physiol 294: H107-H120, 2008.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Gebremedhin, D.1    Yamaura, K.2    Harder, D.R.3
  • 23
    • 0033192760 scopus 로고    scopus 로고
    • Increased Ca2_ sensitivity as a key mechanism of PKC-induced constriction in pressurized cerebral arteries
    • Gokina NI, Knot HJ, Nelson MT, Osol G. Increased Ca2_ sensitivity as a key mechanism of PKC-induced constriction in pressurized cerebral arteries. Am J Physiol Heart Circ Physiol 277: H1178-H1188, 1999.
    • (1999) Am J Physiol Heart Circ Physiol , vol.277
    • Gokina, N.I.1    Knot, H.J.2    Nelson, M.T.3    Osol, G.4
  • 25
    • 0035665315 scopus 로고    scopus 로고
    • Blood pressure and dementia in persons 75_ years old: 3-year follow-up results from the Kungsholmen Project
    • Guo Z, Qiu C, Viitanen M, Fastbom J, Winblad B, Fratiglioni L. Blood pressure and dementia in persons 75_ years old: 3-year follow-up results from the Kungsholmen Project. J Alzheimers Dis 3: 585-591, 2001.
    • (2001) J Alzheimers Dis , vol.3 , pp. 585-591
    • Guo, Z.1    Qiu, C.2    Viitanen, M.3    Fastbom, J.4    Winblad, B.5    Fratiglioni, L.6
  • 26
    • 79955787397 scopus 로고    scopus 로고
    • Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow
    • Harder DR, Narayanan J, Gebremedhin D. Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow. Am J Physiol Heart Circ Physiol 300: H1557-H1565, 2011.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300
    • Harder, D.R.1    Narayanan, J.2    Gebremedhin, D.3
  • 27
    • 0021240196 scopus 로고
    • Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats
    • Harper SL, Bohlen HG. Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats. Hypertension 6: 408-419, 1984.
    • (1984) Hypertension , vol.6 , pp. 408-419
    • Harper, S.L.1    Bohlen, H.G.2
  • 28
    • 84864389192 scopus 로고    scopus 로고
    • Age-related changes in the contractile and passive arterial properties of murine mesenteric small arteries are altered by caveolin-1 knockout
    • Hausman N, Martin J, Taggart MJ, Austin C. Age-related changes in the contractile and passive arterial properties of murine mesenteric small arteries are altered by caveolin-1 knockout. J Cell Mol Med 16: 1720-1730, 2012.
    • (2012) J Cell Mol Med , vol.16 , pp. 1720-1730
    • Hausman, N.1    Martin, J.2    Taggart, M.J.3    Austin, C.4
  • 29
    • 62949149460 scopus 로고    scopus 로고
    • Threats to the mind: Aging, amyloid, and hypertension
    • Iadecola C, Park L, Capone C. Threats to the mind: aging, amyloid, and hypertension. Stroke 40: S40-S44, 2009.
    • (2009) Stroke , vol.40
    • Iadecola, C.1    Park, L.2    Capone, C.3
  • 30
    • 67650257887 scopus 로고    scopus 로고
    • Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways
    • Inoue R, Jensen LJ, Jian Z, Shi J, Hai L, Lurie AI, Henriksen FH, Salomonsson M, Morita H, Kawarabayashi Y, Mori M, Mori Y, Ito Y. Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways. Circ Res 104: 1399-1409, 2009.
    • (2009) Circ Res , vol.104 , pp. 1399-1409
    • Inoue, R.1    Jensen, L.J.2    Jian, Z.3    Shi, J.4    Hai, L.5    Lurie, A.I.6    Henriksen, F.H.7    Salomonsson, M.8    Morita, H.9    Kawarabayashi, Y.10    Mori, M.11    Mori, Y.12    Ito, Y.13
  • 32
    • 68249160692 scopus 로고    scopus 로고
    • Aging and muscle fiber type alter K_ channel contributions to the myogenic response in skeletal muscle arterioles
    • Kang LS, Kim S, Dominguez JM, 2nd Sindler AL, Dick GM, Muller- Delp JM. Aging and muscle fiber type alter K_ channel contributions to the myogenic response in skeletal muscle arterioles. J Appl Physiol 107: 389-398, 2009.
    • (2009) J Appl Physiol , vol.107 , pp. 389-398
    • Kang, L.S.1    Kim, S.2    Dominguez II, J.M.3    Sindler, A.L.4    Dick, G.M.5    Muller-Delp, J.M.6
  • 34
    • 0032055663 scopus 로고    scopus 로고
    • Regulation of arterial diameter and wall [Ca2_] in cerebral arteries of rat by membrane potential and intravascular pressure
    • Knot HJ, Nelson MT. Regulation of arterial diameter and wall [Ca2_] in cerebral arteries of rat by membrane potential and intravascular pressure. J Physiol 508: 199-209, 1998.
    • (1998) J Physiol , vol.508 , pp. 199-209
    • Knot, H.J.1    Nelson, M.T.2
  • 35
    • 0028891825 scopus 로고
    • Regulation of membrane potential and diameter by voltage-dependent K_ channels in rabbit myogenic cerebral arteries
    • Knot HJ, Nelson MT. Regulation of membrane potential and diameter by voltage-dependent K_ channels in rabbit myogenic cerebral arteries. Am J Physiol Heart Circ Physiol 269: H348-H355, 1995.
    • (1995) Am J Physiol Heart Circ Physiol , vol.269
    • Knot, H.J.1    Nelson, M.T.2
  • 39
    • 0030774838 scopus 로고    scopus 로고
    • 20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C
    • Lange A, Gebremedhin D, Narayanan J, Harder D. 20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C. J Biol Chem 272: 27345-27352, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 27345-27352
    • Lange, A.1    Gebremedhin, D.2    Narayanan, J.3    Harder, D.4
  • 40
    • 84884637937 scopus 로고    scopus 로고
    • TRPV channels' role in osmotransduction and mechanotransduction
    • Liedtke W. TRPV channels' role in osmotransduction and mechanotransduction. Handb Exp Pharmacol: 473-487, 2007.
    • (2007) Handb Exp Pharmacol , pp. 473-487
    • Liedtke, W.1
  • 45
    • 84869134233 scopus 로고    scopus 로고
    • Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: A cross-sectional study
    • Maillard P, Seshadri S, Beiser A, Himali JJ, Au R, Fletcher E, Carmichael O, Wolf PA, DeCarli C. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. Lancet Neurol 11: 1039-1047, 2012.
    • (2012) Lancet Neurol , vol.11 , pp. 1039-1047
    • Maillard, P.1    Seshadri, S.2    Beiser, A.3    Himali, J.J.4    Au, R.5    Fletcher, E.6    Carmichael, O.7    Wolf, P.A.8    Decarli, C.9
  • 46
    • 0034655330 scopus 로고    scopus 로고
    • Selective measurement of endothelial or smooth muscle [Ca2_]i in pressurized/perfused cerebral arteries with fura-2
    • Marrelli SP. Selective measurement of endothelial or smooth muscle [Ca2_]i in pressurized/perfused cerebral arteries with fura-2. J Neurosci Methods 97: 145-155, 2000.
    • (2000) J Neurosci Methods , vol.97 , pp. 145-155
    • Marrelli, S.P.1
  • 49
    • 0037379084 scopus 로고    scopus 로고
    • Cerebral artery responses to pressure and flow in uremic hypertensive and spontaneously hypertensive rats
    • New DI, Chesser AM, Thuraisingham RC, Yaqoob MM. Cerebral artery responses to pressure and flow in uremic hypertensive and spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 284: H1212-H1216, 2003.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284
    • New, D.I.1    Chesser, A.M.2    Thuraisingham, R.C.3    Yaqoob, M.M.4
  • 50
    • 0036954971 scopus 로고    scopus 로고
    • 20-Hydroxyeicosatetraenoic acid potentiates stretch-induced contraction of canine basilar artery via PKC alpha-mediated inhibition of KCa channel
    • Obara K, Koide M, Nakayama K. 20-Hydroxyeicosatetraenoic acid potentiates stretch-induced contraction of canine basilar artery via PKC alpha-mediated inhibition of KCa channel. Br J Pharmacol 137: 1362-1370, 2002.
    • (2002) Br J Pharmacol , vol.137 , pp. 1362-1370
    • Obara, K.1    Koide, M.2    Nakayama, K.3
  • 51
    • 0022149107 scopus 로고
    • Myogenic properties of cerebral blood vessels from normotensive and hypertensive rats
    • Osol G, Halpern W. Myogenic properties of cerebral blood vessels from normotensive and hypertensive rats. Am J Physiol Heart Circ Physiol 249: H914-H921, 1985.
    • (1985) Am J Physiol Heart Circ Physiol , vol.249
    • Osol, G.1    Halpern, W.2
  • 52
    • 0033921749 scopus 로고    scopus 로고
    • Potassium channels modulate cerebral autoregulation during acute hypertension
    • Paterno R, Heistad DD, Faraci FM. Potassium channels modulate cerebral autoregulation during acute hypertension. Am J Physiol Heart Circ Physiol 278: H2003-H2007, 2000.
    • (2000) Am J Physiol Heart Circ Physiol , vol.278
    • Paterno, R.1    Heistad, D.D.2    Faraci, F.M.3
  • 55
    • 82455192889 scopus 로고    scopus 로고
    • Role of caveolin-1 in endothelial BKCa channel regulation of vasoreactivity
    • Riddle MA, Hughes JM, Walker BR. Role of caveolin-1 in endothelial BKCa channel regulation of vasoreactivity. Am J Physiol Cell Physiol 301: C1404-C1414, 2011.
    • (2011) Am J Physiol Cell Physiol , vol.301
    • Riddle, M.A.1    Hughes, J.M.2    Walker, B.R.3
  • 57
    • 33750802650 scopus 로고    scopus 로고
    • A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
    • Spassova MA, Hewavitharana T, Xu W, Soboloff J, Gill DL. A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci USA 103: 16586-16591, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16586-16591
    • Spassova, M.A.1    Hewavitharana, T.2    Xu, W.3    Soboloff, J.4    Gill, D.L.5
  • 58
    • 0016688310 scopus 로고
    • Upper limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon
    • Strandgaard S, Jones JV, MacKenzie ET, Harper AM. Upper limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circ Res 37: 164-167, 1975.
    • (1975) Circ Res , vol.37 , pp. 164-167
    • Strandgaard, S.1    Jones, J.V.2    Mackenzie, E.T.3    Harper, A.M.4
  • 59
    • 80053573247 scopus 로고    scopus 로고
    • Isolated human and rat cerebral arteries constrict to increases in flow: Role of 20-HETE and TP receptors
    • Toth P, Rozsa B, Springo Z, Doczi T, Koller A. Isolated human and rat cerebral arteries constrict to increases in flow: role of 20-HETE and TP receptors. J Cereb Blood Flow Metab 31: 2096-2105, 2011.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 2096-2105
    • Toth, P.1    Rozsa, B.2    Springo, Z.3    Doczi, T.4    Koller, A.5
  • 61
    • 84861087862 scopus 로고    scopus 로고
    • The emerging role of IGF-1 deficiency in cardiovascular aging: Recent advances
    • Ungvari Z, Csiszar A. The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances. J Gerontol A Biol Sci Med Sci 67: 599-610, 2012.
    • (2012) J Gerontol a Biol Sci Med Sci , vol.67 , pp. 599-610
    • Ungvari, Z.1    Csiszar, A.2
  • 62
    • 0033695617 scopus 로고    scopus 로고
    • Endothelin and PGH2/TXA2 enhances myogenic constricton in hypertension by increasing Ca2_ sensitivity of arteriolar smooth muscle
    • Ungvari Z, Koller A. Endothelin and PGH2/TXA2 enhances myogenic constricton in hypertension by increasing Ca2_ sensitivity of arteriolar smooth muscle. Hypertension 36: 856-861, 2000.
    • (2000) Hypertension , vol.36 , pp. 856-861
    • Ungvari, Z.1    Koller, A.2
  • 63
    • 0034972615 scopus 로고    scopus 로고
    • Selected contribution: NO released to flow reduces myogenic tone of skeletal muscle arterioles by decreasing smooth muscle Ca2_ sensitivity
    • Ungvari Z, Koller A. Selected contribution: NO released to flow reduces myogenic tone of skeletal muscle arterioles by decreasing smooth muscle Ca2_ sensitivity. J Appl Physiol 91: 522-527, 2001.
    • (2001) J Appl Physiol , vol.91 , pp. 522-527
    • Ungvari, Z.1    Koller, A.2
  • 64
    • 0032853968 scopus 로고    scopus 로고
    • Fluoxetine dilates isolated small cerebral arteries of rats and attenuates constrictions to serotonin, norepinephrine, and a voltage-dependent Ca2_ channel opener
    • Ungvari Z, Pacher P, Kecskemeti V, Koller A. Fluoxetine dilates isolated small cerebral arteries of rats and attenuates constrictions to serotonin, norepinephrine, and a voltage-dependent Ca2_ channel opener. Stroke 30: 1949-1954, 1999.
    • (1999) Stroke , vol.30 , pp. 1949-1954
    • Ungvari, Z.1    Pacher, P.2    Kecskemeti, V.3    Koller, A.4
  • 66
    • 0037155047 scopus 로고    scopus 로고
    • Transient receptor potential channels regulate myogenic tone of resistance arteries
    • Welsh DG, Morielli AD, Nelson MT, Brayden JE. Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 90: 248-250, 2002.
    • (2002) Circ Res , vol.90 , pp. 248-250
    • Welsh, D.G.1    Morielli, A.D.2    Nelson, M.T.3    Brayden, J.E.4
  • 69
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57: 178-201, 2008.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


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