Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 44, 2012, Pages 18174-18179

  Bagher, Pooneh ^a   Beleznai, Timea ^a   Kansui, Yasuo ^a,b   Mitchell, Ray ^a   Garland, Christopher J ^a   Dora, Kim A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Cremaster arterioles; Endothelial cell calcium; Mesenteric arteries

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; APAMIN; CALCIUM; CALCIUM CHANNEL; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; VANILLOID RECEPTOR 4;

ANIMAL CELL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENDOTHELIUM; ENDOTHELIUM CELL; INTESTINE PRESSURE; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ANIMALS; ARTERIOLES; CALCIUM; ENDOTHELIUM, VASCULAR; MUSCLE TONUS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PYRAZOLES; RATS; SULFONAMIDES; VASODILATION;

EID: 84868156163     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211946109     Document Type: Article

References (29)

1. Garland CJ, Hiley CR, Dora KA (2011) EDHF: Spreading the influence of the endothelium. Br J Pharmacol 164(3):839-852.
2. Bagher P, Segal SS (2011) Regulation of blood flow in the microcirculation: role of conducted vasodilation. Acta Physiol (Oxf) 202(3):271-284.
3. Crane GJ, Gallagher N, Dora KA, Garland CJ (2003) Small- and intermediate-conductance calcium-activated K+ channels provide different facets of endothelium-dependent hyperpolarization in rat mesenteric artery. J Physiol 553(Pt 1):183-189.
4. Brähler S, et al. (2009) Genetic deficit of SK3 and IK1 channels disrupts the endothelium- derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119(17):2323-2332.
5. Dora KA, Gallagher NT, McNeish A, Garland CJ (2008) Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries. Circ Res 102(10):1247-1255.
6. Edwards G, Dora KA, Gardener MJ, Garland CJ, Weston AH (1998) K+ is an endothelium- derived hyperpolarizing factor in rat arteries. Nature 396(6708):269-272.
7. Ledoux J, et al. (2008) Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections. Proc Natl Acad SciUSA105(28):9627-9632.
8. Duza T, Sarelius IH (2004) Increase in endothelial cell Ca(2+) in response to mouse cremaster muscle contraction. J Physiol 555(Pt 2):459-469.
9. McSherry IN, Spitaler MM, Takano H, Dora KA (2005) Endothelial cell Ca2+ increases are independent of membrane potential in pressurized rat mesenteric arteries. Cell Calcium 38(1):23-33.
10. Kansui Y, Garland CJ, Dora KA (2008) Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries. Cell Calcium 44(2):135-146.
11. Huang A, Sun D, Koller A (1993) Endothelial dysfunction augments myogenic arteriolar constriction in hypertension. Hypertension 22(6):913-921.
12. Falcone JC, Davis MJ, Meininger GA (1991) Endothelial independence of myogenic response in isolated skeletal muscle arterioles. Am J Physiol 260(1 Pt 2):H130-H135.
13. Falcone JC (1995) Endothelial cell calcium and vascular control. Med Sci Sports Exerc 27(8):1165-1169.
14. Nelson MT, et al. (1995) Relaxation of arterial smooth muscle by calcium sparks. Science 270(5236):633-637.
15. Davis MJ (2012) Perspective: Physiological role(s) of the vascular myogenic response. Microcirculation 19(2):99-114.
16. Hill MA, Trippe KM, Li QX, Meininger GA (1992) Arteriolar arcades and pressure distribution in cremaster muscle microcirculation. Microvasc Res 44(1):117-124.
17. Kotecha N, Hill MA (2005) Myogenic contraction in rat skeletal muscle arterioles: smooth muscle membrane potential and Ca(2+) signaling. Am J Physiol Heart Circ Physiol 289(4):H1326-H1334.
18. Sonkusare SK, et al. (2012) Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science 336(6081):597-601.
19. Burdyga T, Shmygol A, Eisner DA, Wray S (2003) A new technique for simultaneous and in situ measurements of Ca2+ signals in arteriolar smooth muscle and endothelial cells. Cell Calcium 34(1):27-33.
20. Ying X, Minamiya Y, Fu C, Bhattacharya J (1996) Ca2+ waves in lung capillary endothelium. Circ Res 79(4):898-908.
21. Yao X, Garland CJ (2005) Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res 97(9):853-863.
22. Saliez J, et al. (2008) Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation: Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells. Circulation 117(8):1065-1074.
23. Earley S, et al. (2009) TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. Am J Physiol Heart Circ Physiol 297(3):H1096-H1102.
24. Mendoza SA, et al. (2010) TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol 298(2):H466-H476.
25. Strotmann R, Schultz G, Plant TD (2003) Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem 278(29):26541-26549.
26. Earley S, Heppner TJ, Nelson MT, Brayden JE (2005) TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. Circ Res 97(12):1270-1279.
27. Watanabe H, et al. (2002) Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem 277(16):13569-13577.
28. Liedtke W, et al. (2000) Vanilloid receptor-related osmotically activated channel (VROAC), a candidate vertebrate osmoreceptor. Cell 103(3):525-535.
29. Iino M (1990) Biphasic Ca2+ dependence of inositol 1,4,5-trisphosphate- induced Ca release in smoothmuscle cells of the guinea pig taenia caeci.J GenPhysiol 95(6):1103-1122.