Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 5, 2011, Pages

  Harder, David R ^a,b   Narayanan, Jayashree ^a   Gebremedhin, Debebe ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

20 hydroxyeicosatetraenoic acid; Cytochrome p 450 4a; Ion channels; Membrane potential

Indexed keywords

17 OCTADECYNOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; ADDUCIN; ADDUCIN 3; ARACHIDONIC ACID; CALCIUM CHANNEL; CYTOCHROME P450; CYTOCHROME P450 2C11; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PROTEIN PHOSPHATASE 5; EPOXYICOSATRIENOIC ACID; MARCKS PROTEIN; PHOSPHOLIPID; POTASSIUM CHANNEL; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTERIAL PRESSURE; ARTERIOLE; ARTERY TONE; ASTROCYTE; AUTOREGULATION; BRAIN ARTERIOLE; BRAIN ARTERY; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CIRCULATION; BRAIN CORTEX; CEREBELLUM; CEREBRAL ARTERIAL TONE; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; ENZYME RELEASE; HIPPOCAMPUS; HUMAN; HYDROLYSIS; HYPEREMIA; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE DEPOLARIZATION; MUSCLE TONE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

ANIMALS; CEREBROVASCULAR CIRCULATION; HOMEOSTASIS; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; ION CHANNELS; MUSCLE, SMOOTH, VASCULAR; REGIONAL BLOOD FLOW; VASOCONSTRICTION;

EID: 79955787397     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01097.2010     Document Type: Review

References (59)

1. Alkayed NJ, Narayanan J, Gebremedhin D, Medhora D, Roman RJ, Harder DR. Molecular characterization of arachidonic acid epoxygenase in rat brain astrocytes. Stroke 27: 971-979, 1995.
2. Bateman GA. Vascular compliance in normal pressure hydrocephalus. Am J Neuroradiol 21: 1574-1585, 2002.
3. Bayliss WM. On the local reactions of the arterial wall to changes of internal pressure. J Physiol 28: 220-231, 1902.
4. Bielefeldt K, Jackson MB. Phosphorylation and dephosphorylation modulate a Ca2_-activated K_ channel in rat peptidergic nerve terminals. J Physiol 475: 241-254, 1994.
5. Brayden JE, Nelson MT. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science 256: 532-535, 1992.
6. Buus NH, Vanbavel E, Mulvany MJ. Differences in sensitivity of rat mesenteric small arteries to agonists when studied as ring preparations or as cannulated preparations. Br J Pharmacol 112: 579-587, 1994.
7. Bylund J, Zhang C, Harder DR. Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. Biochem Biophys Res Commun 296: 677-684, 2002.
8. Bylund J, Harder A, Maier C, Roman RJ, Harder DR. Leukotriene B4 ω-side chain hydroxylation by CYP4F5 and CYP4F6. Arch Biochem Biophys 412: 34-41, 2003.
9. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 78: 415-423, 1996.
10. Chen JK, Falck JR, Reddy KM, Capdevila J, Harris RC. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem 273: 29254-29261, 1998.
11. D'Angelo G, Meininger GA. Transduction mechanisms involved in the regulation of myogenic activity. Hypertension 23: 1096-1105, 1994.
12. Enayetallah AE, French RA, Thibodeau MS, Grant DF. Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues. J Histochem Cytochem 52: 447-754, 2004.
13. Folkow B. Description of the myogenic hypothesis. Circ Res 15, Suppl 1: 1279-1287, 1964.
14. Gebremedhin D, Campbell WB, Pratt PF, Harder DR. Bioassay of an endothelium derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite. J Vasc Res 35: 274-284, 1998.
15. Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, Narayanan J, Falck JR, Okamoto H, Roman RJ, Nithipatikom K, Campbell WB, Harder DR. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res 87: 60-65, 2000.
16. 2+ current. J Physiol 507: 771-781, 1998.
17. Gebremedhin D, Ma YH, Falck JR, Roman RJ, VanRollins M, Harder DR. Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am J Physiol Heart Circ Physiol 263: H519-H525, 1992.
18. Hagemann A, Rohr K, Stiehl SH. Coupling of fluid and elastic models for biomechanical stimulations of brain deformations using FEM. Med Image Anal 6: 375-388, 2002.
19. Harder DR. Pressure-dependent membrane depolarization in cat middle cerebral artery. Circ Res 55: 197-202, 1984.
20. Harder DR, Alkayed NJ, Lange AR, Gebremedhin D, Roman RJ. Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites. Stroke 28: 229-234, 1998.
21. Harder DR, Gebremedhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB, Roman R. Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol Heart Circ Physiol 266: H2098-H2107, 1994.
22. Harder DR, Gilbert R, Lombard JH. Vascular muscle cell depolarization and activation in renal arteries on elevation in transmural pressure. Am J Physiol Renal Fluid Electrolyte Physiol 253: F778-F781, 1987.
23. Harder DR, Narayanan J, Gebremedhin D, Roman RJ. Transduction of physical force by the vascular wall: role of phospholipase and cytochrome P450 metabolites of arachidonic acid. Trends Cardiovasc Med 5: 7-14, 1995.
24. Harder DH, Zhang C, Gebremedhin D. Astroctyes function in matching blood flow to metabolic activity. News Physiol Sci 17: 27-31, 2002.
25. Hill MA, Falcone JC, Meininger GA. Evidence for protein kinase C involvement in arteriolar myogenic reactivity. Am J Physiol Heart Circ Physiol 259: H1586-H1594, 1990.
26. Kauser K, Clark JE, Masters BS, Ortiz de Montellano PR, Ma YH, Harder DR, Roman RJ. Inhibitors of cytochrome P450 attenuate the myogenic response of dog renal arcuate arteries. Circ Res 68: 1154-1163, 1991.
27. + channels in rabbit myogenic cerebral arteries. Am J Physiol Heart Circ Physiol 269: H348-H355, 1995.
28. Kulik TJ, Bialecki RA, Colucci WS, Rothman A, Glennon ET, Underwood RH. Stretch increases inositol triphosphate and inositol tetrakisphosphate in cultured pulmonary vascular smooth muscle cells. Biochem Biophys Res Commun 180: 982-987, 1991.
29. Laher I, Bevan JA. Protein kinase C activation selectively augments a stretch-induced, calcium-dependent tone in vascular smooth muscle. J Pharmacol Exp Ther 242: 566-572, 1987.
30. 2+. Biochem Biophys Res Commun 165: 312-318, 1998.
31. + current in cerebral vascular smooth muscle is dependent on activation of PKC. J Biol Chem 272: 27345-27352, 1997.
32. Laterra J, Goldstein GW. Brain microvessels and microvascular cells in vitro. In: The Blood Brain-Barrier, edited by Pardridge WM. New York: Raven, 1993.
33. Lountos GT, Tropea JE, Cherry S, Augh DS. Overproduction, purification, and structure determination of human dual-specificity phosphatase 14. Acta Crystallogr D Biol Crystallogr 65: 1013-1020, 2009.
34. Ma YH, Gebremedhin D, Schwartzman ML, Falck JR, Clark JE, Masters BS, Harder DR, Roman RJ. 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. Circ Res 72: 126-136, 1993.
35. Matsuoka Y, Li X, Bennett V. Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. J Cell Biol 142: 485-497, 1998.
36. Matsuoka Y, Li X, Bennett V. Adducin: structure, function, regulation. Cell Mol Life Sci 57: 884-895, 2000.
37. Munzenmaier DH, Harder DR. Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. Am J Physiol Heart Circ Physiol 278: H1163-H1167, 2000.
38. Murphy TV, Spurrell BE, Hill MA. Cellular signaling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways. Clin Exp Pharmacol Physiol 29: 612-619, 2002.
39. Narayanan J, Imig M, Roman RJ, Harder DR. Pressurization of isolated renal arteries increases inositol triphosphate and diacylglycerol. Am J Physiol Heart Circ Physiol 266: H1840-H1845, 1994.
40. Nelson DR. Cytochrome P450 and the individuality of species. Arch Biochem Biophys 369: 1-10, 1999.
41. Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. P450 super-family: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6: 1-42, 1996.
42. Nithipatikom K, Grall AJ, Holmes BB, Harder DR, Falck JR, Campbell WB. Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid. Anal Biochem 298: 327-336, 2001.
43. Node K, Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, Liao JK. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 285: 1276-1279, 1999.
44. Osol G, Laher I, Kelly M. Myogenic tone is coupled to phospholipase C and G protein activation in small cerebral arteries. Am J Physiol Heart Circ Physiol 265: H415-H420, 1993.
45. Pohl U, de Wit C. A unique role of NO in the control of blood flow. News Physiol Sci 14: 74-80, 1999.
46. Pohl U, Herlan K, Huang A, Bassenge E. EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries. Am J Physiol Heart Circ Physiol 261: H2016-H2023, 1991.
47. Roman RJ. P450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82: 131-185, 2002.
48. Sachs FC. Ion channels as mechanical transducers. In: Cell Shape: Determinants, Regulation, and Regulatory Role, edited by Stein WD and Brunner F. New York: Academic, 1989, p. 63-92.
49. Shi Y, Kiu X, Gebremedhin D, Falck JR, Harder DR, Koehler RC. Interaction of mechanisms involving epoxyeicosatrienoic acids and adenosine and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. J Cereb Blood Flow Metab 28: 111-125, 2008.
50. Simpson AE. The cytochrome P450 4 (CYP4) family. Gen Pharmacol 28: 351-359, 1997.
51. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
52. Tacconi M, Wurtman RJ. Rat brain phosphatidyl-N,N-dimethylethanolamine is rich in polyunsaturated fatty acids. J Neurochem 45: 805-809, 1985.
53. Tacconi M, Wurtman RJ. Phosphatidylcholine produced in rat synaptosomes by N-methylation is enriched in polyunsaturated fatty acids. Proc Natl Acad Sci USA 82: 4828-4831, 1985.
54. Terashvili M, Tseng LF, Wu HE, Narayanan J, Hart LM, Flack JR, Pratt PF, Harder DR. Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin, and met-enkephalin in the rat ventrolateral periqueductal gray. J Pharmacol Exp Ther 326: 614-622, 2008.
55. Tibbles LA, Woodgett JR. The stress-activated protein kinase pathways. Cell Mol Life Sci 55: 1230-1254, 1999.
56. 2+-ions. Pflügers Arch 414: S183-S184, 1989.
57. Wang Y, Wei X, Xiao X, Hui R, Card JW, Carey MA, Wang DW, Zeldin DC. Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth, and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol3-kinase/Akt signaling pathways. J Pharmacol Exp Ther 314: 522-532, 2005.
58. Zhang B, Cao H, Rao GN. Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15- epoxyeicosatrienoic acid-induced angiogenesis. J Biol Chem 281: 905-914, 2006.
59. Zhang C, Harder DR. Cerebral endothelial cell mitogenesis, and morphogenesis induced by astrocytic epoxyeicosatrienoic acid. Stroke 33: 2957-2964, 2001.