Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/Diacylglycerol and phospholipase A2/ω-hydroxylase/ 20-HETE pathways

Circulation Research

Volumn 104, Issue 12, 2009, Pages 1399-1409

  Inoue, Ryuji ^a   Jensen, Lars J ^b   Jian, Zhong ^a,c   Shi, Juan ^d   Hai, Lin ^a   Lurie, Andrew I ^b   Henriksen, Freja H ^b   Salomonsson, Max ^b   Morita, Hiromitsu ^e   Kawarabayashi, Yasuhiro ^a   Mori, Masayuki ^a   Mori, Yasuo ^f   Ito, Yushi ^g  

^a FUKUOKA UNIVERSITY   (Japan)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c XI'AN JIAOTONG UNIVERSITY   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^e KYUSHU UNIVERSITY HOSPITAL   (Japan)

^f KYOTO UNIVERSITY   (Japan)

^g KUMAMOTO HEALTH SCIENCE UNIVERSITY   (Japan)

Author keywords

Ca2; Entry channel; Gq 11 protein coupled receptor; Mechanotransduction

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ALKANE 1 MONOOXYGENASE; CARBACHOL; DIACYLGLYCEROL; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; 20 HYDROXY 5,8,11,14 EICOSATETRAENOIC ACID; 20-HYDROXY-5,8,11,14-EICOSATETRAENOIC ACID; CHOLINERGIC RECEPTOR STIMULATING AGENT; GSMTX 4 TOXIN; GSMTX-4 TOXIN; HYDROXYICOSATETRAENOIC ACID; MUSCARINIC RECEPTOR; PEPTIDE; SPIDER VENOM; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, HUMAN; TRRP6 PROTEIN, RAT;

ARTICLE; BLOOD VESSEL TONE; CELL STRAIN HEK293; DEPOLARIZATION; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROXYLATION; ION CURRENT; MECHANICAL STIMULATION; MESENTERIC ARTERY; MUSCLE CELL; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; GENETICS; MALE; MECHANOTRANSDUCTION; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

ALKANE 1-MONOOXYGENASE; ANIMALS; CARBACHOL; CELL LINE; CHOLINERGIC AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; HYDROXYLATION; MALE; MECHANOTRANSDUCTION, CELLULAR; MUSCLE CELLS; PEPTIDES; PHOSPHOLIPASES A2; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; SPIDER VENOMS; TRPC CATION CHANNELS; TYPE C PHOSPHOLIPASES;

EID: 67650257887     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.193227     Document Type: Article

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