HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme

British Journal of Pharmacology

Volumn 133, Issue 3, 2001, Pages 325-329

  Miyata, N ^a   Taniguchi, K ^a   Seki, T ^a   Ishimoto, T ^a   Sato Watanabe, M ^a   Yasuda, Y ^a   Doi, M ^a   Kametani, S ^a   Tomishima, Y ^a   Ueki, T ^a   Sato, M ^a   Kameo, K ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

20 HETE; Cytochrome P4504A; EETs; HET0016; Kidney

Indexed keywords

20 HYDROXY 5,8,11,14 EICOSATETRAENOIC ACID; ARACHIDONIC ACID DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; EPOXYICOSATRIENOIC ACID; HET 0016; N HYDROXY N' (4 BUTYL 2 METHYLPHENYL)FORMAMIDINE; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IC 50; KIDNEY METABOLISM; KIDNEY MICROSOME; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0034764957     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704101     Document Type: Article

References (22)

1. Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation
2. Cycloxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonic metabolites
3. Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450
4. Production of 20-HETE and its role in autoregulation of cerebral blood flow
5. + exchange and are mitogenic in cultured rat glomerular mesangial cells
6. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone
7. Formation and action of a P-450 4A metabolite of arachidonic acid in cat middle cerebral microvessels
8. Localization of cytochrome P-450 4A isoforms along the rat nephron
9. Epoxydation of arachidonic acid as an active site probe of cytochrome p-450 2B isoforms
10. Identification of rabbit cytochrome P450 2C1 and 2C2 as arachidonic acid epoxygenase
11. Cytochrome P450 4A expression and arachidonic acid ω-hydroxylation in the kidney of the spontaneously hypertensive rat
12. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11
13. 20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule
14. 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries
15. Prostaglandin and fatty acid ω- and (ω-D-oxidation in rabbit lung. Acetylenic fatty acid mechanism-based inactivators as specific Inhibitors
16. Induction of cytochrome P450 isozymes in rat renal microsomes by cyclosporin A
17. Age-related changes in renal cytochrome P-450 arachidonic acid metabolism in spontaneously hypertensive rats
18. Auto-catalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazol. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct
19. Eicosanoid excretion in hepatic cirrhosis. Predominance of 20-HETE
20. Inhibition of renal arachidonic acid ω- hydroxylase activity with ABT reduces blood pressure in the SHR
21. Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: Characterization of selective inhibitors
22. Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase on renal function in rats