Age-related changes in the contractile and passive arterial properties of murine mesenteric small arteries are altered by caveolin-1 knockout

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 8, 2012, Pages 1720-1730

  Hausman, Natasha ^a   Martin, Julie ^b   Taggart, Michael J ^b   Austin, Clare ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Ageing; Caveolin 1; Vascular properties

Indexed keywords

CAVEOLIN 1; NORADRENALIN;

AGING; ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOMECHANICS; CAVEOLA; DRUG EFFECT; GENE DELETION; GENOTYPE; IN VITRO STUDY; MALE; MESENTERIC ARTERY; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; REPRODUCIBILITY; ULTRASTRUCTURE;

AGING; ANIMALS; BIOMECHANICS; CAVEOLAE; CAVEOLIN 1; GENE DELETION; GENOTYPE; MALE; MESENTERIC ARTERIES; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NOREPINEPHRINE; REPRODUCIBILITY OF RESULTS;

ANIMALIA; MURINAE; MUS;

EID: 84864389192     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01457.x     Document Type: Article

References (49)

1. Cupples LA, D'Agostino RB. Some risk factors related to the annual incidence of cardiovascular disease and death in pooled repeated biennial measurements. In: Kannel WB, Wolf PA, Garrison RJ, editors. The Framingham Study: an epidemiological investigation of cardiovascular disease. Bethesda, MD: US Department of Health and Human Services; 1987; p. 9-20.
2. Taggart M. Vascular function in health and disease review series. J Cell Mol Med. 2010; 14: 1017.
3. Nielsen H, Hasenkam JM, Pilegaard HK, et al. Age-dependent changes in α-adrenoceptor-mediated contractility of isolated human resistance arteries. Am J Physiol. 1992; 263: H1190-6.
4. Briones AM, Salaices M, Vila E. Mechanisms underlying hypertrophic remodeling and increased stiffness of mesenteric resistance arteries from aged rats. J Gerontol A Biol Sci Med Sci. 2007; 62: 696-706.
5. Moreau P, D'Uscio LV, Luscher TF. Structure and reactivity of small arteries in aging. Cardiovasc Res. 1998; 37: 247-53.
6. Gros R, Van Wert R, You X, et al. Effects of age, gender, and blood pressure on myogenic responses of mesenteric arteries from C57BL/6 mice. Am J Physiol. 2002; 282: H380-8.
7. Pani B, Singh BB. Lipid rafts/caveolae as microdomains of calcium signaling. Cell Calcium. 2009; 45: 625-33.
8. Rahman A, Swörd K. The role of caveolin-1 in cardiovascular regulation. Acta Physiol. 2009; 195: 231-45.
9. Thomas CM, Smart EJ. Caveolae structure and function. J Cell Mol Med. 2008; 12: 796-809.
10. Razani B, Engeman JA, Wang XB, et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem. 2001; 276: 38121-38.
11. Scherer PE, Lewis RY, Volonte D, et al. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J Biol Chem. 1997; 272: 29337-46.
12. Anderson RG. The caveolae membrane system. Ann Rev Biochem. 1998; 67: 199-225.
13. Albinsson S, Shakirova Y, Rippe A, et al. Arterial remodeling and plasma volume expansion in caveolin-1-deficient mice. Am J Physiol. 2007; 293: R1222-31.
14. Drab M, Verkade P, Elger M, et al. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science. 2001; 293: 2449-52.
15. Park DS, Cohen AW, Frank PG, et al. Caveolin-1 null (-/-) mice show dramatic reductions in life span. Biochemistry. 2003; 42: 15124-31.
16. Yang G, Timme TL, Naruishi K, et al. Mice with cav-1 gene disruption have benign stromal lesions and compromised epithelial differentiation. Exp Mol Pathol. 2008; 84: 131-40.
17. Head BP, Peart JN, Panneerselvam M, et al. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS ONE. 2011; s12: e15697.
18. Taddei S, Virdis A, Ghiadoni L, et al. Age-related reduction of NO availability and oxidative stress in humans. Hypertension. 2001; 38: 274-9.
19. Shakirova Y, Bonnevier J, Albinsson S, et al. Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1. Am J Physiol. 2006; 291: C1326-35.
20. α subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem. 1996; 271: 29182-90.
21. 2+-calmodulin and caveolin. J Biol Chem. 1997; 272: 15583-6.
22. Schwencke C, Schmeisser A, Walter C, et al. Decreased caveolin-1 in atheroma: loss of antiproliferative control of vascular smooth muscle cells in atherosclerosis. Cardiovasc Res. 2005; 68: 128-35.
23. Razani B, Altschuler Y, Zhu L, et al. Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation. Biochem. 2000; 39: 13916-24.
24. Redheuil A, Yu WC, Wu CO, et al. Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans. Hypertension. 2010; 55: 319-26.
25. Rosei EA, Rizzoni D. Small artery remodelling in diabetes. J Cell Mol Med. 2010; 14: 1030-60.
26. Heagerty AM, Heerkens EH, et al. Small artery structure and function in hypertension. J Cell Mol Med. 2010; 14: 1037-43.
27. Soucy KG, Ryoo S, Benjo A, et al. Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness. J Appl Physiol. 2006; 101: 1751-59.
28. Le Saux O, Teeters K, Miyasato S, et al. The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties. Am J Physiol. 2008; 295: L1007-17.
29. Trushina E, Du Charme J, Parisi J, et al. Neurological abnormalities in caveolin-1 knock out mice. Behav Brain Res. 2006; 172: 24-32.
30. 2+ oscillations and tone. Cardiovasc Res. 2006; 69: 825-35.
31. Shaw L, Taggart MJ, Austin C. Mechanisms of 17-β-oestradiol induced vasodilatation in isolated pressurized rat small arteries. Br J Pharmacol. 2000; 129: 555-65.
32. 1-adrenoceptor mechanisms in the isolated mouse aortic preparation. J Smooth Musc Res. 2006; 42: 131-8.
33. Shipley RD, Muller-Delp JM. Aging decreases vasoconstrictor responses of coronary resistance arterioles through endothelium-dependent mechanisms. Cardiovasc Res. 2005; 66: 374-83.
34. 1-adrenoceptor vasoconstriction in the tail artery during ageing. Br J Pharmacol. 1997; 121: 1017-23.
35. Dohi Y, Thiel MA, Buhler FR, et al. Activation of endothelial L-arginine pathway in resistance arteries. Effect of age and hypertension. Hypertension. 1990; 16: 170-9.
36. Toda N, Okamurta T, Miyazaki M. Age-dependent changes in the response of isolated beagle coronary arteries to transmural electrical stimulation and catecholamines. J Pharmacol Exper Ther. 1986; 238: 319-26.
37. Karaki H, Nakagawa H, Urakawa N. Age-related changes in the sensitivity to verapamil and sodium nitroprusside of vascular smooth muscle of rabbit aorta. Br J Pharmacol. 1985; 85: 223-8.
38. Duckles SP, Carter BJ, Williams CL. Vascular adrenergic neuroeffector function does not decline in aged rats. Circ Res. 1985; 56: 109-16.
39. Matz RL, Andriantsitohaina R. Preservation of vascular contraction during ageing: dual effect on calcium handling and sensitization. Br J Pharmacol. 2003; 138: 745-50.
40. Csiszar A, Ungvari Z, Edwards JG, et al. Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res. 2002; 90: 1159-66.
41. Sun D, Huang A, Yan EH, et al. Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats. Am J Physiol. 2004; 286: H2249-56.
42. Yang YM, Huamg A, Kaley G, et al. eNOS uncoupling and endothelial dysfunction in aged vessels. Am J Physiol. 2009; 297: H1829-36.
43. Murata T, Lin MI, Huang Y, et al. Re-expression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. J Exp Med. 2007; 204: 2373-82.
44. Pojoga LH, Yao TM, Sinha S, et al. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1 deficient mice. Am J Physiol. 2008; 294: H1258-65.
45. Adrian M, Laurant P, Berthelot A. Effect of magnesium on mechanical properties of pressurised mesenteric small arteries from old and adult rats. Clin Experim Pharmacol Physiol. 2004; 31: 306-13.
46. Qiu H, Depre C, Ghosh K, et al. Mechanism of gender-specific differences in aortic stiffness with aging in nonhuman primates. Circulation. 2007; 116: 669-76.
47. Graham HK, Akhtar R, Kridiotis C, et al. Localised micro-mechanical stiffening in the ageing aorta. Mech Ageing Dev. 2011; doi:10.1016/j.mad.2011.07.003.
48. Krieger MH, Di Lorenzo A, Teutsch C, et al. Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice. Lab Invest. 2010; 90: 1573-81.
49. Dubroca C, Loyer X, Retailleau K, Loirand G, et al. RhoA activation and interaction with Caveolin-1 are critical for pressure-induced myogenic tone in rat mesenteric resistance arteries. Cardiovasc Res. 2007; 73: 190-7.