Increased arterial smooth muscle Ca 2+-signaling, vasoconstriction, and myogenic reactivity in milan hypertensive rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 3, 2012, Pages

  Linde, Cristina I ^a   Karashima, Eiji ^a   Raina, Hema ^a   Zulian, Alessandra ^a   Wier, Withrow G ^a   Hamlyn, John M ^a   Ferrari, Patrizia ^b   Blaustein, Mordecai P ^a   Golovina, Vera A ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Prassis Sigma Tau Research Institute   (Italy)

Author keywords

Adducin; Hypertension; Milan normotensive rats; Myogenic tone; Ouabain

Indexed keywords

CALCIUM CHANNEL; INOSITOL 1,4,5 TRISPHOSPHATASE; OUABAIN; PHENYLEPHRINE;

ANIMAL CELL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY CONSTRICTION; ARTERY MUSCLE; ARTICLE; CARDIOVASCULAR AUTOREGULATION; HEART MUSCLE CELL; HYPERTENSION; KIDNEY DYSFUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE;

ANIMALS; BLOOD PRESSURE; CALCIUM; CALCIUM SIGNALING; ENZYME INHIBITORS; HYPERTENSION, RENAL; MESENTERIC ARTERY, SUPERIOR; MUSCLE, SMOOTH, VASCULAR; OUABAIN; RATS; RATS, MUTANT STRAINS; SARCOPLASMIC RETICULUM; SODIUM CHLORIDE, DIETARY; SPAIN; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 84856507878     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00950.2011     Document Type: Article

References (80)

1. Agarwal A, Williams GH, Fisher ND. Genetics of human hypertension. Trends Endocrinol Metab 16: 127-133, 2005.
2. Amberg GC, Santana LF. Downregulation of the BK channel beta1 subunit in genetic hypertension. Circ Res 93: 965-971, 2003.
3. 2+ signaling in arterial myocytes. Am J Physiol Cell Physiol 278: C163-C173, 2000.
4. +. Am J Physiol Heart Circ Physiol 279: H679-H691, 2000.
5. Bae YM, Kim A, Lee YJ, Lim W, Noh YH, Kim EJ, Kim J, Kim TK, Park SW, Kim B, Cho SI, Kim DK, Ho WK. Enhancement of receptor-operated cation current and TRPC6 expression in arterial smooth muscle cells of deoxycorticosterone acetate-salt hypertensive rats. J Hypertens 25: 809-817, 2007.
6. + channels are expressed in mesenteric artery smooth muscle cells. Am J Physiol Heart Circ Physiol 289: H137-H145, 2005.
7. 2+ handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture. Am J Physiol Cell Physiol 295: C779-C790, 2008.
8. Bianchi G. Genetic variations of tubular sodium reabsorption leading to "primary" hypertension: from gene polymorphism to clinical symptoms. Am J Physiol Regul Integr Comp Physiol 289: R1536-R1549, 2005.
9. Bianchi G, Baer PG, Fox U, Duzzi L, Pagetti D, Giovannetti AM. Changes in renin, water balance, and sodium balance during development of high blood pressure in genetically hypertensive rats. Circ Res 36: 153-161, 1975.
10. Bianchi G, Cusi D. Association and linkage analysis of alpha-adducin polymorphism: is the glass half full or half empty? Am J Hypertens 13: 739-743, 2000.
11. Bianchi G, Tripodi G, Casari G, Salardi S, Barber BR, Garcia R, Leoni P, Torielli L, Cusi D, Ferrandi M. Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 91: 3999-4003, 1994.
12. Blaustein MP, Zhang J, Chen L, Song H, Raina H, Kinsey SP, Izuka M, Iwamoto T, Kotlikoff MI, Lingrel JB, Philipson KD, Wier WG, Hamlyn JM. The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension. Hypertension 53: 291-298, 2009.
13. Borst JG, Borst-De Geus A. Hypertension explained by Starling's theory of circulatory homoeostasis. Lancet 1: 677-682, 1963.
14. Briones AM, Xavier FE, Arribas SM, Gonzalez MC, Rossoni LV, Alonso MJ, Salaices M. Alterations in structure and mechanics of resistance arteries from ouabain-induced hypertensive rats. Am J Physiol Heart Circ Physiol 291: H193-H201, 2006.
15. Capasso G, Rizzo M, Garavaglia ML, Trepiccione F, Zacchia M, Mugione A, Ferrari P, Paulmichl M, Lang F, Loffing J, Carrel M, Damiano S, Wagner CA, Bianchi G, Meyer G. Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension. Am J Physiol Renal Physiol 295: F556-F567, 2008.
16. Chiolero A, Wurzner G, Burnier M. Renal determinants of the salt sensitivity of blood pressure. Nephrol Dial Transplant 16: 452-458, 2001.
17. Cusi D, Barlassina C, Azzani T, Casari G, Citterio L, Devoto M, Glorioso N, Lanzani C, Manunta P, Righetti M, Rivera R, Stella P, Troffa C, Zagato L, Bianchi G. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 349: 1353-1357, 1997.
18. Dibb KM, Graham HK, Venetucci LA, Eisner DA, Trafford AW. Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart. Cell Calcium 42: 503-512, 2007.
19. Dostanic-Larson I, Van Huysse JW, Lorenz JN, Lingrel JB. The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci USA 102: 15845-15850, 2005.
20. Dostanic I, Paul RJ, Lorenz JN, Theriault S, Van Huysse JW, Lingrel JB. The o(2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro. Am J Physiol Heart Circ Physiol 288: H477-H485, 2005.
21. Earley S, Waldron BJ, Brayden JE. Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Circ Res 95: 922-929, 2004.
22. 2+ exchange as a key mechanism of TRPC signaling. Pflügers Arch 451: 99-104, 2005.
23. +-ATPase trafficking in response to GPCR signals and intracellular sodium. Circ Res 95: 1100-1108, 2004.
24. 2+ exchange. Am J Physiol Renal Physiol 294: F212-F219, 2008.
25. Ferrandi M, Manunta P, Balzan S, Hamlyn JM, Bianchi G, Ferrari P. Ouabain-like factor quantification in mammalian tissues and plasma: comparison of two independent assays. Hypertension 30: 886-896, 1997.
26. Ferrandi M, Minotti E, Salardi S, Florio M, Bianchi G, Ferrari P. Ouabainlike factor in Milan hypertensive rats. Am J Physiol Renal Fluid Electrolyte Physiol 263: F739-F748, 1992.
27. Ferrandi M, Molinari I, Torielli L, Padoani G, Salardi S, Rastaldi MP, Ferrari P, Bianchi G. Adducin-and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies. Sci Transl Med 2(59): 1-9, 2010.
28. +-ATPase: relation to genetic hypertension. Am J Physiol Heart Circ Physiol 277: H1338-H1349, 1999.
29. Ferrandi M, Tripodi G, Salardi S, Florio M, Modica R, Barassi P, Parenti P, Shainskaya A, Karlish S, Bianchi G, Ferrari P. Renal Na,K-ATPase in genetic hypertension. Hypertension 28: 1018-1025, 1996.
30. Fukata Y, Amano M, Kaibuchi K. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci 22: 32-39, 2001.
31. 2+ homeostasis in hypertension? Am J Physiol Heart Circ Physiol 299: H602-H604, 2010.
32. Grimm PR, Sansom SC. BK channels and a new form of hypertension. Kidney Int 78: 956-962, 2010.
33. Guyton AC, Granger HJ, Coleman TG. Autoregulation of the total systemic circulation and its relation to control of cardiac output and arterial pressure. Circ Res 28, Suppl 1: 93-97, 1971.
34. Hamlyn JM, Blaustein MP, Bova S, DuCharme DW, Harris DW, Mandel F, Mathews WR, Ludens JH. Identification and characterization of a ouabain-like compound from human plasma. Proc Natl Acad Sci USA 88: 6259-6263, 1991.
35. 2+-permeable cation channel. Circ Res 88: 325-332, 2001.
36. 2+ exchanger type-1 in vascular smooth muscle. Nat Med 10: 1193-1199, 2004.
37. + pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells. Proc Natl Acad Sci USA 94: 1800-1805, 1997.
38. 2+ exchanger in vascular smooth muscle, and in neurons and astrocytes. Ann N Y Acad Sci 779: 318-335, 1996.
39. Kaplan NM. Kaplan's Clinical Hypertension. Philadelphia, PA: Lippin-cott, Williams & Wilkins, 2006.
40. 2+ entry in pressure-induced myogenic constriction in rat posterior cerebral arteries. J Pharm Sci 110: 218-222, 2009.
41. Leenen FH. The central role of the brain aldosterone-ouabain pathway in salt-sensitive hypertension. Biochim Biophys Acta 1802: 1132-1139, 2010.
42. Levy MN, Pappano AJ. Cardiovascular Physiology. Philadelphia, PA: Mosby Elsevier, 2007.
43. Li Z, Xie Z. The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades. Pflügers Arch 457: 635-644, 2009.
44. Liu J, Xie ZJ. The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking. Biochim Biophys Acta 1802: 1237-1245, 2010.
45. Liu L, Zhao X, Pierre SV, Askari A. Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes. Am J Physiol Cell Physiol 293: C1489-C1497, 2007.
46. Luft FC. Molecular genetics of salt-sensitivity and hypertension. Drug Metab Dispos 29: 500-504, 2001.
47. Malpas SC. Sympathetic nervous system overactivity and its role in the development of cardiovascular disease. Physiol Rev 90: 513-557, 2010.
48. Manunta P, Bianchi G. Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives-the adducin paradigm. J Am Soc Nephrol 17: S30-S35, 2006.
49. Manunta P, Burnier M, D'Amico M, Buzzi L, Maillard M, Barlassina C, Lanella G, Cusi D, Bianchi G. Adducin polymorphism affects renal proximal tubule reabsorption in hypertension. Hypertension 33: 694-697, 1999.
50. Manunta P, Hamilton J, Rogowski AC, Hamilton BP, Hamlyn JM. Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin. Hypertens Res 23, Suppl: S77-S85, 2000.
51. Manunta P, Maillard M, Tantardini C, Simonini M, Lanzani C, Citterio L, Stella P, Casamassima N, Burnier M, Hamlyn JM, Bianchi G. Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension. J Hypertens 26: 914-920, 2008.
52. Manunta P, Rogowski AC, Hamilton BP, Hamlyn JM. Ouabain-induced hypertension in the rat: relationships among plasma and tissue ouabain and blood pressure. J Hypertens 12: 549-560, 1994.
53. Martinez-Lemus LA, Hill MA, Meininger GA. The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure. Physiology (Bethesda) 24: 45-57, 2009.
54. Mason DT, Braunwald E. Studies on Digitalis. X. Effects of ouabain on forearm vascular resistance and venous tone in normal subjects and in patients in heart failure. J Clin Invest 43: 532-543, 1964.
55. Mulvany MJ. Small artery remodelling in hypertension. Basic Clin Pharmacol Toxicol 110: 49-55, 2012.
56. Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 87: 165-217, 2007.
57. O'Brien WJ, Lingrel JB, Wallick ET. Ouabain binding kinetics of the rat alpha two and alpha three isoforms of the sodium-potassium adenosine triphosphate. Arch Biochem Biophys 310: 32-39, 1994.
58. 2+ entry in purinergically stimulated aorta smooth muscle cells. Circ Res 101: 1030-1038, 2007.
59. 2+ transporters in arterial smooth muscle from ouabain hypertensive rats. Am J Physiol Heart Circ Physiol 298: H263-H274, 2010.
60. Raina H, Zhang Q, Rhee AY, Pallone TL, Wier WG. Sympathetic nerves and endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries. Am J Physiol Heart Circ Physiol 298: H2093-H2101, 2010.
61. Rizzoni D, Castellano M, Porteri E, Giacche M, Ferrari P, Cusi D, De Ciuceis C, Boari GE, Rosei EA. Functional alterations of mesenteric small resistance arteries in Milan hypertensive and normotensive rats. Hypertens Res 32: 581-585, 2009.
62. 2+-dependent activation of phosphoino-sitide 3-kinase class IIalpha isoform-Rho axis in blood vessels of spontaneously hypertensive rats. Hypertension 56: 934-941.
63. + pump alpha2 subunits to specialized plasma membrane microdomains. J Biol Chem 281: 12929-12940, 2006.
64. Sonkusare S, Palade PT, Marsh JD, Telemaque S, Pesic A, Rusch NJ. Vascular calcium channels and high blood pressure: pathophysiology and therapeutic implications. Vascul Pharmacol 44: 131-142, 2006.
65. Staessen JA, Bianchi G. Adducin and hypertension. Pharmacogenomics 6: 665-669, 2005.
66. Thompson LP, Bruner CA, Lamb FS, King CM, Webb RC. Calcium influx and vascular reactivity in systemic hypertension. Am J Cardiol 59: 29A-34A, 1987.
67. + reabsorption. Am J Physiol Renal Physiol 295: F478-F487, 2008.
68. Tripodi G, Valtorta F, Torielli L, Chieregatti E, Salardi S, Trusolino L, Menegon A, Ferrari P, Marchisio PC, Bianchi G. Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. J Clin Invest 97: 2815-2822, 1996.
69. Wang HX, Davis MJ, Rajanayagam MA, Potocnik SJ, Hill MA. Myogenic reactivity of rat epineurial arterioles: potential role in local vasoregulatory events. Am J Physiol Heart Circ Physiol 277: H144-H151, 1999.
70. Williams GH. Genetic factors associated with volume-sensitive hypertension. Mol Cell Endocrinol 217: 41-44, 2004.
71. Yamagishi K, Iso H, Tanigawa T, Cui R, Kudo M, Shimamoto T. Alpha-adducin G460W polymorphism, urinary sodium excretion, and blood pressure in community-based samples. Am J Hypertens 17: 385-390, 2004.
72. Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, Takeshima H. TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance. Cell Metab 14: 231-241, 2011.
73. Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA 101: 13861-13866, 2004.
74. Zhang J, Hamlyn JM, Karashima E, Raina H, Mauban JR, Izuka M, Berra-Romani R, Zulian A, Wier WG, Blaustein MP. Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implica tions for sustained elevation of vascular resistance. Am J Physiol Heart Circ Physiol 297: H1140-H1150, 2009.
75. Zhang J, Lee MY, Cavalli M, Chen L, Berra-Romani R, Balke CW, Bianchi G, Ferrari P, Hamlyn JM, Iwamoto T, Lingrel JB, Mat-teson DR, Wier WG, Blaustein MP. Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice. J Physiol 569: 243-256, 2005.
76. 2+ channel current and lowers blood pressure. Am J Physiol Heart Circ Physiol 298: H1472-H1483, 2010.
77. 2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol 292: C2297-C2305, 2007.
78. 2+ and myosin phosphorylation during myogenic and norepinephrine-induced arteriolar constriction. J Vasc Res 37: 556-567, 2000.
79. 2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats. Am J Physiol Heart Circ Physiol 299: H624-H633, 2010.
80. 2+ exchanger-1/TRPC6 signaling pathway. Hypertension 56: e57, 2010.