Loss of deacetylation activity of Hdac6 affects emotional behavior in mice

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Fukada, Masahide ^a   Hanai, Atsuko ^a   Nakayama, Atsuo ^a   Suzuki, Takayoshi ^b   Miyata, Naoki ^b   Rodriguiz, Ramona M ^c   Wetsel, William C ^c   Yao, Tso Pang ^c   Kawaguchi, Yoshiharu ^a  

^a INSTITUTE FOR DEVELOPMENTAL RESEARCH   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 (ADAMANT 1 YLAMINO) 6 (TERT BUTOXYCARBONYL) 7 OXOHEPTYL 2 METHYLPROPANETHIOATE; ALPHA TUBULIN; CORTACTIN; CORTICOSTEROID; DESIPRAMINE; ENZYME INHIBITOR; FLUOXETINE; HEAT SHOCK PROTEIN 20; HISTONE DEACETYLASE 6; IMIPRAMINE; NCT 14B; UNCLASSIFIED DRUG; HDAC6 PROTEIN, MOUSE; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE; TUBULIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR CHANGE; BRAIN FUNCTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEACETYLATION; DEPRESSION; DORSAL RAPHE NUCLEUS; ENZYME ACTIVITY; ENZYME SUBSTRATE; HYPERACTIVITY; MALE; MEDIAN RAPHE NUCLEUS; MOOD DISORDER; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TASK PERFORMANCE; ACETYLATION; ANIMAL; EMOTION; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RAPHE NUCLEUS; SEROTONINERGIC NERVE CELL;

MUS;

ACETYLATION; ANIMALS; CORTACTIN; EMOTIONS; HISTONE DEACETYLASES; HSP90 HEAT-SHOCK PROTEINS; MICE; MICE, KNOCKOUT; RAPHE NUCLEI; SEROTONERGIC NEURONS; TUBULIN;

EID: 84856643478     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030924     Document Type: Article

References (30)

1. Yang X-J, Seto E, (2008) Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell 31: 449-461.
2. Gregoretti IV, Lee YM, Goodson HV, (2004) Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol 338: 17-31.
3. Means GD, Toy DY, Baum PR, Derry JM, (2000) A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Genomics 65: 213-223.
4. Mahlknecht U, Schnittger S, Landgraf F, Schoch C, Ottmann OG, et al. (2001) Assignment of the human histone deacetylase 6 gene (HDAC6) to X chromosome p11.23 by in situ hybridization. Cytogenet Cell Genet 93: 135-136.
5. Zhang Y, Kwon SH, Yamaguchi T, Cubizolles F, Rousseaux S, et al. (2008) Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol 28: 1688-1701.
6. Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, et al. (2002) HDAC6 is a microtubule-associated deacetylase. Nature 417: 455-458.
7. Matsuyama A, Shimazu T, Sumida Y, Saito A, Yoshimatsu Y, et al. (2002) In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J 21: 6820-6831.
8. Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, et al. (2007) HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell 27: 197-213.
9. Tran ADA, Marmo TP, Salam AA, Che S, Finkelstein E, et al. (2007) HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci 120: 1469-1479.
10. Gao Y-S, Hubbert CC, Lu J, Lee Y-S, Yao T-P, (2007) Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol Cell Biol 27: 8637-8647.
11. Dompierre JP, Godin JD, Charrin BC, Cordelieres FP, King SJ, et al. (2007) Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J Neurosci 27: 3571-3583.
12. Kovacs J, Murphy PJM, Gaillard S, Zhao X, Wu J-T, et al. (2005) HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell 18: 601-607.
13. Iwata A, Riley BE, Johnston JA, Kopito RR, (2005) HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem 280: 40282-40292.
14. Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, et al. (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447: 859-863.
15. Lee J-Y, Koga H, Kawaguchi Y, Tang W, Wong E, et al. (2010) HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J 29: 969-980.
16. Kawaguchi Y, Kovacs J, McLaurin A, Vance JM, Ito A, et al. (2003) The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115: 727-738.
17. Sapolsky RM, Armanini MP, Packan DR, Sutton SW, Plotsky PM, (1990) Glucocorticoid feedback inhibition of adrenocorticotropic hormone secretagogue release. Relationship to corticosteroid receptor occupancy in various limbic sites. Neuroendocrinology 51: 328-336.
18. Wong E, Cuervo AM, (2010) Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13: 805-811.
19. Zhang X, Beaulieu J-M, Sotnikova TD, Gainetdinov RR, Caron MG, (2004) Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305: 217.
20. Berton O, Nestler EJ, (2006) New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7: 137-151.
21. Cryan JF, Mombereau C, Vassout A, (2005) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Nuerosci Biobehav Rev 29: 571-625.
22. Young EA, Haskett RF, Murphy-Weinberg V, Watson SJ, Akil H, (1991) Loss of glucocorticoid fast feedback in depression. Arch Gen Psychiatry 48: 693-698.
23. Itoh Y, Suzuki T, Kouketsu A, Suzuki N, Maeda S, et al. (2007) Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J Med Chem 50: 5425-5438.
24. Zhang Y, Li N, Caron C, Matthias G, Hess D, et al. (2003) HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J 22: 1168-1179.
25. Vertes RP, (1991) A PHL-A analysis of ascending projections of the dorsal raphe nucleus in the rat. J Comp Neurol 313: 643-668.
26. Vertes RP, Fortin WJ, Crane AM, (1999) Projections of the median raphe nucleus in the rat. J Comp Neurol 407: 555-582.
27. Convington HE, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, et al. (2009) Antidepressant actions of histone deacetylase inhibitors. J Neurosci 37: 11451-11460.
28. Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, et al. (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459: 55-60.
29. Nozawa R, Nagao K, Masuda H, Iwasaki O, Hirota T, et al. (2010) Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation. Nat Cell Biol 12: 719-727.
30. Fukada M, Kawachi H, Fujikawa A, Noda M, (2005) Yeast substrate-trapping system for isolating substrates of protein tyrosine phosphatases: isolation of substrates for protein tyrosine phosphatase receptor type Z. Methods 35: 54-63.