Epigenetic analysis of HIV-1 proviral genomes from infected individuals: Predominance of unmethylated CpG's

Virology

Volumn 449, Issue , 2014, Pages 181-189

  Weber, Stefanie ^a   Weiser, Barbara ^b   Kemal, Kimdar S ^c   Burger, Harold ^b   Ramirez, Christina M ^d   Korn, Klaus ^a   Anastos, Kathryn ^c   Kaul, Rupert ^e   Kovacs, Colin ^e   Doerfler, Walter ^a,f  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Bisulfite sequencing; Epigenetics of HIV 1 proviral DNA; Escape from proviral DNA methylation; Fluctuation of CpG methylation in one LTNP individual; Integrated HIV 1 DNA in PBMC's from infected individuals; Methylation analysis of integrated HIV 1 genomes; Predominance of unmethylated CpG's in PBMC's; Wide spectrum of infection outcome

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; PRIMER DNA; VIRUS DNA;

ARTICLE; CD4+ T LYMPHOCYTE; CELL CULTURE; CPG ISLAND; DEMETHYLATION; DISEASE COURSE; DNA EXTRACTION; DNA METHYLATION; DNA SEQUENCE; ENVELOPE GENE; EPIGENETICS; FEMALE; GENE; GENETIC ANALYSIS; GROUP SPECIFIC ANTIGEN GENE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HXB2 K03455 SEQUENCE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROVIRUS; REV GENE; TAT GENE; VIRUS GENE; VIRUS GENOME;

HUMAN IMMUNODEFICIENCY VIRUS 1;

BISULFITE SEQUENCING; EPIGENETICS OF HIV-1 PROVIRAL DNA; ESCAPE FROM PROVIRAL DNA METHYLATION; FLUCTUATION OF CPG METHYLATION IN ONE LTNP INDIVIDUAL; INTEGRATED HIV-1 DNA IN PBMC'S FROM INFECTED INDIVIDUALS; METHYLATION ANALYSIS OF INTEGRATED HIV-1 GENOMES; PREDOMINANCE OF UNMETHYLATED CPG'S IN PBMC'S; WIDE SPECTRUM OF INFECTION OUTCOME;

ADULT; CELLS, CULTURED; DINUCLEOSIDE PHOSPHATES; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENOME, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; PROVIRUSES; YOUNG ADULT;

EID: 84890290379     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2013.11.013     Document Type: Article

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