Lentiviral latency in peripheral CD4+ T cells isolated from feline immunodeficiency virus-infected cats during the asymptomatic phase is not associated with hypermethylation of the proviral promoter

Virus Research

Volumn 169, Issue 1, 2012, Pages 117-126

  Murphy, B ^a   Hillman, C ^a   Mok, M ^a   Vapniarsky, N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

FIV lentivirus; Latency; Methylation; Promoter

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CYTOSINE; INTERLEUKIN 2 RECEPTOR ALPHA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAT; CD4+ T LYMPHOCYTE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; EUKARYOTE; FELINE IMMUNODEFICIENCY VIRUS; GENE REPRESSION; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; LENTIVIRINAE; LONG TERMINAL REPEAT; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROVIRUS; VIRUS GENOME; VIRUS LATENCY;

ANIMALS; CATS; CD4-POSITIVE T-LYMPHOCYTES; CYTOSINE; DNA METHYLATION; GENE EXPRESSION REGULATION, VIRAL; IMMUNODEFICIENCY VIRUS, FELINE; LENTIVIRUS INFECTIONS; PROMOTER REGIONS, GENETIC; PROVIRUSES; TRANSCRIPTION, GENETIC; VIRUS LATENCY;

EUKARYOTA; FELINE IMMUNODEFICIENCY VIRUS; LENTIVIRUS;

EID: 84867214038     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2012.07.017     Document Type: Article

References (33)

1. Barlough J.E., Ackley C.D., George J.W., Levy N., Acevedo R., Moore P.F., Rideout B.A., Cooper M.D., Pedersen N.C. Acquired immune dysfunction in cats with experimentally induced feline immunodeficiency virus infection: comparison of short-term and long-term infections. Journal of Acquired Immune Deficiency Syndromes 1991, 4(3):219-227.
2. Bednarik D.P., Cook J.A., Pitha P.M. Inactivation of the HIV LTR by DNA CpG methylation: evidence for a role in latency. EMBO Journal 1990, 9(4):1157-1164.
3. Bendinelli M., Pistello M., Lombardi S., Poli A., Garzelli C., Matteucci D., Ceccherini-Nelli L., Malvaldi G., Tozzini F. Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen. Clinical Microbiology Reviews 1995, 8(1):87-112.
4. Blazkova J., Murray D., Justement J.S., Funk E.K., Nelson A.K., Moir S., Chun T.W., Fauci A.S. Paucity of HIV DNA methylation in latently infected, resting CD4+ T cells from infected individuals receiving antiretroviral therapy. Journal of Virology 2012, 86(9):5390-5392.
5. Blazkova J., Trejbalova K., Gondois-Rey F., Halfon P., Philibert P., Guiguen A., Verdin E., Olive D., Van Lint C., Hejnar J., Hirsch I. CpG methylation controls reactivation of HIV from latency. PLoS Pathogens 2009, 5(8):e1000554.
6. Boyes J., Bird A. DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell 1991, 64(6):1123-1134.
7. Burkhard M.J., Dean G.A. Transmission and immunopathogenesis of FIV in cats as a model for HIV. Current HIV Research 2003, 1(1):15-29.
8. Chavez L., Kauder S., Verdin E. In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus. Methods 2011, 53(1):47-53.
9. Duverger A., Jones J., May J., Bibollet-Ruche F., Wagner F.A., Cron R.Q., Kutsch O. Determinants of the establishment of human immunodeficiency virus type 1 latency. Journal of Virology 2009, 83(7):3078-3093.
10. Elder J.H., Lin Y.C., Fink E., Grant C.K. Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV. Current HIV Research 2010, 8(1):73-80.
11. Finzi D., Hermankova M., Pierson T., Carruth L.M., Buck C., Chaisson R.E., Quinn T.C., Chadwick K., Margolick J., Brookmeyer R., Gallant J., Markowitz M., Ho D.D., Richman D.D., Siliciano R.F. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997, 278(5341):1295-1300.
12. Frey S.C., Hoover E.A., Mullins J.I. Feline immunodeficiency virus cell entry. Journal of Virology 2001, 75(11):5433-5440.
13. Graf E.H., Mexas A.M., Yu J.J., Shaheen F., Liszewski M.K., Di Mascio M., Migueles S.A., Connors M., O'Doherty U. Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART. PLoS Pathogens 2011, 7(2):e1001300.
14. Harbers K., Schnieke A., Stuhlmann H., Jahner D., Jaenisch R. DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning. Proceedings of the National Academy of Sciences of the United States of America 1981, 78(12):7609-7613.
15. Hendrich B., Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Molecular and Cellular Biology 1998, 18(11):6538-6547.
16. Hu W.S., Fanning T.G., Cardiff R.D. Mouse mammary tumor virus: specific methylation patterns of proviral DNA in normal mouse tissues. Journal of Virology 1984, 49(1):66-71.
17. Ikeda Y., Kawaguchi Y., Tomonaga K., Inoshima Y., Kohmoto M., Miyazawa T., Mikami T. Regulatory properties of the integrated long terminal repeat of the feline immunodeficiency virus. Virus Research 1996, 41(2):201-207.
18. Joshi A., Vahlenkamp T.W., Garg H., Tompkins W.A., Tompkins M.B. Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation. Virology 2004, 321(2):307-322.
19. Kauder S.E., Bosque A., Lindqvist A., Planelles V., Verdin E. Epigenetic regulation of HIV-1 latency by cytosine methylation. PLoS Pathogens 2009, 5(6):e1000495.
20. Koiwa T., Hamano-Usami A., Ishida T., Okayama A., Yamaguchi K., Kamihira S., Watanabe T. 5'-Long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. Journal of Virology 2002, 76(18):9389-9397.
21. Lorincz M.C., Schubeler D., Goeke S.C., Walters M., Groudine M., Martin D.I. Dynamic analysis of proviral induction and de novo methylation: implications for a histone deacetylase-independent, methylation density-dependent mechanism of transcriptional repression. Molecular and Cellular Biology 2000, 20(3):842-850.
22. McDonnel S.J., Sparger E.E., Luciw P.A., Murphy B.G. Transcriptional regulation of latent feline immunodeficiency virus in peripheral CD4+ T-lymphocytes. Viruses 2012, 4(5):878-888.
23. Mok H.P., Lever A.M. Chromatin, gene silencing and HIV latency. Genome Biology 2007, 8(11):228.
24. Murphy B., Jasmer D.P., White S.N., Knowles D. Localization of a TNF-activated transcription site and interactions with the gamma activated site within the CAEV U3 70 base pair repeat. Virology 2007, 364(1):196-207.
25. Murphy B., Vapniarsky N., Hillman C., Castillo D., McDonnel S., Moore P., Luciw P.A., Sparger E.E. FIV establishes a latent infection in feline peripheral blood CD4+ T lymphocytes in vivo during the asymptomatic phase of infection. Retrovirology 2012, 9(1):12.
26. Richman D.D., Margolis D.M., Delaney M., Greene W.C., Hazuda D., Pomerantz R.J. The challenge of finding a cure for HIV infection. Science 2009, 323(5919):1304-1307.
27. Savarino A., Pistello M., D'Ostilio D., Zabogli E., Taglia F., Mancini F., Ferro S., Matteucci D., De Luca L., Barreca M.L., Ciervo A., Chimirri A., Ciccozzi M., Bendinelli M. Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS. Retrovirology 2007, 4:79.
28. Sharkey M.E., Teo I., Greenough T., Sharova N., Luzuriaga K., Sullivan J.L., Bucy R.P., Kostrikis L.G., Haase A., Veryard C., Davaro R.E., Cheeseman S.H., Daly J.S., Bova C., Ellison R.T., Mady B., Lai K.K., Moyle G., Nelson M., Gazzard B., Shaunak S., Stevenson M. Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy. Nature Medicine 2000, 6(1):76-81.
29. Sparger E.E. FIV as a Model for HIV, Animal Models of HIV Disease and Control 2005, Kluwer Academic/Plenum Publishers, New York, pp. 149-199.
30. Teo I., Veryard C., Barnes H., An S.F., Jones M., Lantos P.L., Luthert P., Shaunak S. Circular forms of unintegrated human immunodeficiency virus type 1 DNA and high levels of viral protein expression: association with dementia and multinucleated giant cells in the brains of patients with AIDS. Journal of Virology 1997, 71(4):2928-2933.
31. Watt F., Molloy P.L. Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. Genes and Development 1988, 2(9):1136-1143.
32. Williams S.A., Greene W.C. Regulation of HIV-1 latency by T-cell activation. Cytokine 2007, 39(1):63-74.
33. Yoder K.E., Fishel R. PCR-based detection is unable to consistently distinguish HIV 1LTR circles. Journal of Virological Methods 2006, 138(1-2):201-206.