Infection of lymphoid cells by integration-defective human immunodeficiency virus type 1 increases de novo methylation

Journal of Virology

Volumn 75, Issue 20, 2001, Pages 9753-9761

  Fang, J Y ^a   Mikovits, J A ^a   Bagni, R ^a   Petrow Sadowski, C L ^a   Ruscetti, F W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE; GAMMA INTERFERON; PROTEIN P16;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOID CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRUS GENOME; VIRUS MUTANT; VIRUS PATHOGENESIS; VIRUS REPLICATION;

CELL LINE; DNA METHYLATION; DNA MODIFICATION METHYLASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, P16; HIV-1; HUMANS; INTEGRASES; LYMPHOCYTES; MUTATION; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TIME FACTORS;

EID: 0034812726     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.20.9753-9761.2001     Document Type: Article

References (88)

1. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
2. Genomic imprinting in mammals
3. INK4A (MTS1) in B-cell and T-cell lymphomas
4. Tying it all together: Epigenetics, genetics, cell cycle, and cancer
5. Dissociation of unintegrated viral DNA accumulation from single-cell lysis induced by human immunodeficiency virus type I
6. Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain
7. Creation of genomic methylation patterns
8. DNA methylation de novo
9. Human immunodeficiency virus type 1 integrase: Effect on viral replication of mutations at highly conserved residues
10. HIV-1 protein expression from synthetic circles of DNA mimicking the extrachromosomal forms of viral DNA
11. Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
12. High-level expression of active HIV-1 integrase from a synthetic gene in human cells
13. WAF1
14. Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy
15. High sensitivity mapping of methylated cytosines
16. Alterations in DNA methylation may play a variety of roles in carcinogenesis
17. MethyLight: A high-throughput assay to measure DNA methylation
18. Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro
19. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication
20. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
21. Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas
22. INK4A gene is a frequent finding in Hodgkin's disease
23. Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: Characterization of HIV-1 particles containing mutant nucleocapsid zinc-coordinating sequences
24. Characterization of the lock-in replication of nucleocapsid protein zinc finger mutants from Moloney murine leukemia virus
25. Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia
26. DNA methylation and gene expression: Endogenous retroviral genome becomes infectious after molecular cloning
27. Chromosomal insertion of foreign (adenovirus type 12, plasmid, or bacteriophage lambda) DNA is associated with enhanced methylation of cellular DNA segments
28. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
29. INK4A characterize the major types of hematological malignancies
30. Selective extraction of polyoma DNA from infected mouse cell cultures
31. In vivo activity of murine de novo methyltransferases DNMT3a and DNMT3b
32. Methylation profiling of CpG islands in human breast cancer cells
33. De novo methylation and expression of retroviral genomes during mouse embryogenesis
34. Histone deacetylases: Complex transducers of nuclear signals
35. DNA methylation errors and cancer
36. Cancer epigenetics comes of age
37. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
38. DNA methyltransferase expression and DNA methylation of CpG islands and pericentromeric satellite region in human colorectal and stomach cancers
39. Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses?
40. Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia
41. Cell killing by spleen necrosis virus is correlated with a transient accumulation of spleen necrosis virus DNA
42. DNA methylation affects the formation of active chromatin
43. Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells
44. Mutagenic treatments result in inactivation of expression of a transfected bacterial gene integrated into a human cell line
45. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
46. The mojo of methylation
47. Hypermethylation of the p16 gene in nasopharyngeal carcinoma
48. Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation
49. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
50. + cells
51. Negative regulation of HIV replication in monocytes: Distinctions between restricted and latent expression in THP-1 cells
52. Immune activation of HIV expression from latently infected monocytes from asymptomatic seropositive patients
53. Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-γ) promoter and subsequent downregulation of IFN-γ production
54. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
55. Disease-specific and tissue-specific production of unintegrated feline leukaemia virus variant DNA in feline AIDS
56. Alteration of p16 and p15 genes in human uterine tumors
57. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
58. DNA methylation and chromatin modification
59. Frequent hypermethylation of p16 and p15 genes in multiple myeloma
60. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis
61. CpG suppression in HIV-1 versus HIV-2: Correlation with pathogenicity and possible implications for the design of antiretroviral vaccines
62. DNMT2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells
63. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
64. DNA methyltransferases DNMT3a and DNMT3b are essential for de novo methylation and mammalian development
65. Quantitative PCR by fluorescence monitoring of a double strand DNA specific binding dye
66. Insertion of foreign DNA into an established mammalian genome can alter the methylation of cellular DNA sequences
67. Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation
68. Product differentiation by analysis of DNA melting curves during the polymerase chain reaction
69. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors
70. DNA methylation: Past, present and future directions
71. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
72. Avian leukosis virus-induced osteopetrosis is associated with the persistent synthesis of viral DNA
73. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
74. Human T-lymphotropic virus type I transcriptional regulation by methylation
75. Transcriptional block of HTLV-1 LTR by sequence-specific methylation
76. Genetic analysis of the human immunodeficiency virus type 1 integrase protein
77. Imprinting and the initiation of gene silencing in the germline
78. Circular forms of unintegrated human immunodeficiency virus type 1 DNA and high levels of viral protein expression: Association with dementia and multinucleated giant cells in the brains of patients with AIDS
79. INK4A promoter in HTLV type I-infected T cell lines
80. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5)-methyltransferase
81. 4RF/p16β is frequently altered in non-small cell lung cancer and correlates with p53 overexpression
82. Histone deacetylase directs the dominant silencing of transcription in chromatin: Association with MeCP2 and the Mi-2 chromodomain SWI/SNF ATPase
83. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
84. + encodes a DNA methyltransferase homologue
85. DNA demethylation
86. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells
87. Cytosine methylation and the ecology of intragenomic parasites
88. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure