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Volumn , Issue , 2007, Pages 127-156

Biological Markers of Exposure to Chemical Warfare Agents

Author keywords

CW agents and biological markers of exposure; Highly reactive phosgene electrophile; Nerve agents sarin (GB), VX and tabun (GA) Soman (GD) and cyclosarin (GF); Riot control agents (RCAs) contravening CWC; Sulphur and nitrogen mustards

Indexed keywords


EID: 84890246664     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470060032.ch5     Document Type: Chapter
Times cited : (21)

References (123)
  • 1
    • 1542275600 scopus 로고    scopus 로고
    • The application of the fluoride reactivation process to the detection of sarin and soman nerve agent exposures in biological samples
    • Adams TK, Capacio BR, Smith JR et al. (2004). The application of the fluoride reactivation process to the detection of sarin and soman nerve agent exposures in biological samples. Drug Chem Toxicol, 27, 77-91.
    • (2004) Drug Chem Toxicol , vol.27 , pp. 77-91
    • Adams, T.K.1    Capacio, B.R.2    Smith, J.R.3
  • 2
    • 48749137268 scopus 로고
    • Mercapturic acid pathway metabolites of xenobiotics: generation of potentially toxic metabolites during entereohepatic circulation
    • Bakke J and Gustafsson J-Å. (1984). Mercapturic acid pathway metabolites of xenobiotics: generation of potentially toxic metabolites during entereohepatic circulation. TIPS, 5, 517-521.
    • (1984) TIPS , vol.5 , pp. 517-521
    • Bakke, J.1    Gustafsson, J.-Å.2
  • 3
    • 3242677043 scopus 로고    scopus 로고
    • Quantitation of metabolites of the nerve agents sarin, soman, cyclosarin, VX and Russian VX in human urine using isotope-dilution gas chromatographytandem mass spectrometry
    • Barr JR, Driskell WJ, Aston LS. (2004). Quantitation of metabolites of the nerve agents sarin, soman, cyclosarin, VX and Russian VX in human urine using isotope-dilution gas chromatographytandem mass spectrometry. J Anal Toxicol, 28, 372-378.
    • (2004) J Anal Toxicol , vol.28 , pp. 372-378
    • Barr, J.R.1    Driskell, W.J.2    Aston, L.S.3
  • 4
    • 33947446112 scopus 로고
    • Kinetics of hydrolysis and displacement reactions of β, β'-dichlorodiethyl sulfide (mustard gas) and of β-chloro-β'-hydroxydiethyl sulfide (mustard chlorohydrin)
    • Bartlett PD and Swain CG. (1949). Kinetics of hydrolysis and displacement reactions of β, β'-dichlorodiethyl sulfide (mustard gas) and of β-chloro-β'-hydroxydiethyl sulfide (mustard chlorohydrin). J Am Chem Soc, 71, 1406-1415.
    • (1949) J Am Chem Soc , vol.71 , pp. 1406-1415
    • Bartlett, P.D.1    Swain, C.G.2
  • 5
    • 0030814750 scopus 로고    scopus 로고
    • Verification of exposure to sulfur mustard in two casualties of the Iran-Iraq conflict
    • Benschop HP, Van der Schans GP, Noort D et al. (1997). Verification of exposure to sulfur mustard in two casualties of the Iran-Iraq conflict. J Anal Toxicol, 21, 249-251.
    • (1997) J Anal Toxicol , vol.21 , pp. 249-251
    • Benschop, H.P.1    Van der Schans, G.P.2    Noort, D.3
  • 6
    • 0011436934 scopus 로고    scopus 로고
    • Diagnosis and dosimetry of exposure to sulfur mustard: development of standard operating procedures; further exploratory research on protein adducts
    • NTIS number: ADA381035/XAB. Springfield, VA, USA: NTIS
    • Benschop HP, Noort D, Van der Schans GP et al. (2000). Diagnosis and dosimetry of exposure to sulfur mustard: development of standard operating procedures; further exploratory research on protein adducts. Final Report Cooperative Agreement DAMD17-97-2-7002, NTIS number: ADA381035/XAB. Springfield, VA, USA: NTIS.
    • (2000) Final Report Cooperative Agreement DAMD17-97-2-7002
    • Benschop, H.P.1    Noort, D.2    Van Der Schans, G.P.3
  • 7
    • 85152339811 scopus 로고    scopus 로고
    • Toxicokinetics of nerve agents
    • SM Somani and JA Romano, eds, Boca Raton, FL, USA: CRC Press
    • Benschop HP and De Jong LPA (2001).Toxicokinetics of nerve agents. In: ChemicalWarfare Agents: Toxicity at Low Levels (SM Somani and JA Romano, eds), pp. 25-81. Boca Raton, FL, USA: CRC Press.
    • (2001) ChemicalWarfare Agents: Toxicity at Low Levels , pp. 25-81
    • Benschop, H.P.1    De Jong, L.P.A.2
  • 8
    • 0023759088 scopus 로고
    • Detection of trace levels of thiodiglycol in blood, plasma and urine using gas chromatography-electron capture negative ion chemical ionisation mass spectrometry
    • Black RM and Read RW. (1988). Detection of trace levels of thiodiglycol in blood, plasma and urine using gas chromatography-electron capture negative ion chemical ionisation mass spectrometry. J Chromatogr, 449, 261-270.
    • (1988) J Chromatogr , vol.449 , pp. 261-270
    • Black, R.M.1    Read, R.W.2
  • 9
    • 0025936106 scopus 로고
    • Methods for the analysis of thiodiglycol sulphoxide, a metabolite of sulphur mustard, in urine using gas chromatography-mass spectrometry
    • Black, RM and Read, RW (1991) Methods for the analysis of thiodiglycol sulphoxide, a metabolite of sulphur mustard, in urine using gas chromatography-mass spectrometry. J Chromatogr, 558, 393-404.
    • (1991) J Chromatogr , vol.558 , pp. 393-404
    • Black, R.M.1    Read, R.W.2
  • 10
    • 0026049331 scopus 로고
    • Analysis of 1, 1'-sulphonylbis[2-(methylsulphinyl)ethane] and 1-methylsulphinyl-2-[2-(methylthio)ethylsulphonyl]ethane, metabolites of sulphur mustard, in urine using gas chromatography-mass spectrometry
    • Black RM, Clarke RJ and Read RW. (1991). Analysis of 1, 1'-sulphonylbis[2-(methylsulphinyl)ethane] and 1-methylsulphinyl-2-[2-(methylthio)ethylsulphonyl]ethane, metabolites of sulphur mustard, in urine using gas chromatography-mass spectrometry. J Chromatogr, 558, 405-414.
    • (1991) J Chromatogr , vol.558 , pp. 405-414
    • Black, R.M.1    Clarke, R.J.2    Read, R.W.3
  • 11
    • 0026579407 scopus 로고
    • Biological fate of sulphur mustard, 1, 1-thiobis (2-chloroethane): isolation and identification of urinary metabolites following intraperitoneal administration to rat
    • Black RM, Brewster K, Clarke RJ et al. (1992a). Biological fate of sulphur mustard, 1, 1-thiobis (2-chloroethane): isolation and identification of urinary metabolites following intraperitoneal administration to rat. Xenobiotica, 22, 405-418.
    • (1992) Xenobiotica , vol.22 , pp. 405-418
    • Black, R.M.1    Brewster, K.2    Clarke, R.J.3
  • 12
    • 0026505078 scopus 로고
    • Biological fate of sulfur mustard, 1, 1'-thiobis (2-chloroethane). Urinary excretion profiles of hydrolysis products and β-lyase metabolites of sulfur mustard after cutaneous application in rats
    • Black RM, Hambrook JL, Howells DJ et al. (1992b). Biological fate of sulfur mustard, 1, 1'-thiobis (2-chloroethane). Urinary excretion profiles of hydrolysis products and β-lyase metabolites of sulfur mustard after cutaneous application in rats. J Anal Toxicol, 16, 79-84.
    • (1992) J Anal Toxicol , vol.16 , pp. 79-84
    • Black, R.M.1    Hambrook, J.L.2    Howells, D.J.3
  • 13
    • 0027254328 scopus 로고
    • Metabolism of thiodiglycol (2, 2'-thiobis-ethanol): isolation and identification of urinary metabolites following intraperitoneal administration to rat
    • Black RM, Brewster K, Clarke RJ et al. (1993). Metabolism of thiodiglycol (2, 2'-thiobis-ethanol): isolation and identification of urinary metabolites following intraperitoneal administration to rat. Xenobiotica, 23, 473-481.
    • (1993) Xenobiotica , vol.23 , pp. 473-481
    • Black, R.M.1    Brewster, K.2    Clarke, R.J.3
  • 14
    • 0028940369 scopus 로고
    • Improved methodology for the detection and quantitation of urinary metabolites of sulphur mustard using gas chromatography-tandem mass spectrometry
    • Black RM and Read RW (1995a). Improved methodology for the detection and quantitation of urinary metabolites of sulphur mustard using gas chromatography-tandem mass spectrometry. J Chromatogr B, 665, 97-105.
    • (1995) J Chromatogr B , vol.665 , pp. 97-105
    • Black, R.M.1    Read, R.W.2
  • 15
    • 0028906866 scopus 로고
    • Biological fate of sulphur mustard, 1, 1-thiobis (2-chloroethane): identification of β-lyase metabolites and hydrolysis products in human urine
    • Black RM and Read RW (1995b). Biological fate of sulphur mustard, 1, 1-thiobis (2-chloroethane): identification of β-lyase metabolites and hydrolysis products in human urine. Xenobiotica, 25, 167-173.
    • (1995) Xenobiotica , vol.25 , pp. 167-173
    • Black, R.M.1    Read, R.W.2
  • 16
    • 0030903682 scopus 로고    scopus 로고
    • Biological fate of sulphur mustard: identification of valine and histidine adducts in haemoglobin from casualties of sulphur mustard poisoning
    • Black RM, Clarke RJ, Harrison JM et al. (1997a). Biological fate of sulphur mustard: identification of valine and histidine adducts in haemoglobin from casualties of sulphur mustard poisoning. Xenobiotica, 27, 499-512.
    • (1997) Xenobiotica , vol.27 , pp. 499-512
    • Black, R.M.1    Clarke, R.J.2    Harrison, J.M.3
  • 17
    • 0031025754 scopus 로고    scopus 로고
    • Biological fate of sulphur mustard: in vitro alkylation of human haemoglobin by sulphur mustard
    • Black RM, Harrison JM and Read RW (1997b). Biological fate of sulphur mustard: in vitro alkylation of human haemoglobin by sulphur mustard. Xenobiotica, 27, 11-32.
    • (1997) Xenobiotica , vol.27 , pp. 11-32
    • Black, R.M.1    Harrison, J.M.2    Read, R.W.3
  • 18
    • 0032907461 scopus 로고    scopus 로고
    • The interaction of sarin and soman with plasma proteins: the identification of a novel phosphylation site
    • Black RM, Harrison JM and Read RW. (1999). The interaction of sarin and soman with plasma proteins: the identification of a novel phosphylation site. Arch Toxicol, 73, 123-126.
    • (1999) Arch Toxicol , vol.73 , pp. 123-126
    • Black, R.M.1    Harrison, J.M.2    Read, R.W.3
  • 19
    • 0038693313 scopus 로고    scopus 로고
    • Derivatization reactions in the chromatographic analysis of chemical warfare agents and their degradation products
    • Black RM and Muir R (2003). Derivatization reactions in the chromatographic analysis of chemical warfare agents and their degradation products. J Chromatogr A, 1000, 253-281.
    • (2003) J Chromatogr A , vol.1000 , pp. 253-281
    • Black, R.M.1    Muir, R.2
  • 20
    • 84889412976 scopus 로고    scopus 로고
    • Methods for the retrospective detection of exposure to toxic scheduled chemicals. Part A: analysis of free metabolites
    • M Mesilaakso, ed., Chichester, UK: John Wiley & Sons Ltd
    • Black RM and Noort D (2005). Methods for the retrospective detection of exposure to toxic scheduled chemicals. Part A: analysis of free metabolites. In: Chemical Weapons Convention Related Analysis (M Mesilaakso, ed.), pp. 403-431. Chichester, UK: John Wiley & Sons Ltd.
    • (2005) Chemical Weapons Convention Related Analysis , pp. 403-431
    • Black, R.M.1    Noort, D.2
  • 21
    • 3242739311 scopus 로고    scopus 로고
    • Quantitation of the sulfur mustard metabolites 1, 1'-sulfonylbis[2-(methylthio)ethane] and thiodiglycol in urine using isotope-dilution gas chromatography-tandem mass spectrometry
    • Boyer AE, Ash D, BarrDet al. (2004). Quantitation of the sulfur mustard metabolites 1, 1'-sulfonylbis[2-(methylthio)ethane] and thiodiglycol in urine using isotope-dilution gas chromatography-tandem mass spectrometry. J Anal Toxicol, 28, 327-332.
    • (2004) J Anal Toxicol , vol.28 , pp. 327-332
    • Boyer, A.E.1    Ash, D.2    Barr, D.3
  • 22
    • 0023203048 scopus 로고
    • The fate of 2-chlorobenzylidene malononitrile (CS) in rats
    • Brewster K, Harrison JM, Leadbeater J et al. (1987). The fate of 2-chlorobenzylidene malononitrile (CS) in rats. Xenobiotica, 17, 911-924.
    • (1987) Xenobiotica , vol.17 , pp. 911-924
    • Brewster, K.1    Harrison, J.M.2    Leadbeater, J.3
  • 23
    • 0000130061 scopus 로고
    • The reaction of mustard gas with nucleic acids in vitro and in vivo
    • Brookes P and Lawley PD. (1960). The reaction of mustard gas with nucleic acids in vitro and in vivo. Biochem J, 77, 478-484.
    • (1960) Biochem J , vol.77 , pp. 478-484
    • Brookes, P.1    Lawley, P.D.2
  • 24
    • 84890239293 scopus 로고
    • Development of a confirmatory chemical test for exposure to 3-quinuclidinyl benzilate (BZ)
    • Report 1987 Order No. AD-A191746. US Army Medical Research & Development Command, Fort Dietrick, Maryland (Chem Abstr, 110, 70602)
    • Byrd GD, Sniegoski LT and White VE (1987). Development of a confirmatory chemical test for exposure to 3-quinuclidinyl benzilate (BZ). Report 1987 Order No. AD-A191746. US Army Medical Research & Development Command, Fort Dietrick, Maryland (Chem Abstr, 110, 70602).
    • (1987)
    • Byrd, G.D.1    Sniegoski, L.T.2    White, V.E.3
  • 26
    • 3242668881 scopus 로고    scopus 로고
    • Monitoring of sulfur mustard exposure by gas chromatography-mass spectrometry: analysis of thiodiglycol cleaved from blood proteins
    • Capacio BR, Smith JR, DeLion MT et al. (2004). Monitoring of sulfur mustard exposure by gas chromatography-mass spectrometry: analysis of thiodiglycol cleaved from blood proteins. J Anal Toxicol, 28, 306-311.
    • (2004) J Anal Toxicol , vol.28 , pp. 306-311
    • Capacio, B.R.1    Smith, J.R.2    DeLion, M.T.3
  • 27
    • 0014972934 scopus 로고
    • Biochemical interactions and metabolic fate of riot control agents
    • Cucinell SA, Swentzel KC, Biskup R et al. (1971). Biochemical interactions and metabolic fate of riot control agents. Fed Proc, 30, 86-91.
    • (1971) Fed Proc , vol.30 , pp. 86-91
    • Cucinell, S.A.1    Swentzel, K.C.2    Biskup, R.3
  • 28
    • 50549181939 scopus 로고
    • Metabolism of bis-β-chloroethyl sulfide (sulfur mustard gas)
    • Davison C, Rozman RS and Smith PK. (1961). Metabolism of bis-β-chloroethyl sulfide (sulfur mustard gas). Biochem Pharmacol, 7, 65-74.
    • (1961) Biochem Pharmacol , vol.7 , pp. 65-74
    • Davison, C.1    Rozman, R.S.2    Smith, P.K.3
  • 29
    • 3242692397 scopus 로고    scopus 로고
    • Improvements of the fluoride reactivation method for the verification of nerve agent exposure
    • Degenhardt CEAM, Pleijsier K, Van der Schans MJ et al. (2004). Improvements of the fluoride reactivation method for the verification of nerve agent exposure. J Anal Toxicol, 28, 364-371.
    • (2004) J Anal Toxicol , vol.28 , pp. 364-371
    • Degenhardt, C.E.A.M.1    Pleijsier, K.2    Van Der Schans, M.J.3
  • 30
    • 0018875361 scopus 로고
    • Covalent binding of chloroform metabolites to nuclear proteins-no evidence for binding to nucleic acids
    • Diaz Gomez MI and Castro JA. (1980). Covalent binding of chloroform metabolites to nuclear proteins-no evidence for binding to nucleic acids. Cancer Lett, 9, 213-218.
    • (1980) Cancer Lett , vol.9 , pp. 213-218
    • Diaz Gomez, M.I.1    Castro, J.A.2
  • 31
    • 0035925067 scopus 로고    scopus 로고
    • Correlation of a specific mitochondrial phospholipid-phosgene adduct with chloroform acute toxicity
    • Di Consiglio E, De Angelis G, Testai E et al. (2001). Correlation of a specific mitochondrial phospholipid-phosgene adduct with chloroform acute toxicity. Toxicology, 159, 43-53.
    • (2001) Toxicology , vol.159 , pp. 43-53
    • Di Consiglio, E.1    De Angelis, G.2    Testai, E.3
  • 32
    • 0023618503 scopus 로고
    • Concentrations of mustard gas [bis (2-chloroethyl)sulfide] in the tissues of a victim of vesicant exposure
    • Drasch G, Kretschmer E, Kauert G et al. (1987). Concentrations of mustard gas [bis (2-chloroethyl)sulfide] in the tissues of a victim of vesicant exposure. J Forensic Sci, 32, 1788-1793.
    • (1987) J Forensic Sci , vol.32 , pp. 1788-1793
    • Drasch, G.1    Kretschmer, E.2    Kauert, G.3
  • 33
    • 0342471381 scopus 로고    scopus 로고
    • Pretreatment for nerve agent exposure
    • FR Sidell, ET Takafuji and DR Franz, eds, Washington, DC, USA: Office of the Surgeon General at TMM Publications, Borden Institute, Walter Read Army Medical Center
    • Dunn MA, Brennie EH and Sidell FR (1997). Pretreatment for nerve agent exposure. In: Medical Aspects of Chemical and BiologicalWarfare (FR Sidell, ET Takafuji and DR Franz, eds), pp. 181-196. Washington, DC, USA: Office of the Surgeon General at TMM Publications, Borden Institute, Walter Read Army Medical Center.
    • (1997) Medical Aspects of Chemical and BiologicalWarfare , pp. 181-196
    • Dunn, M.A.1    Brennie, E.H.2    Sidell, F.R.3
  • 34
    • 0034933842 scopus 로고    scopus 로고
    • Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: MALDI-TOF/MS analysis of various nerve agent phosphyl adducts
    • Elhanany E, Ordentlich A, Dgany O et al. (2001). Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: MALDI-TOF/MS analysis of various nerve agent phosphyl adducts. Chem Res Toxicol, 14, 912-918.
    • (2001) Chem Res Toxicol , vol.14 , pp. 912-918
    • Elhanany, E.1    Ordentlich, A.2    Dgany, O.3
  • 35
    • 33644811612 scopus 로고
    • A newand rapid colorimetric determination of acetylcholinesterase activity
    • Ellman GL, Courtney KD and Anders V. (1961). A newand rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol, 7, 88-95.
    • (1961) Biochem Pharmacol , vol.7 , pp. 88-95
    • Ellman, G.L.1    Courtney, K.D.2    Anders, V.3
  • 36
    • 0035697649 scopus 로고    scopus 로고
    • Adducts of the chloroform metabolite phosgene
    • Dansette PM, Snyder R, Delaforge M, eds, New York, NY, USA and Amsterdam, The Netherlands: Kluwer Academic/Plenum Publishers
    • Fabrizi L, Taylor GW, Edwards RJ et al. (2001). Adducts of the chloroform metabolite phosgene. In: Biological Reactive Intermediates VI (Dansette PM, Snyder R, Delaforge M, eds), pp. 129-132. New York, NY, USA and Amsterdam, The Netherlands: Kluwer Academic/Plenum Publishers.
    • (2001) Biological Reactive Intermediates VI , pp. 129-132
    • Fabrizi, L.1    Taylor, G.W.2    Edwards, R.J.3
  • 37
    • 0037350083 scopus 로고    scopus 로고
    • Adduction of the chloroform metabolite phosgene to lysine residues of human histone H2B
    • Fabrizi L, Taylor GW, Cañas B et al. (2003). Adduction of the chloroform metabolite phosgene to lysine residues of human histone H2B. Chem Res Toxicol, 16, 266-275.
    • (2003) Chem Res Toxicol , vol.16 , pp. 266-275
    • Fabrizi, L.1    Taylor, G.W.2    Cañas, B.3
  • 38
    • 0028267005 scopus 로고
    • Synthesis, characterization and quantitation of the major adducts formed between sulfur mustard and DNA of calf thymus and human blood
    • Fidder A, Moes GWH, Scheffer AG et al. (1994). Synthesis, characterization and quantitation of the major adducts formed between sulfur mustard and DNA of calf thymus and human blood. Chem Res Toxicol, 7, 199-204.
    • (1994) Chem Res Toxicol , vol.7 , pp. 199-204
    • Fidder, A.1    Moes, G.W.H.2    Scheffer, A.G.3
  • 39
    • 0030342053 scopus 로고    scopus 로고
    • N7-(2-Hydroxyethylthioethyl)-guanine: a novel urinary metabolite following exposure to sulphur mustard
    • Fidder A, Noort D, de Jong LPA et al. (1996). N7-(2-Hydroxyethylthioethyl)-guanine: a novel urinary metabolite following exposure to sulphur mustard. Arch Toxicol, 70, 854-855.
    • (1996) Arch Toxicol , vol.70 , pp. 854-855
    • Fidder, A.1    Noort, D.2    De Jong, L.P.A.3
  • 40
    • 0033763985 scopus 로고    scopus 로고
    • Biomonitoring of exposure to lewisite based on adducts to haemoglobin
    • Fidder A, Noort D, Hulst AG et al. (2000). Biomonitoring of exposure to lewisite based on adducts to haemoglobin. Arch Toxicol, 74, 207-214.
    • (2000) Arch Toxicol , vol.74 , pp. 207-214
    • Fidder, A.1    Noort, D.2    Hulst, A.G.3
  • 41
    • 0036113678 scopus 로고    scopus 로고
    • Retrospective detection of exposure to organophosphorus anti-cholinesterases: mass spectrometric analysis of phosphylated human butyrylcholinesterase
    • Fidder A, Noort D, Hulst AG et al. (2002). Retrospective detection of exposure to organophosphorus anti-cholinesterases: mass spectrometric analysis of phosphylated human butyrylcholinesterase. Chem Res Toxicol, 15, 582-590.
    • (2002) Chem Res Toxicol , vol.15 , pp. 582-590
    • Fidder, A.1    Noort, D.2    Hulst, A.G.3
  • 42
    • 0029120955 scopus 로고
    • Trace determination of alkyl methylphosphonic acids in environmental and biological samples using gas chromatography/negative-ion chemical ionization mass spectrometry and tandem mass spectrometry
    • Fredriksson S-Å, Hammarström L.-G, Henriksson L et al. (1995). Trace determination of alkyl methylphosphonic acids in environmental and biological samples using gas chromatography/negative-ion chemical ionization mass spectrometry and tandem mass spectrometry. J Mass Spectrom, 30, 1133-1143.
    • (1995) J Mass Spectrom , vol.30 , pp. 1133-1143
    • Fredriksson S.-Å. Hammarström, L.-G.1    Henriksson, L.2
  • 43
    • 0020559660 scopus 로고
    • The fate of dibenz[b, f ]-1, 4-oxazepine (CR) in the rat, rhesus monkey and guinea-pig. Part I. Metabolism in vivo
    • French MC, Harrison JM, Inch TD et al. (1983a). The fate of dibenz[b, f ]-1, 4-oxazepine (CR) in the rat, rhesus monkey and guinea-pig. Part I. Metabolism in vivo. Xenobiotica, 13, 345-359.
    • (1983) Xenobiotica , vol.13 , pp. 345-359
    • French, M.C.1    Harrison, J.M.2    Inch, T.D.3
  • 44
    • 0020965851 scopus 로고
    • The fate of dibenz[b, f ]-1, 4-oxazepine (CR) in the rat. Part III. The intermediary metabolites
    • French MC, Harrison JM, Newman J. et al. (1983b). The fate of dibenz[b, f ]-1, 4-oxazepine (CR) in the rat. Part III. The intermediary metabolites. Xenobiotica, 13, 373-381.
    • (1983) Xenobiotica , vol.13 , pp. 373-381
    • French, M.C.1    Harrison, J.M.2    Newman, J.3
  • 45
    • 0016770128 scopus 로고
    • The alkylation of hemoglobin S by nitrogen mustard
    • Fung LW-M, Ho C, Roth EF et al. (1975). The alkylation of hemoglobin S by nitrogen mustard. J Biol Chem, 250, 4786-4789.
    • (1975) J Biol Chem , vol.250 , pp. 4786-4789
    • Fung, L.W.-M.1    Ho, C.2    Roth, E.F.3
  • 47
    • 0027225506 scopus 로고
    • Biological fate of sulphur mustard (1, 1'-thiobis (2-chloroethane)): uptake, distribution and retention of 35S in skin and in blood after cutaneous application of 35S-sulphur mustard in rat and comparison with human blood in vitro
    • Hambrook JL, Howells DJ and Schock C. (1993). Biological fate of sulphur mustard (1, 1'-thiobis (2-chloroethane)): uptake, distribution and retention of 35S in skin and in blood after cutaneous application of 35S-sulphur mustard in rat and comparison with human blood in vitro. Xenobiotica, 23, 537-561.
    • (1993) Xenobiotica , vol.23 , pp. 537-561
    • Hambrook, J.L.1    Howells, D.J.2    Schock, C.3
  • 48
    • 0017845899 scopus 로고
    • The metabolism of dibenz[b, f]-1, 4-oxazepine (CR): in vivo hydroxylation of 10, 11-dihydrodibenz[b, f]-1, 4-oxazepin-11-(1OH)-one and the NIH shift
    • Harrison JM, Clarke RJ, Inch TD et al. (1978). The metabolism of dibenz[b, f]-1, 4-oxazepine (CR): in vivo hydroxylation of 10, 11-dihydrodibenz[b, f]-1, 4-oxazepin-11-(1OH)-one and the NIH shift. Experientia, 34, 698-699.
    • (1978) Experientia , vol.34 , pp. 698-699
    • Harrison, J.M.1    Clarke, R.J.2    Inch, T.D.3
  • 49
    • 34547800796 scopus 로고    scopus 로고
    • Phosphylated tyrosine as a biomarker of exposure to organophosphorus nerve agents
    • in press
    • Harrison JM, Read RW, Williams NH et al. (2007). Phosphylated tyrosine as a biomarker of exposure to organophosphorus nerve agents. Arch Toxicol, in press.
    • (2007) Arch Toxicol
    • Harrison, J.M.1    Read, R.W.2    Williams, N.H.3
  • 50
    • 0032533539 scopus 로고    scopus 로고
    • Determination of cyanide in whole blood by capillary gas chromatography with cryogenic oven trapping
    • Ishii A, Seno H, Watanabe-Suzuki K, et al. (1998). Determination of cyanide in whole blood by capillary gas chromatography with cryogenic oven trapping. Anal Chem, 70, 4873-4876.
    • (1998) Anal Chem , vol.70 , pp. 4873-4876
    • Ishii, A.1    Seno, H.2    Watanabe-Suzuki, K.3
  • 51
    • 0025317021 scopus 로고
    • Quantification of thiodiglycol in urine by electron ionization gas chromatography-mass spectrometry
    • Jakubowski EM, Woodard CL, Mershon MM et al. (1990). Quantification of thiodiglycol in urine by electron ionization gas chromatography-mass spectrometry. J Chromatogr, 528, 184-190.
    • (1990) J Chromatogr , vol.528 , pp. 184-190
    • Jakubowski, E.M.1    Woodard, C.L.2    Mershon, M.M.3
  • 52
    • 0007385859 scopus 로고
    • Verification of lewisite exposure: quantification of chlorovinyl arsonous acid in biological samples
    • 10-13 May, Aberdeen Proving Ground, MD, USA:USArmy Medical Research Institute of Chemical Defense
    • Jakubowski EM, Smith JR, Logan TP et al. (1993). Verification of lewisite exposure: quantification of chlorovinyl arsonous acid in biological samples. In: Proceedings of the 1993 Medical Defense Bioscience Review, 10-13 May, pp. 361-368. Aberdeen Proving Ground, MD, USA:USArmy Medical Research Institute of Chemical Defense.
    • (1993) Proceedings of the 1993 Medical Defense Bioscience Review , pp. 361-368
    • Jakubowski, E.M.1    Smith, J.R.2    Logan, T.P.3
  • 53
    • 0346388347 scopus 로고    scopus 로고
    • Quantification of thiodiglycol in human urine after an accidental sulfur mustard exposure
    • Jakubowski EM, Sidell FR, Evans RA et al. (2000). Quantification of thiodiglycol in human urine after an accidental sulfur mustard exposure. Toxicol Methods, 10, 143-150.
    • (2000) Toxicol Methods , vol.10 , pp. 143-150
    • Jakubowski, E.M.1    Sidell, F.R.2    Evans, R.A.3
  • 54
    • 3242729444 scopus 로고    scopus 로고
    • Quantitation of fluoride ion released sarin in red blood cell samples by gas chromatography-chemical ionization mass spectrometry using isotope dilution and large-volume injection
    • Jakubowski EM, McGuire JM, Evans RA et al. (2004). Quantitation of fluoride ion released sarin in red blood cell samples by gas chromatography-chemical ionization mass spectrometry using isotope dilution and large-volume injection. J Anal Toxicol, 28, 357-363.
    • (2004) J Anal Toxicol , vol.28 , pp. 357-363
    • Jakubowski, E.M.1    McGuire, J.M.2    Evans, R.A.3
  • 55
    • 0021932668 scopus 로고
    • In vivo and in vitro metabolism of dihydrocapsaicin, a pungent principle of hot pepper, in rats
    • Kawada T and Iwai K. (1985). In vivo and in vitro metabolism of dihydrocapsaicin, a pungent principle of hot pepper, in rats. Agric Biol Chem, 49, 441-448.
    • (1985) Agric Biol Chem , vol.49 , pp. 441-448
    • Kawada, T.1    Iwai, K.2
  • 56
    • 0019310781 scopus 로고
    • Metabolism of carbon tetrachloride to phosgene
    • Kubic VL and Anders MW (1980). Metabolism of carbon tetrachloride to phosgene. Life Sci, 26, 2151-2156.
    • (1980) Life Sci , vol.26 , pp. 2151-2156
    • Kubic, V.L.1    Anders, M.W.2
  • 57
    • 0015789133 scopus 로고
    • The absorption of ochlorobenzylidene malononitrile (CS) by the respiratory tract
    • Leadbeater L. (1973). The absorption of ochlorobenzylidene malononitrile (CS) by the respiratory tract. Toxicol Appl Pharmacol, 25, 101-110.
    • (1973) Toxicol Appl Pharmacol , vol.25 , pp. 101-110
    • Leadbeater, L.1
  • 58
    • 0037253580 scopus 로고    scopus 로고
    • Quantitative determination of the hydrolysis products of nitrogen mustards in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry
    • Lemire SW, Ashley DL and Calafat AM. (2003). Quantitative determination of the hydrolysis products of nitrogen mustards in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry. J Anal Toxicol, 27, 1-6.
    • (2003) J Anal Toxicol , vol.27 , pp. 1-6
    • Lemire, S.W.1    Ashley, D.L.2    Calafat, A.M.3
  • 59
    • 3242718664 scopus 로고    scopus 로고
    • Quantitation of biomarkers of exposure to nitrogen mustards in urine from rats dosed with nitrogen mustards and from an unexposed human population
    • Lemire SW, Barr JR, Ashley DL et al. (2004). Quantitation of biomarkers of exposure to nitrogen mustards in urine from rats dosed with nitrogen mustards and from an unexposed human population. J Anal Toxicol, 28, 320-326.
    • (2004) J Anal Toxicol , vol.28 , pp. 320-326
    • Lemire, S.W.1    Barr, J.R.2    Ashley, D.L.3
  • 60
    • 0029782555 scopus 로고    scopus 로고
    • Pharmacokinetics of N-methyldiethanolamine following acute cutaneous and intravenous dosing in the rat
    • Leung H-W, Ballantyne B and Frantgz SW. (1996). Pharmacokinetics of N-methyldiethanolamine following acute cutaneous and intravenous dosing in the rat. J Toxicol-Cutaneous Ocular Toxicol, 15, 343-353.
    • (1996) J Toxicol-Cutaneous Ocular Toxicol , vol.15 , pp. 343-353
    • Leung, H.-W.1    Ballantyne, B.2    Frantgz, S.W.3
  • 61
    • 0032760143 scopus 로고    scopus 로고
    • Verification of lewisite exposure by the analysis of 2-chlorovinyl arsonous acid in urine
    • Logan TP, Smith JR, Jakubowski EM et al. (1999). Verification of lewisite exposure by the analysis of 2-chlorovinyl arsonous acid in urine. Toxicol Methods, 9, 275-284.
    • (1999) Toxicol Methods , vol.9 , pp. 275-284
    • Logan, T.P.1    Smith, J.R.2    Jakubowski, E.M.3
  • 62
    • 17144383186 scopus 로고    scopus 로고
    • Determination of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid in urine and plasma by gas chromatography-mass spectrometry
    • Logue BA, Kirschten NP, Petrikovics I et al. (2005). Determination of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid in urine and plasma by gas chromatography-mass spectrometry. J Chromatogr B, 819, 237-244.
    • (2005) J Chromatogr B , vol.819 , pp. 237-244
    • Logue, B.A.1    Kirschten, N.P.2    Petrikovics, I.3
  • 64
    • 0029036158 scopus 로고
    • Analysis of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid in urine by high-performance liquid chromatography
    • Lundquist P, Kagedal B, Nilsson L et al. (1995). Analysis of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid in urine by high-performance liquid chromatography. Anal Biochem, 228, 27-34.
    • (1995) Anal Biochem , vol.228 , pp. 27-34
    • Lundquist, P.1    Kagedal, B.2    Nilsson, L.3
  • 65
    • 84872118706 scopus 로고
    • The inhibition of thiol enzymes by lachrymators
    • Mackworth JR. (1948). The inhibition of thiol enzymes by lachrymators. Biochem J, 42, 82-90.
    • (1948) Biochem J , vol.42 , pp. 82-90
    • Mackworth, J.R.1
  • 66
    • 0027236212 scopus 로고
    • Biological fate of sulphur mustard in rat: toxicokinetics and disposition
    • Maisonneuve A, Callebat I, Debordes L et al. (1993). Biological fate of sulphur mustard in rat: toxicokinetics and disposition. Xenobiotica, 23, 771-180.
    • (1993) Xenobiotica , vol.23 , pp. 771-180
    • Maisonneuve, A.1    Callebat, I.2    Debordes, L.3
  • 67
    • 0032103413 scopus 로고    scopus 로고
    • Detection of sarin hydrolysis product in formalin-fixed brain tissues of victims of the Tokyo subway terrorist attack
    • Matsuda Y, Nagao M, Takatori T et al. (1998). Detection of sarin hydrolysis product in formalin-fixed brain tissues of victims of the Tokyo subway terrorist attack. Toxicol Appl Pharmacol, 150, 310-320.
    • (1998) Toxicol Appl Pharmacol , vol.150 , pp. 310-320
    • Matsuda, Y.1    Nagao, M.2    Takatori, T.3
  • 68
    • 0035901868 scopus 로고    scopus 로고
    • Determination of degradation products of nerve agents in human serum by solid phase extraction using molecularly imprinted polymer
    • Meng ZH and Qin L. (2001). Determination of degradation products of nerve agents in human serum by solid phase extraction using molecularly imprinted polymer. Anal Chim Acta, 435, 121-127.
    • (2001) Anal Chim Acta , vol.435 , pp. 121-127
    • Meng, Z.H.1    Qin, L.2
  • 69
    • 0033001849 scopus 로고    scopus 로고
    • Determination of alkyl methylphosphonic acids, the main metabolites of organophosphorus nerve agents, in biofluids by gas chromatography-mass spectrometry by liquid-liquid-solid-phasetransfer-catalyzed pentafluorobenzylation
    • Miki A, Katagi M, Tsuchihashi H et al. (1999). Determination of alkyl methylphosphonic acids, the main metabolites of organophosphorus nerve agents, in biofluids by gas chromatography-mass spectrometry by liquid-liquid-solid-phasetransfer-catalyzed pentafluorobenzylation. J Anal Toxicol, 23, 86-93.
    • (1999) J Anal Toxicol , vol.23 , pp. 86-93
    • Miki, A.1    Katagi, M.2    Tsuchihashi, H.3
  • 70
    • 0030808137 scopus 로고    scopus 로고
    • Method for the analysis of the methylphosphonic acid metabolites of sarin and its ethanol-substituted analogue in urine as applied to the victims of the Tokyo sarin disaster
    • Minami M, Hui D-M, Katsumata M et al. (1997). Method for the analysis of the methylphosphonic acid metabolites of sarin and its ethanol-substituted analogue in urine as applied to the victims of the Tokyo sarin disaster. J Chromatogr B, 695, 237-244.
    • (1997) J Chromatogr B , vol.695 , pp. 237-244
    • Minami, M.1    Hui, D.-M.2    Katsumata, M.3
  • 71
    • 4244190551 scopus 로고
    • A general reaction of diisopropyl phosphorofluoridate with proteins without direct effect on enzymic activities
    • Murachi T. (1963). A general reaction of diisopropyl phosphorofluoridate with proteins without direct effect on enzymic activities. Biochim Biophys Acta, 71, 239-241.
    • (1963) Biochim Biophys Acta , vol.71 , pp. 239-241
    • Murachi, T.1
  • 72
    • 0031149936 scopus 로고    scopus 로고
    • Definitive evidence for the acute sarin poisoning diagnosis in the Tokyo subway
    • Nagao M, Takatori T, Matsuda Y et al. (1997). Definitive evidence for the acute sarin poisoning diagnosis in the Tokyo subway. Toxicol Appl Pharmacol, 144, 198-203.
    • (1997) Toxicol Appl Pharmacol , vol.144 , pp. 198-203
    • Nagao, M.1    Takatori, T.2    Matsuda, Y.3
  • 73
    • 0031719349 scopus 로고    scopus 로고
    • Urinary metabolites of sarin in a patient of the Matsumoto sarin incident
    • Nakajima T, Sasaki K, Ozawa H et al. (1998). Urinary metabolites of sarin in a patient of the Matsumoto sarin incident. Arch Toxicol, 72, 601-603.
    • (1998) Arch Toxicol , vol.72 , pp. 601-603
    • Nakajima, T.1    Sasaki, K.2    Ozawa, H.3
  • 74
    • 0029670559 scopus 로고    scopus 로고
    • A 32P-postlabeling method for the detection of adducts in the DNA of human fibroblasts exposed to sulfur mustard
    • Niu T, Matijasevic Z, Austin-Ritchie P et al. (1996). A 32P-postlabeling method for the detection of adducts in the DNA of human fibroblasts exposed to sulfur mustard. Chem Biol Interact, 100, 77-84.
    • (1996) Chem Biol Interact , vol.100 , pp. 77-84
    • Niu, T.1    Matijasevic, Z.2    Austin-Ritchie, P.3
  • 75
    • 0029894028 scopus 로고    scopus 로고
    • Characterization of sulfur mustard induced structural modifications in human hemoglobin by liquid chromatography-tandem mass spectrometry
    • Noort D, Verheij ER, Hulst AG et al. (1996). Characterization of sulfur mustard induced structural modifications in human hemoglobin by liquid chromatography-tandem mass spectrometry. Chem Res Toxicol, 9, 781-787.
    • (1996) Chem Res Toxicol , vol.9 , pp. 781-787
    • Noort, D.1    Verheij, E.R.2    Hulst, A.G.3
  • 76
    • 0031724974 scopus 로고    scopus 로고
    • Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: estimation of internal dosage
    • Noort D, Hulst AG, Platenburg DHJM et al. (1998). Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: estimation of internal dosage. Arch Toxicol, 72, 671-675.
    • (1998) Arch Toxicol , vol.72 , pp. 671-675
    • Noort, D.1    Hulst, A.G.2    Platenburg, D.H.J.M.3
  • 77
    • 0032793485 scopus 로고    scopus 로고
    • Alkylation of human serum albumin by sulfur mustard in vitro and in vivo: mass spectrometric analysis of a cysteine adduct as a sensitive biomarker of exposure
    • Noort D, Hulst AG, De Jong LPA et al. (1999). Alkylation of human serum albumin by sulfur mustard in vitro and in vivo: mass spectrometric analysis of a cysteine adduct as a sensitive biomarker of exposure. Chem Res Toxicol, 12, 715-721.
    • (1999) Chem Res Toxicol , vol.12 , pp. 715-721
    • Noort, D.1    Hulst, A.G.2    De Jong, L.P.A.3
  • 78
    • 0033841207 scopus 로고    scopus 로고
    • In vitro adduct formation of phosgene with albumin and hemoglobin in human blood
    • Noort D, Hulst AG, Fidder A et al. (2000). In vitro adduct formation of phosgene with albumin and hemoglobin in human blood. Chem Res Toxicol, 13, 719-726.
    • (2000) Chem Res Toxicol , vol.13 , pp. 719-726
    • Noort, D.1    Hulst, A.G.2    Fidder, A.3
  • 79
    • 0036431612 scopus 로고    scopus 로고
    • Biomonitoring of exposure to chemical warfare agents: a review
    • Noort D, Benschop HP and Black RM (2002a). Biomonitoring of exposure to chemical warfare agents: a review. Toxicol Appl Pharmacol, 184, 116-126.
    • (2002) Toxicol Appl Pharmacol , vol.184 , pp. 116-126
    • Noort, D.1    Benschop, H.P.2    Black, R.M.3
  • 80
    • 0036210212 scopus 로고    scopus 로고
    • Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin
    • Noort D, Hulst AG and Jansen R (2002b). Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin. Arch Toxicol, 76, 83-88.
    • (2002) Arch Toxicol , vol.76 , pp. 83-88
    • Noort, D.1    Hulst, A.G.2    Jansen, R.3
  • 81
    • 3242730357 scopus 로고    scopus 로고
    • Procedure for monitoring exposure to sulfur mustard based on modified Edman degradation of globin
    • Noort D, Fidder A, Benschop HP et al. (2004a). Procedure for monitoring exposure to sulfur mustard based on modified Edman degradation of globin. J Anal Toxicol, 28, 311-315.
    • (2004) J Anal Toxicol , vol.28 , pp. 311-315
    • Noort, D.1    Fidder, A.2    Benschop, H.P.3
  • 82
    • 3242682512 scopus 로고    scopus 로고
    • Retrospective detection of exposure to sulfur mustard: improvements on an assay for liquid chromatography-tandem mass spectrometry analysis of albumin/sulfur mustard adducts
    • Noort D, Fidder A, Hulst AG et al. (2004b). Retrospective detection of exposure to sulfur mustard: improvements on an assay for liquid chromatography-tandem mass spectrometry analysis of albumin/sulfur mustard adducts. J Anal Toxicol, 28, 333-338.
    • (2004) J Anal Toxicol , vol.28 , pp. 333-338
    • Noort, D.1    Fidder, A.2    Hulst, A.G.3
  • 83
    • 34547740177 scopus 로고    scopus 로고
    • Methods for the retrospective detection of exposure to toxic scheduled chemicals. Part B: analysis of covalent adducts to proteins and DNA
    • MMesilaakso, ed., Chichester, UK: John Wiley & Sons Ltd
    • Noort D and Black RM (2005). Methods for the retrospective detection of exposure to toxic scheduled chemicals. Part B: analysis of covalent adducts to proteins and DNA. In: ChemicalWeapons Convention Related Analysis (MMesilaakso, ed.), pp. 433-451. Chichester, UK: John Wiley & Sons Ltd.
    • (2005) ChemicalWeapons Convention Related Analysis , pp. 433-451
    • Noort, D.1    Black, R.M.2
  • 84
    • 9744249463 scopus 로고    scopus 로고
    • Determination of thiodiglycol, a mustard gas hydrolysis product, by gas chromatography-mass spectrometry after tertbutyldimethylsilylation
    • Ohsawa I, Kanamori-Kataoka M, Tsuge K et al. (2004). Determination of thiodiglycol, a mustard gas hydrolysis product, by gas chromatography-mass spectrometry after tertbutyldimethylsilylation. J Chromatogr B, 1061, 235-241.
    • (2004) J Chromatogr B , vol.1061 , pp. 235-241
    • Ohsawa, I.1    Kanamori-Kataoka, M.2    Tsuge, K.3
  • 85
    • 0034793667 scopus 로고    scopus 로고
    • Riot control agents: pharmacology, toxicology, biochemistry and chemistry
    • Olajos EJ and Salem H. (2001). Riot control agents: pharmacology, toxicology, biochemistry and chemistry. J Appl Toxicol, 21, 355-391.
    • (2001) J Appl Toxicol , vol.21 , pp. 355-391
    • Olajos, E.J.1    Salem, H.2
  • 86
    • 0028943798 scopus 로고
    • Alkylation of DNA by the nitrogen mustard bis (2-chloroethyl)methylamine
    • Osborne MR, Wilman DE and Lawley PD. (1995). Alkylation of DNA by the nitrogen mustard bis (2-chloroethyl)methylamine. Chem Res Toxicol, 8, 316-320.
    • (1995) Chem Res Toxicol , vol.8 , pp. 316-320
    • Osborne, M.R.1    Wilman, D.E.2    Lawley, P.D.3
  • 87
    • 13644261755 scopus 로고    scopus 로고
    • Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry
    • Peeples ES, Schopfer LM, Duysen EG et al. (2005). Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol Sci, 83, 303-312.
    • (2005) Toxicol Sci , vol.83 , pp. 303-312
    • Peeples, E.S.1    Schopfer, L.M.2    Duysen, E.G.3
  • 88
    • 0019481016 scopus 로고
    • The formation of diglutathionyl dithiocarbonate as a metabolite of chloroform, bromotrichloromethane and carbon tetrachloride
    • Pohl LR, Branchflower RV, Highet RJ et al. (1981). The formation of diglutathionyl dithiocarbonate as a metabolite of chloroform, bromotrichloromethane and carbon tetrachloride. Drug Metab Disp, 9, 334-339.
    • (1981) Drug Metab Disp , vol.9 , pp. 334-339
    • Pohl, L.R.1    Branchflower, R.V.2    Highet, R.J.3
  • 89
    • 0030884927 scopus 로고    scopus 로고
    • Newmethod for retrospective detection of exposure to organophosphorus anticholinesterases: application to alleged sarin victims of Japanese terrorists
    • Polhuijs M, Langenberg JP and Benschop HP. (1997). Newmethod for retrospective detection of exposure to organophosphorus anticholinesterases: application to alleged sarin victims of Japanese terrorists. Toxicol Appl Pharmacol, 146, 156-161.
    • (1997) Toxicol Appl Pharmacol , vol.146 , pp. 156-161
    • Polhuijs, M.1    Langenberg, J.P.2    Benschop, H.P.3
  • 90
    • 3242657246 scopus 로고    scopus 로고
    • Analysis of the sulfur mustard metabolite 1, 1'-sulfonylbis[2-S-(Nacetylcysteinyl) ethane] in urine by negative ion electrospray liquid chromatography-tandem mass spectrometry
    • Read RW and Black RM (2004a). Analysis of the sulfur mustard metabolite 1, 1'-sulfonylbis[2-S-(Nacetylcysteinyl) ethane] in urine by negative ion electrospray liquid chromatography-tandem mass spectrometry. J Anal Toxicol, 28, 352-356.
    • (2004) J Anal Toxicol , vol.28 , pp. 352-356
    • Read, R.W.1    Black, R.M.2
  • 91
    • 3242686936 scopus 로고    scopus 로고
    • Analysis of β-lyase metabolites of sulfur mustard in urine by electrospray liquid chromatography-tandem mass spectrometry
    • Read RW and Black RM (2004b). Analysis of β-lyase metabolites of sulfur mustard in urine by electrospray liquid chromatography-tandem mass spectrometry. J Anal Toxicol, 28, 346-351.
    • (2004) J Anal Toxicol , vol.28 , pp. 346-351
    • Read, R.W.1    Black, R.M.2
  • 92
    • 0037348385 scopus 로고    scopus 로고
    • Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells
    • Reilly CA, Ehlhardt WJ, Jackson DA et al. (2003). Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol, 16, 336-349.
    • (2003) Chem Res Toxicol , vol.16 , pp. 336-349
    • Reilly, C.A.1    Ehlhardt, W.J.2    Jackson, D.A.3
  • 93
    • 15344350833 scopus 로고    scopus 로고
    • Structural and enzymatic parameters that determine alkyl dehydrogenation/hydroxylation of capsaicinoids by cytochrome p450 enzymes
    • Reilly CA and Yost GS. (2005). Structural and enzymatic parameters that determine alkyl dehydrogenation/hydroxylation of capsaicinoids by cytochrome p450 enzymes. Drug Metab Dispos, 33, 530-536.
    • (2005) Drug Metab Dispos , vol.33 , pp. 530-536
    • Reilly, C.A.1    Yost, G.S.2
  • 94
    • 12444264948 scopus 로고    scopus 로고
    • The trace analysis of alkyl alkylphosphonic acids in urine using gas chromatography-ion trap negative ion tandem mass spectrometry
    • Riches J, Morton I, Read RW et al. (2005). The trace analysis of alkyl alkylphosphonic acids in urine using gas chromatography-ion trap negative ion tandem mass spectrometry. J Chromatogr B, 816, 251-258.
    • (2005) J Chromatogr B , vol.816 , pp. 251-258
    • Riches, J.1    Morton, I.2    Read, R.W.3
  • 95
    • 33751501040 scopus 로고    scopus 로고
    • Analysis of the sulphur mustard metabolite thiodiglycol in urine using isotope-dilution gas chromatographyion trap tandem mass spectrometry
    • Riches J, Read RW and Black RM. (2007). Analysis of the sulphur mustard metabolite thiodiglycol in urine using isotope-dilution gas chromatographyion trap tandem mass spectrometry. J Chromatogr B, 845, 114-120.
    • (2007) J Chromatogr B , vol.845 , pp. 114-120
    • Riches, J.1    Read, R.W.2    Black, R.M.3
  • 96
    • 0020515842 scopus 로고
    • 2-Chlorobenzylmercapturic acid, a metabolite of the riot control agent chlorobenzylidine malononitrile (CS) in the rat
    • Rietveld EC, Delbressine LPC, Waegemaekers THJM et al. (1983). 2-Chlorobenzylmercapturic acid, a metabolite of the riot control agent chlorobenzylidine malononitrile (CS) in the rat. Arch Toxicol, 54, 139-144.
    • (1983) Arch Toxicol , vol.54 , pp. 139-144
    • Rietveld, E.C.1    Delbressine, L.P.C.2    Waegemaekers, T.H.J.M.3
  • 97
    • 0001622323 scopus 로고
    • Studies of the mode of action of alkylating agents-VI. The metabolism of bis-2-chloroethylsulphide (mustard gas) and related compounds
    • Roberts JJ and Warwick GP. (1963). Studies of the mode of action of alkylating agents-VI. The metabolism of bis-2-chloroethylsulphide (mustard gas) and related compounds. Biochem Pharmacol, 12, 1329-1334.
    • (1963) Biochem Pharmacol , vol.12 , pp. 1329-1334
    • Roberts, J.J.1    Warwick, G.P.2
  • 98
    • 0026612157 scopus 로고
    • N1-(2-Hydroxyethylthioethyl)-4-methylimidazole (4-met-1-imid-thiodiglycol) in plasma and urine: a novel metabolite following dermal exposure to sulphur mustard
    • Sandelowsky I, Simon GA, Bel P et al. (1992). N1-(2-Hydroxyethylthioethyl)-4-methylimidazole (4-met-1-imid-thiodiglycol) in plasma and urine: a novel metabolite following dermal exposure to sulphur mustard. Arch Toxicol, 66, 296-297.
    • (1992) Arch Toxicol , vol.66 , pp. 296-297
    • Sandelowsky, I.1    Simon, G.A.2    Bel, P.3
  • 99
    • 0026262193 scopus 로고
    • Detection of metabolites of toxic alkyl methylphosphonates in biological samples
    • Shih ML, Smith JR, McMonagle JD et al. (1991). Detection of metabolites of toxic alkyl methylphosphonates in biological samples. Biol Mass Spectrom, 20, 717-723.
    • (1991) Biol Mass Spectrom , vol.20 , pp. 717-723
    • Shih, M.L.1    Smith, J.R.2    McMonagle, J.D.3
  • 100
    • 0028337249 scopus 로고
    • Metabolite pharmacokinetics of soman, sarin and GF in rats and biological monitoring of exposure to toxic organophosphorus agents
    • Shih ML, McMonagle JD, Dolzine TW et al. (1994). Metabolite pharmacokinetics of soman, sarin and GF in rats and biological monitoring of exposure to toxic organophosphorus agents. J Appl Toxicol, 14, 195-199.
    • (1994) J Appl Toxicol , vol.14 , pp. 195-199
    • Shih, M.L.1    McMonagle, J.D.2    Dolzine, T.W.3
  • 101
    • 0032566746 scopus 로고    scopus 로고
    • High-performance liquid chromatographic determination of N-[2-(hydroxyethyl)-N-(2-(7-guaninyl)ethyl]methylamine, a reaction product between nitrogen mustard and DNA and its application to biological samples
    • Sperry ML, Skanchy D and Marino MT. (1998). High-performance liquid chromatographic determination of N-[2-(hydroxyethyl)-N-(2-(7-guaninyl)ethyl]methylamine, a reaction product between nitrogen mustard and DNA and its application to biological samples. J Chromatogr B, 716, 187-193.
    • (1998) J Chromatogr B , vol.716 , pp. 187-193
    • Sperry, M.L.1    Skanchy, D.2    Marino, M.T.3
  • 102
    • 0033806528 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice
    • Stott WT, Waechter JM, Rick DL et al. (2000). Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice. Food Chem Toxicol, 38, 1043-1051.
    • (2000) Food Chem Toxicol , vol.38 , pp. 1043-1051
    • Stott, W.T.1    Waechter, J.M.2    Rick, D.L.3
  • 103
    • 0009574128 scopus 로고
    • Metabolism of capsaicinoids: evidence for aliphatic hydroxylation and its pharmacological implications
    • Surh YJ, Ahn SH, Kim KCet al.. (1995). Metabolism of capsaicinoids: evidence for aliphatic hydroxylation and its pharmacological implications. Life Sci, 56, PL305-PL311.
    • (1995) Life Sci , vol.56
    • Surh, Y.J.1    Ahn, S.H.2    Kim, K.C.3
  • 104
    • 0030025555 scopus 로고    scopus 로고
    • Oxazolidonylethyl adducts to hemoglobin and DNA following nornitrogen mustard exposure
    • Thulin H, Zorcec V, Segerback D et al. (1996). Oxazolidonylethyl adducts to hemoglobin and DNA following nornitrogen mustard exposure. Chem-Bio Interact, 99, 263-275.
    • (1996) Chem-Bio Interact , vol.99 , pp. 263-275
    • Thulin, H.1    Zorcec, V.2    Segerback, D.3
  • 105
    • 1942436006 scopus 로고    scopus 로고
    • Noninvasive biomonitoring approaches to determine dosimetry and risk following acute chemical exposure: analysis of lead or organophosphate insecticide in saliva
    • Timchalk C, Poet TS, Kousba AA et al. (2004). Noninvasive biomonitoring approaches to determine dosimetry and risk following acute chemical exposure: analysis of lead or organophosphate insecticide in saliva. J Toxicol Environ Health Curr Issues, 67, 635-650.
    • (2004) J Toxicol Environ Health Curr Issues , vol.67 , pp. 635-650
    • Timchalk, C.1    Poet, T.S.2    Kousba, A.A.3
  • 106
    • 0022491941 scopus 로고    scopus 로고
    • Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method
    • Törnqvist M, Mowrer J, Jensen S et al. (1996). Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method. Anal Biochem, 154, 255-266.
    • (1996) Anal Biochem , vol.154 , pp. 255-266
    • Törnqvist, M.1    Mowrer, J.2    Jensen, S.3
  • 107
    • 0037027003 scopus 로고    scopus 로고
    • Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications
    • Törnqvist M, Fred C, Haglund J et al. (2002). Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications. J Chromatogr B, 778, 279-308.
    • (2002) J Chromatogr B , vol.778 , pp. 279-308
    • Törnqvist, M.1    Fred, C.2    Haglund, J.3
  • 108
    • 77049282903 scopus 로고
    • Studies on the N-dealkylation of nitrogen mustard and triethylenediamine by liver homogenates
    • Trams EG and Nadkarni MV. (1956). Studies on the N-dealkylation of nitrogen mustard and triethylenediamine by liver homogenates. Cancer Res, 16, 1069-1075.
    • (1956) Cancer Res , vol.16 , pp. 1069-1075
    • Trams, E.G.1    Nadkarni, M.V.2
  • 109
    • 0031658508 scopus 로고    scopus 로고
    • Identification of metabolites of nerve agent VX in serum collected from a victim
    • Tsuchihashi H, Katagi M, Nishikawa M et al. (1998). Identification of metabolites of nerve agent VX in serum collected from a victim. J Anal Toxicol, 22, 383-388.
    • (1998) J Anal Toxicol , vol.22 , pp. 383-388
    • Tsuchihashi, H.1    Katagi, M.2    Nishikawa, M.3
  • 110
    • 0042094965 scopus 로고    scopus 로고
    • Determination of metabolites of nerve agent Oethyl-S-2-diisopropylaminoethyl methylphosphonothioate (VX)
    • Tu AT and Gaffield W, eds), ACS Symposium Series, Washington, DC, USA: American Chemical Society
    • Tsuchihashi H, Katagi M, Tatsuno M et al. (2000). Determination of metabolites of nerve agent Oethyl-S-2-diisopropylaminoethyl methylphosphonothioate (VX). In: Natural and Selected Synthetic Toxins (Tu AT and Gaffield W, eds), ACS Symposium Series, 745, pp. 369-386. Washington, DC, USA: American Chemical Society.
    • (2000) Natural and Selected Synthetic Toxins , vol.745 , pp. 369-386
    • Tsuchihashi, H.1    Katagi, M.2    Tatsuno, M.3
  • 111
    • 0004038696 scopus 로고
    • Report of the mission dispatched by the Secretary-General to investigate allegations of the use of chemical weapons in the conflict between the Islamic Republic of Iran and Iraq
    • United Nations, Report No. S/17911, 12 March. New York, NY, USA: United Nations
    • United Nations (1986). Report of the mission dispatched by the Secretary-General to investigate allegations of the use of chemical weapons in the conflict between the Islamic Republic of Iran and Iraq, Report No. S/17911, 12 March. New York, NY, USA: United Nations.
    • (1986)
  • 112
    • 0028227075 scopus 로고
    • Immunochemical detection of adducts of sulfur mustard to DNA of calf thymus and human white blood cells
    • Van der Schans GP, Scheffer AG, Mars-Groenendijk RH et al. (1994). Immunochemical detection of adducts of sulfur mustard to DNA of calf thymus and human white blood cells. Chem Res Toxicol, 7, 408-413.
    • (1994) Chem Res Toxicol , vol.7 , pp. 408-413
    • Van der Schans, G.P.1    Scheffer, A.G.2    Mars-Groenendijk, R.H.3
  • 113
    • 0036153868 scopus 로고    scopus 로고
    • Immunochemical detection of sulfur mustard adducts with keratins in the stratum corneum of human skin
    • Van der Schans GP, Noort D, Mars-Groenendijk RH et al. (2003). Immunochemical detection of sulfur mustard adducts with keratins in the stratum corneum of human skin. Chem Res Toxicol, 15, 21-25.
    • (2003) Chem Res Toxicol , vol.15 , pp. 21-25
    • Van der Schans, G.P.1    Noort, D.2    Mars-Groenendijk, R.H.3
  • 114
    • 3242736601 scopus 로고    scopus 로고
    • Standard Operating Procedure for immunoslotblot assay for analysis of DNA/sulfur mustard adducts in human blood and skin
    • Van der Schans GP, Mars-Groenendijk R, De Jong LPA et al. (2004). Standard Operating Procedure for immunoslotblot assay for analysis of DNA/sulfur mustard adducts in human blood and skin. J Anal Toxicol, 28, 316-319.
    • (2004) J Anal Toxicol , vol.28 , pp. 316-319
    • Van der Schans, G.P.1    Mars-Groenendijk, R.2    De Jong, L.P.A.3
  • 115
    • 0042063598 scopus 로고    scopus 로고
    • Toxicokinetics of the nerve agent (+/-)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration
    • Van der Schans MJ, Lander BJ, Van der Wiel H et al. (2003). Toxicokinetics of the nerve agent (+/-)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration. Toxicol Appl Pharmacol, 191, 48-62.
    • (2003) Toxicol Appl Pharmacol , vol.191 , pp. 48-62
    • Van der Schans, M.J.1    Lander, B.J.2    Van der Wiel, H.3
  • 116
    • 5344245964 scopus 로고    scopus 로고
    • Retrospective detection of exposure to nerve agents: analysis of phosphofluoridates originating from fluoride-induced reactivation of phosphylated BuChE
    • Van der Schans MJ, Polhuijs M, Van Dijk C et al. (2004). Retrospective detection of exposure to nerve agents: analysis of phosphofluoridates originating from fluoride-induced reactivation of phosphylated BuChE. Arch Toxicol, 78, 508-524.
    • (2004) Arch Toxicol , vol.78 , pp. 508-524
    • Van Der Schans, M.J.1    Polhuijs, M.2    Van Dijk, C.3
  • 117
    • 0027050667 scopus 로고
    • Mercapturic acids, protein adducts and DNA adducts as biomarkers of electrophilic chemicals
    • Van Welie RTH, van Dijck RGJM and Vermeulen NPE. (1992). Mercapturic acids, protein adducts and DNA adducts as biomarkers of electrophilic chemicals. Crit Rev Toxicol, 22, 271-306.
    • (1992) Crit Rev Toxicol , vol.22 , pp. 271-306
    • Van Welie, R.T.H.1    Van Dijck, R.G.J.M.2    Vermeulen, N.P.E.3
  • 118
    • 0022379833 scopus 로고
    • Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas
    • Wils ERJ, Hulst AG, de Jong ALet al. (1985). Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas. J Anal Toxicol, 9, 254-257.
    • (1985) J Anal Toxicol , vol.9 , pp. 254-257
    • Wils, E.R.J.1    Hulst, A.G.2    De Jong, A.L.3
  • 119
    • 0023846358 scopus 로고
    • Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas, Part II
    • Wils ERJ, Hulst AG and van Laar J. (1988). Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas, Part II. J Anal Toxicol, 12, 15-19.
    • (1988) J Anal Toxicol , vol.12 , pp. 15-19
    • Wils, E.R.J.1    Hulst, A.G.2    Van Laar, J.3
  • 120
    • 0037172354 scopus 로고    scopus 로고
    • Quantitation of 2-chlorovinylarsonous acid in human urine by automated solid-phase microextractiongas chromatography-mass spectrometry
    • Wooten JV, Ashley DL and Calafat AM (2002). Quantitation of 2-chlorovinylarsonous acid in human urine by automated solid-phase microextractiongas chromatography-mass spectrometry. J Chromatog B, 772, 147-153.
    • (2002) J Chromatog B , vol.772 , pp. 147-153
    • Wooten, J.V.1    Ashley, D.L.2    Calafat, A.M.3
  • 121
    • 0032842978 scopus 로고    scopus 로고
    • Improved determination of acetylcholinesterase activity in human blood
    • Worek F, Mast U, Kiderlen D et al. (1999). Improved determination of acetylcholinesterase activity in human blood. Clin Chim Acta, 288, 73-90.
    • (1999) Clin Chim Acta , vol.288 , pp. 73-90
    • Worek, F.1    Mast, U.2    Kiderlen, D.3
  • 122
    • 33749531945 scopus 로고    scopus 로고
    • Hydrogen cyanide and cyanides: human health aspects
    • World Health Organization, New York, NY, USA: World Health Organization, Geneva
    • World Health Organization (2004). Hydrogen cyanide and cyanides: human health aspects. Concise International Chemical Assessment Document 61. New York, NY, USA: World Health Organization, Geneva.
    • (2004) Concise International Chemical Assessment Document , vol.61
  • 123
    • 3242708617 scopus 로고    scopus 로고
    • A rapid, sensitive method for the quantitation of specific metabolites of sulfur mustard using isotope-dilution gas chromatography-tandem mass spectrometry
    • Young CL, Ash D, Driskell WJ et al. (2004). A rapid, sensitive method for the quantitation of specific metabolites of sulfur mustard using isotope-dilution gas chromatography-tandem mass spectrometry. J Anal Toxicol, 28, 339-345.
    • (2004) J Anal Toxicol , vol.28 , pp. 339-345
    • Young, C.L.1    Ash, D.2    Driskell, W.J.3


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