The interaction of sarin and soman with plasma proteins: The identification of a novel phosphonylation site

Archives of Toxicology

Volumn 73, Issue 2, 1999, Pages 123-126

  Black, Robin M ^a   Harrison, John M ^a   Read, Robert W ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Biomarker; Protein binding; Satin; Soman; Tyrosine residue

Indexed keywords

SARIN; SOMAN;

ARTICLE; BINDING AFFINITY; CHEMICAL WARFARE; DRUG PROTEIN BINDING; HUMAN; INTOXICATION; PRIORITY JOURNAL; PROTEIN BINDING;

BIOLOGICAL MARKERS; CHEMICAL WARFARE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; PROTEIN BINDING; SARIN; SERUM ALBUMIN; SOMAN; TYROSINE;

EID: 0032907461     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050596     Document Type: Article

References (15)

1. Barak R, Ordentlich A, Barak D, Fischer M, Benschop HP, De Jong LPA, Segall Y, Velan B, Shafferman A (1997) Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry. FEBS Lett 407: 347-352
2. Benschop HP, van der Schans GP, Noort D, Mars-Groenesdijk RH, de Jong LPA (1997) Verification of exposure to sulfur mustard in two casualties of the Iran-Iraq war. J Anal Toxicol 21:249-251
3. Black RM, Read RW (1995) Biological fate of sulphur mustard, 1,1′-thiobis(2-chloroethane): Identification of β-lyase metabolites and hydrolysis products in human urine. Xenobiotica 25: 167-173
4. Black RM, Clarke RJ, Harrison JM, Read RW (1997) Biological fate of sulphur mustard: Identification of valine and histidine adducts in haemoglobin from casualties of sulphur mustard poisoning. Xenobiotica 27: 499-512
5. Fidder A, Noort S, de Jong LPA, Benschop HP, Hulst AG (1996) N7-(2-hydroxyethylthioethyl)-guanine: A novel urinary metabolite following exposure to sulfur mustard. Arch Toxicol 70: 854-855
6. 3H]-sarin and its metabolites in mice. Toxicol Appl Pharmacol 83: 412-419
7. Murachi T (1963) General reaction of diisopropyl phosphorofluoridate (DFP) with proteins without general effect on enzymic activities. Biochim Biophys Acta 71: 239-241
8. Nagao M, Takatori T, Matsuda Y, Nakajima M, Iwase H, Iwadate K (1997) Definitive evidence for the acute sarin poisoning diagnosis in the Tokyo subway. Toxicol Appl Pharmacol 144: 198-203
9. Polak RL, Cohen EM (1970) The binding of sarin in the blood plasma of the rat. Biochem Pharmacol 19: 877-881
10. Polhuijs M, Langenberg JP, Benschop HP (1997) New method for retrospective detection of exposure to organophosphorus anticholinesterases: Application to alleged sarin victims of Japanese terrorists. Toxicol Appl Pharmacol 146: 156-161
11. 3H]-soman and its pharmacological effects in mice. Toxicol Appl Pharmacol 83: 412-419
12. Sogorb MA, Diaz-Alejo N, Escudero MA, Vilanova, E (1998a) Phosphotriesterase activity identified in purified serum albumins. Arch Toxicol 72: 219-226
13. Sogorb MA, Monroy A, Vicedo JL, Barril J, Vilanova, E (1998b) Serum albumin can hydrolyse organophosphorus compounds by an intermediate phosphorylated mechanism. Where is the borderline dividing A and B-esterases? Third International Meeting on Esterases Hydrolysing Organophosphorus Compounds, 21-24 April 1998. Dubrovnik, Croatia
14. Shih ML, McMonagle JD, Dolzine TW, Gresham VC (1994) Metabolite kinetics of soman, sarin and GF in rats and biological monitoring of exposure to toxic organophosphorus agents. J Appl Toxicol 14: 195-199
15. Walker CH, Mackness MI (1987) 'A' esterases and their role in regulating the toxicity of organophosphates. Arch Toxicol 60: 30-33