Analysis of the sulfur mustard metabolite 1,1′-sulfonylbis[2-S-(N- acetylcysteinyl)ethane] in urine by negative ion electrospray liquid chromatography-tandem mass spectrometry

Journal of Analytical Toxicology

Volumn 28, Issue 5, 2004, Pages 352-356

  Read, Robert W ^a   Black, Robin M ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' SULFONYLBIS[2 (N ACETYLCYSTEINYL)ETHANE]; MUSTARD GAS; MUSTARD GAS DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CHEMICAL WARFARE; CHROMATOGRAPHY; CONTROLLED STUDY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; NEGATIVE ION ELECTROSPRAY; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 3242657246     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/28.5.352     Document Type: Article

References (8)

1. R.M. Black, K. Brewster, R.J. Clarke, J.L. Hambrook, J.M. Harrison, and D.J. Howells. Biological fate of sulfur mustard, [1,1-thiobis(2-chloroethane): isolation and identification of urinary metabolites following intraperitoneal administration to rat. Xenobiotica 22: 405-418 (1992).
2. R.M. Black and R.W. Read. Detection of trace levels of thiodiglycol in blood, plasma and urine using gas chromatography-electron capture negative ion chemical ionization ass spectrometry. J. Chromatogr. 449: 261-270 (1988).
3. R.M. Black and R.W. Read. Methods for the analysis of thiodiglycol sulfoxide, a metabolite of sulfur mustard, in urine using gas chromatography-mass spectrometry. J. Chromatogr. 558: 393-404 (1991).
4. R.M. Black, R.J. Clarke and R.W. Read. Analysis of 1,1′-sul fonylbis[2-(methylsulfinyl)ethane] and 1-methylsulfinyl-2-[2-(methylthio)- ethylsulfonyl]ethane, metabolites of sulfur mustard, in urine using gas chromatography-mass spectrometry. J. Chromatogr. 558: 405-414 (1991).
5. R.M. Black and R.W. Read. Improved methodology for th detection and quantitation of urinary metabolites of sulfur mustard using gas chromatography-tandem mass spectrometry. J. Chromatogr. B 665: 97-105 (1995).
6. R.M. Black and R.W. Read. Biological fate of sulfur mustard, 1,1′-thiobis(2-chloroethane): identification of β-lyase metabolites and hydrolysis products in human urine. Xenobiotica 25: 167-173 (1995).
7. R.M. Black, K. Brewster, R.J. Clarke, and J.M. Harrison. The chemistry of 1,1′-thiobis(2-chloroethane) (sulfur mustard) Part II. The synthesis of some conjugates with cysteine, N-acetylcysteine and N-acetylcysteine methyl ester. Phosphorus, Sulfur and Silicon 71: 49-58 (1992).
8. R.W. Read and R.M. Black. Analysis of β-lyase metabolites of sulfur mustard in urine by electrospray liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 28: 3464-351 (2004).