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Volumn , Issue , 2000, Pages 25-81

Toxicokinetics of Nerve Agents

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EID: 85152339811     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781420041576-5     Document Type: Chapter
Times cited : (66)

References (118)
  • 1
    • 0019352495 scopus 로고
    • Persistence of the anticholinesterase soman in rats; antagonism with a non-toxic simulator of this organophosphate
    • Wolthuis, O.L., Benschop, H.P., and Berends, F., Persistence of the anticholinesterase soman in rats; antagonism with a non-toxic simulator of this organophosphate, Eur. J. Pharmacol., 69, 379, 1981.
    • (1981) Eur. J. Pharmacol. , vol.69 , pp. 379
    • Wolthuis, O.L.1    Benschop, H.P.2    Berends, F.3
  • 2
    • 84988073257 scopus 로고
    • Micocolumn liquid chromatography with thermionic detection of the enantiomers of O-ethyl S-diisopropylaminoethyl methylphosphonothioate (VX)
    • Kientz, C.E., Langenberg, J.P., and Brinkman, U.A.Th., Micocolumn liquid chromatography with thermionic detection of the enantiomers of O-ethyl S-diisopropylaminoethyl methylphosphonothioate (VX), J. High Resolut. Chromatogr., 17, 95, 1994.
    • (1994) J. High Resolut. Chromatogr. , vol.17 , pp. 95
    • Kientz, C.E.1    Langenberg, J.P.2    Brinkman, U.A.T.3
  • 3
    • 0343121411 scopus 로고
    • Gas chromatographic separation and identification of the four stereoisomers of 1, 2, 2-trimethylpropyl methylphosphonofluoridate (soman). Stereospecificity of in vitro “detoxification” reactions
    • Benschop, H.P., Konings, C.A.G., and De Jong, L.P.A., Gas chromatographic separation and identification of the four stereoisomers of 1, 2, 2-trimethylpropyl methylphosphonofluoridate (soman). Stereospecificity of in vitro “detoxification” reactions, J. Am. Chem. Soc., 103, 4260, 1981.
    • (1981) J. Am. Chem. Soc. , vol.103 , pp. 4260
    • Benschop, H.P.1    Konings, C.A.G.2    De Jong, L.P.A.3
  • 4
    • 0022311727 scopus 로고
    • Stabilization and gas chromatographic analysis of the four stereoisomers of 1, 2, 2-trimethylpropyl methylphosphonofluoridate (soman) in rat blood
    • Benschop, H.P., Bijleveld, E.C., Otto, M.F., Degenhardt, C.E.A.M., Van Helden, H.P.M., and De Jong, L.P.A., Stabilization and gas chromatographic analysis of the four stereoisomers of 1, 2, 2-trimethylpropyl methylphosphonofluoridate (soman) in rat blood, Anal. Biochem., 151, 242, 1985.
    • (1985) Anal. Biochem. , vol.151 , pp. 242
    • Benschop, H.P.1    Bijleveld, E.C.2    Otto, M.F.3    Degenhardt, C.E.A.M.4    Van Helden, H.P.M.5    De Jong, L.P.A.6
  • 5
    • 0000737686 scopus 로고
    • Nerve agent stereoisomers: Analysis, isolation and toxicology
    • Benschop, H.P. and De Jong, L.P.A., Nerve agent stereoisomers: Analysis, isolation and toxicology, Acc. Chem. Res., 21, 368, 1988.
    • (1988) Acc. Chem. Res. , vol.21 , pp. 368
    • Benschop, H.P.1    De Jong, L.P.A.2
  • 6
    • 85152337270 scopus 로고
    • (R)-(+)-O-isopropyl-S-(trimethylammonioethyl) methylphosphonothioate iodide
    • Mehlsen-Sørensen, A., (R)-(+)-O-isopropyl-S-(trimethylammonioethyl) methylphosphonothioate iodide, Acta Crystallogr., Sect. B, B33, 1693, 1977.
    • (1977) Acta Crystallogr., Sect. B , vol.B33 , pp. 1693
    • Mehlsen-Sørensen, A.1
  • 7
    • 0016680126 scopus 로고
    • Absolute configuration of chiral organophosphorus anticholinesterases
    • Benschop, H.P., Absolute configuration of chiral organophosphorus anticholinesterases, Pestic. Biochem. Physiol., 5, 348, 1975.
    • (1975) Pestic. Biochem. Physiol. , vol.5 , pp. 348
    • Benschop, H.P.1
  • 8
    • 0039210833 scopus 로고
    • Biochemical and toxicological implications of chirality in anticholinesterase organophosphates
    • Ariens, E.J., Van Rensen, J.J.S., and Welling, W., eds., Elsevier, Amsterdam, chap. 4
    • De Jong, L.P.A. and Benschop, H.P., Biochemical and toxicological implications of chirality in anticholinesterase organophosphates, in Stereoselectivity of Pesticides. Biological and Chemical Problems, Ariens, E.J., Van Rensen, J.J.S., and Welling, W., eds., Elsevier, Amsterdam, 1988, chap. 4.
    • (1988) Stereoselectivity of Pesticides. Biological and Chemical Problems
    • De Jong, L.P.A.1    Benschop, H.P.2
  • 10
    • 0021358209 scopus 로고
    • Isolation, anticholinesterase properties and acute toxicity in mice of the four stereoisomers of soman
    • Benschop, H.P., Konings, C.A.G., Van Genderen, J., and De Jong, L.P.A., Isolation, anticholinesterase properties and acute toxicity in mice of the four stereoisomers of soman, Toxicol. Appl. Pharmacol., 90, 61, 1984.
    • (1984) Toxicol. Appl. Pharmacol. , vol.90 , pp. 61
    • Benschop, H.P.1    Konings, C.A.G.2    Van Genderen, J.3    De Jong, L.P.A.4
  • 11
    • 0014592739 scopus 로고
    • Stereospecificity of hydrolytic enzymes on reaction with asymmetric organophosphorus compounds. III. The inhibition of acetylcholinesterase and butyrylcholinesterase by enantiomeric forms of sarin
    • Boter, H.L. and Van Dijk, C., Stereospecificity of hydrolytic enzymes on reaction with asymmetric organophosphorus compounds. III. The inhibition of acetylcholinesterase and butyrylcholinesterase by enantiomeric forms of sarin, Biochem. Pharmacol., 18, 2403, 1969.
    • (1969) Biochem. Pharmacol. , vol.18 , pp. 2403
    • Boter, H.L.1    Van Dijk, C.2
  • 12
    • 0017393315 scopus 로고
    • Differences between some biological properties of enantiomers of alkyl S-alkyl methylphosphonothioates
    • Hall, C.R., Inch, T.D., Inns, R.H., Muir, A.W., Sellers, D.J., and Smith, A.P., Differences between some biological properties of enantiomers of alkyl S-alkyl methylphosphonothioates, J. Pharm. Pharmacol., 29, 574, 1977.
    • (1977) J. Pharm. Pharmacol. , vol.29 , pp. 574
    • Hall, C.R.1    Inch, T.D.2    Inns, R.H.3    Muir, A.W.4    Sellers, D.J.5    Smith, A.P.6
  • 16
    • 0021285675 scopus 로고
    • Detoxification of soman and O-cyclopentyl S-diethylaminoethyl methylphosphonothioate in vivo
    • Harris, L., Broomfield, C., Adams, N., and Stitcher, D., Detoxification of soman and O-cyclopentyl S-diethylaminoethyl methylphosphonothioate in vivo, Proc. West. Pharmacol. Soc., 27, 315, 1984.
    • (1984) Proc. West. Pharmacol. Soc. , vol.27 , pp. 315
    • Harris, L.1    Broomfield, C.2    Adams, N.3    Stitcher, D.4
  • 18
    • 0012597176 scopus 로고
    • Inhalation toxicokinetics of C(±)P(±)-soman and (±)-sarin in the guinea pig
    • Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., and Taylor, P., eds., Plenum Press, New York
    • Benschop, H.P., De Jong, L.P.A., and Langenberg, J.P., Inhalation toxicokinetics of C(±)P(±)-soman and (±)-sarin in the guinea pig, in Enzymes of the Cholinesterase Family, Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., and Taylor, P., eds., Plenum Press, New York, 1995, 361.
    • (1995) Enzymes of the Cholinesterase Family , pp. 361
    • Benschop, H.P.1    De Jong, L.P.A.2    Langenberg, J.P.3
  • 19
    • 0025822416 scopus 로고
    • Toxicokinetics of soman: Species variation and stereospecificity in elimination pathways
    • Benschop, H.P. and De Jong, L.P.A., Toxicokinetics of soman: Species variation and stereospecificity in elimination pathways, Neurosci. Biobehav. Rev., 15, 73, 1991.
    • (1991) Neurosci. Biobehav. Rev. , vol.15 , pp. 73
    • Benschop, H.P.1    De Jong, L.P.A.2
  • 20
    • 85152304323 scopus 로고
    • Toxicokinetic investigations of C(±)P(±)-soman in the rat, guinea pig and marmoset at low doses-Quantification of elimination pathways
    • NTIS AD-A 226
    • Benschop, H.P. and De Jong, L.P.A., Toxicokinetic investigations of C(±)P(±)-soman in the rat, guinea pig and marmoset at low doses-Quantification of elimination pathways. Final Report Grant DAMD17-87-7015, NTIS AD-A 226 807, 1990.
    • (1990) Final Report Grant DAMD17-87-7015 , pp. 807
    • Benschop, H.P.1    De Jong, L.P.A.2
  • 21
    • 0023633188 scopus 로고
    • The effect of CaE’s inhibition on interspecies differences in soman toxicity
    • Maxwell, D.M., Brecht, K.M., and O’Neill, B.L., The effect of CaE’s inhibition on interspecies differences in soman toxicity, Toxicol. Lett., 39, 35, 1987.
    • (1987) Toxicol. Lett. , vol.39 , pp. 35
    • Maxwell, D.M.1    Brecht, K.M.2    O’Neill, B.L.3
  • 22
    • 0027423629 scopus 로고
    • The effect of pretreatment with CBDP on the toxicokinetics of soman stereoisomers in rats and guinea pigs
    • Due, A.H., Trap, H.C., Van der Wiel, H.J., and Benschop, H.P., The effect of pretreatment with CBDP on the toxicokinetics of soman stereoisomers in rats and guinea pigs, Arch. Toxicol., 67, 706, 1993.
    • (1993) Arch. Toxicol. , vol.67 , pp. 706
    • Due, A.H.1    Trap, H.C.2    van der Wiel, H.J.3    Benschop, H.P.4
  • 23
    • 85037425517 scopus 로고
    • Toxicokinetics of the four stereoisomers of soman in the rat., guinea pig and marmoset
    • NTIS AD-A199
    • Benschop, H.P. and De Jong, L.P.A., Toxicokinetics of the four stereoisomers of soman in the rat., guinea pig and marmoset, Annual/Final Report Grant DAMD17-85-G-5004, NTIS AD-A199 573, 1987.
    • (1987) Annual/Final Report Grant DAMD17-85-G-5004 , pp. 573
    • Benschop, H.P.1    De Jong, L.P.A.2
  • 26
    • 0028012037 scopus 로고
    • Toxicokinetics of soman stereoisomers after subcutaneous administration to atropinized guinea pigs
    • Due, A.H., Trap, H.C., Langenberg, J. P., and Benschop, H.P., Toxicokinetics of soman stereoisomers after subcutaneous administration to atropinized guinea pigs, Arch. Toxicol., 68, 60, 1994.
    • (1994) Arch. Toxicol. , vol.68 , pp. 60
    • Due, A.H.1    Trap, H.C.2    Langenberg, J.P.3    Benschop, H.P.4
  • 27
    • 0006607045 scopus 로고
    • Factors affecting inhalation and retention of toxic vapors
    • Davies, C. N., ed., Pergamon Press, Oxford
    • Oberst, F.W., Factors affecting inhalation and retention of toxic vapors, in Inhaled Particles and Vapours, Davies, C. N., ed., Pergamon Press, Oxford, 1961, 249.
    • (1961) Inhaled Particles and Vapours , pp. 249
    • Oberst, F.W.1
  • 30
    • 0345329262 scopus 로고
    • The intrabronchial distribution of soluble vapors at selected rates of gas flow
    • C.N. Davies, ed., Pergamon Press, Oxford
    • Ainsworth, M. and Shepherd, R.J., The intrabronchial distribution of soluble vapors at selected rates of gas flow, in Inhaled Particles and Vapours, C.N. Davies, ed., Pergamon Press, Oxford, 1961, 233.
    • (1961) Inhaled Particles and Vapours , pp. 233
    • Ainsworth, M.1    Shepherd, R.J.2
  • 31
    • 0027502038 scopus 로고
    • Drug metabolism in the nasal cavity: Relevance to toxicology
    • Reed, C.J., Drug metabolism in the nasal cavity: Relevance to toxicology, Drug Metab. Rev., 25, 173, 1993.
    • (1993) Drug Metab. Rev. , vol.25 , pp. 173
    • Reed, C.J.1
  • 32
    • 0028610242 scopus 로고
    • Uptake and metabolism of toxicants in the respiratory tract
    • Dahl, A.R. and Gerde, P., Uptake and metabolism of toxicants in the respiratory tract. Environm. Health Perspect., 102, 67, 1994;
    • (1994) Environm. Health Perspect. , vol.102 , pp. 67
    • Dahl, A.R.1    Gerde, P.2
  • 33
    • 0003894715 scopus 로고
    • Regional dosimetry of inhaled reactive gases
    • McClellan, R.O. and Henderson, R.F., eds., Taylor and Francis, Washington
    • see also Miller, F.J. and Kimball, J.S., Regional dosimetry of inhaled reactive gases, in Concepts in Inhalation Toxicology, McClellan, R.O. and Henderson, R.F., eds., Taylor and Francis, Washington, 1995, 257.
    • (1995) Concepts in Inhalation Toxicology , pp. 257
    • Miller, F.J.1    Kimball, J.S.2
  • 34
    • 33751155342 scopus 로고    scopus 로고
    • Probe of troops’ exposure to chemical arms failed
    • Sept
    • Ember, L., Probe of troops’ exposure to chemical arms failed, Chem. Eng. News, Sept. 23, 40, 1996.
    • (1996) Chem. Eng. News , vol.23 , pp. 40
    • Ember, L.1
  • 36
    • 0000661753 scopus 로고
    • Urban terrorism-chemical warfare in Japan
    • November
    • Croddy, E., Urban terrorism-chemical warfare in Japan,. Jane’s Intelligence Rev., November 1995, 520.
    • (1995) Jane’s Intelligence Rev. , pp. 520
    • Croddy, E.1
  • 39
    • 0030788121 scopus 로고    scopus 로고
    • Unexpected nerve gas exposure in the city of Matsumoto: Report of rescue activity in the first sarin gas terrorism
    • Okudera, H., Morita, H., Iwashita, H., Shibata, T., Otagiri, T., Kobayashi, S., and Yanagisawa, N., Unexpected nerve gas exposure in the city of Matsumoto: Report of rescue activity in the first sarin gas terrorism, Am. J. Emerg. Med., 15, 527, 1997.
    • (1997) Am. J. Emerg. Med. , vol.15 , pp. 527
    • Okudera, H.1    Morita, H.2    Iwashita, H.3    Shibata, T.4    Otagiri, T.5    Kobayashi, S.6    Yanagisawa, N.7
  • 41
    • 0030807303 scopus 로고    scopus 로고
    • Sarin poisoning of a rescue team in the Matsumoto incident in Japan
    • Nakajima, T., Sato, S., Morita, H., and Yanagisawa, N., Sarin poisoning of a rescue team in the Matsumoto incident in Japan, Occup. Environ. Med., 54, 697, 1997.
    • (1997) Occup. Environ. Med. , vol.54 , pp. 697
    • Nakajima, T.1    Sato, S.2    Morita, H.3    Yanagisawa, N.4
  • 42
    • 85152316924 scopus 로고
    • Final Report. Current health status of test subjects. NTIS AD-A163
    • National Research Council (Committee on Toxicology), Possible Long-Term Effects of Short Term Exposure to Chemical Agents. Vol. 3. Final Report. Current health status of test subjects. NTIS AD-A163 614, 1985.
    • (1985) Possible Long-Term Effects of Short Term Exposure to Chemical Agents. , vol.3 , pp. 614
  • 44
    • 0030687921 scopus 로고    scopus 로고
    • Asymptomatic sequelae to acute sarin poisoning in the central and autonomic nervous system 6 months after the Tokyo subway attack
    • Murata, K., Araki, S., Yokoyama, K., Okumura, T., Ishimatsu, S., Takasu, N. and White, R.F., Asymptomatic sequelae to acute sarin poisoning in the central and autonomic nervous system 6 months after the Tokyo subway attack, J. Neurol., 244, 601, 1997.
    • (1997) J. Neurol. , vol.244 , pp. 601
    • Murata, K.1    Araki, S.2    Yokoyama, K.3    Okumura, T.4    Ishimatsu, S.5    Takasu, N.6    White, R.F.7
  • 46
    • 0033217964 scopus 로고    scopus 로고
    • Sequelae of sarin toxicity at one and three years after exposure in Matsumoto, Japan
    • Nakajima, T., Ohta, S., Fukushima, Y., and Yanagisawa, N., Sequelae of sarin toxicity at one and three years after exposure in Matsumoto, Japan, J. Epidemiol., 9, 337, 1999.
    • (1999) J. Epidemiol. , vol.9 , pp. 337
    • Nakajima, T.1    Ohta, S.2    Fukushima, Y.3    Yanagisawa, N.4
  • 47
    • 0032443820 scopus 로고    scopus 로고
    • Low level-nose only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
    • Benschop, H.P., Trap, H.C., Spruit, E.T., Van Der Wiel, H.J., Langenberg, J.P., and De Jong, L.P.A., Low level-nose only exposure to the nerve agent soman: toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs, Toxicol. Appl. Pharmacol., 153, 179, 1998.
    • (1998) Toxicol. Appl. Pharmacol. , vol.153 , pp. 179
    • Benschop, H.P.1    Trap, H.C.2    Spruit, E.T.3    Van Wiel, H.J.4    Langenberg, J.P.5    De Jong, L.P.A.6
  • 48
    • 0013547906 scopus 로고
    • Studies of chronic exposures of dogs to GB (isopropyl methylphosphonofluoridate) vapor
    • Jacobson, K.H., Christensen, M.K., DeArmon, I.A., and Oberst, F.W., Studies of chronic exposures of dogs to GB (isopropyl methylphosphonofluoridate) vapor, Arch. Ind. Health, 19, 5, 1959.
    • (1959) Arch. Ind. Health , vol.19 , pp. 5
    • Jacobson, K.H.1    Christensen, M.K.2    DeArmon, I.A.3    Oberst, F.W.4
  • 51
    • 0000749061 scopus 로고
    • Effect of sarin on dark adaptation in man: Threshold changes
    • Rubin, L.S. and Goldberg, M.N., Effect of sarin on dark adaptation in man: threshold changes, J. Appl. Physiol., 11, 439, 1957.
    • (1957) J. Appl. Physiol. , vol.11 , pp. 439
    • Rubin, L.S.1    Goldberg, M.N.2
  • 52
    • 0004835746 scopus 로고    scopus 로고
    • Evaluation of airborne exposure limits for G-agents: Occupational and general population exposure criteria
    • Edgewood Research, Development and Engineering Center, April, See also: Fact sheet on exposure limits for sarin (GB), July, 1997
    • Mioduszewski, R.J., Reutter, S.A., Miller, L.L., Olajos, E.J., and Thomson, S.A., Evaluation of airborne exposure limits for G-agents: occupational and general population exposure criteria, Report ERDEC-TR-489, Edgewood Research, Development and Engineering Center, April 1998. See also: Fact sheet on exposure limits for sarin (GB), July 1997, http://www.gulflink.osd.mil/dugway/low_lv_chem_fact.htm.
    • (1998) Report ERDEC-TR-489
    • Mioduszewski, R.J.1    Reutter, S.A.2    Miller, L.L.3    Olajos, E.J.4    Thomson, S.A.5
  • 53
    • 0030884927 scopus 로고    scopus 로고
    • New method for retrospective detection of exposure to organophosphate anticholinesterases: Application to alleged sarin victims of Japanese terrorists
    • Polhuijs, M., Langenberg, J.P., and Benschop, H.P., New method for retrospective detection of exposure to organophosphate anticholinesterases: Application to alleged sarin victims of Japanese terrorists, Toxicol. Appl. Pharmacol., 146, 156, 1997.
    • (1997) Toxicol. Appl. Pharmacol. , vol.146 , pp. 156
    • Polhuijs, M.1    Langenberg, J.P.2    Benschop, H.P.3
  • 54
    • 85152353501 scopus 로고    scopus 로고
    • Low level exposure to GB vapor in air: Diagnosis/dosimetry, lowest observable effect levels, performance-incapacitation and possible delayed effects
    • U.S. Army Medical Research and Materiel Command. See also: Trap, H.C., Kuijpers, W.C., Groen, B., Oostdijk, J.P., Vanwersch, R.A.P., Philippens, H.C., Langenberg, J.P., Benschop, H.P., and Van Helden, H.P.M., Low-level exposure to GB in air: diagnosis/dosimetry, lowest observable effect level (LOEL), and lowest observable adverse effect level (LOAEL), Grant DAMD17-97-1-7360, U.S. Army Medical Command
    • Van Helden, H.P.M., Langenberg, J.P., and Benschop, H.P., Low level exposure to GB vapor in air: diagnosis/dosimetry, lowest observable effect levels, performance-incapacitation and possible delayed effects, Contract DAMD17-97-1-7360, U.S. Army Medical Research and Materiel Command. See also: Trap, H.C., Kuijpers, W.C., Groen, B., Oostdijk, J.P., Vanwersch, R.A.P., Philippens, H.C., Langenberg, J.P., Benschop, H.P., and Van Helden, H.P.M., Low-level exposure to GB in air: diagnosis/dosimetry, lowest observable effect level (LOEL), and lowest observable adverse effect level (LOAEL), Grant DAMD17-97-1-7360, U.S. Army Medical Command.
    • Contract DAMD17-97-1-7360
    • Van Helden, H.P.M.1    Langenberg, J.P.2    Benschop, H.P.3
  • 55
    • 84872639802 scopus 로고
    • An enzyme in animal tissues capable of hydrolyzing the phosphorus-fluorine bond of alkyl fluorophosphates
    • Mazur, A., An enzyme in animal tissues capable of hydrolyzing the phosphorus-fluorine bond of alkyl fluorophosphates, J. Biol. Chem., 164, 271, 1946.
    • (1946) J. Biol. Chem. , vol.164 , pp. 271
    • Mazur, A.1
  • 57
    • 0013493305 scopus 로고
    • The intracellular localization of liver and kidney sarinase
    • Adie, P.A. and Tuba, J., The intracellular localization of liver and kidney sarinase, Can. J. Biochem. Biophys., 36, 21, 1958.
    • (1958) Can. J. Biochem. Biophys. , vol.36 , pp. 21
    • Adie, P.A.1    Tuba, J.2
  • 59
    • 1542763306 scopus 로고
    • The enzymic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolyzing tabun
    • Augustinsson, K.-B. and Heimburger, G., The enzymic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolyzing tabun, Acta Chem. Scand., 8, 753, 1954.
    • (1954) Acta Chem. Scand. , vol.8 , pp. 753
    • Augustinsson, K.-B.1    Heimburger, G.2
  • 60
    • 0002477523 scopus 로고
    • Purification and properties of dialkylfluorophosphatase
    • Cohen, J.A. and Warringa, M.P.G.J., Purification and properties of dialkylfluorophosphatase, Biochim. Biophys. Acta, 26, 29, 1957.
    • (1957) Biochim. Biophys. Acta , vol.26 , pp. 29
    • Cohen, J.A.1    Warringa, M.P.G.J.2
  • 61
    • 0028788139 scopus 로고
    • Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase
    • Millard, C.B., Lockridge, O., and Broomfield, C.A., Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase, Biochemistry, 34, 15925, 1995.
    • (1995) Biochemistry , vol.34 , pp. 15925
    • Millard, C.B.1    Lockridge, O.2    Broomfield, C.A.3
  • 62
    • 0031054145 scopus 로고    scopus 로고
    • A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase
    • Lockridge, O., Blong, R.M., Masson, P., Froment, M.T., Millard, C.B., and Broomfield, C.A., A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase, Biochemistry, 36, 786, 1997.
    • (1997) Biochemistry , vol.36 , pp. 786
    • Lockridge, O.1    Blong, R.M.2    Masson, P.3    Froment, M.T.4    Millard, C.B.5    Broomfield, C.A.6
  • 63
    • 0031724974 scopus 로고    scopus 로고
    • Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: Estimation of internal dose
    • Noort, D., Hulst, A.G., Platenburg, D.H.J.M., Polhuijs, M., and Benschop, H.P., Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: Estimation of internal dose, Arch. Toxicol., 72, 671, 1998.
    • (1998) Arch. Toxicol. , vol.72 , pp. 671
    • Noort, D.1    Hulst, A.G.2    Platenburg, D.H.J.M.3    Polhuijs, M.4    Benschop, H.P.5
  • 64
    • 0030808137 scopus 로고    scopus 로고
    • Method for the analysis of methylphosphonic acid metabolites of sarin and its ethanol-substituted analogue in urine as applied to the victims of the Tokyo sarin disaster
    • Minami, M., Hui, D.-M., Katsumata, M., Inagaki, H., and Boulet, C., Method for the analysis of methylphosphonic acid metabolites of sarin and its ethanol-substituted analogue in urine as applied to the victims of the Tokyo sarin disaster, J. Chromatogr. B., 695, 237, 1997.
    • (1997) J. Chromatogr. B. , vol.695 , pp. 237
    • Minami, M.1    Hui, D.-M.2    Katsumata, M.3    Inagaki, H.4    Boulet, C.5
  • 65
    • 8244246015 scopus 로고
    • Metabolites of pinacolyl methylphosphonofluoridate (soman) after enzymatic hydrolysis in vitro
    • Harris, L.W., Braswell, L.M., Fleisher, J.H., and Cliff, W.J., Metabolites of pinacolyl methylphosphonofluoridate (soman) after enzymatic hydrolysis in vitro, Biochem. Pharmacol., 13, 1129, 1964.
    • (1964) Biochem. Pharmacol. , vol.13 , pp. 1129
    • Harris, L.W.1    Braswell, L.M.2    Fleisher, J.H.3    Cliff, W.J.4
  • 66
    • 0014155292 scopus 로고
    • 32P) from the mouse circulatory system
    • 32P) from the mouse circulatory system, Biochem. Pharmacol., 16, 2061, 1967.
    • (1967) Biochem. Pharmacol. , vol.16 , pp. 2061
    • Ramachandran, B.V.1
  • 68
    • 0013854012 scopus 로고
    • The enzymatic isolation and fluoride catalysed racemisation of optically active sarin
    • Christen, P.J. and Van den Muysenberg, J.A.C.M., The enzymatic isolation and fluoride catalysed racemisation of optically active sarin, Biochim. Biophys. Acta, 110, 217, 1965.
    • (1965) Biochim. Biophys. Acta , vol.110 , pp. 217
    • Christen, P.J.1    Van den Muysenberg, J.A.C.M.2
  • 69
    • 84913768935 scopus 로고
    • The influence of stereoisomerism of sarin on various reactions with sarinase and cholinesterase
    • Christen, P.J., Berends, F., and Cohen, E.M., The influence of stereoisomerism of sarin on various reactions with sarinase and cholinesterase, Acta Physiol. Pharmacol. Neerl., 14, 338, 1967.
    • (1967) Acta Physiol. Pharmacol. Neerl. , vol.14 , pp. 338
    • Christen, P.J.1    Berends, F.2    Cohen, E.M.3
  • 70
    • 0021837405 scopus 로고
    • In vitro degradation of the four stereoisomers of soman in human serum
    • De Bisschop, H.C., Mainil, J.G., and Willems, J.L., In vitro degradation of the four stereoisomers of soman in human serum, Biochem. Pharmacol., 34, 1895, 1985.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 1895
    • De Bisschop, H.C.1    Mainil, J.G.2    Willems, J.L.3
  • 73
    • 0023927313 scopus 로고
    • Hydrolysis of the four stereoisomers of soman catalyzed by liver homogenate and plasma from rat, guinea pig and marmoset and by human plasma
    • De Jong, L.P.A., Van Dijk, C., and Benschop, H.P., Hydrolysis of the four stereoisomers of soman catalyzed by liver homogenate and plasma from rat, guinea pig and marmoset and by human plasma, Biochem. Pharmacol., 37, 2939, 1988.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 2939
    • De Jong, L.P.A.1    Van Dijk, C.2    Benschop, H.P.3
  • 74
    • 0027438584 scopus 로고
    • Hydrolysis and binding of a toxic stereoisomer of soman in plasma and tissue homogenates from rat, guinea pig and marmoset, and in human plasma
    • De Jong, L.P.A., Van Dijk, C., Berhitoe, D., and Benschop, H.P., Hydrolysis and binding of a toxic stereoisomer of soman in plasma and tissue homogenates from rat, guinea pig and marmoset, and in human plasma, Biochem. Pharmacol., 46, 1413, 1993.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 1413
    • De Jong, L.P.A.1    Van Dijk, C.2    Berhitoe, D.3    Benschop, H.P.4
  • 75
    • 0030946754 scopus 로고    scopus 로고
    • Development of a physiologically based model for the toxicokinetics of C(±)P(±)-soman in the atropinized guinea pig
    • Langenberg, J.P., Van Dijk, C., Sweeney, R.E., Maxwell, D.M., De Jong, L.P.A., and Benschop, H.P., Development of a physiologically based model for the toxicokinetics of C(±)P(±)-soman in the atropinized guinea pig, Arch. Toxicol., 71, 320, 1997.
    • (1997) Arch. Toxicol. , vol.71 , pp. 320
    • Langenberg, J.P.1    Van Dijk, C.2    Sweeney, R.E.3    Maxwell, D.M.4    De Jong, L.P.A.5    Benschop, H.P.6
  • 76
    • 80052809472 scopus 로고
    • Enzymatic hydrolysis of organophosphorus compounds. VII. The stereospecificity of phosphoryl phosphatases
    • Augustinsson, K.-B., Enzymatic hydrolysis of organophosphorus compounds. VII. The stereospecificity of phosphoryl phosphatases, Acta Chem. Scand., 11, 1371, 1957.
    • (1957) Acta Chem. Scand. , vol.11 , pp. 1371
    • Augustinsson, K.-B.1
  • 77
    • 0006332887 scopus 로고
    • Enantiospecific complexation gas chromatography of nerve agents. Isolation and properties of the stereoisomers of ethyl N, N-dimethylphosphoramido-cyanidate (tabun)
    • Degenhardt, C.E.A.M., Van den Berg, G.R., De Jong, L.P.A., Benschop, H.P., Van Genderen, J., and Van de Meent, D., Enantiospecific complexation gas chromatography of nerve agents. Isolation and properties of the stereoisomers of ethyl N, N-dimethylphosphoramido-cyanidate (tabun), J. Am. Chem. Soc., 108, 8290, 1986.
    • (1986) J. Am. Chem. Soc. , vol.108 , pp. 8290
    • Degenhardt, C.E.A.M.1    Van den Berg, G.R.2    De Jong, L.P.A.3    Benschop, H.P.4    Van Genderen, J.5    Van de Meent, D.6
  • 78
    • 84958292595 scopus 로고
    • Cholinesterase. VII. Determination of the molar concentration of pseudocholinesterase in serum
    • Myers, D.K., Cholinesterase. VII. Determination of the molar concentration of pseudocholinesterase in serum, Biochem. J., 51, 303, 1952.
    • (1952) Biochem. J. , vol.51 , pp. 303
    • Myers, D.K.1
  • 80
    • 84910589198 scopus 로고
    • Detoxification of organophosphorus compounds
    • Brzin, M., Barnard, E.A., and Sket, D., eds., de Gruyter, Berlin
    • Sterri, S.H. and Fonnum, F., Detoxification of organophosphorus compounds, in Cholinesterases. Fundamental and Applied Aspects, Brzin, M., Barnard, E.A., and Sket, D., eds., de Gruyter, Berlin, 1984, 110.
    • (1984) Cholinesterases. Fundamental and Applied Aspects , pp. 110
    • Sterri, S.H.1    Fonnum, F.2
  • 81
    • 84882924631 scopus 로고
    • 32P-sarin to esterases and other proteins in plasma from rat, man and guinea-pig
    • 32P-sarin to esterases and other proteins in plasma from rat, man and guinea-pig, Acta Physiol. Pharmacol. Neerl., 15, 36, 1969.
    • (1969) Acta Physiol. Pharmacol. Neerl. , vol.15 , pp. 36
    • Christen, P.J.1    Cohen, E.M.2
  • 82
    • 0032907461 scopus 로고    scopus 로고
    • The interaction of sarin and soman with plasma proteins: The identification of a novel phosphylation site
    • Black, R.M., Harrison, J.M., and Read, R.W., The interaction of sarin and soman with plasma proteins: the identification of a novel phosphylation site, Arch. Toxicol., 73, 123, 1999.
    • (1999) Arch. Toxicol. , vol.73 , pp. 123
    • Black, R.M.1    Harrison, J.M.2    Read, R.W.3
  • 83
    • 0023248549 scopus 로고
    • The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats
    • Maxwell, D.M., Lenz, D.E., Groff, W.A., Kaminskis, A., and Froehlich, H.L., The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats, Toxicol. Appl. Pharmacol., 88, 66, 1987.
    • (1987) Toxicol. Appl. Pharmacol. , vol.88 , pp. 66
    • Maxwell, D.M.1    Lenz, D.E.2    Groff, W.A.3    Kaminskis, A.4    Froehlich, H.L.5
  • 84
    • 0002730239 scopus 로고
    • Mechanism of the prophylactic action of diacetylmonoxime against sarin poisoning
    • Myers, D.K., Mechanism of the prophylactic action of diacetylmonoxime against sarin poisoning, Biochim. Biophys. Acta, 34, 555, 1959.
    • (1959) Biochim. Biophys. Acta , vol.34 , pp. 555
    • Myers, D.K.1
  • 85
    • 0015164637 scopus 로고
    • The synergistic action of 2-(o-cresyl)-4H-1:3:2- benzodioxaphosphorin-2-oxide with soman and physostigmine
    • McKay, D.H., Jardine, R.V., and Adie, P.A., The synergistic action of 2-(o-cresyl)-4H-1:3:2- benzodioxaphosphorin-2-oxide with soman and physostigmine, Toxicol. Appl. Pharmacol., 20, 474, 1971.
    • (1971) Toxicol. Appl. Pharmacol. , vol.20 , pp. 474
    • McKay, D.H.1    Jardine, R.V.2    Adie, P.A.3
  • 86
    • 0000440545 scopus 로고
    • CaE’s-the soman scavenger in rodents; heterogeneity and hormonal influence
    • Reiner, E., Aldridge, W.N., and Hoskin, F.C.G., eds., Ellis Horwood Ltd., Chichester, chap. 14
    • Sterri, S.H. and Fonnum, F., CaE’s-the soman scavenger in rodents; heterogeneity and hormonal influence, in Enzymes Hydrolysing Organophosphorus Compounds, Reiner, E., Aldridge, W.N., and Hoskin, F.C.G., eds., Ellis Horwood Ltd., Chichester, 1989, chap. 14.
    • (1989) Enzymes Hydrolysing Organophosphorus Compounds
    • Sterri, S.H.1    Fonnum, F.2
  • 87
    • 0018834701 scopus 로고
    • Toxicity of soman after repetitive injection of sublethal doses in rats
    • Sterri, S.H., Lyngaas, S., and Fonnum, F., Toxicity of soman after repetitive injection of sublethal doses in rats, Acta Pharmacol. Toxicol., 46, 1, 1980.
    • (1980) Acta Pharmacol. Toxicol. , vol.46 , pp. 1
    • Sterri, S.H.1    Lyngaas, S.2    Fonnum, F.3
  • 88
    • 0019487374 scopus 로고
    • Toxicity of soman after repetitive injection of sublethal doses in guinea-pig and mouse
    • Sterri, S.H., Lyngaas, S., and Fonnum, F., Toxicity of soman after repetitive injection of sublethal doses in guinea-pig and mouse, Acta Pharmacol. Toxicol., 49, 8, 1981.
    • (1981) Acta Pharmacol. Toxicol. , vol.49 , pp. 8
    • Sterri, S.H.1    Lyngaas, S.2    Fonnum, F.3
  • 91
    • 0031193319 scopus 로고    scopus 로고
    • The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase
    • Raveh, L., Grauer, E., Grunwald, J., Cohen, E., and Ashani, Y., The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase, Toxicol. Appl. Pharmacol., 145, 43, 1997.
    • (1997) Toxicol. Appl. Pharmacol. , vol.145 , pp. 43
    • Raveh, L.1    Grauer, E.2    Grunwald, J.3    Cohen, E.4    Ashani, Y.5
  • 92
    • 0031879541 scopus 로고    scopus 로고
    • Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase
    • Allon, N., Raveh, L., Gilat, E., Cohen, E., Grunwald, J., and Ashani, Y., Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase, Toxicol. Sci., 43, 121, 1998.
    • (1998) Toxicol. Sci. , vol.43 , pp. 121
    • Allon, N.1    Raveh, L.2    Gilat, E.3    Cohen, E.4    Grunwald, J.5    Ashani, Y.6
  • 93
    • 0013881069 scopus 로고
    • 32P mouse organs. I. The effect of route of administration on incorporation and toxicity
    • 32P mouse organs. I. The effect of route of administration on incorporation and toxicity, Biochem. Pharmacol., 15, 169, 1966.
    • (1966) Biochem. Pharmacol. , vol.15 , pp. 169
    • Ramachandran, B.V.1
  • 95
    • 49749207775 scopus 로고
    • The fate of tabun in atropine and atropine oxime treated rats and mice
    • Heilbronn, E., Appelgren, I.-E., and Sundwall, A., The fate of tabun in atropine and atropine oxime treated rats and mice, Biochem. Pharmacol., 13, 1189, 1964.
    • (1964) Biochem. Pharmacol. , vol.13 , pp. 1189
    • Heilbronn, E.1    Appelgren, I.-E.2    Sundwall, A.3
  • 96
    • 0014235942 scopus 로고
    • Distribution and metabolism of diisopropyl phosphorofluoridate (DFP) in the guinea pig
    • Hansen, D., Schaum, E., and Wasserman, O., Distribution and metabolism of diisopropyl phosphorofluoridate (DFP) in the guinea pig, Arch. Toxicol., 23, 73, 1968.
    • (1968) Arch. Toxicol. , vol.23 , pp. 73
    • Hansen, D.1    Schaum, E.2    Wasserman, O.3
  • 97
    • 0014314180 scopus 로고
    • Serum level and excretion of diisopropyl fluorophosphate (DFP) in cats
    • Hansen, D., Schaum, E., and Wasserman, O., Serum level and excretion of diisopropyl fluorophosphate (DFP) in cats, Biochem. Pharmacol., 17, 1159, 1968.
    • (1968) Biochem. Pharmacol. , vol.17 , pp. 1159
    • Hansen, D.1    Schaum, E.2    Wasserman, O.3
  • 99
    • 0021324918 scopus 로고
    • Formation of soman (1, 2, 2-trimethylpropyl methylphosphonofluoridate) via fluoride-induced reactivation of soman-inhibited aliesterase in rat plasma
    • De Jong, L.P.A. and Van Dijk, C., Formation of soman (1, 2, 2-trimethylpropyl methylphosphonofluoridate) via fluoride-induced reactivation of soman-inhibited aliesterase in rat plasma, Biochem. Pharmacol., 33, 663, 1984.
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 663
    • De Jong, L.P.A.1    Van Dijk, C.2
  • 101
    • 0020575171 scopus 로고
    • Physiological model of the pharmacokinetics of 2, 3, 7, 8-tetrachlorodibenzofuran in several species
    • King, F.G., Dedrick, R.L., Collins, J.M., Matthews, H.B., and Birnbaum, L.S., Physiological model of the pharmacokinetics of 2, 3, 7, 8-tetrachlorodibenzofuran in several species, Toxicol. Appl. Pharmacol., 67, 390, 1983.
    • (1983) Toxicol. Appl. Pharmacol. , vol.67 , pp. 390
    • King, F.G.1    Dedrick, R.L.2    Collins, J.M.3    Matthews, H.B.4    Birnbaum, L.S.5
  • 102
    • 0021129859 scopus 로고
    • Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model
    • Lutz, R.J., Dedrick, R.L., Tuey, D., Sipes, I.G., Anderson, M.W., and Matthews, H.B., Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model, Drug Metab. Dispos., 12, 527, 1984.
    • (1984) Drug Metab. Dispos. , vol.12 , pp. 527
    • Lutz, R.J.1    Dedrick, R.L.2    Tuey, D.3    Sipes, I.G.4    Anderson, M.W.5    Matthews, H.B.6
  • 103
    • 0021279862 scopus 로고
    • A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans
    • Ramsey, J.C. and Andersen, M.E., A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans, Toxicol. Appl. Pharmacol., 73, 159, 1984.
    • (1984) Toxicol. Appl. Pharmacol. , vol.73 , pp. 159
    • Ramsey, J.C.1    Andersen, M.E.2
  • 104
    • 0023724364 scopus 로고
    • A pharmacodynamic model for soman in the rat
    • Maxwell, D.M., Vlahacos, C.P., and Lenz, D.E., A pharmacodynamic model for soman in the rat, Toxicol. Lett., 43, 175, 1988.
    • (1988) Toxicol. Lett. , vol.43 , pp. 175
    • Maxwell, D.M.1    Vlahacos, C.P.2    Lenz, D.E.3
  • 105
    • 0025604621 scopus 로고
    • Physiologically based pharmacokinetics and the pharmacodynamic model for inhibition of acetylcholinesterase by diisopropyl fluorophosphate
    • Gearhart, J.M., Jepson, G.W., Clewell III, H.J., Andersen, M.E., and Conolly, R.B., Physiologically based pharmacokinetics and the pharmacodynamic model for inhibition of acetylcholinesterase by diisopropyl fluorophosphate, Toxicol. Appl. Pharmacol., 106, 295, 1990.
    • (1990) Toxicol. Appl. Pharmacol. , vol.106 , pp. 295
    • Gearhart, J.M.1    Jepson, G.W.2    Clewell, H.J.3    Andersen, M.E.4    Conolly, R.B.5
  • 106
    • 8244264989 scopus 로고
    • The distribution of radioactive phosphorus in the blood and tissues of rabbits treated with tagged sarin
    • McPhail, M.K. and Adie, P.A., The distribution of radioactive phosphorus in the blood and tissues of rabbits treated with tagged sarin, Can. J. Biochem. Physiol., 38, 945, 1960.
    • (1960) Can. J. Biochem. Physiol. , vol.38 , pp. 945
    • McPhail, M.K.1    Adie, P.A.2
  • 108
    • 0016374892 scopus 로고
    • Cardiac output distribution in rats measured by injection of radioactive microspheres via cardiac puncture
    • Rakusan, K. and Blahitka, J., Cardiac output distribution in rats measured by injection of radioactive microspheres via cardiac puncture, Can. J. Physiol. Pharmacol., 52, 230, 1974.
    • (1974) Can. J. Physiol. Pharmacol. , vol.52 , pp. 230
    • Rakusan, K.1    Blahitka, J.2
  • 110
    • 0014462269 scopus 로고
    • Stereospecific aging of phosphonylated cholinesterases
    • Keijer, J.H. and Wolring, G.Z., Stereospecific aging of phosphonylated cholinesterases, Biochim. Biophys. Acta, 185, 465, 1969.
    • (1969) Biochim. Biophys. Acta , vol.185 , pp. 465
    • Keijer, J.H.1    Wolring, G.Z.2
  • 111
    • 84915650337 scopus 로고
    • Some pharmacological actions of oximes and atropine on the cadiovascular effects produced by pinacolyl methylphosphonofluoridate (soman) in rats
    • Vojvodic, V. and Milosevic, M., Some pharmacological actions of oximes and atropine on the cadiovascular effects produced by pinacolyl methylphosphonofluoridate (soman) in rats, Iugosl. Physiol. Pharmacol. Acta, 7, 439, 1971.
    • (1971) Iugosl. Physiol. Pharmacol. Acta , vol.7 , pp. 439
    • Vojvodic, V.1    Milosevic, M.2
  • 112
    • 0020429017 scopus 로고
    • The effects of HS-3 and HS-6 on cardiovascular changes in rats caused by soman
    • Kentera, D., Susic, D., and Stamenovic, B., The effects of HS-3 and HS-6 on cardiovascular changes in rats caused by soman, Arh. Hig. Rada Toksikol., 33, 143, 1982.
    • (1982) Arh. Hig. Rada Toksikol. , vol.33 , pp. 143
    • Kentera, D.1    Susic, D.2    Stamenovic, B.3
  • 114
    • 0018240178 scopus 로고
    • Detoxication of phosphonothioates and phosphonofluoridates in the rat
    • Bajgar, J., Fusek, J., Patocka, J., and Hrdina, V., Detoxication of phosphonothioates and phosphonofluoridates in the rat, Acta Biol. Med. Germ., 37, 1261, 1978.
    • (1978) Acta Biol. Med. Germ. , vol.37 , pp. 1261
    • Bajgar, J.1    Fusek, J.2    Patocka, J.3    Hrdina, V.4
  • 115
    • 0031616843 scopus 로고    scopus 로고
    • Purification and properties of somanhydrolyzing enzyme from human liver
    • Wang, Q., Sun, M., Zhang, H., and Huang, C., Purification and properties of somanhydrolyzing enzyme from human liver, J. Biochem. Mol. Toxicol., 12, 213, 1998.
    • (1998) J. Biochem. Mol. Toxicol. , vol.12 , pp. 213
    • Wang, Q.1    Sun, M.2    Zhang, H.3    Huang, C.4
  • 116
    • 0026639319 scopus 로고
    • The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds
    • Maxwell, D.M., The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds, Toxicol. Appl. Pharmacol., 114, 306, 1992.
    • (1992) Toxicol. Appl. Pharmacol. , vol.114 , pp. 306
    • Maxwell, D.M.1
  • 117
    • 0033566755 scopus 로고    scopus 로고
    • Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: Toxicological relevance of cholinesterase-independent actions
    • Rocha, E.S., Santos, M.D., Chebabo, S.R., Aracava, Y., and Albuquerque, E.X., Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: Toxicological relevance of cholinesterase-independent actions, Toxicol. Appl. Pharmacol., 159, 31, 1999.
    • (1999) Toxicol. Appl. Pharmacol. , vol.159 , pp. 31
    • Rocha, E.S.1    Santos, M.D.2    Chebabo, S.R.3    Aracava, Y.4    Albuquerque, E.X.5
  • 118
    • 85031136189 scopus 로고    scopus 로고
    • Toxicokinetics of O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate [(±)-VX] in hairless guinea pigs and marmosets-Identification of metabolic pathways
    • Van der Schans, M.J., Langenberg, J.P., and Benschop, H.P., Toxicokinetics of O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate [(±)-VX] in hairless guinea pigs and marmosets-Identification of metabolic pathways, Final Report Contract DAMD17-97-2-7001, 2000.
    • (2000) Final Report Contract DAMD17-97-2-7001
    • van der Schans, M.J.1    Langenberg, J.P.2    Benschop, H.P.3


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