메뉴 건너뛰기




Volumn 78, Issue 12, 2013, Pages

Investigating flavonoids as m olecular templates for the design of small-molecule inhibitors of cell signaling

Author keywords

Antiplatelet drugs; Cardiovascular disease; Drug design; Flavonoid molecular templates; Flavonoids; Rational screening

Indexed keywords

ANTHOCYANIN; ANTITHROMBOCYTIC AGENT; FLAVONOID; HYDROXYBENZOIC ACID DERIVATIVE; PHENOLIC ACID; POLYPHENOL; STILBENE DERIVATIVE;

EID: 84890150338     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/1750-3841.12293     Document Type: Article
Times cited : (8)

References (32)
  • 1
    • 0030842112 scopus 로고    scopus 로고
    • Relationship between flavonoids structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition
    • Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Remesy C, Chap H, Payrastre B. 1997. Relationship between flavonoids structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 53(11):1649-57.
    • (1997) Biochem Pharmacol , vol.53 , Issue.11 , pp. 1649-1657
    • Agullo, G.1    Gamet-Payrastre, L.2    Manenti, S.3    Viala, C.4    Remesy, C.5    Chap, H.6    Payrastre, B.7
  • 2
    • 0037392942 scopus 로고    scopus 로고
    • The selectivity of protein kinase inhibitors: an update
    • Bain J, McLauchlan H, Elliott M, Cohen P. 2003. The selectivity of protein kinase inhibitors: an update. Biochem J 371(Pt 1):199-204.
    • (2003) Biochem J , vol.371 , Issue.1 PART , pp. 199-204
    • Bain, J.1    McLauchlan, H.2    Elliott, M.3    Cohen, P.4
  • 6
    • 0036090191 scopus 로고    scopus 로고
    • Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets
    • Cicmil M, Thomas JM, Leduc M, Bon C, Gibbins JM. 2002. Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets. Blood 99(1):137-44.
    • (2002) Blood , vol.99 , Issue.1 , pp. 137-144
    • Cicmil, M.1    Thomas, J.M.2    Leduc, M.3    Bon, C.4    Gibbins, J.M.5
  • 8
    • 84863691513 scopus 로고    scopus 로고
    • Drug repositioning through incomplete bi-cliques in an integrated drug-target-disease network
    • Daminelli S, Haupt VJ, Reimann M, Schroeder M. 2012. Drug repositioning through incomplete bi-cliques in an integrated drug-target-disease network. Integr Biol (Camb) 4(7):778-88.
    • (2012) Integr Biol (Camb) , vol.4 , Issue.7 , pp. 778-788
    • Daminelli, S.1    Haupt, V.J.2    Reimann, M.3    Schroeder, M.4
  • 9
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P. 2000. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351(Pt 1):95-105.
    • (2000) Biochem J , vol.351 , Issue.1 PART , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 11
    • 4444260266 scopus 로고    scopus 로고
    • Platelet adhesion signalling and the regulation of thrombus formation
    • Gibbins JM. 2004. Platelet adhesion signalling and the regulation of thrombus formation. J Cell Sci 117(Pt 16):3415-25.
    • (2004) J Cell Sci , vol.117 , Issue.16 PART , pp. 3415-3425
    • Gibbins, J.M.1
  • 12
    • 0029894287 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets
    • Gibbins J, Asselin J, Farndale R, Barnes M, Law CL, Watson SP. 1996. Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets. J Biol Chem 271(30):18095-9.
    • (1996) J Biol Chem , vol.271 , Issue.30 , pp. 18095-18099
    • Gibbins, J.1    Asselin, J.2    Farndale, R.3    Barnes, M.4    Law, C.L.5    Watson, S.P.6
  • 13
    • 0032545307 scopus 로고    scopus 로고
    • The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activator of T cells (LAT) in platelets stimulated by collagen and convulxin
    • Gibbins JM, Briddon S, Shutes A, van Vugt MJ, de Winkel JGJ, Saito T, Watson SP. 1998. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activator of T cells (LAT) in platelets stimulated by collagen and convulxin. J Biol Chem 273(51):34437-43.
    • (1998) J Biol Chem , vol.273 , Issue.51 , pp. 34437-34443
    • Gibbins, J.M.1    Briddon, S.2    Shutes, A.3    van Vugt, M.J.4    de Winkel, J.G.J.5    Saito, T.6    Watson, S.P.7
  • 14
    • 78650033886 scopus 로고    scopus 로고
    • Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids
    • Goettert M, Schattel V, Koch P, Merfort I, Laufer S. 2010. Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids. Chembiochem 11(18):2579-88.
    • (2010) Chembiochem , vol.11 , Issue.18 , pp. 2579-2588
    • Goettert, M.1    Schattel, V.2    Koch, P.3    Merfort, I.4    Laufer, S.5
  • 17
    • 2442543550 scopus 로고    scopus 로고
    • Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signalling pathway
    • Hubbard GP, Stevens JM, Cicmil M, Sage T, Jordan PA, Williams CM, Lovegrove JA, Gibbins JM. 2003. Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signalling pathway. J Thromb Haemost 1(5):1079-88.
    • (2003) J Thromb Haemost , vol.1 , Issue.5 , pp. 1079-1088
    • Hubbard, G.P.1    Stevens, J.M.2    Cicmil, M.3    Sage, T.4    Jordan, P.A.5    Williams, C.M.6    Lovegrove, J.A.7    Gibbins, J.M.8
  • 18
    • 61449168794 scopus 로고    scopus 로고
    • Fyn kinase is a direct target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha
    • Hwang MK, Kang NJ, Heo YS, Lee KW, Lee HJ. 2009. Fyn kinase is a direct target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha. Biochem Pharmacol 77(7):1213-22.
    • (2009) Biochem Pharmacol , vol.77 , Issue.7 , pp. 1213-1222
    • Hwang, M.K.1    Kang, N.J.2    Heo, Y.S.3    Lee, K.W.4    Lee, H.J.5
  • 19
    • 84871515859 scopus 로고    scopus 로고
    • Platelet secretion is kinetically heterogeneous in an agonist-responsive manner
    • Jonnalagadda D, Izu LT, Whiteheart SW. 2012. Platelet secretion is kinetically heterogeneous in an agonist-responsive manner. Blood 120(26):5209-16.
    • (2012) Blood , vol.120 , Issue.26 , pp. 5209-5216
    • Jonnalagadda, D.1    Izu, L.T.2    Whiteheart, S.W.3
  • 23
    • 0026726483 scopus 로고
    • The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs
    • Matter WF, Brown RF, Vlahos CJ. 1992. The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs. Biochem Biophys Res Commun 186(2):624-31.
    • (1992) Biochem Biophys Res Commun , vol.186 , Issue.2 , pp. 624-631
    • Matter, W.F.1    Brown, R.F.2    Vlahos, C.J.3
  • 24
    • 33646776371 scopus 로고    scopus 로고
    • von Willebrand factor mediates platelet spreading through glycoprotein Ib and aIIbb3 in the presence of botrocetin and ristocetin, respectively
    • Mccarty OJT, Calaminus SDJ, Berndt MC, Machesky M, Watson SP. 2006. von Willebrand factor mediates platelet spreading through glycoprotein Ib and aIIbb3 in the presence of botrocetin and ristocetin, respectively. J Thromb Haemost 4(6):1367-78.
    • (2006) J Thromb Haemost , vol.4 , Issue.6 , pp. 1367-1378
    • Mccarty, O.J.T.1    Calaminus, S.D.J.2    Berndt, M.C.3    Machesky, M.4    Watson, S.P.5
  • 25
    • 0020374878 scopus 로고
    • Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain
    • Picq M, Prigent AF, Nemoz G, Andre AC, Pacheco H. 1982. Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain. J Med Chem 25(10):1192-8.
    • (1982) J Med Chem , vol.25 , Issue.10 , pp. 1192-1198
    • Picq, M.1    Prigent, A.F.2    Nemoz, G.3    Andre, A.C.4    Pacheco, H.5
  • 27
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos CJ, Matter WF, Hui KY, Brown RF. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269(7):5241-8.
    • (1994) J Biol Chem , vol.269 , Issue.7 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 28
    • 0033634827 scopus 로고    scopus 로고
    • Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine
    • Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL. 2000. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine. Mol Cell 6(4):909-19.
    • (2000) Mol Cell , vol.6 , Issue.4 , pp. 909-919
    • Walker, E.H.1    Pacold, M.E.2    Perisic, O.3    Stephens, L.4    Hawkins, P.T.5    Wymann, M.P.6    Williams, R.L.7
  • 29
    • 84873297322 scopus 로고    scopus 로고
    • Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication
    • Wang X, Xu X, Li Y, Li X, Tao W, Li B, Wang Y, Yang L. 2013. Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication. Integr Biol (Camb) 5(2):351-71.
    • (2013) Integr Biol (Camb) , vol.5 , Issue.2 , pp. 351-371
    • Wang, X.1    Xu, X.2    Li, Y.3    Li, X.4    Tao, W.5    Li, B.6    Wang, Y.7    Yang, L.8
  • 30
    • 77949389166 scopus 로고    scopus 로고
    • A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids
    • Wright B, Moraes LA, Kemp CF, Mullen W, Crozier A, Lovegrove JA, Gibbins JM. 2010. A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. Br J Pharmacol 159(6):1312-25.
    • (2010) Br J Pharmacol , vol.159 , Issue.6 , pp. 1312-1325
    • Wright, B.1    Moraes, L.A.2    Kemp, C.F.3    Mullen, W.4    Crozier, A.5    Lovegrove, J.A.6    Gibbins, J.M.7
  • 31
    • 84861610134 scopus 로고    scopus 로고
    • A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data
    • doi: 10.1371/journal.pone.0037608.
    • Yu H, Chen J, Xu X, Li Y, Zhao H, Fang Y, Li X, Zhou W, Wang W, Wang Y. 2012. A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data. PLoSOne 7(5):e37608. doi: 10.1371/journal.pone.0037608.
    • (2012) PLoSOne , vol.7 , Issue.5
    • Yu, H.1    Chen, J.2    Xu, X.3    Li, Y.4    Zhao, H.5    Fang, Y.6    Li, X.7    Zhou, W.8    Wang, W.9    Wang, Y.10
  • 32
    • 82955161663 scopus 로고    scopus 로고
    • Concomitant inhibition of HSP90, its mitochondrial localised homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells
    • doi: 10.1002/pmic.201100242
    • Zhang L, Pang E, Loo RR, Rao J, Go VL, Loo JA, Lu QY. 2011. Concomitant inhibition of HSP90, its mitochondrial localised homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells. Proteomics 11(24):4638-47. doi: 10.1002/pmic.201100242.
    • (2011) Proteomics , vol.11 , Issue.24 , pp. 4638-4647
    • Zhang, L.1    Pang, E.2    Loo, R.R.3    Rao, J.4    Go, V.L.5    Loo, J.A.6    Lu, Q.Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.