Biological Evaluation and Structural Determinants of p38α Mitogen-Activated-Protein Kinase and c-Jun-N-Terminal Kinase 3 Inhibition by Flavonoids

ChemBioChem

Volumn 11, Issue 18, 2010, Pages 2579-2588

  Goettert, Márcia ^a   Schattel, Verena ^a   Koch, Pierre ^a   Merfort, Irmgard ^b   Laufer, Stefan ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Flavonoids; JNK3; Molecular modeling; P38alpha MAP kinase; Structure activity relationships

Indexed keywords

APIGENIN; CATECHIN; CHRYSIN; DIOSMETIN; EPICATECHIN; EPIGALLOCATECHIN GALLATE; EUPAFOLIN; FISETIN; FLAVONOID; GALLOCATECHIN; GENISTEIN; HESPERETIN; HISPIDULIN; HYPERIN; ISOQUERCITRIN; ISORHAMNETIN; JACEOSIDIN; KAEMPFEROL; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE 10; MITOGEN ACTIVATED PROTEIN KINASE 14; MORIN; MYRICETIN; NEVADENSIN; QUERCETIN; QUERCITRIN; RUTOSIDE; TAXIFOLIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VELUTIN;

ARTICLE; ENZYME INHIBITION; GLUCURONIDATION; GLYCOSYLATION; IC 50; MOLECULAR DOCKING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; FLAVONOIDS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 10; MITOGEN-ACTIVATED PROTEIN KINASE 14; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650033886     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201000487     Document Type: Article

References (35)

1. J. Li, Y. Jiang, Molecules 2007, 12, 745-758.
2. J. P. E. Spencer, Genes Nutr. 2007, 2, 257-273.
3. S. L. Warber, M. Seymour, P. B. Kaufman, A. Kirakosyan, L. J. Cseke, Natural Products from Plants, 2nd ed., CRC, Boca Raton, 2006, pp. 415-440.
4. C. Santangelo, R. Vari, B. Scazzocchio, R. Di Benedetto, C. Filesi, R. Masella, Ann. Ist. Super. Sanita 2007, 43, 394-405.
5. E. Middleton, Jr., C. Kandaswami, T. C. Theoharides, Pharmacol. Rev. 2000, 52, 673-751.
6. G. Seelinger, I. Merfort, U. Woelfle, C. M. Schempp, Molecules 2008, 13, 2628-2651.
7. G. Seelinger, I. Merfort, C. M. Schempp, Planta Med. 2008, 74, 1667-1677.
8. E. Middleton, Jr., C. Kandaswami, T. C. Theoharides, Pharmacol. Rev. 2000, 52, 673-751.
9. J. Zhang, B. Shen, A. Lin, Trends Pharmacol. Sci. 2007, 28, 286-295.
10. G. L. Johnson, R. Lapadat, Science 2002, 298, 1911-1912.
11. A. Garcia-Lafuente, E. Guillamon, A. Villares, M. A. Rostagno, J. A. Martinez, Inflammation Res. 2009, 58, 537-552.
12. M. H. Cobb, E. J. Goldsmith, J. Biol. Chem. 1995, 270, 14843-14846.
13. J. C. Lee, S. Kumar, D. E. Griswold, D. C. Underwood, B. J. Votta, J. L. Adams, Immunopharmacology 2000, 47, 185-201.
14. P. P. Roux, J. Blenis, Microbiol. Mol. Biol. Rev. 2004, 68, 320-344.
15. J. F. Schindler, J. B. Monahan, W. G. Smith, J. Dent. Res. 2007, 86, 800-811.
16. T. Kamenecka, J. Habel, D. Duckett, W. Chen, Y. Y. Ling, B. Frackowiak, R. Jiang, Y. Shin, X. Song, P. LoGrasso, J. Biol. Chem. 2009, 284, 12853-12861.
17. X. Xie, Y. Gu, T. Fox, J. T. Coll, M. A. Fleming, W. Markland, P. R. Caron, K. P. Wilson, M. S. S. Su, Structure 1998, 6, 983-991.
18. P. Traxler, Expert Opin. Ther. Pat. 1998, 8, 1599-1625.
19. P. M. Traxler, Expert Opin. Ther. Pat. 1997, 7, 571-588.
20. G. Scapin, S. B. Patel, J. Lisnock, J. W. Becker, P. V. LoGrasso, Chem. Biol. 2003, 10, 705-712.
21. F. Zuccotto, E. Ardini, E. Casale, M. Angiolini, J. Med. Chem. 2010, 53, 2681-2694.
22. Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective (Eds.: H. Kubinyi, G. Müller), Wiley-VCH, Weinheim, 2004, p. 463.
23. P. C. Ferriola, V. Cody, E. Middleton, Jr., Biochem. Pharmacol. 1989, 38, 1617-1624.
24. M. Hagiwara, S. Inoue, T. Tanaka, K. Nunoki, M. Ito, H. Hidaka, Biochem. Pharmacol. 1988, 37, 2987-2992.
25. E. H. Walker, M. E. Pacold, O. Perisic, L. Stephens, P. T. Hawkins, M. P. Wymann, R. L. Williams, Mol. Cell 2000, 6, 909-919.
26. A. M. Senderowicz, Invest. New Drugs 1999, 17, 313-320.
27. C. Sekine, T. Sugihara, S. Miyake, H. Hirai, M. Yoshida, N. Miyasaka, H. Kohsaka, J. Immunol. 2008, 180, 1954-1961.
28. C. Peifer, S. Luik, S. Thuma, Y. Herweh, S. Laufer, Comb. Chem. High Throughput Screen. 2006, 9, 613-618.
29. S. Laufer, S. Thuma, C. Peifer, C. Greim, Y. Herweh, A. Albrecht, F. Dehner, Anal. Biochem. 2005, 344, 135-137.
30. M. Goettert, R. Graeser, S. A. Laufer, Anal. Biochem. 2010, 406, 233-234.
31. E. H. Walker, M. E. Pacold, O. Perisic, L. Stephens, P. T. Hawkins, M. P. Wymann, R. L. Williams, Mol. Cell 2000, 6, 909-919.
32. Maestro, version 8.5, Schrödinger Inc, LLC, New York, 2008.
33. LigPrep, version 2.2, Schrödinger, LLC, New York, 2005.
34. Schroedinger Suite 2008, Induced Fit Docking Protocol; Glide version 5.0, Schroedinger, LLC, New York, 2005.
35. W. L. DeLano, The PyMOL Molecular Graphics System 2002, DeLano Scientific, San Carlos