Synthesis and evaluation of novel chromone analogs for their inhibitory activity against interleukin-5

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2531-2536

  Thanigaimalai, Pillaiyar ^a   Le Hoang, Tuan Anh ^a   Lee, Ki Cheul ^a   Sharma, Vinay K ^a   Bang, Seong Cheol ^a   Yun, Jun Ho ^b   Roh, Eunmiri ^b   Kim, Youngsoo ^b   Jung, Sang Hun ^a  

^a Center for Nano bio Engineering and Spintronics   (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

Chromone analogs; Eosinophils; Inhibitor; Interleukin 5

Indexed keywords

3 (4 CHLOROBENZYL) 5 (CYCLOHEXYLMETHOXY) 4H CHROMEN 4 ONE; 3 (4 HYDROXYBENZYL) 5 (ISOPENTYLOXY) 4H CHROMEN 4 ONE; 3 (5 ISOBUTOXY 4 OXO 4H CHROMEN 3 YL)PROPANOIC ACID; 3 (CHLOROMETHYL) 5 (CYCLOHEXYLMETHOXY) 4H CHROMEN 4 ONE; 3 (CHLOROMETHYL) 5 ISOBUTOXY 4H CHROMEN 4 ONE; 3 (HYDROXYMETHYL) 5 ISOBUTOXY 4H CHROMEN 4 ONE; 3 [5 (CYCLOHEXYLMETHOXY) 4 OXO 4H CHROMEN 3 YL]PROPANOIC ACID; 3 BENZYL 5 (CYCLOHEXYLMETHOXY) 4H CHROMEN 4 ONE; 4 [(5 ISOBUTOXY 4 OXO 4H CHROMEN 3 YL)METHYL]BENZOIC ACID; 4 [[5 (CYCLOHEXYLMETHOXY) 4 OXO 4H CHROMEN 3 YL]METHYL]BENZENE SULFONAMIDE; 4 [[5 (CYCLOHEXYLMETHOXY) 4 OXO 4H CHROMEN 3 YL]METHYL]BENZOIC ACID; 5 (CYCLOHEXYLMETHOXY) 3 (3,4,5 TRIMETHOXYBENZYL) 4H CHROMEN 4 ONE; 5 (CYCLOHEXYLMETHOXY) 3 (4 ETHYLBENZYL) 4H CHROMEN 4 ONE; 5 (CYCLOHEXYLMETHOXY) 3 (4 HYDROXYBENZYL) 4H CHROMEN 4 ONE; 5 (CYCLOHEXYLMETHOXY) 3 (4 METHYLBENZYL) 4H CHROMEN 4 ONE; 5 (CYCLOHEXYLMETHOXY) 3 (HYDROXYMETHYL) 4H CHROMEN 4 ONE; 5 (CYCLOHEXYLMETHOXY) 3 [4 (TRIFLUOROMETHYL)BENZYL] 4H CHROMEN 4 ONE; 5 (CYCLOHEXYLMETHOXY) 4 OXO 4H CHROMENE 3 CARBALDEHYDE; 5 (CYCLOHEXYLMETHOXY) 4 OXO 4H CHROMENE 3 CARBALDEHYDE OXIME; 5 (CYCLOHEXYLMETHOXY) 4 OXO 4H CHROMENE 3 CARBOXYLIC ACID; 5 (ISOPENTYLOXY) 3 (4 METHYLBENZYL) 4H CHROMEN 4 ONE; 5 ISOBUTOXY 4 OXO 4H CHROMENE 3 CARBALDEHYDE; 5 ISOBUTOXY 4 OXO 4H CHROMENE 3 CARBALDEHYDE OXIME; 5 ISOBUTOXY 4 OXO 4H CHROMENE 3 CARBOXYLIC ACID; CHROMONE DERIVATIVE; INTERLEUKIN 5; METHYLCYCLOHEXANE; PHENOL; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOKINE PRODUCTION; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON; HYDROGEN BOND; HYDROPHOBICITY; IC 50;

CELL LINE; CHROMONES; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; INTERLEUKIN-5; PERMEABILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950917428     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.041     Document Type: Article

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