-
1
-
-
77955273537
-
-
Ver.1.2: Accessed 29th, January, 2012
-
Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Ver.1.2: http://globocan.iarc.fr. Accessed 29th, January, 2012.
-
Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
Parkin, D.M.6
-
2
-
-
1242307281
-
Hepatectomy for hepatocellular carcinoma: Patient selection and postoperative outcome
-
Poon RT and Fan ST: Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome. Liver Transpl 10 : S39-45, 2004.
-
(2004)
Liver Transpl
, vol.10
-
-
Poon, R.T.1
Fan, S.T.2
-
3
-
-
0036217866
-
Invasive growth: From development to metastasis
-
Comoglio PM and Trusolino L: Invasive growth: from development to metastasis. J Clin Invest 109 : 857-862, 2002.
-
(2002)
J Clin Invest
, vol.109
, pp. 857-862
-
-
Comoglio, P.M.1
Trusolino, L.2
-
4
-
-
0030293598
-
Matrix metalloproteinases and the development of cancer
-
Coussens LM and Werb Z: Matrix metalloproteinases and the development of cancer. Chem Biol 3: 895-904, 1996.
-
(1996)
Chem Biol
, vol.3
, pp. 895-904
-
-
Coussens, L.M.1
Werb, Z.2
-
5
-
-
0036534375
-
Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: A prospective study
-
Poon RT, Ng IO, Lau C, Yu WC, Yang ZF, Fan ST and Wong J: Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study. J Clin Oncol 20 : 1775-1785, 2002.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1775-1785
-
-
Poon, R.T.1
Ng, I.O.2
Lau, C.3
Yu, W.C.4
Yang, Z.F.5
Fan, S.T.6
Wong, J.7
-
6
-
-
0038118504
-
Overexpression of VEGF and angiopoietin 2: A key to high vascularity of hepatocellular carcinoma?
-
Moon WS, Rhyu KH, Kang MJ, Lee DG, Yu HC, Yeum JH, Koh GY and Tarnawski AS: Overexpression of VEGF and angiopoietin 2: A key to high vascularity of hepatocellular carcinoma? Mod Pathol 16: 552-557, 2003.
-
(2003)
Mod Pathol
, vol.16
, pp. 552-557
-
-
Moon, W.S.1
Rhyu, K.H.2
Kang, M.J.3
Lee, D.G.4
Yu, H.C.5
Yeum, J.H.6
Koh, G.Y.7
Tarnawski, A.S.8
-
7
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammationassociated cancer
-
Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E and Ben-Neriah Y: NF-kappaB functions as a tumour promoter in inflammationassociated cancer. Nature 431: 461-466, 2004.
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
Abramovitch, R.4
Amit, S.5
Kasem, S.6
Gutkovich-Pyest, E.7
Urieli-Shoval, S.8
Galun, E.9
Ben-Neriah, Y.10
-
8
-
-
80053088189
-
Hepatocellular Carcinoma
-
El-Serag HB: Hepatocellular Carcinoma. N Engl J Med 365: 1118-1127, 2011.
-
(2011)
N Engl J Med
, vol.365
, pp. 1118-1127
-
-
El-Serag, H.B.1
-
9
-
-
33745298519
-
Nuclear factor-kappaB in cancer development and progression
-
Karin M: Nuclear factor-kappaB in cancer development and progression. Nature 441 : 431-436, 2006.
-
(2006)
Nature
, vol.441
, pp. 431-436
-
-
Karin, M.1
-
10
-
-
79751492851
-
NF-kappaB in the liver - Linking injury, fibrosis and hepatocellular carcinoma
-
Luedde T and Schwabe RF: NF-kappaB in the liver - linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 8 : 108-118, 2011.
-
(2011)
Nat Rev Gastroenterol Hepatol
, vol.8
, pp. 108-118
-
-
Luedde, T.1
Schwabe, R.F.2
-
11
-
-
21244472975
-
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
-
Maeda S, Kamata H, Luo JL, Leffert H and Karin M: IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121: 977-990, 2005.
-
(2005)
Cell
, vol.121
, pp. 977-990
-
-
Maeda, S.1
Kamata, H.2
Luo, J.L.3
Leffert, H.4
Karin, M.5
-
12
-
-
64649087510
-
NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy
-
Wu JM, Sheng H, Saxena R, Skill NJ, Bhat-Nakshatri P, Yu M, Nakshatri H and Maluccio MA: NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy. Cancer Lett 278: 145-155, 2009.
-
(2009)
Cancer Lett
, vol.278
, pp. 145-155
-
-
Wu, J.M.1
Sheng, H.2
Saxena, R.3
Skill, N.J.4
Bhat-Nakshatri, P.5
Yu, M.6
Nakshatri, H.7
Maluccio, M.A.8
-
13
-
-
0038705309
-
An absolute role of the PKC-dependent NFkappaB activation for induction of MMP-9 in hepatocellular carcinoma cells
-
Hah N and Lee ST: An absolute role of the PKC-dependent NFkappaB activation for induction of MMP-9 in hepatocellular carcinoma cells. Biochem Biophys Res Commun 305: 428-433, 2003.
-
(2003)
Biochem Biophys Res Commun
, vol.305
, pp. 428-433
-
-
Hah, N.1
Lee, S.T.2
-
14
-
-
0037180757
-
Inflammation and cancer
-
Coussens LM and Werb Z: Inflammation and cancer. Nature 420: 860-867, 2002.
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
15
-
-
33744948611
-
Regulation of IkappaB kinase (IKK) complex by IKKgammadependent phosphorylation of the T-loop and C terminus of IKKbeta
-
Schomer-Miller B, Higashimoto T, Lee YK and Zandi E: Regulation of IkappaB kinase (IKK) complex by IKKgammadependent phosphorylation of the T-loop and C terminus of IKKbeta. J Biol Chem 281: 15268-15276, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 15268-15276
-
-
Schomer-Miller, B.1
Higashimoto, T.2
Lee, Y.K.3
Zandi, E.4
-
16
-
-
84863273256
-
Using NF-κB as a molecular target for theranostics in radiation oncology research
-
Liu YC, Chiang IT, Hsu FT and Hwang JJ: Using NF-κB as a molecular target for theranostics in radiation oncology research. Expert Rev Mol Diagn 12 : 139-146, 2012.
-
(2012)
Expert Rev Mol Diagn
, vol.12
, pp. 139-146
-
-
Liu, Y.C.1
Chiang, I.T.2
Hsu, F.T.3
Hwang, J.J.4
-
17
-
-
33645976174
-
Ubiquitous activation of RAS and JAK/STAT pathways in human HCC
-
Calvisi DF, Ladu S, Gorden A, Farina M, Conner EA, Lee JS, Factor VM and Thorgeirsson SS: Ubiquitous activation of RAS and JAK/STAT pathways in human HCC. Gastroenterology 130: 1117-1128, 2006.
-
(2006)
Gastroenterology
, vol.130
, pp. 1117-1128
-
-
Calvisi, D.F.1
Ladu, S.2
Gorden, A.3
Farina, M.4
Conner, E.A.5
Lee, J.S.6
Factor, V.M.7
Thorgeirsson, S.S.8
-
19
-
-
4944249117
-
BAY 43-9006 exhibits broadspectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G and Trail PA: BAY 43-9006 exhibits broadspectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64 : 7099-7109, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
20
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M and Carter C: Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 66: 11851-11858, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
Zhang, X.4
McNabola, A.5
Wilkie, D.6
Wilhelm, S.7
Lynch, M.8
Carter, C.9
-
21
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Haussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D and Bruix J: Sorafenib in advanced hepatocellular carcinoma. New Engl J M 359 : 378-390, 2008.
-
(2008)
New Engl J M
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
De Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Haussinger, D.19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
-
22
-
-
0033623830
-
Role of the IkappaB kinase complex in oncogenic Ras- And Raf-mediated transformation of rat liver epithelial cells
-
Arsura M, Mercurio F, Oliver AL, Thorgeirsson SS and Sonenshein GE: Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells. Mol Cell Biol 20: 5381-5391, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5381-5391
-
-
Arsura, M.1
Mercurio, F.2
Oliver, A.L.3
Thorgeirsson, S.S.4
Sonenshein, G.E.5
-
23
-
-
77956501267
-
12-O-Tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB- Dependent MMP-9 expression
-
Lin CW, Shen SC, Chien CC, Yang LY, Shia LT and Chen YC: 12-O-Tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB- dependent MMP-9 expression. J Cell Physiol 225: 472- 481, 2010.
-
(2010)
J Cell Physiol
, vol.225
, pp. 472-481
-
-
Lin, C.W.1
Shen, S.C.2
Chien, C.C.3
Yang, L.Y.4
Shia, L.T.5
Chen, Y.C.6
-
24
-
-
67349099566
-
Silibinin prevents TPAinduced MMP-9 expression and VEGF secretion by inactivation of the RAF/MEK/ERK pathway in MCF-7 human breast cancer cells
-
Kim S, Choi JH, Lim HI, Lee SK, Kim WW, Kim JS, Kim JH, Choe JH, Yang JH, Nam SJ and Lee JE: Silibinin prevents TPAinduced MMP-9 expression and VEGF secretion by inactivation of the RAF/MEK/ERK pathway in MCF-7 human breast cancer cells. Phytomedicine 16: 573-580, 2009.
-
(2009)
Phytomedicine
, vol.16
, pp. 573-580
-
-
Kim, S.1
Choi, J.H.2
Lim, H.I.3
Lee, S.K.4
Kim, W.W.5
Kim, J.S.6
Kim, J.H.7
Choe, J.H.8
Yang, J.H.9
Nam, S.J.10
Lee, J.E.11
-
25
-
-
84863337986
-
Cucurbitacin B inhibits 12 - O-tetradecanoylphorbol-13-acetateinduced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/AKT signal transduction pathways
-
Zhou X, Yang J, Wang Y, Li W, Li-Ling J, Deng Y and Zhang M: Cucurbitacin B inhibits 12 - O-tetradecanoylphorbol-13-acetateinduced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/AKT signal transduction pathways. Hepatol Res 42: 401-411, 2012.
-
(2012)
Hepatol Res
, vol.42
, pp. 401-411
-
-
Zhou, X.1
Yang, J.2
Wang, Y.3
Li, W.4
Li-Ling, J.5
Deng, Y.6
Zhang, M.7
-
26
-
-
84862777510
-
Sorafenib sensitizes human colorectal carcinoma to radiation via suppression of NF-κB expression in vitro and in vivo
-
Kuo YC, Lin WC, Chiang IT, Chang YF, Chen CW, Su SH, Chen CL and Hwang JJ: Sorafenib sensitizes human colorectal carcinoma to radiation via suppression of NF-κB expression in vitro and in vivo. Biomed Pharmacother 66 : 12-20, 2012.
-
(2012)
Biomed Pharmacother
, vol.66
, pp. 12-20
-
-
Kuo, Y.C.1
Lin, W.C.2
Chiang, I.T.3
Chang, Y.F.4
Chen, C.W.5
Su, S.H.6
Chen, C.L.7
Hwang, J.J.8
-
27
-
-
0036857484
-
A scaleable synthesis of BAY 43-9006: A potent RAF kinase inhibitor for the treatment of cancer
-
Bankston D, Dumas J, Natero R, Riedl B, Monahan M and Sibley R: A scaleable synthesis of BAY 43-9006: A potent RAF kinase inhibitor for the treatment of cancer. Org Process Res Dev 6: 777-781, 2002.
-
(2002)
Org Process Res Dev
, vol.6
, pp. 777-781
-
-
Bankston, D.1
Dumas, J.2
Natero, R.3
Riedl, B.4
Monahan, M.5
Sibley, R.6
-
28
-
-
0034710539
-
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide
-
Patel NM, Nozaki S, Shortle NH, Bhat-Nakshatri P, Newton TR, Rice S, Gelfanov V, Boswell SH, Goulet RJ Jr., Sledge GW Jr. and Nakshatri H: Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide. Oncogene 19: 4159-4169, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 4159-4169
-
-
Patel, N.M.1
Nozaki, S.2
Shortle, N.H.3
Bhat-Nakshatri, P.4
Newton, T.R.5
Rice, S.6
Gelfanov, V.7
Boswell, S.H.8
Goulet Jr., R.J.9
Sledge Jr., G.W.10
Nakshatri, H.11
-
29
-
-
61649106928
-
Inflammation and liver cancer: New molecular links
-
Berasain C, Castillo J, Perugorria MJ, Latasa MU, Prieto J and Avila MA: Inflammation and liver cancer: new molecular links. Ann N Y Acad Sci 1155: 206-221, 2009.
-
(2009)
Ann N y Acad Sci
, vol.1155
, pp. 206-221
-
-
Berasain, C.1
Castillo, J.2
Perugorria, M.J.3
Latasa, M.U.4
Prieto, J.5
Avila, M.A.6
-
30
-
-
79959929521
-
Molecular targeted therapy of hepatocellular carcinoma - Results of the first clinical studies
-
Wiedmann MW and Mossner J: Molecular targeted therapy of hepatocellular carcinoma - results of the first clinical studies. Curr Cancer Drug Targets 11: 714-733, 2011.
-
(2011)
Curr Cancer Drug Targets
, vol.11
, pp. 714-733
-
-
Wiedmann, M.W.1
Mossner, J.2
-
31
-
-
17844404832
-
Prostaglandin E2 promotes migration and adhesion in hepatocellular carcinoma cells
-
Mayoral R, Fernandez-Martinez A, Bosca L and Martin-Sanz P: Prostaglandin E2 promotes migration and adhesion in hepatocellular carcinoma cells. Carcinogenesis 26: 753-761, 2005.
-
(2005)
Carcinogenesis
, vol.26
, pp. 753-761
-
-
Mayoral, R.1
Fernandez-Martinez, A.2
Bosca, L.3
Martin-Sanz, P.4
-
32
-
-
79951957724
-
Dihydroavenanthramide D inhibits human breast cancer cell invasion through suppression of MMP-9 expression
-
Lee YR, Noh EM, Oh HJ, Hur H, Kim JM, Han JH, Hwang JK, Park BH, Park JW, Youn HJ, Jung SH, Kim BS, Jung JY, Lee SH, Park CS and Kim JS: Dihydroavenanthramide D inhibits human breast cancer cell invasion through suppression of MMP-9 expression. Biochem Biophys Res Commun 405 : 552-557, 2011.
-
(2011)
Biochem Biophys Res Commun
, vol.405
, pp. 552-557
-
-
Lee, Y.R.1
Noh, E.M.2
Oh, H.J.3
Hur, H.4
Kim, J.M.5
Han, J.H.6
Hwang, J.K.7
Park, B.H.8
Park, J.W.9
Youn, H.J.10
Jung, S.H.11
Kim, B.S.12
Jung, J.Y.13
Lee, S.H.14
Park, C.S.15
Kim, J.S.16
-
33
-
-
0038339538
-
Secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, IL-1beta: A role for the dual signalling pathways, AKT and ERK
-
Ruhul Amin AR, Senga T, Oo ML, Thant AA and Hamaguchi M: Secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, IL-1beta: a role for the dual signalling pathways, AKT and ERK. Genes Cells 8: 515-523, 2003.
-
(2003)
Genes Cells
, vol.8
, pp. 515-523
-
-
Ruhul Amin, A.R.1
Senga, T.2
Oo, M.L.3
Thant, A.A.4
Hamaguchi, M.5
-
34
-
-
79251485284
-
Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model
-
Feng YX, Wang T, Deng YZ, Yang P, Li JJ, Guan DX, Yao F, Zhu YQ, Qin Y, Wang H, Li N, Wu MC, Wang HY, Wang XF, Cheng SQ and Xie D: Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology 53: 483-492, 2011.
-
(2011)
Hepatology
, vol.53
, pp. 483-492
-
-
Feng, Y.X.1
Wang, T.2
Deng, Y.Z.3
Yang, P.4
Li, J.J.5
Guan, D.X.6
Yao, F.7
Zhu, Y.Q.8
Qin, Y.9
Wang, H.10
Li, N.11
Wu, M.C.12
Wang, H.Y.13
Wang, X.F.14
Cheng, S.Q.15
Xie, D.16
-
35
-
-
34347246278
-
Reduction of TRAIL-induced MCL-1 and cIAP2 by c-MYC or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death
-
Ricci MS, Kim SH, Ogi K, Plastaras JP, Ling J, Wang W, Jin Z, Liu YY, Dicker DT, Chiao PJ, Flaherty KT, Smith CD and El- Deiry WS: Reduction of TRAIL-induced MCL-1 and cIAP2 by c-MYC or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell 12: 66-80, 2007.
-
(2007)
Cancer Cell
, vol.12
, pp. 66-80
-
-
Ricci, M.S.1
Kim, S.H.2
Ogi, K.3
Plastaras, J.P.4
Ling, J.5
Wang, W.6
Jin, Z.7
Liu, Y.Y.8
Dicker, D.T.9
Chiao, P.J.10
Flaherty, K.T.11
Smith, C.D.12
El-Deiry, W.S.13
-
36
-
-
77953798273
-
Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics
-
Rausch V, Liu L, Kallifatidis G, Baumann B, Mattern J, Gladkich J, Wirth T, Schemmer P, Buchler MW, Zoller M, Salnikov AV and Herr I: Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. Cancer Res 70 : 5004-5013, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 5004-5013
-
-
Rausch, V.1
Liu, L.2
Kallifatidis, G.3
Baumann, B.4
Mattern, J.5
Gladkich, J.6
Wirth, T.7
Schemmer, P.8
Buchler, M.W.9
Zoller, M.10
Salnikov, A.V.11
Herr, I.12
|