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Volumn 12, Issue 1, 2013, Pages

Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase

Author keywords

CXCR2; Elastase; Inflammation; K ras; Lung cancer; Neutrophil

Indexed keywords

ANIMALS; ANTINEOPLASTIC AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; CARCINOGENESIS; CHEMOKINES; HUMANS; LEUKOCYTE ELASTASE; LUNG; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; NEOPLASMS, EXPERIMENTAL; NEUTROPHILS; RECEPTORS, INTERLEUKIN-8B;

EID: 84889840938     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-154     Document Type: Article
Times cited : (139)

References (61)
  • 1
    • 84887127947 scopus 로고    scopus 로고
    • Cancer statistics for Hispanics/Latinos, 2012
    • Siegel R, Naishadham D, Jemal A. Cancer statistics for Hispanics/Latinos, 2012. CA Cancer J Clin 2012, 2012:62.
    • (2012) CA Cancer J Clin , vol.2012 , pp. 62
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 3
    • 0036484856 scopus 로고    scopus 로고
    • Chronic inflammation and cancer
    • 229; discussion 230-212
    • Shacter E, Weitzman SA. Chronic inflammation and cancer. Oncology (Williston Park) 2002, 16:217-226. 229; discussion 230-212.
    • (2002) Oncology (Williston Park) , vol.16 , pp. 217-226
    • Shacter, E.1    Weitzman, S.A.2
  • 4
    • 84862616765 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease and lung cancer: common pathogenesis, shared clinical challenges
    • 10.1513/pats.201107-039MS, 22550249
    • Celli BR. Chronic obstructive pulmonary disease and lung cancer: common pathogenesis, shared clinical challenges. Proc Am Thorac Soc 2012, 9:74-79. 10.1513/pats.201107-039MS, 22550249.
    • (2012) Proc Am Thorac Soc , vol.9 , pp. 74-79
    • Celli, B.R.1
  • 6
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • 10.1038/nature01322, 2803035, 12490959
    • Coussens LM, Werb Z. Inflammation and cancer. Nature 2002, 420:860-867. 10.1038/nature01322, 2803035, 12490959.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 7
    • 0035423344 scopus 로고    scopus 로고
    • End-stage chronic obstructive pulmonary disease: the cigarette is burned out but inflammation rages on
    • 10.1164/ajrccm.164.3.2105072c, 11500330
    • Shapiro SD. End-stage chronic obstructive pulmonary disease: the cigarette is burned out but inflammation rages on. Am J Respir Crit Care Med 2001, 164:339-340. 10.1164/ajrccm.164.3.2105072c, 11500330.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 339-340
    • Shapiro, S.D.1
  • 8
    • 84860484044 scopus 로고    scopus 로고
    • Tumor-associated neutrophils: friend or foe?
    • 10.1093/carcin/bgs123, 22425643
    • Fridlender ZG, Albelda SM. Tumor-associated neutrophils: friend or foe?. Carcinogenesis 2012, 33:949-955. 10.1093/carcin/bgs123, 22425643.
    • (2012) Carcinogenesis , vol.33 , pp. 949-955
    • Fridlender, Z.G.1    Albelda, S.M.2
  • 10
    • 25144493776 scopus 로고    scopus 로고
    • Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model
    • 10.1038/sj.bjc.6602702, 2361564, 16052222
    • Schmidt H, Bastholt L, Geertsen P, Christensen IJ, Larsen S, Gehl J, von der Maase H. Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model. Br J Cancer 2005, 93:273-278. 10.1038/sj.bjc.6602702, 2361564, 16052222.
    • (2005) Br J Cancer , vol.93 , pp. 273-278
    • Schmidt, H.1    Bastholt, L.2    Geertsen, P.3    Christensen, I.J.4    Larsen, S.5    Gehl, J.6    von der Maase, H.7
  • 12
    • 81455131498 scopus 로고    scopus 로고
    • Increased interleukin (IL)-8 and decreased IL-17 production in chronic obstructive pulmonary disease (COPD) provoked by cigarette smoke
    • 10.1016/j.cyto.2011.09.010, 21996014
    • Zhang X, Zheng H, Zhang H, Ma W, Wang F, Liu C, He S. Increased interleukin (IL)-8 and decreased IL-17 production in chronic obstructive pulmonary disease (COPD) provoked by cigarette smoke. Cytokine 2011, 56:717-725. 10.1016/j.cyto.2011.09.010, 21996014.
    • (2011) Cytokine , vol.56 , pp. 717-725
    • Zhang, X.1    Zheng, H.2    Zhang, H.3    Ma, W.4    Wang, F.5    Liu, C.6    He, S.7
  • 13
    • 84861879876 scopus 로고    scopus 로고
    • Mechanisms of neutrophil transmigration across the vascular endothelium in COPD
    • 10.1136/thoraxjnl-2011-200088, 21543441
    • Gane J, Stockley R. Mechanisms of neutrophil transmigration across the vascular endothelium in COPD. Thorax 2012, 67:553-561. 10.1136/thoraxjnl-2011-200088, 21543441.
    • (2012) Thorax , vol.67 , pp. 553-561
    • Gane, J.1    Stockley, R.2
  • 15
    • 63349088232 scopus 로고    scopus 로고
    • Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model
    • 10.1165/rcmb.2008-0198OC, 2660561, 18927348
    • Moghaddam SJ, Li H, Cho SN, Dishop MK, Wistuba II, Ji L, Kurie JM, Dickey BF, Demayo FJ. Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model. Am J Respir Cell Mol Biol 2009, 40:443-453. 10.1165/rcmb.2008-0198OC, 2660561, 18927348.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 443-453
    • Moghaddam, S.J.1    Li, H.2    Cho, S.N.3    Dishop, M.K.4    Wistuba, I.I.5    Ji, L.6    Kurie, J.M.7    Dickey, B.F.8    Demayo, F.J.9
  • 20
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-associated neutrophil phenotype by TGF-beta: " N1" versus " N2" TAN
    • 10.1016/j.ccr.2009.06.017, 2754404, 19732719
    • Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, Worthen GS, Albelda SM. Polarization of tumor-associated neutrophil phenotype by TGF-beta: " N1" versus " N2" TAN. Cancer Cell 2009, 16:183-194. 10.1016/j.ccr.2009.06.017, 2754404, 19732719.
    • (2009) Cancer Cell , vol.16 , pp. 183-194
    • Fridlender, Z.G.1    Sun, J.2    Kim, S.3    Kapoor, V.4    Cheng, G.5    Ling, L.6    Worthen, G.S.7    Albelda, S.M.8
  • 21
    • 69249242897 scopus 로고    scopus 로고
    • The yin-yang of tumor-associated neutrophils
    • 10.1016/j.ccr.2009.08.014, 19732714
    • Mantovani A. The yin-yang of tumor-associated neutrophils. Cancer Cell 2009, 16:173-174. 10.1016/j.ccr.2009.08.014, 19732714.
    • (2009) Cancer Cell , vol.16 , pp. 173-174
    • Mantovani, A.1
  • 23
    • 84871710094 scopus 로고    scopus 로고
    • Confocal laser endomicroscopy for the morphometric evaluation of microvessels in human colorectal cancer using targeted anti-CD31 antibodies
    • 10.1371/journal.pone.0052815, 3532115, 23285192
    • Cartana T, Saftoiu A, Gruionu LG, Gheonea DI, Pirici D, Georgescu CV, Ciocalteu A, Gruionu G. Confocal laser endomicroscopy for the morphometric evaluation of microvessels in human colorectal cancer using targeted anti-CD31 antibodies. PLoS One 2012, 7:e52815. 10.1371/journal.pone.0052815, 3532115, 23285192.
    • (2012) PLoS One , vol.7
    • Cartana, T.1    Saftoiu, A.2    Gruionu, L.G.3    Gheonea, D.I.4    Pirici, D.5    Georgescu, C.V.6    Ciocalteu, A.7    Gruionu, G.8
  • 24
    • 58149232586 scopus 로고    scopus 로고
    • The interleukin-8 pathway in cancer
    • 10.1158/1078-0432.CCR-07-4843, 18980965
    • Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res 2008, 14:6735-6741. 10.1158/1078-0432.CCR-07-4843, 18980965.
    • (2008) Clin Cancer Res , vol.14 , pp. 6735-6741
    • Waugh, D.J.1    Wilson, C.2
  • 25
    • 84864296516 scopus 로고    scopus 로고
    • Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of alpha1-antitrypsin in lung cancer
    • 10.1016/j.molonc.2012.03.005, 22507634
    • Xu Y, Zhang J, Han J, Pan X, Cao Y, Guo H, Pan Y, An Y, Li X. Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of alpha1-antitrypsin in lung cancer. Mol Oncol 2012, 6:405-417. 10.1016/j.molonc.2012.03.005, 22507634.
    • (2012) Mol Oncol , vol.6 , pp. 405-417
    • Xu, Y.1    Zhang, J.2    Han, J.3    Pan, X.4    Cao, Y.5    Guo, H.6    Pan, Y.7    An, Y.8    Li, X.9
  • 27
    • 84879291920 scopus 로고    scopus 로고
    • The Neutrophil in COPD: Too Little Too Late, or Too Much Too Soon?
    • Hoenderdos K, Condliffe A. The Neutrophil in COPD: Too Little Too Late, or Too Much Too Soon?. Am J Respir Cell Mol Biol 2013
    • (2013) Am J Respir Cell Mol Biol
    • Hoenderdos, K.1    Condliffe, A.2
  • 28
    • 84865589453 scopus 로고    scopus 로고
    • Hallmarks of cancer: of all cancer cells, all the time?
    • 10.1016/j.molmed.2012.06.005, 22795735
    • Floor SL, Dumont JE, Maenhaut C, Raspe E. Hallmarks of cancer: of all cancer cells, all the time?. Trends Mol Med 2012, 18:509-515. 10.1016/j.molmed.2012.06.005, 22795735.
    • (2012) Trends Mol Med , vol.18 , pp. 509-515
    • Floor, S.L.1    Dumont, J.E.2    Maenhaut, C.3    Raspe, E.4
  • 29
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • 10.1016/j.cell.2011.02.013, 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674. 10.1016/j.cell.2011.02.013, 21376230.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 30
    • 56749107194 scopus 로고    scopus 로고
    • The tumor microenvironment and its contribution to tumor evolution toward metastasis
    • 10.1007/s00418-008-0530-8, 18987874
    • Lorusso G, Ruegg C. The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem Cell Biol 2008, 130:1091-1103. 10.1007/s00418-008-0530-8, 18987874.
    • (2008) Histochem Cell Biol , vol.130 , pp. 1091-1103
    • Lorusso, G.1    Ruegg, C.2
  • 31
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • 10.1038/nature07205, 18650914
    • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008, 454:436-444. 10.1038/nature07205, 18650914.
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 32
    • 78650434229 scopus 로고    scopus 로고
    • The role of inflammation in the pathogenesis of non-small cell lung cancer
    • 10.1097/JTO.0b013e3181f387e4, 21155185
    • O'Callaghan DS, O'Donnell D, O'Connell F, O'Byrne KJ. The role of inflammation in the pathogenesis of non-small cell lung cancer. J Thorac Oncol 2010, 5:2024-2036. 10.1097/JTO.0b013e3181f387e4, 21155185.
    • (2010) J Thorac Oncol , vol.5 , pp. 2024-2036
    • O'Callaghan, D.S.1    O'Donnell, D.2    O'Connell, F.3    O'Byrne, K.J.4
  • 33
    • 0035219462 scopus 로고    scopus 로고
    • Lymphocytes, chronic bronchitis and chronic obstructive pulmonary disease
    • discussion 161-148
    • Jeffery PK. Lymphocytes, chronic bronchitis and chronic obstructive pulmonary disease. Novartis Found Symp 2001, 234:149-161. discussion 161-148.
    • (2001) Novartis Found Symp , vol.234 , pp. 149-161
    • Jeffery, P.K.1
  • 34
    • 79953328298 scopus 로고    scopus 로고
    • Tumor-associated neutrophils: new targets for cancer therapy
    • 10.1158/0008-5472.CAN-10-2583, 21427354
    • Gregory AD, Houghton AM. Tumor-associated neutrophils: new targets for cancer therapy. Cancer Res 2011, 71:2411-2416. 10.1158/0008-5472.CAN-10-2583, 21427354.
    • (2011) Cancer Res , vol.71 , pp. 2411-2416
    • Gregory, A.D.1    Houghton, A.M.2
  • 35
    • 79957968154 scopus 로고    scopus 로고
    • Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8
    • 10.1186/1471-2407-11-226, 3130703, 21649887
    • Carpagnano GE, Palladino GP, Lacedonia D, Koutelou A, Orlando S, Foschino-Barbaro MP. Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8. BMC Cancer 2011, 11:226. 10.1186/1471-2407-11-226, 3130703, 21649887.
    • (2011) BMC Cancer , vol.11 , pp. 226
    • Carpagnano, G.E.1    Palladino, G.P.2    Lacedonia, D.3    Koutelou, A.4    Orlando, S.5    Foschino-Barbaro, M.P.6
  • 36
    • 33947515407 scopus 로고    scopus 로고
    • Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice
    • 10.2353/ajpath.2007.060566, 1851863, 17255336
    • Redente EF, Orlicky DJ, Bouchard RJ, Malkinson AM. Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice. Am J Pathol 2007, 170:693-708. 10.2353/ajpath.2007.060566, 1851863, 17255336.
    • (2007) Am J Pathol , vol.170 , pp. 693-708
    • Redente, E.F.1    Orlicky, D.J.2    Bouchard, R.J.3    Malkinson, A.M.4
  • 38
    • 79953070128 scopus 로고    scopus 로고
    • Neutrophil survival and c-kit(+)-progenitor proliferation in Staphylococcus aureus-infected skin wounds promote resolution
    • 10.1182/blood-2010-07-296970, 3069674, 21278352
    • Kim MH, Granick JL, Kwok C, Walker NJ, Borjesson DL, Curry FR, Miller LS, Simon SI. Neutrophil survival and c-kit(+)-progenitor proliferation in Staphylococcus aureus-infected skin wounds promote resolution. Blood 2011, 117:3343-3352. 10.1182/blood-2010-07-296970, 3069674, 21278352.
    • (2011) Blood , vol.117 , pp. 3343-3352
    • Kim, M.H.1    Granick, J.L.2    Kwok, C.3    Walker, N.J.4    Borjesson, D.L.5    Curry, F.R.6    Miller, L.S.7    Simon, S.I.8
  • 39
    • 33646255924 scopus 로고    scopus 로고
    • High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras
    • 10.1158/0008-5472.CAN-05-3842, 16618742
    • Wislez M, Fujimoto N, Izzo JG, Hanna AE, Cody DD, Langley RR, Tang H, Burdick MD, Sato M, Minna JD, et al. High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res 2006, 66:4198-4207. 10.1158/0008-5472.CAN-05-3842, 16618742.
    • (2006) Cancer Res , vol.66 , pp. 4198-4207
    • Wislez, M.1    Fujimoto, N.2    Izzo, J.G.3    Hanna, A.E.4    Cody, D.D.5    Langley, R.R.6    Tang, H.7    Burdick, M.D.8    Sato, M.9    Minna, J.D.10
  • 40
    • 79959705253 scopus 로고    scopus 로고
    • Inhibition of neutrophil infiltration into A549 lung tumors in vitro and in vivo using a CXCR2-specific antagonist is associated with reduced tumor growth
    • 10.1002/ijc.25987, 21328342
    • Tazzyman S, Barry ST, Ashton S, Wood P, Blakey D, Lewis CE, Murdoch C. Inhibition of neutrophil infiltration into A549 lung tumors in vitro and in vivo using a CXCR2-specific antagonist is associated with reduced tumor growth. Int J Cancer 2011, 129:847-858. 10.1002/ijc.25987, 21328342.
    • (2011) Int J Cancer , vol.129 , pp. 847-858
    • Tazzyman, S.1    Barry, S.T.2    Ashton, S.3    Wood, P.4    Blakey, D.5    Lewis, C.E.6    Murdoch, C.7
  • 41
    • 84861440163 scopus 로고    scopus 로고
    • Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis
    • 10.1038/bjc.2012.177, 3364111, 22617157
    • Lee YS, Choi I, Ning Y, Kim NY, Khatchadourian V, Yang D, Chung HK, Choi D, LaBonte MJ, Ladner RD, et al. Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. Br J Cancer 2012, 106:1833-1841. 10.1038/bjc.2012.177, 3364111, 22617157.
    • (2012) Br J Cancer , vol.106 , pp. 1833-1841
    • Lee, Y.S.1    Choi, I.2    Ning, Y.3    Kim, N.Y.4    Khatchadourian, V.5    Yang, D.6    Chung, H.K.7    Choi, D.8    LaBonte, M.J.9    Ladner, R.D.10
  • 42
    • 84868000178 scopus 로고    scopus 로고
    • High expression of CXCR2 is associated with tumorigenesis, progression, and prognosis of laryngeal squamous cell carcinoma
    • 10.1007/s12032-011-0152-1, 22274915
    • Han L, Jiang B, Wu H, Wang X, Tang X, Huang J, Zhu J. High expression of CXCR2 is associated with tumorigenesis, progression, and prognosis of laryngeal squamous cell carcinoma. Med Oncol 2012, 29:2466-2472. 10.1007/s12032-011-0152-1, 22274915.
    • (2012) Med Oncol , vol.29 , pp. 2466-2472
    • Han, L.1    Jiang, B.2    Wu, H.3    Wang, X.4    Tang, X.5    Huang, J.6    Zhu, J.7
  • 43
    • 28244495191 scopus 로고    scopus 로고
    • Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia
    • 2723739, 16301661
    • Jones MR, Simms BT, Lupa MM, Kogan MS, Mizgerd JP. Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J Immunol 2005, 175:7530-7535. 2723739, 16301661.
    • (2005) J Immunol , vol.175 , pp. 7530-7535
    • Jones, M.R.1    Simms, B.T.2    Lupa, M.M.3    Kogan, M.S.4    Mizgerd, J.P.5
  • 44
    • 79951823584 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties
    • 10.1189/jlb.0310162, 21106641
    • Brandau S, Trellakis S, Bruderek K, Schmaltz D, Steller G, Elian M, Suttmann H, Schenck M, Welling J, Zabel P, Lang S. Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties. J Leukoc Biol 2011, 89:311-317. 10.1189/jlb.0310162, 21106641.
    • (2011) J Leukoc Biol , vol.89 , pp. 311-317
    • Brandau, S.1    Trellakis, S.2    Bruderek, K.3    Schmaltz, D.4    Steller, G.5    Elian, M.6    Suttmann, H.7    Schenck, M.8    Welling, J.9    Zabel, P.10    Lang, S.11
  • 45
    • 70949091447 scopus 로고    scopus 로고
    • The cytokine network in chronic obstructive pulmonary disease
    • 10.1165/rcmb.2009-0220TR, 19717810
    • Barnes PJ. The cytokine network in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2009, 41:631-638. 10.1165/rcmb.2009-0220TR, 19717810.
    • (2009) Am J Respir Cell Mol Biol , vol.41 , pp. 631-638
    • Barnes, P.J.1
  • 47
    • 77954642877 scopus 로고    scopus 로고
    • CXC chemokines in cancer angiogenesis and metastases
    • 3069502, 20399957
    • Keeley EC, Mehrad B, Strieter RM. CXC chemokines in cancer angiogenesis and metastases. Adv Cancer Res 2010, 106:91-111. 3069502, 20399957.
    • (2010) Adv Cancer Res , vol.106 , pp. 91-111
    • Keeley, E.C.1    Mehrad, B.2    Strieter, R.M.3
  • 48
    • 84872591539 scopus 로고    scopus 로고
    • CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma
    • 10.1158/0008-5472.CAN-12-0263, 23204236
    • Saintigny P, Massarelli E, Lin S, Ahn YH, Chen Y, Goswami S, Erez B, O'Reilly MS, Liu D, Lee JJ, et al. CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma. Cancer Res 2013, 73:571-582. 10.1158/0008-5472.CAN-12-0263, 23204236.
    • (2013) Cancer Res , vol.73 , pp. 571-582
    • Saintigny, P.1    Massarelli, E.2    Lin, S.3    Ahn, Y.H.4    Chen, Y.5    Goswami, S.6    Erez, B.7    O'Reilly, M.S.8    Liu, D.9    Lee, J.J.10
  • 49
    • 1342324748 scopus 로고    scopus 로고
    • Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer
    • Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM. Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J Immunol 2004, 172:2853-2860.
    • (2004) J Immunol , vol.172 , pp. 2853-2860
    • Keane, M.P.1    Belperio, J.A.2    Xue, Y.Y.3    Burdick, M.D.4    Strieter, R.M.5
  • 50
    • 0031836105 scopus 로고    scopus 로고
    • Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis
    • 10.1038/nm0598-615, 9585238
    • Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN, Shapiro SD. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med 1998, 4:615-618. 10.1038/nm0598-615, 9585238.
    • (1998) Nat Med , vol.4 , pp. 615-618
    • Belaaouaj, A.1    McCarthy, R.2    Baumann, M.3    Gao, Z.4    Ley, T.J.5    Abraham, S.N.6    Shapiro, S.D.7
  • 51
    • 0344413022 scopus 로고    scopus 로고
    • Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice
    • 10.1016/S0002-9440(10)63589-4, 1892384, 14633606
    • Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol 2003, 163:2329-2335. 10.1016/S0002-9440(10)63589-4, 1892384, 14633606.
    • (2003) Am J Pathol , vol.163 , pp. 2329-2335
    • Shapiro, S.D.1    Goldstein, N.M.2    Houghton, A.M.3    Kobayashi, D.K.4    Kelley, D.5    Belaaouaj, A.6
  • 53
    • 33749189340 scopus 로고    scopus 로고
    • Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway
    • 10.1165/rcmb.2006-0012OC, 16690986
    • Lee KY, Ho SC, Lin HC, Lin SM, Liu CY, Huang CD, Wang CH, Chung KF, Kuo HP. Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway. Am J Respir Cell Mol Biol 2006, 35:407-414. 10.1165/rcmb.2006-0012OC, 16690986.
    • (2006) Am J Respir Cell Mol Biol , vol.35 , pp. 407-414
    • Lee, K.Y.1    Ho, S.C.2    Lin, H.C.3    Lin, S.M.4    Liu, C.Y.5    Huang, C.D.6    Wang, C.H.7    Chung, K.F.8    Kuo, H.P.9
  • 54
    • 84871330172 scopus 로고    scopus 로고
    • Crucial involvement of tumor-associated neutrophils in the regulation of chronic colitis-associated carcinogenesis in mice
    • 10.1371/journal.pone.0051848, 3525572, 23272179
    • Shang K, Bai YP, Wang C, Wang Z, Gu HY, Du X, Zhou XY, Zheng CL, Chi YY, Mukaida N, Li YY. Crucial involvement of tumor-associated neutrophils in the regulation of chronic colitis-associated carcinogenesis in mice. PLoS One 2012, 7:e51848. 10.1371/journal.pone.0051848, 3525572, 23272179.
    • (2012) PLoS One , vol.7
    • Shang, K.1    Bai, Y.P.2    Wang, C.3    Wang, Z.4    Gu, H.Y.5    Du, X.6    Zhou, X.Y.7    Zheng, C.L.8    Chi, Y.Y.9    Mukaida, N.10    Li, Y.Y.11
  • 55
    • 84863571937 scopus 로고    scopus 로고
    • Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response
    • 10.1158/0008-5472.CAN-11-4135, 3397251, 22564522
    • Mittendorf EA, Alatrash G, Qiao N, Wu Y, Sukhumalchandra P, St John LS, Philips AV, Xiao H, Zhang M, Ruisaard K, et al. Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response. Cancer Res 2012, 72:3153-3162. 10.1158/0008-5472.CAN-11-4135, 3397251, 22564522.
    • (2012) Cancer Res , vol.72 , pp. 3153-3162
    • Mittendorf, E.A.1    Alatrash, G.2    Qiao, N.3    Wu, Y.4    Sukhumalchandra, P.5    St John, L.S.6    Philips, A.V.7    Xiao, H.8    Zhang, M.9    Ruisaard, K.10
  • 56
    • 64249117999 scopus 로고    scopus 로고
    • Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity
    • 10.1152/ajplung.90505.2008, 2660218, 19136576
    • Kurtagic E, Jedrychowski MP, Nugent MA. Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity. Am J Physiol Lung Cell Mol Physiol 2009, 296:L534-L546. 10.1152/ajplung.90505.2008, 2660218, 19136576.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296
    • Kurtagic, E.1    Jedrychowski, M.P.2    Nugent, M.A.3
  • 57
    • 35548933234 scopus 로고    scopus 로고
    • Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines
    • Wada Y, Yoshida K, Tsutani Y, Shigematsu H, Oeda M, Sanada Y, Suzuki T, Mizuiri H, Hamai Y, Tanabe K, et al. Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines. Oncol Rep 2007, 17:161-167.
    • (2007) Oncol Rep , vol.17 , pp. 161-167
    • Wada, Y.1    Yoshida, K.2    Tsutani, Y.3    Shigematsu, H.4    Oeda, M.5    Sanada, Y.6    Suzuki, T.7    Mizuiri, H.8    Hamai, Y.9    Tanabe, K.10
  • 58
    • 34447506658 scopus 로고    scopus 로고
    • Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
    • 10.1101/gad.1549407, 1920165, 17639077
    • Ancrile B, Lim KH, Counter CM. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev 2007, 21:1714-1719. 10.1101/gad.1549407, 1920165, 17639077.
    • (2007) Genes Dev , vol.21 , pp. 1714-1719
    • Ancrile, B.1    Lim, K.H.2    Counter, C.M.3
  • 60
    • 45849151057 scopus 로고    scopus 로고
    • Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury
    • 10.1165/rcmb.2007-0315OC, 2438448, 18276796
    • Kaynar AM, Houghton AM, Lum EH, Pitt BR, Shapiro SD. Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Am J Respir Cell Mol Biol 2008, 39:53-60. 10.1165/rcmb.2007-0315OC, 2438448, 18276796.
    • (2008) Am J Respir Cell Mol Biol , vol.39 , pp. 53-60
    • Kaynar, A.M.1    Houghton, A.M.2    Lum, E.H.3    Pitt, B.R.4    Shapiro, S.D.5
  • 61
    • 11144355464 scopus 로고    scopus 로고
    • Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium
    • 10.1158/0008-5472.CAN-03-3376, 15059877
    • Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, et al. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res 2004, 64:2307-2316. 10.1158/0008-5472.CAN-03-3376, 15059877.
    • (2004) Cancer Res , vol.64 , pp. 2307-2316
    • Nikitin, A.Y.1    Alcaraz, A.2    Anver, M.R.3    Bronson, R.T.4    Cardiff, R.D.5    Dixon, D.6    Fraire, A.E.7    Gabrielson, E.W.8    Gunning, W.T.9    Haines, D.C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.