Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 296, Issue 3, 2009, Pages

  Kurtagic, Elma ^a   Jedrychowski, Mark P ^a   Nugent, Matthew A ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Boston University   (United States)

Author keywords

Extracellular matrix; Heparin binding; Lung injury; Proteases; Vascular endothelial growth factor receptors

Indexed keywords

DISULFIDE; LEUKOCYTE ELASTASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN 165; VASCULOTROPIN RECEPTOR 2; HEPARIN; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VEGFA PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; LUNG EMPHYSEMA; MASS SPECTROMETRY; MOLECULAR WEIGHT; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CATTLE; ENZYME SPECIFICITY; GENETICS; HUMAN; LUNG INJURY; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEPARIN; HUMANS; LEUKOCYTE ELASTASE; LUNG INJURY; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 64249117999     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90505.2008     Document Type: Article

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