Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer

Molecular Oncology

Volumn 6, Issue 4, 2012, Pages 405-417

  Xu, Yan ^a   Zhang, Jingjie ^a   Han, Jing ^a   Pan, Xueyang ^a   Cao, Yajun ^a,b   Guo, Hao ^a   Pan, Yan ^a   An, Yu ^a   Li, Xuejun ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b SHIHEZI UNIVERSITY   (China)

Author keywords

Curcumin; Neutrophil elastase; Tumor proliferation; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; CURCUMIN; LEUKOCYTE ELASTASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TUMOR MICROENVIRONMENT; UPREGULATION;

MUS;

EID: 84864296516     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2012.03.005     Document Type: Article

References (45)

1. Cadranel J., Bellocq A., Antoine M., Flahault A., Philippe C., Crestani B., Bernaudin J.F., Mayaud C., Milleron B., Baud L. Neutrophil alveolitis in bronchioloalveolar carcinoma - induction by tumor-derived interleukin-8 and relation to clinical outcome. Am. J. Pathol. 1998, 152:83-92.
2. Cheng A.L., Hsu C.H., Lin J.K., Hsu M.M., Ho Y.F., Shen T.S., Ko J.Y., Lin J.T., Lin B.R., Ming-Shiang W., Yu H.S., Jee S.H., Chen G.S., Chen T.M., Chen C.A., Lai M.K., Pu Y.S., Pan M.H., Wang Y.J., Tsai C.C., Hsieh C.Y. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001, 21:2895-2900.
3. Choi B.H., Kim C.G., Lim Y., Shin S.Y., Lee Y.H. Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett. 2008, 259:111-118.
4. El-Akawi Z.J., Abu-Awad A.M., Sharara A.M., Khader Y. The importance of alpha-1 antitrypsin (alpha1-AT) and neopterin serum levels in the evaluation of non-small cell lung and prostate cancer patients. Neuroendocrinol. Lett. 2010, 31:113-116.
5. El-Rayes B.F., Ali S., Ali I.F., Philip P.A., Abbruzzese J., Sarkar F.H. Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB. Cancer Res. 2006, 66:10553-10559.
6. Fingleton B. Inflammatory proteinase slips into tumor cells. Nat. Med. 2010, 16:161-163.
7. Granot Z., Henke E., Comen E.A., King T.A., Norton L., Benezra R. Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 2011, 20:300-314.
8. Goel A., Kunnumakkara A.B., Aggarwal B.B. Curcumin as "Curecumin": from kitchen to clinic. Biochem. Pharmacol. 2008, 75:787-809.
9. Gregory A.D., Houghton A.M. Tumor-associated neutrophils: new targets for cancer therapy. Cancer Res. 2011, 71:2411-2416.
10. Higashiyama M., Doi O., Kodama K., Yokouchi H., Tateishi R. An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis. Br. J. Cancer 1992, 65:300-302.
11. Hopkins P.C., Chang W.S., Wardell M.R., Stone S.R. Inhibitory mechanism of serpins. Mobility of the C-terminal region of the reactive-site loop. J. Biol. Chem. 1997, 272:3905-3909.
12. Houghton A.M., Rzymkiewicz D.M., Ji H., Gregory A.D., Egea E.E., Metz H.E., Stolz D.B., Land S.R., Marconcini L.A., Kliment C.R., Jenkins K.M., Beaulieu K.A., Mouded M., Frank S.J., Wong K.K., Shapiro S.D. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat. Med. 2010, 16:219-224.
13. Huang H., Campbell S.C., Nelius T., Bedford D.F., Veliceasa D., Bouck N.P., Volpert O.V. Alpha1-antitrypsin inhibits angiogenesis and tumor growth. Int. J. Cancer 2004, 112:1042-1048.
14. Ichiki K., Mitani N., Doki Y., Hara H., Misaki T., Saiki I. Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer. Clin. Exp. Metastasis 2000, 18:539-545.
15. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J. Clin. 2011, 61:69-90.
16. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Thun M.J. Cancer statistics, 2009. CA Cancer J. Clin. 2009, 59:225-249.
17. Johnson S.M., Gulhati P., Arrieta I., Wang X., Uchida T., Gao T., Evers B.M. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res. 2009, 29:3185-3190.
18. Jones S.H. Pulmonary emphysema and alpha1-antitrypsin deficiency. Phys. Ther. 1974, 54:579-583.
19. Jurenka J.S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern. Med. Rev. 2009, 14:141-153.
20. Kamat A.M., Tharakan S.T., Sung B., Aggarwal B.B. Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. Cancer Res. 2009, 69:8958-8966.
21. Koshiol J., Rotunno M., Consonni D., Pesatori A.C., De Matteis S., Goldstein A.M., Chaturvedi A.K., Wacholder S., Landi M.T., Lubin J.H., Caporaso N.E. Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study. PLoS One 2009, 4:e7380.
22. Kunnumakkara A.B., Anand P., Aggarwal B.B. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008, 269:199-225.
23. Kunnumakkara A.B., Guha S., Krishnan S., Diagaradjane P., Gelovani J., Aggarwal B.B. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res. 2007, 67:3853-3861.
24. Lee J.M., Yanagawa J., Peebles K.A., Sharma S., Mao J.T., Dubinett S.M. Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment. Crit. Rev. Oncol. Hematol. 2008, 66:208-217.
25. Lee J.Y., Lee Y.M., Chang G.C., Yu S.L., Hsieh W.Y., Chen J.J., Chen H.W., Yang P.C. Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy. PLoS ONE 2011, 6:e23756.
26. Lin S.S., Lai K.C., Hsu S.C., Yang J.S., Kuo C.L., Lin J.P., Ma Y.S., Wu C.C., Chung J.G. Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF). Cancer Lett. 2009, 285:127-133.
27. Liou T.G., Campbell E.J. Quantum proteolysis resulting from release of single granules by human neutrophils: a novel, nonoxidative mechanism of extracellular proteolytic activity. J. Immunol. 1996, 157:2624-2631.
28. Liu Z., Zhou X., Shapiro S.D., Shipley J.M., Twining S.S., Diaz L.A., Senior R.M., Werb Z. The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell 2000, 102:647-655.
29. Lungarella G., Cavarra E., Lucattelli M., Martorana P.A. The dual role of neutrophil elastase in lung destruction and repair. Int. J. Biochem. Cell Biol. 2008, 40:1287-1296.
30. Ma B., Pan Y., Song Q., Tie L., Zhang Y., Xiao Y., Zhang J., Han J., Xu Y., Xiang Y., Yu H.M., Li X.J. The effect of topiramate on tumor-related angiogenesis and on the serum proteome of mice bearing Lewis lung carcinoma. Eur. J. Pharmacol. 2011, 663:9-16.
31. Mantovani A., Allavena P., Sica A., Balkwill F. Cancer-related inflammation. Nature 2008, 454:436-444.
32. Moghaddam S.J., Barta P., Mirabolfathinejad S.G., Ammar-Aouchiche Z., Garza N.T., Vo T.T., Newman R.A., Aggarwal B.B., Evans C.M., Tuvim M.J., Lotan R., Dickey B.F. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 2009, 30:1949-1956.
33. Morgan K., Chappell S., Guetta-Baranes T., Morley S., Kalsheker N. The alpha-1-antitrypsin gene promoter in human A549 lung derived cells, and a novel transcription initiation site. Int. J. Biochem. Cell Biol. 2009, 41:1157-1164.
34. Normandin K., Peant B., Le Page C., de Ladurantaye M., Ouellet V., Tonin P.N., Provencher D.M., Mes-Masson A.M. Protease inhibitor SERPINA1 expression in epithelial ovarian cancer. Clin. Exp. Metastasis 2010, 27:55-69.
35. Patz E.F., Campa M.J., Gottlin E.B., Kusmartseva I., Guan X.R., Herndon J.E. Panel of serum biomarkers for the diagnosis of lung cancer. J. Clin. Oncol. 2007, 25:5578-5583.
36. Prakobwong S., Gupta S.C., Kim J.H., Sung B., Pinlaor P., Hiraku Y., Wongkham S., Sripa B., Pinlaor S., Aggarwal B.B. Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. Carcinogenesis 2011, 32:1372-1380.
37. Rausch O. High content cellular screening. Curr. Opin. Chem. Biol. 2006, 10:316-320.
38. Sun Z., Yang P. Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression. Lancet Oncol. 2004, 5:182-190.
39. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 2001, 480-481:243-268.
40. Weir N.M., Selvendiran K., Kutala V.K., Tong L., Vishwanath S., Rajaram M., Tridandapani S., Anant S., Kuppusamy P. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol. Ther. 2007, 6:178-184.
41. Wu S.H., Hang L.W., Yang J.S., Chen H.Y., Lin H.Y., Chiang J.H., Lu C.C., Yang J.L., Lai T.Y., Ko Y.C., Chung J.G. Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways. Anticancer Res. 2010, 30:2125-2133.
42. Yu S., Shen G., Khor T.O., Kim J.H., Kong A.N. Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol. Cancer Ther. 2008, 7:2609-2620.
43. Zelvyte I., Sjogren H.O., Janciauskiene S. Effects of native and cleaved forms of alpha1-antitrypsin on ME 1477 tumor cell functional activity. Cancer Detect. Prev. 2002, 26:256-265.
44. Zelvyte I., Stevens T., Westin U., Janciauskiene S. alpha1-antitrypsin and its C-terminal fragment attenuate effects of degranulated neutrophil-conditioned medium on lung cancer HCC cells, in vitro. Cancer Cell Int. 2004, 4:7.
45. Zheng M., Ekmekcioglu S., Walch E.T., Tang C.H., Grimm E.A. Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells. Melanoma Res. 2004, 14:165-171.