메뉴 건너뛰기




Volumn 33, Issue 50, 2013, Pages 19423-19433

Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PREALBUMIN; THYROXINE BINDING PROTEIN;

EID: 84889780860     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2561-13.2013     Document Type: Article
Times cited : (119)

References (53)
  • 3
    • 33847057319 scopus 로고    scopus 로고
    • Thermodynamic studies on the interaction of antibodies with betaamyloid peptide
    • CrossRef Medline
    • Brockhaus M, Ganz P, Huber W, Bohrmann B, Loetscher HR, Seelig J (2007) Thermodynamic studies on the interaction of antibodies with betaamyloid peptide. J Phys Chem B 111:1238-1243. CrossRef Medline
    • (2007) J Phys Chem B , vol.111 , pp. 1238-1243
    • Brockhaus, M.1    Ganz, P.2    Huber, W.3    Bohrmann, B.4    Loetscher, H.R.5    Seelig, J.6
  • 6
    • 33645776682 scopus 로고    scopus 로고
    • Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects
    • CrossRef Medline
    • Castaño EM, Roher AE, Esh CL, Kokjohn TA, Beach T (2006) Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects. Neurol Res 28:155-163. CrossRef Medline
    • (2006) Neurol Res , vol.28 , pp. 155-163
    • Castaño, E.M.1    Roher, A.E.2    Esh, C.L.3    Kokjohn, T.A.4    Beach, T.5
  • 8
    • 34347364708 scopus 로고    scopus 로고
    • Accelerated A beta deposition in APPswe/PS1 Delta E9 mice with hemizygous deletions of TTR (transthyretin)
    • CrossRef Medline
    • Choi SH, Leight SN, Lee VMY, Li T, Wong PC, Johnson JA, Saraiva MJ, Sisodia SS (2007) Accelerated A beta deposition in APPswe/PS1 Delta E9 mice with hemizygous deletions of TTR (transthyretin). J Neurosci 27:7006-7010. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 7006-7010
    • Choi, S.H.1    Leight, S.N.2    Lee, V.M.Y.3    Li, T.4    Wong, P.C.5    Johnson, J.A.6    Saraiva, M.J.7    Sisodia, S.S.8
  • 10
    • 33748792821 scopus 로고    scopus 로고
    • Opposing activities protect against age-onset proteotoxicity
    • CrossRef Medline
    • Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A (2006) Opposing activities protect against age-onset proteotoxicity. Science 313:1604-1610. CrossRef Medline
    • (2006) Science , vol.313 , pp. 1604-1610
    • Cohen, E.1    Bieschke, J.2    Perciavalle, R.M.3    Kelly, J.W.4    Dillin, A.5
  • 12
    • 51449096179 scopus 로고    scopus 로고
    • Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: A mechanism sensitive to the Kunitz protease inhibitor
    • CrossRef Medline
    • Costa R, Ferreira-da-Silva F, Saraiva MJ, Cardoso I (2008a) Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor. Plos One 3:e2899. CrossRef Medline
    • (2008) Plos One , vol.3
    • Costa, R.1    Ferreira-da-Silva, F.2    Saraiva, M.J.3    Cardoso, I.4
  • 13
    • 40149086952 scopus 로고    scopus 로고
    • Transthyretin binding to A-Beta peptide: Impact on A-Beta fibrillogenesis and toxicity
    • CrossRef Medline
    • Costa R, Gonçalves A, Saraiva MJ, Cardoso I (2008b) Transthyretin binding to A-Beta peptide: impact on A-Beta fibrillogenesis and toxicity. FEBS Lett 582:936-942. CrossRef Medline
    • (2008) FEBS Lett , vol.582 , pp. 936-942
    • Costa, R.1    Gonçalves, A.2    Saraiva, M.J.3    Cardoso, I.4
  • 14
    • 77950941375 scopus 로고    scopus 로고
    • Amyloid-beta fibrillogenesis: Structural insight and therapeutic intervention
    • CrossRef Medline
    • Dasilva KA, Shaw JE, McLaurin J (2010) Amyloid-beta fibrillogenesis: structural insight and therapeutic intervention. Exp Neurol 223:311-321. CrossRef Medline
    • (2010) Exp Neurol , vol.223 , pp. 311-321
    • Dasilva, K.A.1    Shaw, J.E.2    McLaurin, J.3
  • 15
    • 34249672242 scopus 로고    scopus 로고
    • A beta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
    • CrossRef Medline
    • De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL (2007) A beta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem 282:11590-11601. CrossRef Medline
    • (2007) J Biol Chem , vol.282 , pp. 11590-11601
    • De Felice, F.G.1    Velasco, P.T.2    Lambert, M.P.3    Viola, K.4    Fernandez, S.J.5    Ferreira, S.T.6    Klein, W.L.7
  • 16
    • 79952371319 scopus 로고    scopus 로고
    • A kinetic aggregation assay allowing selective and sensitive amyloid-beta quantification in cells and tissues
    • CrossRef Medline
    • Du D, Murray AN, Cohen E, Kim HE, Simkovsky R, Dillin A, Kelly JW (2011) A kinetic aggregation assay allowing selective and sensitive amyloid-beta quantification in cells and tissues. Biochemistry 50:1607-1617. CrossRef Medline
    • (2011) Biochemistry , vol.50 , pp. 1607-1617
    • Du, D.1    Murray, A.N.2    Cohen, E.3    Kim, H.E.4    Simkovsky, R.5    Dillin, A.6    Kelly, J.W.7
  • 17
    • 77957042274 scopus 로고    scopus 로고
    • Characterization of the interaction of betaamyloid with transthyretin monomers and tetramers
    • CrossRef Medline
    • Du J, Murphy RM (2010) Characterization of the interaction of betaamyloid with transthyretin monomers and tetramers. Biochemistry 49: 8276-8289. CrossRef Medline
    • (2010) Biochemistry , vol.49 , pp. 8276-8289
    • Du, J.1    Murphy, R.M.2
  • 18
    • 84862994625 scopus 로고    scopus 로고
    • Identification of beta-amyloidbinding sites on transthyretin
    • CrossRef Medline
    • DuJ, Cho PY, Yang DT, MurphyRM (2012) Identification of beta-amyloidbinding sites on transthyretin. Protein Eng Des Sel 25:337-345. CrossRef Medline
    • (2012) Protein Eng Des Sel , vol.25 , pp. 337-345
    • Du, J.1    Cho, P.Y.2    Yang, D.T.3    Murphy, R.M.4
  • 20
    • 0034799733 scopus 로고    scopus 로고
    • Transthyretin: A review from a structural perspective
    • CrossRef Medline
    • Hamilton JA, Benson MD (2001) Transthyretin: a review from a structural perspective. Cell Mol Life Sci 58:1491-1521. CrossRef Medline
    • (2001) Cell Mol Life Sci , vol.58 , pp. 1491-1521
    • Hamilton, J.A.1    Benson, M.D.2
  • 21
    • 0035949632 scopus 로고    scopus 로고
    • Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy
    • CrossRef Medline
    • Hammarström P, Jiang X, Deechongkit S, Kelly JW (2001) Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy. Biochemistry 40:11453-11459. CrossRef Medline
    • (2001) Biochemistry , vol.40 , pp. 11453-11459
    • Hammarström, P.1    Jiang, X.2    Deechongkit, S.3    Kelly, J.W.4
  • 22
    • 0037058942 scopus 로고    scopus 로고
    • Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity
    • CrossRef
    • Hammarström P, Jiang X, Hurshman AR, Powers ET, Kelly JW (2002) Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity. Proc Natl Acad Sci U S A 99 [Suppl 4]:16427-16432. CrossRef
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.SUPPL. 4 , pp. 16427-16432
    • Hammarström, P.1    Jiang, X.2    Hurshman, A.R.3    Powers, E.T.4    Kelly, J.W.5
  • 24
    • 46049085810 scopus 로고    scopus 로고
    • Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: The relationship between stability and amyloidosis
    • CrossRef Medline
    • Hurshman Babbes AR, Powers ET, Kelly JW (2008) Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis. Biochemistry 47:6969-6984. CrossRef Medline
    • (2008) Biochemistry , vol.47 , pp. 6969-6984
    • Hurshman Babbes, A.R.1    Powers, E.T.2    Kelly, J.W.3
  • 26
    • 84861421529 scopus 로고    scopus 로고
    • The transthyretin amyloidoses: From delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug
    • Medline
    • Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW (2012) The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug. J Mol Biol 421:185-203. Medline
    • (2012) J Mol Biol , vol.421 , pp. 185-203
    • Johnson, S.M.1    Connelly, S.2    Fearns, C.3    Powers, E.T.4    Kelly, J.W.5
  • 27
    • 0242668337 scopus 로고    scopus 로고
    • Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    • CrossRef Medline
    • Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300:486-489. CrossRef Medline
    • (2003) Science , vol.300 , pp. 486-489
    • Kayed, R.1    Head, E.2    Thompson, J.L.3    McIntire, T.M.4    Milton, S.C.5    Cotman, C.W.6    Glabe, C.G.7
  • 28
    • 79952796718 scopus 로고    scopus 로고
    • Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways
    • CrossRef Medline
    • Ladiwala AR, Dordick JS, Tessier PM (2011) Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways. J Biol Chem 286:3209-3218. CrossRef Medline
    • (2011) J Biol Chem , vol.286 , pp. 3209-3218
    • Ladiwala, A.R.1    Dordick, J.S.2    Tessier, P.M.3
  • 31
    • 81555232259 scopus 로고    scopus 로고
    • Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?
    • CrossRef Medline
    • Li X, Buxbaum JN (2011) Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease? Mol Neurodegener 6:79. CrossRef Medline
    • (2011) Mol Neurodegener , vol.6 , pp. 79
    • Li, X.1    Buxbaum, J.N.2
  • 32
    • 80052350163 scopus 로고    scopus 로고
    • Neuronal production of transthyretin in human and murine Alzheimer's disease: Is it protective?
    • CrossRef Medline
    • Li X, Masliah E, Reixach N, Buxbaum JN (2011) Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective? J Neurosci 31:12483-12490. CrossRef Medline
    • (2011) J Neurosci , vol.31 , pp. 12483-12490
    • Li, X.1    Masliah, E.2    Reixach, N.3    Buxbaum, J.N.4
  • 33
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
    • CrossRef Medline
    • Link CD (1995) Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad SciU S A 92:9368-9372. CrossRef Medline
    • (1995) Proc Natl Acad SciU S A , vol.92 , pp. 9368-9372
    • Link, C.D.1
  • 34
    • 33845953463 scopus 로고    scopus 로고
    • Kinetics of inhibition of beta-amyloid aggregation by transthyretin
    • CrossRef Medline
    • Liu L, Murphy RM (2006) Kinetics of inhibition of beta-amyloid aggregation by transthyretin. Biochemistry 45:15702-15709. CrossRef Medline
    • (2006) Biochemistry , vol.45 , pp. 15702-15709
    • Liu, L.1    Murphy, R.M.2
  • 35
    • 0028806980 scopus 로고
    • Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's β-amyloid peptide in cultured vascular smooth muscle cells
    • CrossRef Medline
    • Mazur-Kolecka B, Frackowiak J, Wiśniewski HM (1995) Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's β-amyloid peptide in cultured vascular smooth muscle cells. Brain Res 698:217-222. CrossRef Medline
    • (1995) Brain Res , vol.698 , pp. 217-222
    • Mazur-Kolecka, B.1    Frackowiak, J.2    Wiśniewski, H.M.3
  • 36
    • 0029062667 scopus 로고
    • Structure of a complex of two plasma proteins: Transthyretin and retinol-binding protein
    • CrossRef Medline
    • Monaco HL, Rizzi M, Coda A (1995) Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. Science 268:1039-1041. CrossRef Medline
    • (1995) Science , vol.268 , pp. 1039-1041
    • Monaco, H.L.1    Rizzi, M.2    Coda, A.3
  • 38
    • 38349085003 scopus 로고    scopus 로고
    • Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic: A lesson in the generation of transgenic models of diseases involving oligomeric proteins
    • CrossRef Medline
    • Reixach N, Foss TR, Santelli E, Pascual J, Kelly JW, Buxbaum JN (2008) Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic: a lesson in the generation of transgenic models of diseases involving oligomeric proteins. J Biol Chem 283:2098-2107. CrossRef Medline
    • (2008) J Biol Chem , vol.283 , pp. 2098-2107
    • Reixach, N.1    Foss, T.R.2    Santelli, E.3    Pascual, J.4    Kelly, J.W.5    Buxbaum, J.N.6
  • 39
    • 0024260006 scopus 로고
    • Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer's disease
    • CrossRef Medline
    • Riisøen H (1988) Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer's disease. Acta Neurol Scand 78:455-459. CrossRef Medline
    • (1988) Acta Neurol Scand , vol.78 , pp. 455-459
    • Riisøen, H.1
  • 40
    • 79953688220 scopus 로고    scopus 로고
    • Transformation of amyloid beta(1-40) oligomers into fibrils is characterized by a major change in secondary structure
    • CrossRef Medline
    • Sarroukh R, Cerf E, Derclaye S, Dufrêne YF, Goormaghtigh E, Ruysschaert JM, Raussens V (2011) Transformation of amyloid beta(1-40) oligomers into fibrils is characterized by a major change in secondary structure. Cell Mol Life Sci 68:1429-1438. CrossRef Medline
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1429-1438
    • Sarroukh, R.1    Cerf, E.2    Derclaye, S.3    Dufrêne, Y.F.4    Goormaghtigh, E.5    Ruysschaert, J.M.6    Raussens, V.7
  • 41
    • 77649165856 scopus 로고    scopus 로고
    • Transthyretin as a potential CSF biomarker for Alzheimer's disease and dementia with Lewy bodies: Effects of treatment with cholinesterase inhibitors
    • CrossRef Medline
    • Schultz K, Nilsson K, Nielsen JE, Lindquist SG, Hjermind LE, Andersen BB, Wallin A, Nilsson C, Petersén A (2010) Transthyretin as a potential CSF biomarker for Alzheimer's disease and dementia with Lewy bodies: effects of treatment with cholinesterase inhibitors. Eur J Neurol 17:456-460. CrossRef Medline
    • (2010) Eur J Neurol , vol.17 , pp. 456-460
    • Schultz, K.1    Nilsson, K.2    Nielsen, J.E.3    Lindquist, S.G.4    Hjermind, L.E.5    Andersen, B.B.6    Wallin, A.7    Nilsson, C.8    Petersén, A.9
  • 43
    • 2542450276 scopus 로고    scopus 로고
    • Amyloidogenic and anti-amyloidogenic properties of recombinant transthyretin variants
    • CrossRef Medline
    • Schwarzman AL, Tsiper M, Wente H, Wang A, Vitek MP, Vasiliev V, Goldgaber D (2004) Amyloidogenic and anti-amyloidogenic properties of recombinant transthyretin variants. Amyloid 11:1-9. CrossRef Medline
    • (2004) Amyloid , vol.11 , pp. 1-9
    • Schwarzman, A.L.1    Tsiper, M.2    Wente, H.3    Wang, A.4    Vitek, M.P.5    Vasiliev, V.6    Goldgaber, D.7
  • 44
    • 0035669730 scopus 로고    scopus 로고
    • Serum transthyretin monomer in patients with familial amyloid polyneuropathy
    • CrossRef Medline
    • Sekijima Y, Tokuda T, Kametani F, Tanaka K, Maruyama K, Ikeda S (2001) Serum transthyretin monomer in patients with familial amyloid polyneuropathy. Amyloid 8:257-262. CrossRef Medline
    • (2001) Amyloid , vol.8 , pp. 257-262
    • Sekijima, Y.1    Tokuda, T.2    Kametani, F.3    Tanaka, K.4    Maruyama, K.5    Ikeda, S.6
  • 46
    • 0030864769 scopus 로고    scopus 로고
    • Cerebrospinal fluid transthyretin: Aging and late onset Alzheimer's disease
    • CrossRef Medline
    • Serot JM, Christmann D, Dubost T, Couturier M (1997) Cerebrospinal fluid transthyretin: aging and late onset Alzheimer's disease. J Neurol Neurosurg Psychiatry 63:506-508. CrossRef Medline
    • (1997) J Neurol Neurosurg Psychiatry , vol.63 , pp. 506-508
    • Serot, J.M.1    Christmann, D.2    Dubost, T.3    Couturier, M.4
  • 47
    • 0036759157 scopus 로고    scopus 로고
    • Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways
    • Medline
    • Stein TD, Johnson JA (2002) Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. J Neurosci 22:7380-7388. Medline
    • (2002) J Neurosci , vol.22 , pp. 7380-7388
    • Stein, T.D.1    Johnson, J.A.2
  • 48
    • 4444255624 scopus 로고    scopus 로고
    • Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APP(Sw) mice resulting in tau phosphorylation and loss of hippocampal neurons: Support for the amyloid hypothesis
    • CrossRef Medline
    • Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA (2004) Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APP(Sw) mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci 24:7707-7717. CrossRef Medline
    • (2004) J Neurosci , vol.24 , pp. 7707-7717
    • Stein, T.D.1    Anders, N.J.2    DeCarli, C.3    Chan, S.L.4    Mattson, M.P.5    Johnson, J.A.6
  • 49
    • 32344451179 scopus 로고    scopus 로고
    • The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: A step by step conformational analysis suggests the location of beta conformation seeding
    • CrossRef Medline
    • Tomaselli S, Esposito V, Vangone P, van Nuland NA, Bonvin AM, Guerrini R, Tancredi T, Temussi PA, PiconeD (2006) The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation seeding. Chembiochem 7:257-267. CrossRef Medline
    • (2006) Chembiochem , vol.7 , pp. 257-267
    • Tomaselli, S.1    Esposito, V.2    Vangone, P.3    van Nuland, N.A.4    Bonvin, A.M.5    Guerrini, R.6    Tancredi, T.7    Temussi, P.A.8    Picone, D.9
  • 50
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • CrossRef Medline
    • Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539. CrossRef Medline
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 51
    • 77956307401 scopus 로고    scopus 로고
    • Thermodynamic analysis of the molecular interactions between amyloid beta-peptide 42 and (-)-epigallocatechin-3-gallate
    • CrossRef Medline
    • Wang SH, Liu FF, Dong XY, Sun Y (2010) Thermodynamic analysis of the molecular interactions between amyloid beta-peptide 42 and (-)-epigallocatechin-3-gallate. J Phys Chem B 114:11576-11583. CrossRef Medline
    • (2010) J Phys Chem B , vol.114 , pp. 11576-11583
    • Wang, S.H.1    Liu, F.F.2    Dong, X.Y.3    Sun, Y.4
  • 52
    • 67650732998 scopus 로고    scopus 로고
    • Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
    • CrossRef Medline
    • Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X (2009) Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29:9090-9103. CrossRef Medline
    • (2009) J Neurosci , vol.29 , pp. 9090-9103
    • Wang, X.1    Su, B.2    Lee, H.G.3    Li, X.4    Perry, G.5    Smith, M.A.6    Zhu, X.7
  • 53
    • 84877049480 scopus 로고    scopus 로고
    • Transthyretin as both a sensor and a scavenger of beta-amyloid oligomers
    • CrossRef Medline
    • Yang DT, Joshi G, Cho PY, Johnson JA, Murphy RM (2013) Transthyretin as both a sensor and a scavenger of beta-amyloid oligomers. Biochemistry 52:2849-2861. CrossRef Medline
    • (2013) Biochemistry , vol.52 , pp. 2849-2861
    • Yang, D.T.1    Joshi, G.2    Cho, P.Y.3    Johnson, J.A.4    Murphy, R.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.