Unique Properties of Fluorine and their Relevance to Medicinal Chemistry and Chemical Biology

Fluorine in Medicinal Chemistry and Chemical Biology

Volumn , Issue , 2009, Pages 1-46

  Yamazaki, Takashi ^a   Taguchi, Takeo ^b   Ojima, Iwao ^c  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Fluorine in medicinal chemistry and chemical biology; High electrophilicity of fluoroalkyl carbonyl moieties; Huge successes of fluorine containing drugs stimulating research on fluorine in medicinal chemistry for drug discovery; In vivo 19 F magnetic resonance spectroscopy; Inductive effect of fluorine and fluorine containing groups; Mimic effect and block effect; Orthogonal multipolar C F bond protein interactions; Two fluorine containing drugs; Unique properties of fluorine and their relevance

Indexed keywords

EID: 84889483761     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444312096.ch1     Document Type: Chapter

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