Rotational-echo double-resonance NMR distance measurements for the tubulin-bound paclitaxel conformation

Journal of the American Chemical Society

Volumn 129, Issue 2, 2007, Pages 361-370

  Paik, Younkee ^d   Yang, Chao ^a   Metaferia, Belhu ^a   Tang, Shoubin ^a   Bane, Susan ^b   Ravindra, Rudravajhala ^b   Shanker, Natasha ^b   Alcaraz, Ana A ^c   Johnson, Scott A ^c   Schaefer, Jacob ^d   O'Connor, Robert D ^d   Cegelski, Lynette ^d   Snyder, James P ^c   Kingston, David G I ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b BINGHAMTON UNIVERSITY   (United States)

^c EMORY UNIVERSITY   (United States)

^d WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERS; DRUG PRODUCTS; MOLECULAR STRUCTURE; POLYMERIZATION; TUMORS; X RAY CRYSTALLOGRAPHY;

ELECTRON CRYSTALLOGRAPHY; LIGANDS; STOICHIOMETRIC RATIO; TUBULIN BOUND PACLITAXEL;

NUCLEAR MAGNETIC RESONANCE;

PACLITAXEL; PACLITAXEL DERIVATIVE; TUBULIN;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; MEASUREMENT; MICROTUBULE; NUCLEAR MAGNETIC RESONANCE; ROTATION; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PACLITAXEL; PROTEIN CONFORMATION; ROTATION; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TUBULIN;

EID: 33846201709     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0656604     Document Type: Article

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