The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 24, 1996, Pages 13699-13703

  Lauble, H ^a   Kennedy, M C ^b   Emptage, M H ^c   Beinert, H ^d   Stout, C D ^e  

^a UNIVERSITY OF STUTTGART   (Germany)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c DUPONT COMPANY   (United States)

^d UNIVERSITY OF WISCONSIN   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

low barrier hydrogen bonds; mechanism based inhibitor; Fe S enzyme

Indexed keywords

ACONITATE HYDRATASE; FLUOROCITRIC ACID; MITOCHONDRIAL ENZYME;

ANIMAL CELL; CATTLE; CONFERENCE PAPER; ENZYME BINDING; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME MECHANISM; HYDROGEN BOND; INHIBITION KINETICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANIMALIA; BOS TAURUS;

EID: 0030447979     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.24.13699     Document Type: Article

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