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Volumn , Issue , 2007, Pages 287-317

Applications of Liquid Radiochromatography Techniques in Drug Metabolism Studies

Author keywords

Liquid radiochromatographic techniques; Metabolite structural characterization; Off line liquid radiochromatographic detection technique

Indexed keywords


EID: 84889482584     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470191699.ch10     Document Type: Chapter
Times cited : (5)

References (58)
  • 1
    • 0034663268 scopus 로고    scopus 로고
    • Use of a microplate scintillation counter as a radioactivity detector for miniaturized separation techniques in drug metabolism
    • Boernsen KO, Floeckher JM, Bruin GJ. Use of a microplate scintillation counter as a radioactivity detector for miniaturized separation techniques in drug metabolism. Anal Chem 2000;72:3956-3959.
    • (2000) Anal Chem , vol.72 , pp. 3956-3959
    • Boernsen, K.O.1    Floeckher, J.M.2    Bruin, G.J.3
  • 2
    • 30144437351 scopus 로고    scopus 로고
    • Accelerator mass spectrometry for biomedical research
    • Brown K, Dingley KH, Turteltaub KW. Accelerator mass spectrometry for biomedical research. Methods Enzymol 2005;402:423-443.
    • (2005) Methods Enzymol , vol.402 , pp. 423-443
    • Brown, K.1    Dingley, K.H.2    Turteltaub, K.W.3
  • 3
    • 33644650632 scopus 로고    scopus 로고
    • Applications of accelerator mass spectrometry for pharmacological and toxicological research
    • Brown K, Tompkins EM, White IN. Applications of accelerator mass spectrometry for pharmacological and toxicological research. Mass Spectrom Rev 2006;25:127-145.
    • (2006) Mass Spectrom Rev , vol.25 , pp. 127-145
    • Brown, K.1    Tompkins, E.M.2    White, I.N.3
  • 4
    • 33750102850 scopus 로고    scopus 로고
    • A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: validation and applications
    • Bruin GJ, Waldmeier F, Boernsen KO, Pfaar U, Gross G, Zollinger M. A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: validation and applications. J Chromatogr A 2006;1133:184-194.
    • (2006) J Chromatogr A , vol.1133 , pp. 184-194
    • Bruin, G.J.1    Waldmeier, F.2    Boernsen, K.O.3    Pfaar, U.4    Gross, G.5    Zollinger, M.6
  • 5
    • 24944455859 scopus 로고    scopus 로고
    • A simple sequential incubation method for deconvoluting the complicated sequential metabolism of capravirine in humans
    • Bu HZ, Kang P, Zhao P, Pool WF, Wu EY. A simple sequential incubation method for deconvoluting the complicated sequential metabolism of capravirine in humans. Drug Metab Dispos 2005;33:1438-1445.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1438-1445
    • Bu, H.Z.1    Kang, P.2    Zhao, P.3    Pool, W.F.4    Wu, E.Y.5
  • 8
    • 0033935230 scopus 로고    scopus 로고
    • Recent advances in the applications of radioisotopes in drug metabolism, toxicology, and pharmacokinetics
    • Dalvie D. Recent advances in the applications of radioisotopes in drug metabolism, toxicology, and pharmacokinetics. Curr Pharm Des 2000;6:1009-1028.
    • (2000) Curr Pharm Des , vol.6 , pp. 1009-1028
    • Dalvie, D.1
  • 9
    • 33846019976 scopus 로고    scopus 로고
    • TopCount coupled to ultraperformance liquid chromatography for the profiling of radiolabeled drug metabolites in complex biological samples
    • Dear GJ, Patel N, Kelly PJ, Webber L, Yung M. TopCount coupled to ultraperformance liquid chromatography for the profiling of radiolabeled drug metabolites in complex biological samples. J Chromatogr B Analyt Technol Biomed Life Sci 2006;844:96-103.
    • (2006) J Chromatogr B Analyt Technol Biomed Life Sci , vol.844 , pp. 96-103
    • Dear, G.J.1    Patel, N.2    Kelly, P.J.3    Webber, L.4    Yung, M.5
  • 10
    • 0036027838 scopus 로고    scopus 로고
    • Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites
    • Egnash LA, Ramanathan R. Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites. J Pharm Biomed Anal 2002;27:271-284.
    • (2002) J Pharm Biomed Anal , vol.27 , pp. 271-284
    • Egnash, L.A.1    Ramanathan, R.2
  • 11
    • 0031974584 scopus 로고    scopus 로고
    • A universal radiochemical high-performance liquid chromatographic assay for the determination of UDP-glucuronosyltransferase activity
    • Ethell BT, Anderson GD, Beaumont K, Rance DJ, Burchell B. A universal radiochemical high-performance liquid chromatographic assay for the determination of UDP-glucuronosyltransferase activity. Anal Biochem 1998;255:142-147.
    • (1998) Anal Biochem , vol.255 , pp. 142-147
    • Ethell, B.T.1    Anderson, G.D.2    Beaumont, K.3    Rance, D.J.4    Burchell, B.5
  • 12
    • 1642281756 scopus 로고    scopus 로고
    • Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development
    • Evans DC, Watt AP, Nicoll-Griffith DA, Baillie TA. Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development. Chem Res Toxicol 2004;17:3-16.
    • (2004) Chem Res Toxicol , vol.17 , pp. 3-16
    • Evans, D.C.1    Watt, A.P.2    Nicoll-Griffith, D.A.3    Baillie, T.A.4
  • 15
    • 0034281129 scopus 로고    scopus 로고
    • Accelerator mass spectrometry in pharmaceutical research and development a new ultrasensitive analytical method for isotope measurement
    • Garner RC. Accelerator mass spectrometry in pharmaceutical research and development a new ultrasensitive analytical method for isotope measurement. Curr Drug Metab 2000;1:205-213.
    • (2000) Curr Drug Metab , vol.1 , pp. 205-213
    • Garner, R.C.1
  • 16
    • 0035987901 scopus 로고    scopus 로고
    • Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor
    • Garner RC, Goris I, Laenen AA, Vanhoutte E, Meuldermans W, Gregory S, Garner JV, Leong D, Whattam M, Calam A, Snel CA. Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor. Drug Metab Dispos 2002;30:823-830.
    • (2002) Drug Metab Dispos , vol.30 , pp. 823-830
    • Garner, R.C.1    Goris, I.2    Laenen, A.A.3    Vanhoutte, E.4    Meuldermans, W.5    Gregory, S.6    Garner, J.V.7    Leong, D.8    Whattam, M.9    Calam, A.10    Snel, C.A.11
  • 17
    • 84889341880 scopus 로고    scopus 로고
    • A sensitive method for plasma metabolite identification using nano LC/ion trap MS in conjunction with a microplate scintillation counter
    • ASMS Archive Abstract
    • Gedamke R, Zhao W, Gozo S, Mitroka J, Zhu M. A sensitive method for plasma metabolite identification using nano LC/ion trap MS in conjunction with a microplate scintillation counter. ASMS Archive Abstract 2003.
    • (2003)
    • Gedamke, R.1    Zhao, W.2    Gozo, S.3    Mitroka, J.4    Zhu, M.5
  • 19
    • 0344197565 scopus 로고    scopus 로고
    • Whole-body autoradiography and quantitative organ-level distribution study of deramciclane in rats
    • Hazai I, Patfalusi M, Klebovich I, Urmos I. Whole-body autoradiography and quantitative organ-level distribution study of deramciclane in rats. J Pharm Pharmacol 1999;51:165-174.
    • (1999) J Pharm Pharmacol , vol.51 , pp. 165-174
    • Hazai, I.1    Patfalusi, M.2    Klebovich, I.3    Urmos, I.4
  • 20
    • 0031059632 scopus 로고    scopus 로고
    • Narrow-bore liquid chromatography-tandem mass spectrometry with simultaneous radioactivity monitoring for partially characterizing the biliary metabolites of an arginine fluoroalkyl ketone analog of D-MePhe-Pro-Arg, a potent thrombin inhibitor
    • Heath TG, Mooney JP, Broersma R. Narrow-bore liquid chromatography-tandem mass spectrometry with simultaneous radioactivity monitoring for partially characterizing the biliary metabolites of an arginine fluoroalkyl ketone analog of D-MePhe-Pro-Arg, a potent thrombin inhibitor. J Chromatogr B Biomed Sci Appl 1997;688:281-289.
    • (1997) J Chromatogr B Biomed Sci Appl , vol.688 , pp. 281-289
    • Heath, T.G.1    Mooney, J.P.2    Broersma, R.3
  • 21
    • 0033015350 scopus 로고    scopus 로고
    • On the use of liquid chromatography with radio-and ultraviolet absorbance detection coupled to mass spectrometry for improved sensitivity and selectivity in determination of specific radioactivity of radiopharmaceuticals
    • Hyllbrant B, Tyrefors N, Markides KE, Langstrom B. On the use of liquid chromatography with radio-and ultraviolet absorbance detection coupled to mass spectrometry for improved sensitivity and selectivity in determination of specific radioactivity of radiopharmaceuticals. J Pharm Biomed Anal 1999;20:493-501.
    • (1999) J Pharm Biomed Anal , vol.20 , pp. 493-501
    • Hyllbrant, B.1    Tyrefors, N.2    Markides, K.E.3    Langstrom, B.4
  • 23
    • 23944461321 scopus 로고    scopus 로고
    • Investigating the human metabolism of acetaminophen using UPLC and exact mass oa-TOF MS
    • Johnson KA, Plumb R. Investigating the human metabolism of acetaminophen using UPLC and exact mass oa-TOF MS. J Pharm Biomed Anal 2005;39:805-810.
    • (2005) J Pharm Biomed Anal , vol.39 , pp. 805-810
    • Johnson, K.A.1    Plumb, R.2
  • 24
    • 0037442597 scopus 로고    scopus 로고
    • Combination of high-performance liquid chromatography and microplate scintillation counting for crop and animal metabolism studies: a comparison with classical on-line and thin-layer chromatography radioactivity detection
    • Kiffe M, Jehle A, Ruembeli R. Combination of high-performance liquid chromatography and microplate scintillation counting for crop and animal metabolism studies: a comparison with classical on-line and thin-layer chromatography radioactivity detection. Anal Chem 2003;75:723-730.
    • (2003) Anal Chem , vol.75 , pp. 723-730
    • Kiffe, M.1    Jehle, A.2    Ruembeli, R.3
  • 25
    • 0032727881 scopus 로고    scopus 로고
    • Radiochemical high-performance liquid chromatographic assay for the determination of catechol O-methyltransferase activity towards various substrates
    • Lautala P, Ulmanen I, Taskinen J. Radiochemical high-performance liquid chromatographic assay for the determination of catechol O-methyltransferase activity towards various substrates. J Chromatogr B Biomed Sci Appl 1999;736:143-151.
    • (1999) J Chromatogr B Biomed Sci Appl , vol.736 , pp. 143-151
    • Lautala, P.1    Ulmanen, I.2    Taskinen, J.3
  • 26
    • 84889434280 scopus 로고    scopus 로고
    • A novel dynamic flow system for sensitive radioactivity detection in LC/MS
    • Lee DY. A novel dynamic flow system for sensitive radioactivity detection in LC/MS. Drug Metab Rev 2006;38 (Suppl 2):33.
    • (2006) Drug Metab Rev , vol.38 , Issue.SUPPL. 2 , pp. 33
    • Lee, D.Y.1
  • 27
    • 33645827999 scopus 로고    scopus 로고
    • Biotransformation of carbon-14-labeled muraglitazar in male mice: interspecies difference in metabolic pathways leading to unique metabolites
    • Li W, Zhang D, Wang L, Zhang H, Cheng PT, Everett DW, Humphreys WG. Biotransformation of carbon-14-labeled muraglitazar in male mice: interspecies difference in metabolic pathways leading to unique metabolites. Drug Metab Dispos 2006;34:807-820.
    • (2006) Drug Metab Dispos , vol.34 , pp. 807-820
    • Li, W.1    Zhang, D.2    Wang, L.3    Zhang, H.4    Cheng, P.T.5    Everett, D.W.6    Humphreys, W.G.7
  • 30
    • 4544295323 scopus 로고    scopus 로고
    • The use of radiolabeled compounds for ADME studies in discovery and exploratory development
    • Marathe PH, Shyu WC, Humphreys WG. The use of radiolabeled compounds for ADME studies in discovery and exploratory development. Curr Pharm Des 2004;10:2991-3008.
    • (2004) Curr Pharm Des , vol.10 , pp. 2991-3008
    • Marathe, P.H.1    Shyu, W.C.2    Humphreys, W.G.3
  • 31
  • 32
    • 0036867888 scopus 로고    scopus 로고
    • Metabolite analysis, isolation, and purity assessment using various liquid chromatographic techniques combined with radioactivity detection
    • Morovjan G, Dalmadi-Kiss B, Klebovich I, Mincsovics E. Metabolite analysis, isolation, and purity assessment using various liquid chromatographic techniques combined with radioactivity detection. J Chromatogr Sci 2002;40:603-608.
    • (2002) J Chromatogr Sci , vol.40 , pp. 603-608
    • Morovjan, G.1    Dalmadi-Kiss, B.2    Klebovich, I.3    Mincsovics, E.4
  • 33
    • 0037032253 scopus 로고    scopus 로고
    • Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-(14)C]quercetin-40-glucoside
    • Mullen W, Graf BA, Caldwell ST, Hartley RC, Duthie GG, Edwards CA, Lean ME, Crozier A. Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-(14)C]quercetin-40-glucoside. J Agric Food Chem 2002;50:6902-6909.
    • (2002) J Agric Food Chem , vol.50 , pp. 6902-6909
    • Mullen, W.1    Graf, B.A.2    Caldwell, S.T.3    Hartley, R.C.4    Duthie, G.G.5    Edwards, C.A.6    Lean, M.E.7    Crozier, A.8
  • 34
    • 1542715066 scopus 로고    scopus 로고
    • Detection and identification of 14C-labeled flavonol metabolites by high-performance liquid chromatography-radiocounting and tandem mass spectrometry
    • Mullen W, Hartley RC, Crozier A. Detection and identification of 14C-labeled flavonol metabolites by high-performance liquid chromatography-radiocounting and tandem mass spectrometry. J Chromatogr A 2003;1007:21-29.
    • (2003) J Chromatogr A , vol.1007 , pp. 21-29
    • Mullen, W.1    Hartley, R.C.2    Crozier, A.3
  • 35
    • 0037442578 scopus 로고    scopus 로고
    • On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development
    • Nassar AE, Bjorge SM, Lee DY. On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development. Anal Chem 2003;75:785-790.
    • (2003) Anal Chem , vol.75 , pp. 785-790
    • Nassar, A.E.1    Bjorge, S.M.2    Lee, D.Y.3
  • 36
    • 4143116643 scopus 로고    scopus 로고
    • Liquid chromatography-accurate radioisotope counting and microplate scintillation counter technologies in drug metabolism-studies
    • Nassar AE, Parmentier Y, Martinet M, Lee DY. Liquid chromatography-accurate radioisotope counting and microplate scintillation counter technologies in drug metabolism-studies. J Chromatogr Sci 2004;42:348-353.
    • (2004) J Chromatogr Sci , vol.42 , pp. 348-353
    • Nassar, A.E.1    Parmentier, Y.2    Martinet, M.3    Lee, D.Y.4
  • 37
    • 0842281553 scopus 로고    scopus 로고
    • The use of 96-well Scintiplates to facilitate definitive metabolism studies for drug candidates
    • Nedderman AN, Savage ME, White KL, Walker DK. The use of 96-well Scintiplates to facilitate definitive metabolism studies for drug candidates. J Pharm Biomed Anal 2004;34:607-617.
    • (2004) J Pharm Biomed Anal , vol.34 , pp. 607-617
    • Nedderman, A.N.1    Savage, M.E.2    White, K.L.3    Walker, D.K.4
  • 38
    • 34547344360 scopus 로고    scopus 로고
    • New analytical strategies in drug metabolism
    • Staack RF and Hopfgarner G. New analytical strategies in drug metabolism. Anal Bioanal Chem 2007;388:1365-1380.
    • (2007) Anal Bioanal Chem , vol.388 , pp. 1365-1380
    • Staack, R.F.1    Hopfgarner, G.2
  • 39
    • 0028831731 scopus 로고
    • Quinone methide formation from para isomers of methylphenol (cresol), ethylphenol, and isopropylphenol: relationship to toxicity
    • Thompson DC, Perera K, London R. Quinone methide formation from para isomers of methylphenol (cresol), ethylphenol, and isopropylphenol: relationship to toxicity. Chem Res Toxicol 1995;8:55-60.
    • (1995) Chem Res Toxicol , vol.8 , pp. 55-60
    • Thompson, D.C.1    Perera, K.2    London, R.3
  • 40
    • 0025144610 scopus 로고
    • Radiochromatography in pharmaceutical and biomedical analysis
    • Veltkamp AC. Radiochromatography in pharmaceutical and biomedical analysis. J Chromatogr 1990;531:101-129.
    • (1990) J Chromatogr , vol.531 , pp. 101-129
    • Veltkamp, A.C.1
  • 41
    • 19244381865 scopus 로고    scopus 로고
    • Study of cytokinin metabolism using HPLC with radioisotope detection
    • Vlasakova V, Brezinova A, Holik J. Study of cytokinin metabolism using HPLC with radioisotope detection. J Pharm Biomed Anal 1998;17:39-44.
    • (1998) J Pharm Biomed Anal , vol.17 , pp. 39-44
    • Vlasakova, V.1    Brezinova, A.2    Holik, J.3
  • 42
    • 1642383605 scopus 로고    scopus 로고
    • Comparison of benchtop microplate beta counters with the traditional gamma counting method for measurement of chromium-51 release in cytotoxic assays
    • Wallace D, Hildesheim A, Pinto LA. Comparison of benchtop microplate beta counters with the traditional gamma counting method for measurement of chromium-51 release in cytotoxic assays. Clin Diagn Lab Immunol 2004;11:255-260.
    • (2004) Clin Diagn Lab Immunol , vol.11 , pp. 255-260
    • Wallace, D.1    Hildesheim, A.2    Pinto, L.A.3
  • 43
    • 33745902227 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples
    • Wang G, Hsieh Y, Cui X, Cheng KC, Korfmacher WA. Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples. Rapid Commun Mass Spectrom 2006a;20:2215-2221.
    • (2006) Rapid Commun Mass Spectrom , vol.20 , pp. 2215-2221
    • Wang, G.1    Hsieh, Y.2    Cui, X.3    Cheng, K.C.4    Korfmacher, W.A.5
  • 44
    • 56449125931 scopus 로고    scopus 로고
    • Metabolite fingerprint and biomarkers identification of rat urine after dosed with ginsenoside Rg3 based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (UPLC/TOF-MS)]
    • Wang J, Zhao X, Zheng Y, Kong H, Lu G, Cai Z, Xu G. Metabolite fingerprint and biomarkers identification of rat urine after dosed with ginsenoside Rg3 based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (UPLC/TOF-MS)]. Se Pu 2006b;24:5-9.
    • (2006) Se Pu , vol.24 , pp. 5-9
    • Wang, J.1    Zhao, X.2    Zheng, Y.3    Kong, H.4    Lu, G.5    Cai, Z.6    Xu, G.7
  • 45
    • 3242776195 scopus 로고    scopus 로고
    • Techniques: the application of accelerator mass spectrometry to pharmacology and toxicology
    • White IN, Brown K. Techniques: the application of accelerator mass spectrometry to pharmacology and toxicology. Trends Pharmacol Sci 2004;25:442-447.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 442-447
    • White, I.N.1    Brown, K.2
  • 48
    • 33845961553 scopus 로고    scopus 로고
    • Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar
    • Zhang D, Wang L, Chandrasena G, Ma L, Zhu M, Zhang H, Davis CD, Humphreys WG. Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos 2007a;35:139-149.
    • (2007) Drug Metab Dispos , vol.35 , pp. 139-149
    • Zhang, D.1    Wang, L.2    Chandrasena, G.3    Ma, L.4    Zhu, M.5    Zhang, H.6    Davis, C.D.7    Humphreys, W.G.8
  • 50
    • 2042474751 scopus 로고    scopus 로고
    • Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans
    • Zhang D, Zhao W, Roongta VA, Mitroka JG, Klunk LJ, Zhu M. Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans. Drug Metab Dispos 2004;32:545-551.
    • (2004) Drug Metab Dispos , vol.32 , pp. 545-551
    • Zhang, D.1    Zhao, W.2    Roongta, V.A.3    Mitroka, J.G.4    Klunk, L.J.5    Zhu, M.6
  • 51
    • 34248544162 scopus 로고    scopus 로고
    • Rapid and sensitive determination of enzyme kinetics of drug metabolism using HPLC coupled with a stop-flow radioactivity flow detector
    • Zhao W, Wang L, Zhang D, Zhu M. Rapid and sensitive determination of enzyme kinetics of drug metabolism using HPLC coupled with a stop-flow radioactivity flow detector. Drug Metab Rev 2004;36:257.
    • (2004) Drug Metab Rev , vol.36 , pp. 257
    • Zhao, W.1    Wang, L.2    Zhang, D.3    Zhu, M.4
  • 52
    • 84889303393 scopus 로고    scopus 로고
    • An integrated method for quantification and identification of radiolabeled metabolites:application of chip-based nanoelectrospray and mass defect filter techniques
    • ASMS Archive Abstract
    • Zhao W, Zhang H, ZH, Zhu M, Warrack B, Ma L, Humphreys WG, Sanders M. An integrated method for quantification and identification of radiolabeled metabolites:application of chip-based nanoelectrospray and mass defect filter techniques. ASMS Archive Abstract.
    • Zhao, W.1    Zhang, H.Z.H.2    Zhu, M.3    Warrack, B.4    Ma, L.5    Humphreys, W.G.6    Sanders, M.7
  • 53
    • 33748902567 scopus 로고    scopus 로고
    • Detection and characterization of metabolites in biological matrices using Mass defect filtering of liquid chromatography/High resolution mass spectrometry data
    • Zhu M, Ma L, Zhang D, Ray K, Zhao W, Humphreys WG, Skiles G, Sanders M, Zhang H. Detection and characterization of metabolites in biological matrices using Mass defect filtering of liquid chromatography/High resolution mass spectrometry data. Drug Metab Dispos. 2006;34:1722-1733.
    • (2006) Drug Metab Dispos. , vol.34 , pp. 1722-1733
    • Zhu, M.1    Ma, L.2    Zhang, D.3    Ray, K.4    Zhao, W.5    Humphreys, W.G.6    Skiles, G.7    Sanders, M.8    Zhang, H.9
  • 54
    • 33644579276 scopus 로고    scopus 로고
    • Determination of radioactivity distribution and metabolite profiles in tissues using a combination of microplate scintillation counting, capillary LC/MS and whole-body autoradiography
    • Zhu M, Wang L, Gedamke R, Zhao W, Zhang D, Gozo S. Determination of radioactivity distribution and metabolite profiles in tissues using a combination of microplate scintillation counting, capillary LC/MS and whole-body autoradiography. Drug Metab Rev 2003;35:76.
    • (2003) Drug Metab Rev , vol.35 , pp. 76
    • Zhu, M.1    Wang, L.2    Gedamke, R.3    Zhao, W.4    Zhang, D.5    Gozo, S.6
  • 55
    • 15344344810 scopus 로고    scopus 로고
    • A novel in vitro approach, using a microplate scintillation counter and LC/MS, for determining formation pathways and structures of sequential metabolites: Buspirone as an example
    • Zhu M, Zhang H, Zhao W, Mitroka J, Klunk L. A novel in vitro approach, using a microplate scintillation counter and LC/MS, for determining formation pathways and structures of sequential metabolites: Buspirone as an example. Drug Metab Rev 2002;34:167.
    • (2002) Drug Metab Rev , vol.34 , pp. 167
    • Zhu, M.1    Zhang, H.2    Zhao, W.3    Mitroka, J.4    Klunk, L.5
  • 57
    • 23444454671 scopus 로고    scopus 로고
    • Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation and application
    • Zhu M, Zhao W, Vazquez N, Mitroka JG. Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation and application. J Pharm Biomed Anal 2005b;39:233-245.
    • (2005) J Pharm Biomed Anal , vol.39 , pp. 233-245
    • Zhu, M.1    Zhao, W.2    Vazquez, N.3    Mitroka, J.G.4
  • 58
    • 77957070673 scopus 로고    scopus 로고
    • Quantification and structural elucidation of low quantities for radiolabeled metabolites using microplate scintillation counting (MSC) techniques in conjunction with LC/MS
    • In: Chowdhurry SK, editor. Identification and quantification of Drugs, Metabolites and Metabolizing Enzymes. Amsterdam:Elsevier
    • Zhu M, Zhang D, Skills G. Quantification and structural elucidation of low quantities for radiolabeled metabolites using microplate scintillation counting (MSC) techniques in conjunction with LC/MS. In: Chowdhurry SK, editor. Identification and quantification of Drugs, Metabolites and Metabolizing Enzymes. Amsterdam:Elsevier; 2005c. p 195-223.
    • (2005) , pp. 195-223
    • Zhu, M.1    Zhang, D.2    Skills, G.3


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