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Volumn 26, Issue 5, 1998, Pages 408-417

Biotransformation of irbesartan in man

Author keywords

[No Author keywords available]

Indexed keywords

IRBESARTAN;

EID: 0031902451     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (83)

References (13)
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    • Angiotensin II receptor blockade: An innovative approach to cardiovascular pharmacotherapy
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    • Eberhardt, R.T.1    Kevak, R.M.2    Kang, P.M.3    Frishman, W.H.4
  • 3
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    • Hemodynamic and neurohormonal effects of the angiotensin II antagonist losartan in patients with congestive heart failure
    • Gottlieb SS, Dickstein K, Fleck E, Kostis J, Levine TB, LeJemtel T and DeKock M (1993) Hemodynamic and neurohormonal effects of the angiotensin II antagonist losartan in patients with congestive heart failure. Circulation 88:1602-1609.
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    • Gottlieb, S.S.1    Dickstein, K.2    Fleck, E.3    Kostis, J.4    Levine, T.B.5    LeJemtel, T.6    DeKock, M.7
  • 4
    • 0027451525 scopus 로고
    • I. N-Glucuronidation reactions: Terazole N-glucuronidation of selected angiotensin II receptor antagonists in hepatic microsomes from rats, dogs, monkeys, and humans
    • Huskey S-EW, Miller RR and Chiu S-HL (1993) I. N-Glucuronidation reactions: Terazole N-glucuronidation of selected angiotensin II receptor antagonists in hepatic microsomes from rats, dogs, monkeys, and humans. Drug Metab Dispos 21:792-799.
    • (1993) Drug Metab Dispos , vol.21 , pp. 792-799
    • Huskey, S.-E.W.1    Miller, R.R.2    Chiu, S.-H.L.3
  • 5
    • 0029781981 scopus 로고    scopus 로고
    • Characterization of conjugated metabolites of a new angiotensin II receptor antagonist, candesartan cilexetil, in rats by liquid chromatography/electrospray tandem mass spectroscopy following chemical derivatization
    • Kondo T, Yoshida K, Yoshimura Y, Motohashi M and Tanayama S (1996) Characterization of conjugated metabolites of a new angiotensin II receptor antagonist, candesartan cilexetil, in rats by liquid chromatography/electrospray tandem mass spectroscopy following chemical derivatization. J Mass Spectrom 31:873-878.
    • (1996) J Mass Spectrom , vol.31 , pp. 873-878
    • Kondo, T.1    Yoshida, K.2    Yoshimura, Y.3    Motohashi, M.4    Tanayama, S.5
  • 7
    • 0343091889 scopus 로고
    • Pharmacokinetics of SR 47436 (BMS-186295), a new angiotensin II receptor antagonist in man
    • Necciari J, Denolle T, Le Coz F, Donazollo Y, Pastor G and Sissmann J (1994) Pharmacokinetics of SR 47436 (BMS-186295), a new angiotensin II receptor antagonist in man. J Hypertens 12:88.
    • (1994) J Hypertens , vol.12 , pp. 88
    • Necciari, J.1    Denolle, T.2    Le Coz, F.3    Donazollo, Y.4    Pastor, G.5    Sissmann, J.6
  • 8
    • 0028097103 scopus 로고
    • In vitro N-glucuronidation of SR 47436 (BMS 186295), a new AT1 nonpeptide angiotensin II receptor antagonist, by rat, monkey and human hepatic microsomal fractions
    • Perrier L, Bourrie M, Marti E, Tronquet C, Masse D, Berger Y, Magdalou J and Fabre G (1994) In vitro N-glucuronidation of SR 47436 (BMS 186295), a new AT1 nonpeptide angiotensin II receptor antagonist, by rat, monkey and human hepatic microsomal fractions. J Pharmacol Exp Ther 271:91-99.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 91-99
    • Perrier, L.1    Bourrie, M.2    Marti, E.3    Tronquet, C.4    Masse, D.5    Berger, Y.6    Magdalou, J.7    Fabre, G.8
  • 9
    • 0025719938 scopus 로고
    • Synthesis and identification of a novel tetrazole metabolite of the angiotensin II receptor antagonist DuP 753
    • Stearns RA, Doss GA, Miller RR and Chiu S-HL (1991) Synthesis and identification of a novel tetrazole metabolite of the angiotensin II receptor antagonist DuP 753. Drug Metab Dispos 19:1160-1162.
    • (1991) Drug Metab Dispos , vol.19 , pp. 1160-1162
    • Stearns, R.A.1    Doss, G.A.2    Miller, R.R.3    Chiu, S.-H.L.4
  • 11
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    • Excretion and metabolism following single oral administration (10 mg/kg) of irbesartan to Macaca fascicularis monkeys
    • Abstract presented at the Seventh American ISSX Meeting, San Diego, CA, 1996
    • Tronquet C, Mandray M, Masse D, Miscoria G and Berger Y (1996) Excretion and metabolism following single oral administration (10 mg/kg) of irbesartan to Macaca fascicularis monkeys. Abstract presented at the Seventh American ISSX Meeting, San Diego, CA, 1996. ISSX Proceedings 10:321.
    • (1996) ISSX Proceedings , vol.10 , pp. 321
    • Tronquet, C.1    Mandray, M.2    Masse, D.3    Miscoria, G.4    Berger, Y.5
  • 12
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    • Vachharajani N, Chang SY, Shyu WC., Greene D and Barbhaiya R (1995) Absolute bioavailability of irbesartan, an angiotensin II receptor antagonist, in man. Pharm Res 12:S-388.
    • (1995) Pharm Res , vol.12
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.