Distribution of deramciclane (EGIS-3886) in rat brain regions

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 2, 1998, Pages 125-131

  Magyar, K ^a   Lengyel, J ^a   Klebovich, I ^b   Urmos I ^b   Grezal G ^b  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b EGIS PHARMACEUTICALS LTD   (Hungary)

Author keywords

Brain regions; Deramciclane; Distribution; Pharmacokinetics

Indexed keywords

ANXIOLYTIC AGENT; CARBON 14; DERAMCICLANE FUMARATE; TRACER; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; BRAIN REGION; COMPARTMENT MODEL; CONFERENCE PAPER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; ENTEROHEPATIC CIRCULATION; GASTROINTESTINAL TRACT; HYPOPHYSIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SPINAL CORD;

EID: 0031693701     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03189327     Document Type: Conference Paper

References (10)

1. Budai Z., Magdányi L., Lay-Kónya L., Mezei T., Grasser K., Petócz L., Kosoczky I. (1980): Basic ethers pharmaceutical compositions containing the same. Patent No.: HU 179164 (1979), US 4342762.
2. Darvas F., Lopata A., Budai Z., Petöcz L. (1985): Prediction of the therapeutical index for a novel type of tranquillant. Pharmacochem. Libr. (OSAR Toxico Xenobiochem) 8, 199-200; Chem. Abstr. 103, 205. 554.
3. Darvas F., Lopata A., Budai Z., Petöcz L. (1985): Prediction of the therapeutical index for a novel type of tranquillant. Pharmacochem. Libr. (OSAR Toxico Xenobiochem) 8, 199-200; Chem. Abstr. 103, 205. 554.
4. Darvas F., Lopata A., Budai Z., Petcz L. (1986): Computer assisted design of a novel type of tranquillant. Chem. Abst. 104, 28.386.
5. Gachályi I., Gyertyán L., Petöcz L., Buday, Z.. (1988): Psychopharmacology of a new anxiolytic agent EGIS-3886. Pharm. Res. Comm., 20, 115-117.
6. Berényi E., Blaskó G., Fekete M., Nógrádi M. (1990): EGIS-3886, Drugs of the Future, 15 No. 12 1174-1175.
7. Kovács I., Maksai G., Simonyi M. (1989): Inhibition of High-Affinity Synaptosomal Uptake of γ-Aminobutyric Acid by a Bicyclo Heptane Derivative. Arzneim. Forsch./Drug Res., 39 (I) 295-297.
8. Investigator's Brochure of deramciclane fumarate (EGIS-3886), EGIS Pharmaceutical Ltd., 1994 November, EGIS Doc. No.: 5963/A
9. Paxinos E., Watson C. (1986): The rat brain in stereotaxic, Coordinates, Second Edition, Academic Press, Perth, Australia.
10. Hazai I., Ürmös I., Klebovich I. (1995): Application of TLC-Digital Autoradiography as a Rapid Method in Pilot Study of Deramciclane Metabolism. J. Planar Chromatogr., 8, 92-97.