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Volumn 6, Issue C, 2005, Pages 195-223

Chapter 9 Quantification and structural elucidation of low quantities of radiolabeled metabolites using microplate scintillation counting (msc) techniques in conjunction with lc-ms

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EID: 77957070673     PISSN: 14643456     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1464-3456(05)80011-0     Document Type: Article
Times cited : (9)

References (35)
  • 1
    • 0031472588 scopus 로고    scopus 로고
    • Role of pharmacokinetics and metabolism in drug discovery and development
    • Lin J.H., and Lu A.Y.H. Role of pharmacokinetics and metabolism in drug discovery and development. Pharm. Rev. 49 (1997) 403-449
    • (1997) Pharm. Rev. , vol.49 , pp. 403-449
    • Lin, J.H.1    Lu, A.Y.H.2
  • 2
    • 0034883375 scopus 로고    scopus 로고
    • Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus
    • Tucker G.T., Houston J.B., and Huang S.-M. Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus. Clin. Pharm. Ther. 70 (2001) 103-114
    • (2001) Clin. Pharm. Ther. , vol.70 , pp. 103-114
    • Tucker, G.T.1    Houston, J.B.2    Huang, S.-M.3
  • 3
    • 77957025651 scopus 로고    scopus 로고
    • The European Agency for the Evaluation of Medicinal Products: Human Medicines Evaluation Unit, 1997. Note for Guidance on the Investigation of Drug Interactions. (CPMP/EW/560/95).
    • The European Agency for the Evaluation of Medicinal Products: Human Medicines Evaluation Unit, 1997. Note for Guidance on the Investigation of Drug Interactions. (CPMP/EW/560/95).
  • 5
    • 0032727881 scopus 로고    scopus 로고
    • Radiochemical high-performance liq-uid Chromatographic assay for the determination of catechol O-methyltransferase activity towards various substrates
    • Lautala P., Ulmanen I., and Taskine J. Radiochemical high-performance liq-uid Chromatographic assay for the determination of catechol O-methyltransferase activity towards various substrates. J. Chromatogr. B 736 (1999) 143-151
    • (1999) J. Chromatogr. B , vol.736 , pp. 143-151
    • Lautala, P.1    Ulmanen, I.2    Taskine, J.3
  • 6
    • 0025144610 scopus 로고
    • Radiochromatography in pharmaceutical and biomedical analysis
    • Veltkamp A.C. Radiochromatography in pharmaceutical and biomedical analysis. J. Chromatogr. 531 (1990) 101-129
    • (1990) J. Chromatogr. , vol.531 , pp. 101-129
    • Veltkamp, A.C.1
  • 7
    • 0036874502 scopus 로고    scopus 로고
    • 14C-labeled glyceryl trinitrate and its metabolites by OPLC coupled with on-line or off-line radioactivity detection
    • 14C-labeled glyceryl trinitrate and its metabolites by OPLC coupled with on-line or off-line radioactivity detection. J. Planar. Chromatogr. 15 (2002) 404-409
    • (2002) J. Planar. Chromatogr. , vol.15 , pp. 404-409
    • Klebovich, I.1    Morovjan, G.2    Hazai, I.3    Mincsovice, E.4
  • 8
    • 0036027838 scopus 로고    scopus 로고
    • Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites
    • Egnash L.A., and Ramanathan R. Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites. J. Pharm. Biomed. Anal. 27 (2002) 271-284
    • (2002) J. Pharm. Biomed. Anal. , vol.27 , pp. 271-284
    • Egnash, L.A.1    Ramanathan, R.2
  • 9
    • 0031059632 scopus 로고    scopus 로고
    • Narrow-bore liquid chromatog-raphy-tandem mass spectrometry with simultaneous radioactivity monitoring for partially characterizing the biliary metabolites of an arginine fluoroalkyl ketone analog of D-MePhe-Pro-Arg, a potent thrombin inhibitor
    • Heath T.G., Mooney J.P., and Broersma R. Narrow-bore liquid chromatog-raphy-tandem mass spectrometry with simultaneous radioactivity monitoring for partially characterizing the biliary metabolites of an arginine fluoroalkyl ketone analog of D-MePhe-Pro-Arg, a potent thrombin inhibitor. J. Chromatogr. B 688 (1997) 281-289
    • (1997) J. Chromatogr. B , vol.688 , pp. 281-289
    • Heath, T.G.1    Mooney, J.P.2    Broersma, R.3
  • 10
    • 19244381865 scopus 로고    scopus 로고
    • Study of cytokinin metabo-lism using HPLC with radioisotope detection
    • Vlasakova V., Brezinova A., and Holik J. Study of cytokinin metabo-lism using HPLC with radioisotope detection. J. Pharm. Biomed. Anal. 17 (1998) 39-44
    • (1998) J. Pharm. Biomed. Anal. , vol.17 , pp. 39-44
    • Vlasakova, V.1    Brezinova, A.2    Holik, J.3
  • 11
    • 0036099429 scopus 로고    scopus 로고
    • Radiochemical detection for packed capillary liquid chroma-tography-mass spectrometry
    • Onisko B.C. Radiochemical detection for packed capillary liquid chroma-tography-mass spectrometry. J. Am. Soc. Mass Spectrom. 13 (2001) 82-84
    • (2001) J. Am. Soc. Mass Spectrom. , vol.13 , pp. 82-84
    • Onisko, B.C.1
  • 12
    • 1542715066 scopus 로고    scopus 로고
    • 14C-labelled flavonol metabolites by high-performance liquid chromatogra-phy-radiocounting and tandem mass spectrometry
    • 14C-labelled flavonol metabolites by high-performance liquid chromatogra-phy-radiocounting and tandem mass spectrometry. J. Chromatogr. A 1007 (2003) 21-29
    • (2003) J. Chromatogr. A , vol.1007 , pp. 21-29
    • Mullen, W.1    Hartley, R.C.2    Crozier, A.3
  • 13
    • 0036867888 scopus 로고    scopus 로고
    • Metabo-lite analysis, isolation and purity assessment using various liquid Chromato-graphic techniques combined with radioactivity detection
    • Morvovjan G.D., almadi-Kiss B., Klebovich I., and Mincsovice E. Metabo-lite analysis, isolation and purity assessment using various liquid Chromato-graphic techniques combined with radioactivity detection. J. Chromatogr. Sci. 40 (2002) 603-608
    • (2002) J. Chromatogr. Sci. , vol.40 , pp. 603-608
    • Morvovjan, G.D.1    almadi-Kiss, B.2    Klebovich, I.3    Mincsovice, E.4
  • 14
    • 0028942350 scopus 로고
    • Qualitative analysis of potential metabolites and degradation products of a new antiinfective drug in rat urine, using HPLC with radiochemical detection and HPLC-mass spectrometry
    • Iavarone L., Scandola M., Pugnaghi F., and Gross P. Qualitative analysis of potential metabolites and degradation products of a new antiinfective drug in rat urine, using HPLC with radiochemical detection and HPLC-mass spectrometry. J. Pharm. Biomed. Anal. 13 (1995) 607-614
    • (1995) J. Pharm. Biomed. Anal. , vol.13 , pp. 607-614
    • Iavarone, L.1    Scandola, M.2    Pugnaghi, F.3    Gross, P.4
  • 16
    • 0038342378 scopus 로고    scopus 로고
    • Use of HPLC with 96-well microplate scintillation counter for rapid profiling of low levels of radioactive metabolites in biological fluids
    • Zhu M., Bering N., and Mitroka J.G. Use of HPLC with 96-well microplate scintillation counter for rapid profiling of low levels of radioactive metabolites in biological fluids. Drug Metab. Rev. 32 Suppl. 2 (2000) 177
    • (2000) Drug Metab. Rev. , vol.32 , Issue.SUPPL. 2 , pp. 177
    • Zhu, M.1    Bering, N.2    Mitroka, J.G.3
  • 17
    • 33644568655 scopus 로고    scopus 로고
    • A rapid and efficient method for off-line radiodetection using HPLC with TopCount and 96-well plate technology
    • Kelly P.J., Harrell A.W., North S.E., and Boyle G.W. A rapid and efficient method for off-line radiodetection using HPLC with TopCount and 96-well plate technology. Drug Metab. Rev. 32 Suppl. 2 (2000) 178
    • (2000) Drug Metab. Rev. , vol.32 , Issue.SUPPL. 2 , pp. 178
    • Kelly, P.J.1    Harrell, A.W.2    North, S.E.3    Boyle, G.W.4
  • 18
    • 0034663268 scopus 로고    scopus 로고
    • Use of microplate scintil-lation counter as a radioactivity detector for miniaturized separation techniques in drug metabolism
    • Boernsen K.O., Floeckher J.M., and Bruin G.J.M. Use of microplate scintil-lation counter as a radioactivity detector for miniaturized separation techniques in drug metabolism. Anal. Chem. 72 (2000) 3956-3959
    • (2000) Anal. Chem. , vol.72 , pp. 3956-3959
    • Boernsen, K.O.1    Floeckher, J.M.2    Bruin, G.J.M.3
  • 19
    • 77957049608 scopus 로고
    • Application of Wallac MicroBeta radioactivity plate counter and Wallac Scintiplate in metabolite profiling and identification studies
    • Yin H., Greenberg G.E., and Fischer V. Application of Wallac MicroBeta radioactivity plate counter and Wallac Scintiplate in metabolite profiling and identification studies. Application Note. PerkinElmer Life Sciences (1900)
    • (1900) Application Note. PerkinElmer Life Sciences
    • Yin, H.1    Greenberg, G.E.2    Fischer, V.3
  • 20
    • 0037442597 scopus 로고    scopus 로고
    • Combination of high performance liquid chromatography and microplate scintillation counting for crop and animal metabolism studies: a comparison with classical on-line and thin-layer chroma-tography radioactivity detection
    • Kiffe M., Jehle A., and Ruembeli R. Combination of high performance liquid chromatography and microplate scintillation counting for crop and animal metabolism studies: a comparison with classical on-line and thin-layer chroma-tography radioactivity detection. Anal. Chem. 75 (2003) 723-730
    • (2003) Anal. Chem. , vol.75 , pp. 723-730
    • Kiffe, M.1    Jehle, A.2    Ruembeli, R.3
  • 21
    • 0037636516 scopus 로고    scopus 로고
    • Protein covalent binding of MaxiPost through a cytochrome P450-mediated ortho-quinone methoide intermediate in rats
    • Zhang D., Organ M., Gedamke R., Roongta V., Dai R., Zhu M., Rinehart J., Klunk L., and Mitroka J. Protein covalent binding of MaxiPost through a cytochrome P450-mediated ortho-quinone methoide intermediate in rats. Drug Metab. Dispos. 31 (2003) 837-845
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 837-845
    • Zhang, D.1    Organ, M.2    Gedamke, R.3    Roongta, V.4    Dai, R.5    Zhu, M.6    Rinehart, J.7    Klunk, L.8    Mitroka, J.9
  • 22
    • 0842281553 scopus 로고    scopus 로고
    • The use of 96-well scintiplates to facilitate definitive metabolism studies for drug candidates
    • Nedderman A.N.R., Savage M.E., White K.L., and Walder D.K. The use of 96-well scintiplates to facilitate definitive metabolism studies for drug candidates. J. Pharm. Biomed. Anal. 34 (2004) 607-617
    • (2004) J. Pharm. Biomed. Anal. , vol.34 , pp. 607-617
    • Nedderman, A.N.R.1    Savage, M.E.2    White, K.L.3    Walder, D.K.4
  • 23
    • 2042474751 scopus 로고    scopus 로고
    • Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans
    • Zhang D., Zhao W., Roongta V.A., Mitroka J.G., Klunk L.J., and Zhu M. Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans. Drug Metab. Dispos. 32 (2004) 545-551
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 545-551
    • Zhang, D.1    Zhao, W.2    Roongta, V.A.3    Mitroka, J.G.4    Klunk, L.J.5    Zhu, M.6
  • 25
    • 15344344810 scopus 로고    scopus 로고
    • A novel in vitro approach, using a microplate scintillation counter and LC/MS, for determining formation pathways and structures of sequential metabolites: buspirone as an example
    • Zhu M., Zhang H., Zhao W., Mitroka J., and Klunk L. A novel in vitro approach, using a microplate scintillation counter and LC/MS, for determining formation pathways and structures of sequential metabolites: buspirone as an example. Drug Metab. Rev. 34 (2002) 167
    • (2002) Drug Metab. Rev. , vol.34 , pp. 167
    • Zhu, M.1    Zhang, H.2    Zhao, W.3    Mitroka, J.4    Klunk, L.5
  • 26
    • 0242521617 scopus 로고    scopus 로고
    • A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spec-trometric analyses
    • Zhang H., Zhang D., and Ray K. A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spec-trometric analyses. J. Mass Spectrom. 38 (2004) 1110-1112
    • (2004) J. Mass Spectrom. , vol.38 , pp. 1110-1112
    • Zhang, H.1    Zhang, D.2    Ray, K.3
  • 27
    • 77957051268 scopus 로고    scopus 로고
    • A new approach utilizing mass defect filter on high resolution LC/MS data to identify metabolite ions in biological matrices: omeprazole as an example
    • Zhang H., Ray K., Zhao W., Zhang D., Gozo S., and Zhu M. A new approach utilizing mass defect filter on high resolution LC/MS data to identify metabolite ions in biological matrices: omeprazole as an example. ASMS Archive Abstract (2004)
    • (2004) ASMS Archive Abstract
    • Zhang, H.1    Ray, K.2    Zhao, W.3    Zhang, D.4    Gozo, S.5    Zhu, M.6
  • 28
    • 33644561432 scopus 로고    scopus 로고
    • A sensitive method for plasma metabolite identification using nano LC/ion trap MS in conjunction with a microplate scintillation counter
    • Gedamke R., Zhao W., Gozo S., Mitroka J., and Zhu M. A sensitive method for plasma metabolite identification using nano LC/ion trap MS in conjunction with a microplate scintillation counter. ASMS Archive Abstract (2003)
    • (2003) ASMS Archive Abstract
    • Gedamke, R.1    Zhao, W.2    Gozo, S.3    Mitroka, J.4    Zhu, M.5
  • 29
    • 33644579276 scopus 로고    scopus 로고
    • Determination of radioactivity distribution and metabolite profiles in tissues using a combination of microplate scintillation counting, capillary LC/MS and whole-body autoradiography
    • Zhu M., Wang L., Gedamke R., Zhao W., Zhang D., and Gozo S. Determination of radioactivity distribution and metabolite profiles in tissues using a combination of microplate scintillation counting, capillary LC/MS and whole-body autoradiography. Metab. Rev. 35 (2003) 76
    • (2003) Metab. Rev. , vol.35 , pp. 76
    • Zhu, M.1    Wang, L.2    Gedamke, R.3    Zhao, W.4    Zhang, D.5    Gozo, S.6
  • 30
    • 23444454671 scopus 로고    scopus 로고
    • Analysis of low level radio- active metabolites in biological fluids using high-performance liquid chromatog- raphy with microplate scintillation counting: method validation and application
    • in press
    • in press. Zhu M., Zhao W., Vazquez N., and Mitroka J.G. Analysis of low level radio- active metabolites in biological fluids using high-performance liquid chromatog- raphy with microplate scintillation counting: method validation and application. J. Pharm. Biomed. Anal. (2005)
    • (2005) J. Pharm. Biomed. Anal.
    • Zhu, M.1    Zhao, W.2    Vazquez, N.3    Mitroka, J.G.4
  • 32
    • 23544462582 scopus 로고
    • Limits for qualitative detection and quantitative determination: application to radiochemistry
    • Currie L.A. Limits for qualitative detection and quantitative determination: application to radiochemistry. Anal. Chem. 40 (1968) 586-593
    • (1968) Anal. Chem. , vol.40 , pp. 586-593
    • Currie, L.A.1
  • 33
    • 0037442578 scopus 로고    scopus 로고
    • On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development
    • Nassar A.-E.F., Bjorge S.M., and Lee D.Y. On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development. Anal. Chem. 75 (2003) 785-790
    • (2003) Anal. Chem. , vol.75 , pp. 785-790
    • Nassar, A.-E.F.1    Bjorge, S.M.2    Lee, D.Y.3
  • 35
    • 0035416421 scopus 로고    scopus 로고
    • Systematic LC/MS metabolite identification in drug discovery
    • Clarke N.J., Rindgen D., Korfmacher W.A., and Cox K. Systematic LC/MS metabolite identification in drug discovery. Anal. Chem. 73 (2001) 431A-439A
    • (2001) Anal. Chem. , vol.73
    • Clarke, N.J.1    Rindgen, D.2    Korfmacher, W.A.3    Cox, K.4


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