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Volumn 33, Issue 1, 2005, Pages 83-93

Metabolism, pharmacokinetics, and protein covalent binding of radiolabeled maxipost (BMS-204352) in humans

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; CARBON 14;

EID: 19944412145     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.001412     Document Type: Article
Times cited : (48)

References (31)
  • 1
    • 0029079316 scopus 로고
    • A structural assignment for a stable acetaldehyde-lysine adduct
    • Braun KP, Cody RB, Jones DR, and Peterson CM (1995) A structural assignment for a stable acetaldehyde-lysine adduct. J Biol Chem 270:11263-11266.
    • (1995) J Biol Chem , vol.270 , pp. 11263-11266
    • Braun, K.P.1    Cody, R.B.2    Jones, D.R.3    Peterson, C.M.4
  • 2
    • 0031127042 scopus 로고    scopus 로고
    • Differential expression of the a and b subunits of large-conductance calcium-activated potassium channel: Implication for channel diversity
    • Chang CP, Dworetzky SI, Wang J, and Goldstein ME (1997) Differential expression of the a and b subunits of large-conductance calcium-activated potassium channel: implication for channel diversity. Mol Brain Res 45:33-40.
    • (1997) Mol Brain Res , vol.45 , pp. 33-40
    • Chang, C.P.1    Dworetzky, S.I.2    Wang, J.3    Goldstein, M.E.4
  • 4
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies B and Morris T (1993) Physiological parameters in laboratory animals and humans. Pharm Res (NY) 10:1993-1996.
    • (1993) Pharm Res (NY) , vol.10 , pp. 1993-1996
    • Davies, B.1    Morris, T.2
  • 5
    • 0033017135 scopus 로고    scopus 로고
    • Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: Involvement of catechols in covalent binding to hepatic proteins
    • Dehal SS and Kupfer D (1999) Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. Drug Metab Dispos 27:681-688.
    • (1999) Drug Metab Dispos , vol.27 , pp. 681-688
    • Dehal, S.S.1    Kupfer, D.2
  • 7
    • 1642281756 scopus 로고    scopus 로고
    • Drug-protein adduces: An industrial perspective on minimizing the potential for drug bioactivation in drug discovery and development
    • Evans DC, Watt AP, Nicoll-Griffith DA, and Baillie TA (2004) Drug-protein adduces: an industrial perspective on minimizing the potential for drug bioactivation in drug discovery and development. Chem Res Toxicol 17:3-16.
    • (2004) Chem Res Toxicol , vol.17 , pp. 3-16
    • Evans, D.C.1    Watt, A.P.2    Nicoll-Griffith, D.A.3    Baillie, T.A.4
  • 8
    • 0000804786 scopus 로고    scopus 로고
    • Safety assessment of BMS-204352, a novel therapeutic agent for the treatment of acute stroke
    • Frantz SW, Srinivas N, Dominick M, Kelly W, Sanderson T, and Schilling B (2000) Safety assessment of BMS-204352, a novel therapeutic agent for the treatment of acute stroke. Eur J Neurol 7 (Suppl 3):110.
    • (2000) Eur J Neurol , vol.7 , Issue.3 SUPPL. , pp. 110
    • Frantz, S.W.1    Srinivas, N.2    Dominick, M.3    Kelly, W.4    Sanderson, T.5    Schilling, B.6
  • 11
    • 0036737540 scopus 로고    scopus 로고
    • Effect of dose and input rate on the brain penetration of BMS-204352 following intravenous administration to rats
    • Krishna R, Palme H, Zeng J, and Srinivas NR (2002a) Effect of dose and input rate on the brain penetration of BMS-204352 following intravenous administration to rats. Biopharm Drug Dispos 23:227-231.
    • (2002) Biopharm Drug Dispos , vol.23 , pp. 227-231
    • Krishna, R.1    Palme, H.2    Zeng, J.3    Srinivas, N.R.4
  • 12
    • 0036740553 scopus 로고    scopus 로고
    • Pharmacokinetics and dose proportionality of BMS-204352 after intraarterial administration to rats
    • Krishna R, Palme H, Zeng J, and Srinivas NR (2002b) Pharmacokinetics and dose proportionality of BMS-204352 after intraarterial administration to rats. Biopharm Drug Dispos 23:233-237.
    • (2002) Biopharm Drug Dispos , vol.23 , pp. 233-237
    • Krishna, R.1    Palme, H.2    Zeng, J.3    Srinivas, N.R.4
  • 13
    • 0036098573 scopus 로고    scopus 로고
    • Pharmacokinetics and dose proportionality of BMS-204352 after intravenous administration to dogs
    • Krishna R, Shah V, Mantha S, Vachharajani N, and Srinivas NR (2002c) Pharmacokinetics and dose proportionality of BMS-204352 after intravenous administration to dogs. Biopharm Drug Dispos 23:83-86.
    • (2002) Biopharm Drug Dispos , vol.23 , pp. 83-86
    • Krishna, R.1    Shah, V.2    Mantha, S.3    Vachharajani, N.4    Srinivas, N.R.5
  • 15
    • 20644465609 scopus 로고    scopus 로고
    • Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: Implications for fluperlapine-induced agranulocytosis
    • Lai WG, Gardner I, Zahid N, and Uetrecht JP (2000) Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: implications for fluperlapine-induced agranulocytosis. Drug Metab Dispos 28:255-263.
    • (2000) Drug Metab Dispos , vol.28 , pp. 255-263
    • Lai, W.G.1    Gardner, I.2    Zahid, N.3    Uetrecht, J.P.4
  • 16
    • 0035996571 scopus 로고    scopus 로고
    • The metabolism and toxicity of quinones, quinonimines, quinone methide and quinone-thioether
    • Monks TJ and Jones DC (2002) The metabolism and toxicity of quinones, quinonimines, quinone methide and quinone-thioether. Curr Drug Metab 3:425-438.
    • (2002) Curr Drug Metab , vol.3 , pp. 425-438
    • Monks, T.J.1    Jones, D.C.2
  • 17
    • 0022536521 scopus 로고
    • Glycosylation accelerates albumin degradation in normal and diabetic dogs
    • Morris MA and Preddy L (1986) Glycosylation accelerates albumin degradation in normal and diabetic dogs. Biochem Med Metab Biol 35:267-270.
    • (1986) Biochem Med Metab Biol , vol.35 , pp. 267-270
    • Morris, M.A.1    Preddy, L.2
  • 18
    • 0030927213 scopus 로고    scopus 로고
    • Protein targets of xenobiotic reactive intermediates
    • Pumford NR and Halmes C (1997) Protein targets of xenobiotic reactive intermediates. Annu Rev Pharmacol Toxicol 37:91-117.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 91-117
    • Pumford, N.R.1    Halmes, C.2
  • 19
    • 0023719903 scopus 로고
    • Non-resolving jaundice: Bilirubin covalently attached to serum albumin circulates with the same metabolic half-life as albumin
    • Reed RG, Davison LK, Burrington CM, and Peters T Jr (1988) Non-resolving jaundice: bilirubin covalently attached to serum albumin circulates with the same metabolic half-life as albumin. Clin Chem 34:1992-1994.
    • (1988) Clin Chem , vol.34 , pp. 1992-1994
    • Reed, R.G.1    Davison, L.K.2    Burrington, C.M.3    Peters Jr., T.4
  • 20
    • 0015239824 scopus 로고
    • The secretion of serum protein and the synthesis of albumin and total protein in regenerating rat liver
    • Schreiber G, Urban J, Zahringer J, Reutter VV, and Frosch U (1970) The secretion of serum protein and the synthesis of albumin and total protein in regenerating rat liver. J Biol Chem 246:4531-4538.
    • (1970) J Biol Chem , vol.246 , pp. 4531-4538
    • Schreiber, G.1    Urban, J.2    Zahringer, J.3    Reutter, V.V.4    Frosch, U.5
  • 21
    • 0035459493 scopus 로고    scopus 로고
    • Enzyme immunoassay for aflatoxin B1-lysine adduct and its validation
    • Sujatha N, Suryakala S, and Rao BS (2001) Enzyme immunoassay for aflatoxin B1-lysine adduct and its validation. J Assoc Off Anal Chem 84:1465-1474.
    • (2001) J Assoc off Anal Chem , vol.84 , pp. 1465-1474
    • Sujatha, N.1    Suryakala, S.2    Rao, B.S.3
  • 22
    • 0027535124 scopus 로고
    • Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonneal. Selective modification of an active-site lysine
    • Szweda LI, Uchida K, Tsai L, and Stadtman ER (1993) Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonneal. Selective modification of an active-site lysine. J Biol Chem 268:3342-3347.
    • (1993) J Biol Chem , vol.268 , pp. 3342-3347
    • Szweda, L.I.1    Uchida, K.2    Tsai, L.3    Stadtman, E.R.4
  • 23
    • 0035819930 scopus 로고    scopus 로고
    • Studies using structural analogs and inbred strain differences to support a role for quinone methide metabolites of butylated hydroxytoluene (BHT) in mouse lung tumor promotion
    • Thompson JA, Carlson TJ, Sun Y, Dwyer-Nield LD, and Malkinson AM (2001) Studies using structural analogs and inbred strain differences to support a role for quinone methide metabolites of butylated hydroxytoluene (BHT) in mouse lung tumor promotion. Toxicology 160:197-205.
    • (2001) Toxicology , vol.160 , pp. 197-205
    • Thompson, J.A.1    Carlson, T.J.2    Sun, Y.3    Dwyer-Nield, L.D.4    Malkinson, A.M.5
  • 24
    • 0026645711 scopus 로고
    • The role of leukocyte-generated metabolites in the pathogenesis of idiosyncratic drug reactions
    • Uetrecht JP (1992) The role of leukocyte-generated metabolites in the pathogenesis of idiosyncratic drug reactions. Drug Metab Rev 24:299-366.
    • (1992) Drug Metab Rev , vol.24 , pp. 299-366
    • Uetrecht, J.P.1
  • 25
    • 0042831348 scopus 로고    scopus 로고
    • Screening for the potential of a drug candidate to cause idiosyncratic drug reactions
    • Uetrecht JP (2003) Screening for the potential of a drug candidate to cause idiosyncratic drug reactions. Drug Discov Today 8:832-837.
    • (2003) Drug Discov Today , vol.8 , pp. 832-837
    • Uetrecht, J.P.1
  • 27
    • 0032735073 scopus 로고    scopus 로고
    • Incidence and occurrence of total (first-ever and recurrent) stroke
    • Williams GR, Jiang JG, Atchar DB, and Samsa GP (1999) Incidence and occurrence of total (first-ever and recurrent) stroke. Stroke 30:2523-2528.
    • (1999) Stroke , vol.30 , pp. 2523-2528
    • Williams, G.R.1    Jiang, J.G.2    Atchar, D.B.3    Samsa, G.P.4
  • 28
    • 0024416367 scopus 로고
    • Mechanisms of 3-methylindole pneumotoxicity
    • Yost GS (1989) Mechanisms of 3-methylindole pneumotoxicity. Chem Res Toxicol 2:273-279.
    • (1989) Chem Res Toxicol , vol.2 , pp. 273-279
    • Yost, G.S.1
  • 29
    • 11144330305 scopus 로고    scopus 로고
    • 14C]BMS-275291 in cryopreserved hepatocytes of mice, rabbits, dogs, monkeys and humans and correlation with in vivo biotransformation in BDC rats
    • 14C]BMS-275291 in cryopreserved hepatocytes of mice, rabbits, dogs, monkeys and humans and correlation with in vivo biotransformation in BDC rats. Drug Metab Rev 32 (Suppl 2):260.
    • (2000) Drug Metab Rev , vol.32 , Issue.2 SUPPL. , pp. 260
    • Zhang, D.L.1    Mitroka, J.2    Bonacorsi Jr., S.3    Gupta, E.4    Kripalani, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.