Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity

Molecular Metabolism

Volumn 2, Issue 4, 2013, Pages 447-456

  Bochkis, Irina Mikhailovna ^a   Shin, Soona ^a   Kaestner, Klaus Hermann ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Aging; Bile acids; Foxa proteins; Hepatic lip genesis; MTOR pathway; Winged helix transcription factors

Indexed keywords

ADIPONECTIN; ALPHA 2 MACROGLOBULIN; BILE ACID; C REACTIVE PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; INTERFERON REGULATORY FACTOR 3; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MESSENGER RNA; STAT3 PROTEIN; STAT5B PROTEIN; TRIACYLGLYCEROL;

ACUTE PHASE RESPONSE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID INDUCED INFLAMMATION; BIOACCUMULATION; CONTROLLED STUDY; DOWN REGULATION; ENERGY EXPENDITURE; ENZYME ACTIVATION; ENZYME REPRESSION; FOOD INTAKE; FOXA2 GENE; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LOSS; HEPATIC LIPOGENESIS; INFLAMMATION; LIPID STORAGE; LIPOGENESIS; MALE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OBESITY; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; WEIGHT GAIN;

MAMMALIA; MUS;

EID: 84889082596     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2013.08.005     Document Type: Article

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