-
2
-
-
0037003892
-
The role of circulating IGF-1: lessons from human and animal models
-
Yakar S., et al. The role of circulating IGF-1: lessons from human and animal models. Endocrine 19 (2002) 239-248
-
(2002)
Endocrine
, vol.19
, pp. 239-248
-
-
Yakar, S.1
-
3
-
-
0035175162
-
Roles of GH and IGF-1 in mouse postnatal growth
-
Lupu F., et al. Roles of GH and IGF-1 in mouse postnatal growth. Dev. Biol. 229 (2001) 141-162
-
(2001)
Dev. Biol.
, vol.229
, pp. 141-162
-
-
Lupu, F.1
-
4
-
-
0030833570
-
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
-
Udy G.B., et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 7239-7244
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 7239-7244
-
-
Udy, G.B.1
-
5
-
-
0000943469
-
STAT5a and STAT5b proteins have essential and nonessential, or redundant, roles in cytokine responses
-
Teglund S., et al. STAT5a and STAT5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93 (1998) 841-850
-
(1998)
Cell
, vol.93
, pp. 841-850
-
-
Teglund, S.1
-
6
-
-
0034878836
-
STAT5b is required for GH-induced liver IGF-1 gene expression
-
Davey H.W., et al. STAT5b is required for GH-induced liver IGF-1 gene expression. Endocrinology 142 (2001) 3836-3841
-
(2001)
Endocrinology
, vol.142
, pp. 3836-3841
-
-
Davey, H.W.1
-
7
-
-
85047681536
-
Growth enhancement in SOCS-2 deficient mice is dependent on STAT5b
-
Greenhalgh C.J., et al. Growth enhancement in SOCS-2 deficient mice is dependent on STAT5b. Mol. Endocrinol. 16 (2002) 1394-1406
-
(2002)
Mol. Endocrinol.
, vol.16
, pp. 1394-1406
-
-
Greenhalgh, C.J.1
-
8
-
-
33947362429
-
Postnatal body growth is dependent on the transcription factors STAT5a/b in muscle: a role for autocrine/paracrine IGF-1
-
Klover P., and Hennighausen L. Postnatal body growth is dependent on the transcription factors STAT5a/b in muscle: a role for autocrine/paracrine IGF-1. Endocrinology 148 (2007) 1489-1497
-
(2007)
Endocrinology
, vol.148
, pp. 1489-1497
-
-
Klover, P.1
Hennighausen, L.2
-
9
-
-
0037590103
-
Acute control of IGF-1 gene transcription by GH through STAT5b
-
Woelfle J., et al. Acute control of IGF-1 gene transcription by GH through STAT5b. J. Biol. Chem. 278 (2003) 22696-22702
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22696-22702
-
-
Woelfle, J.1
-
10
-
-
0346435095
-
Mechanisms of GH action. Identification of conserved STAT5 binding sites that mediate GH-induced IGF-1 gene activation
-
Woelfle J., et al. Mechanisms of GH action. Identification of conserved STAT5 binding sites that mediate GH-induced IGF-1 gene activation. J. Biol. Chem. 278 (2003) 51261-51266
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 51261-51266
-
-
Woelfle, J.1
-
11
-
-
0141567775
-
GH insensitivity associated with STAT5b mutation
-
Kofoed E.M., et al. GH insensitivity associated with STAT5b mutation. N. Engl. J. Med. 349 (2003) 1139-1147
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1139-1147
-
-
Kofoed, E.M.1
-
12
-
-
12644257576
-
A mammalian model for Laron syndrome produced by targeted disruption of the mouse GH receptor/binding protein gene
-
Zhou Y., et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse GH receptor/binding protein gene. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 13215-13220
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 13215-13220
-
-
Zhou, Y.1
-
13
-
-
19944417551
-
In vivo analysis of GH receptor signaling domains and their associated transcripts
-
Rowland J.E., et al. In vivo analysis of GH receptor signaling domains and their associated transcripts. Mol. Cell. Biol. 25 (2005) 66-77
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 66-77
-
-
Rowland, J.E.1
-
14
-
-
27844510453
-
Heterozygote effects in mice with partial truncations in the GH receptor cytoplasmic domain: assessment of growth parameters and phenotype
-
Rowland J.E., et al. Heterozygote effects in mice with partial truncations in the GH receptor cytoplasmic domain: assessment of growth parameters and phenotype. Endocrinology 146 (2005) 5278-5286
-
(2005)
Endocrinology
, vol.146
, pp. 5278-5286
-
-
Rowland, J.E.1
-
15
-
-
0029752754
-
The hepatocyte nuclear factor 3beta stimulates the transcription of the human IGF-1 gene in a direct and indirect manner
-
Nolten L.A., et al. The hepatocyte nuclear factor 3beta stimulates the transcription of the human IGF-1 gene in a direct and indirect manner. J. Biol. Chem. 271 (1996) 31846-31854
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31846-31854
-
-
Nolten, L.A.1
-
16
-
-
18244432009
-
JAK2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
-
Neubauer H., et al. JAK2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93 (1998) 397-409
-
(1998)
Cell
, vol.93
, pp. 397-409
-
-
Neubauer, H.1
-
17
-
-
34249070257
-
Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression
-
Engblom D., et al. Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev. 21 (2007) 1157-1162
-
(2007)
Genes Dev.
, vol.21
, pp. 1157-1162
-
-
Engblom, D.1
-
18
-
-
0027455584
-
GH deficiency in "little" mice results in abberant body composition, reduced IGF-1 and IGFBP-3, but does not affect IGFBP-2, -1 or -4
-
Donahue L.R., and Beamer W.G. GH deficiency in "little" mice results in abberant body composition, reduced IGF-1 and IGFBP-3, but does not affect IGFBP-2, -1 or -4. J. Endocrinol. 136 (1993) 91-104
-
(1993)
J. Endocrinol.
, vol.136
, pp. 91-104
-
-
Donahue, L.R.1
Beamer, W.G.2
-
19
-
-
0033372801
-
Characterization of hepatic CYP450 isozyme composition in the transgenic rat expressing low level of human GH
-
Takahashi J., et al. Characterization of hepatic CYP450 isozyme composition in the transgenic rat expressing low level of human GH. Xenobiotica 29 (1999) 1203-1212
-
(1999)
Xenobiotica
, vol.29
, pp. 1203-1212
-
-
Takahashi, J.1
-
20
-
-
33748747698
-
Clinical and biochemical characteristics of a male patient with a novel homozygous STAT5b mutation
-
Vidarsdottir S., et al. Clinical and biochemical characteristics of a male patient with a novel homozygous STAT5b mutation. J. Clin. Endocrinol. Metab. 91 (2006) 3482-3485
-
(2006)
J. Clin. Endocrinol. Metab.
, vol.91
, pp. 3482-3485
-
-
Vidarsdottir, S.1
-
21
-
-
34548321210
-
Loss of STAT5 leads to hepatosteatosis and impaired liver regeneration
-
Cui Y., et al. Loss of STAT5 leads to hepatosteatosis and impaired liver regeneration. Hepatology 46 (2007) 504-513
-
(2007)
Hepatology
, vol.46
, pp. 504-513
-
-
Cui, Y.1
-
22
-
-
0027510448
-
Human GH and human aging
-
Corpas E., et al. Human GH and human aging. Endocr. Rev. 14 (1993) 20-39
-
(1993)
Endocr. Rev.
, vol.14
, pp. 20-39
-
-
Corpas, E.1
-
23
-
-
33745196434
-
Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity)
-
Laron Z., et al. Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity). Clin. Endocrinol. (Oxf.) 65 (2006) 114-117
-
(2006)
Clin. Endocrinol. (Oxf.)
, vol.65
, pp. 114-117
-
-
Laron, Z.1
-
24
-
-
0041965899
-
Bovine GH-transgenic mice have major alterations in hepatic expression of metabolic genes
-
Olsson B., et al. Bovine GH-transgenic mice have major alterations in hepatic expression of metabolic genes. Am. J. Physiol. Endocrinol. Metab. 285 (2003) E504-E511
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.285
-
-
Olsson, B.1
-
25
-
-
23244434592
-
Exploring hepatic hormone actions using a compilation of gene expression profiles
-
Stahlberg N., et al. Exploring hepatic hormone actions using a compilation of gene expression profiles. BMC Physiol. 5 (2005) 1-17
-
(2005)
BMC Physiol.
, vol.5
, pp. 1-17
-
-
Stahlberg, N.1
-
26
-
-
0034967001
-
Microarray analysis of the in vivo effects of hypophysectomay and GH treatment on gene expression in the rat
-
Flores-Morales A., et al. Microarray analysis of the in vivo effects of hypophysectomay and GH treatment on gene expression in the rat. Endocrinology 142 (2001) 3163-3176
-
(2001)
Endocrinology
, vol.142
, pp. 3163-3176
-
-
Flores-Morales, A.1
-
27
-
-
0035122576
-
Gene expression profile of the aging process in rat liver: normalizing effects of GH replacement
-
Tollet-Egnell P., et al. Gene expression profile of the aging process in rat liver: normalizing effects of GH replacement. Mol. Endocrinol. 15 (2001) 308-318
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 308-318
-
-
Tollet-Egnell, P.1
-
28
-
-
1442282945
-
GH-mediated alteration of fuel metabolism in the aged rat as determined from transcript profiles
-
Tollet-Egnell P., et al. GH-mediated alteration of fuel metabolism in the aged rat as determined from transcript profiles. Physiol. Genomics 16 (2004) 261-267
-
(2004)
Physiol. Genomics
, vol.16
, pp. 261-267
-
-
Tollet-Egnell, P.1
-
29
-
-
7644237617
-
Effects of GH on mRNA levels of uncoupling proteins 1, 2 and 3 in brown and white adipose tissues and skeletal muscle in obese mice
-
Hioki C., et al. Effects of GH on mRNA levels of uncoupling proteins 1, 2 and 3 in brown and white adipose tissues and skeletal muscle in obese mice. Horm. Res. 36 (2004) 607-613
-
(2004)
Horm. Res.
, vol.36
, pp. 607-613
-
-
Hioki, C.1
-
30
-
-
0033575871
-
Stimulation of lipolysis but not of leptin release by GH is abolished in adipose tissue from STAT5a and b knockout mice
-
Fain J.N., et al. Stimulation of lipolysis but not of leptin release by GH is abolished in adipose tissue from STAT5a and b knockout mice. Biochem. Biophys. Res. Commun. 263 (1999) 201-205
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.263
, pp. 201-205
-
-
Fain, J.N.1
-
31
-
-
33744497029
-
Sex dependent liver gene expression is extensive and largely dependent on STAT5b: STAT5b dependent activation of male genes and repression of female genes revealed by microarray analysis
-
Clodfelter K.H., et al. Sex dependent liver gene expression is extensive and largely dependent on STAT5b: STAT5b dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol. Endocrinol. 20 (2006) 1333-1351
-
(2006)
Mol. Endocrinol.
, vol.20
, pp. 1333-1351
-
-
Clodfelter, K.H.1
-
32
-
-
21344434092
-
The regulation of fatty acid synthase by STAT5a
-
Hogan J.C., and Stephens J.M. The regulation of fatty acid synthase by STAT5a. Diabetes 54 (2005) 1968-1975
-
(2005)
Diabetes
, vol.54
, pp. 1968-1975
-
-
Hogan, J.C.1
Stephens, J.M.2
-
33
-
-
0035465178
-
Transcriptional regulation of fatty acid synthase gene by somatotropin in 3T3-F442A adipocytes
-
Yin D., et al. Transcriptional regulation of fatty acid synthase gene by somatotropin in 3T3-F442A adipocytes. J. Anim. Sci. 79 (2001) 2336-2345
-
(2001)
J. Anim. Sci.
, vol.79
, pp. 2336-2345
-
-
Yin, D.1
-
34
-
-
37349077360
-
The STAT5a mediated induction of PDK4 expression by prolactin or GH in adipocytes
-
White U.A., et al. The STAT5a mediated induction of PDK4 expression by prolactin or GH in adipocytes. Diabetes 56 (2007) 1638-1646
-
(2007)
Diabetes
, vol.56
, pp. 1638-1646
-
-
White, U.A.1
-
35
-
-
33646710890
-
Sex and the liver-a journey through five decades
-
Mode A., and Gustafsson J.-A. Sex and the liver-a journey through five decades. Drug Metab. Rev. 38 (2006) 197-207
-
(2006)
Drug Metab. Rev.
, vol.38
, pp. 197-207
-
-
Mode, A.1
Gustafsson, J.-A.2
-
36
-
-
17644408362
-
Sexual dimorphism in mammalian gene expression
-
Rinn J.L., and Snyder M. Sexual dimorphism in mammalian gene expression. Trends Genet. 21 (2005) 298-305
-
(2005)
Trends Genet.
, vol.21
, pp. 298-305
-
-
Rinn, J.L.1
Snyder, M.2
-
37
-
-
1542357569
-
sexual dimorphism of rat liver gene expression: regulatory role of GH revealed by DNA microarray analysis
-
Ahluwalia A., et al. sexual dimorphism of rat liver gene expression: regulatory role of GH revealed by DNA microarray analysis. Mol. Endocrinol. 18 (2004) 747-760
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 747-760
-
-
Ahluwalia, A.1
-
38
-
-
33744456856
-
Growth hormone regulation of sex-dependent liver gene expression
-
Waxman D.J., and O'Connor C. Growth hormone regulation of sex-dependent liver gene expression. Mol. Endocrinol. 20 (2006) 2613-2629
-
(2006)
Mol. Endocrinol.
, vol.20
, pp. 2613-2629
-
-
Waxman, D.J.1
O'Connor, C.2
-
39
-
-
0034750031
-
Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity
-
Tannenbaum G.S., et al. Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity. Endocrinology 142 (2001) 4595-4598
-
(2001)
Endocrinology
, vol.142
, pp. 4595-4598
-
-
Tannenbaum, G.S.1
-
40
-
-
0035900726
-
Inhibitory cross-talk between STAT5b and liver HGNF3beta: impact on the regulation of GH pulse stimulated male-specific liver cytochrome P-450 gene expression
-
Park S.H., and Waxman D.J. Inhibitory cross-talk between STAT5b and liver HGNF3beta: impact on the regulation of GH pulse stimulated male-specific liver cytochrome P-450 gene expression. J. Biol. Chem. 276 (2001) 43031-43039
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 43031-43039
-
-
Park, S.H.1
Waxman, D.J.2
-
41
-
-
33344457703
-
Co-dependence of GH-responsive, sexually dimorphic hepatic gene expression on STAT5b and HNF4α
-
Holloway M.G., et al. Co-dependence of GH-responsive, sexually dimorphic hepatic gene expression on STAT5b and HNF4α. Mol. Endocrinol. 20 (2006) 647-660
-
(2006)
Mol. Endocrinol.
, vol.20
, pp. 647-660
-
-
Holloway, M.G.1
-
42
-
-
34249795488
-
Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus
-
Holloway M.G., et al. Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus. Endocrinology 148 (2007) 1977-1988
-
(2007)
Endocrinology
, vol.148
, pp. 1977-1988
-
-
Holloway, M.G.1
-
43
-
-
0033548431
-
Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption
-
Park S.H., et al. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption. J. Biol. Chem. 274 (1999) 7421-7430
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7421-7430
-
-
Park, S.H.1
-
44
-
-
12744261279
-
Sexual dimorphism of rat liver nuclear proteins: regulatory role of GH
-
Laz E.V., et al. Sexual dimorphism of rat liver nuclear proteins: regulatory role of GH. Mol. Cell. Proteomics 3 (2004) 1170-1180
-
(2004)
Mol. Cell. Proteomics
, vol.3
, pp. 1170-1180
-
-
Laz, E.V.1
-
45
-
-
0034457934
-
Plasma GH pulse activation of hepatic JAK-STAT5 signaling: developmental regulation and role in male-specific liver gene expression
-
Choi H.K., and Waxman D.J. Plasma GH pulse activation of hepatic JAK-STAT5 signaling: developmental regulation and role in male-specific liver gene expression. Endocrinology 141 (2000) 3245-3255
-
(2000)
Endocrinology
, vol.141
, pp. 3245-3255
-
-
Choi, H.K.1
Waxman, D.J.2
-
46
-
-
3142765079
-
Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice
-
Wiwi C.A., et al. Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. Mol. Endocrinol. 18 (2004) 1975-1987
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 1975-1987
-
-
Wiwi, C.A.1
-
47
-
-
0034602408
-
Synergistic action of hepatic nuclear factors 3- and 6 on CYP2C12 gene expression and suppression by GH activated STAT5b
-
Delesque-Touchard N., et al. Synergistic action of hepatic nuclear factors 3- and 6 on CYP2C12 gene expression and suppression by GH activated STAT5b. J. Biol. Chem. 275 (2000) 34173-34182
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34173-34182
-
-
Delesque-Touchard, N.1
-
48
-
-
33846170496
-
In vivo transfection of rat liver discloses NF1 and HNF6 binding sites as enhancers of GH-dependent and female-specific gene expression
-
Gardmo C., and Mode A. In vivo transfection of rat liver discloses NF1 and HNF6 binding sites as enhancers of GH-dependent and female-specific gene expression. J. Mol. Endocrinol. 37 (2007) 433-441
-
(2007)
J. Mol. Endocrinol.
, vol.37
, pp. 433-441
-
-
Gardmo, C.1
Mode, A.2
-
49
-
-
33846030792
-
In vivo transcript profiling and phylogenetic analysis identifies SOCS2 as a direct STAT5b target in liver
-
Vidal O.M., et al. In vivo transcript profiling and phylogenetic analysis identifies SOCS2 as a direct STAT5b target in liver. Mol. Endocrinol. 21 (2007) 293-311
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 293-311
-
-
Vidal, O.M.1
-
50
-
-
0028796473
-
Early responses of trans-activating factors to GH in preadipocytes: differential regulation of CCAAT enhancer-binding protein-β and C/EBPδ
-
Clarkson R.W., et al. Early responses of trans-activating factors to GH in preadipocytes: differential regulation of CCAAT enhancer-binding protein-β and C/EBPδ. Mol. Endocrinol. 9 (1994) 108-121
-
(1994)
Mol. Endocrinol.
, vol.9
, pp. 108-121
-
-
Clarkson, R.W.1
-
51
-
-
33846213670
-
Multiple mechanisms of GH-regulated gene transcription
-
Cesena T.I., et al. Multiple mechanisms of GH-regulated gene transcription. Mol. Genet. Metab. 90 (2007) 126-133
-
(2007)
Mol. Genet. Metab.
, vol.90
, pp. 126-133
-
-
Cesena, T.I.1
-
53
-
-
0033744098
-
Te biology of somatotropin in adipose tissue growth and nutrient partitioning
-
Etherton T.D. Te biology of somatotropin in adipose tissue growth and nutrient partitioning. J. Nutr. 130 (2000) 2623-2625
-
(2000)
J. Nutr.
, vol.130
, pp. 2623-2625
-
-
Etherton, T.D.1
-
54
-
-
27844456448
-
Control of reproductive processes by growth hormone
-
Sirotkin A.V. Control of reproductive processes by growth hormone. Vet. J. 170 (2005) 307-317
-
(2005)
Vet. J.
, vol.170
, pp. 307-317
-
-
Sirotkin, A.V.1
-
55
-
-
33745218966
-
Beginning to end: cardiovascular implications of GH deficiency and GH therapy
-
Colao A., et al. Beginning to end: cardiovascular implications of GH deficiency and GH therapy. Growth Horm. IGF Res. 16 (2006) S41-S48
-
(2006)
Growth Horm. IGF Res.
, vol.16
-
-
Colao, A.1
-
57
-
-
13444263767
-
Effect of GH on the immune system
-
Meazza C., et al. Effect of GH on the immune system. Paediatr Endocrinol Rev 1 Suppl. 3 (2004) 490-495
-
(2004)
Paediatr Endocrinol Rev
, vol.1
, Issue.SUPPL. 3
, pp. 490-495
-
-
Meazza, C.1
-
58
-
-
31544443260
-
The role of GH in neural development
-
Scheepens A., et al. The role of GH in neural development. Horm. Res. 64 Suppl. 3 (2005) 66-72
-
(2005)
Horm. Res.
, vol.64
, Issue.SUPPL. 3
, pp. 66-72
-
-
Scheepens, A.1
-
60
-
-
33845609734
-
Inhibition of estrogen-independent mammary carcinogenesis by disruption of GH signaling
-
Zhang X., et al. Inhibition of estrogen-independent mammary carcinogenesis by disruption of GH signaling. Carcinogenesis 28 (2007) 143-150
-
(2007)
Carcinogenesis
, vol.28
, pp. 143-150
-
-
Zhang, X.1
-
61
-
-
0035122576
-
Gene expression profile of the aging process in rat liver: normalizing effects of GH treatment
-
Tollet-Egnell P., et al. Gene expression profile of the aging process in rat liver: normalizing effects of GH treatment. Mol. Endocrinol. 15 (2001) 308-318
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 308-318
-
-
Tollet-Egnell, P.1
-
62
-
-
0348112531
-
Interpulse GH secretion in the episodic plasma profile causes the sex reversal of CYP450s in senescent male rats
-
Dhir R.N., and Shapiro B.H. Interpulse GH secretion in the episodic plasma profile causes the sex reversal of CYP450s in senescent male rats. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 15224-15228
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 15224-15228
-
-
Dhir, R.N.1
Shapiro, B.H.2
|