메뉴 건너뛰기




Volumn 14, Issue 16, 2013, Pages 2067-2083

Genetics of antipsychotic-induced weight gain: Update and current perspectives

Author keywords

antipsychotic; genetics; metabolic syndrome; personalized medicine; weight gain

Indexed keywords

ADENYLATE KINASE; ADIPONECTIN; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 3A ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; GHRELIN; HISTAMINE H1 RECEPTOR; NEUROLEPTIC AGENT; NUCLEAR FACTOR Y; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; SEROTONIN 2C RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84889022770     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.13.207     Document Type: Review
Times cited : (34)

References (132)
  • 1
    • 85027939301 scopus 로고    scopus 로고
    • Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics
    • Liou YJ, Bai YM, Lin E et al. Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics. Pharmacogenomics J. 12(1), 54-61 (2012).
    • (2012) Pharmacogenomics J. , vol.12 , Issue.1 , pp. 54-61
    • Liou, Y.J.1    Bai, Y.M.2    Lin, E.3
  • 2
    • 79960752412 scopus 로고    scopus 로고
    • Pharmacogenetics of leptin in antipsychotic-associated weight gain and obesity-related complications
    • Lee AK, Bishop JR. Pharmacogenetics of leptin in antipsychotic-associated weight gain and obesity-related complications. Pharmacogenomics 12(7), 999-1016 (2011).
    • (2011) Pharmacogenomics , vol.12 , Issue.7 , pp. 999-1016
    • Lee, A.K.1    Bishop, J.R.2
  • 3
    • 0642369863 scopus 로고    scopus 로고
    • The National Cholesterol Education Program Adult Treatment Panel III guidelines
    • Lipsy RJ. The National Cholesterol Education Program Adult Treatment Panel III guidelines. J. Manag. Care Pharm. 9(1 Suppl.), S2-S5 (2003).
    • (2003) J. Manag. Care Pharm. , vol.9 , Issue.1 SUPPL.
    • Lipsy, R.J.1
  • 4
    • 16644374783 scopus 로고    scopus 로고
    • Schizophrenia and obesity: Impact of antipsychotic medications
    • Wirshing DA. Schizophrenia and obesity: impact of antipsychotic medications. J. Clin. Psychiatry 65(Suppl. 18), S13-S26 (2004).
    • (2004) J. Clin. Psychiatry , vol.65 , Issue.SUPPL. 18
    • Wirshing, D.A.1
  • 5
    • 84869995013 scopus 로고    scopus 로고
    • Strengths and weaknesses of pharmacogenetic studies of antipsychotic drugs: The potential value of the PEPs study
    • Mas S, Llerena A, Saiz J, Bernardo M, Lafuente A. Strengths and weaknesses of pharmacogenetic studies of antipsychotic drugs: the potential value of the PEPs study. Pharmacogenomics 13(15), 1773-1782 (2012).
    • (2012) Pharmacogenomics , vol.13 , Issue.15 , pp. 1773-1782
    • Mas, S.1    Llerena, A.2    Saiz, J.3    Bernardo, M.4    Lafuente, A.5
  • 6
    • 84872877090 scopus 로고    scopus 로고
    • History of the discovery of the antipsychotic dopamine D2 receptor: A basis for the dopamine hypothesis of schizophrenia
    • Madras BK. History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia. J. Hist. Neurosci. 22(1), 62-78 (2013).
    • (2013) J. Hist. Neurosci. , vol.22 , Issue.1 , pp. 62-78
    • Madras, B.K.1
  • 8
    • 33748998982 scopus 로고    scopus 로고
    • Genetics of antipsychotic treatment emergent weight gain in schizophrenia
    • Müller DJ, Kennedy JL. Genetics of antipsychotic treatment emergent weight gain in schizophrenia. Pharmacogenomics 7(6), 863-887 (2006).
    • (2006) Pharmacogenomics , vol.7 , Issue.6 , pp. 863-887
    • Müller, D.J.1    Kennedy, J.L.2
  • 9
    • 0035094264 scopus 로고    scopus 로고
    • Does fast dissociation from the dopamine D(2) receptor explain the action of atypical antipsychotics?: A new hypothesis
    • Kapur S, Seeman P. Does fast dissociation from the dopamine D(2) receptor explain the action of atypical antipsychotics?: A new hypothesis. Am. J. Psychiatry 158(3), 360-369 (2001).
    • (2001) Am. J. Psychiatry , vol.158 , Issue.3 , pp. 360-369
    • Kapur, S.1    Seeman, P.2
  • 10
    • 80051737051 scopus 로고    scopus 로고
    • Pharmacogenetic testing to predict antipsychotic-induced weight gain: A systematic review
    • Risselada AJ, Mulder H, Heerdink ER, Egberts TC. Pharmacogenetic testing to predict antipsychotic-induced weight gain: a systematic review. Pharmacogenomics 12(8), 1213-1227 (2011).
    • (2011) Pharmacogenomics , vol.12 , Issue.8 , pp. 1213-1227
    • Risselada, A.J.1    Mulder, H.2    Heerdink, E.R.3    Egberts, T.C.4
  • 11
    • 72149090641 scopus 로고    scopus 로고
    • Metabolic side effects of antipsychotic drug treatment-pharmacological mechanisms
    • Reynolds GP, Kirk SL. Metabolic side effects of antipsychotic drug treatment-pharmacological mechanisms. Pharmacol. Ther. 125(1), 169-179 (2010).
    • (2010) Pharmacol. Ther. , vol.125 , Issue.1 , pp. 169-179
    • Reynolds, G.P.1    Kirk, S.L.2
  • 12
    • 77749258320 scopus 로고    scopus 로고
    • Body weight gain induced by atypical antipsychotics: An extension of the monozygotic twin and sib pair study
    • Gebhardt S, Theisen FM, Haberhausen M et al. Body weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair study. J. Clin. Pharm. Ther. 35(2), 207-211 (2010).
    • (2010) J. Clin. Pharm. Ther. , vol.35 , Issue.2 , pp. 207-211
    • Gebhardt, S.1    Theisen, F.M.2    Haberhausen, M.3
  • 13
    • 0031593556 scopus 로고    scopus 로고
    • 5-HT2A receptor blockade in patients with schizophrenia treated with risperidone or clozapine. A SPET study using the novel 5-HT2A ligand 123I-5-I-R-91150
    • Travis MJ, Busatto GF, Pilowsky LS et al. 5-HT2A receptor blockade in patients with schizophrenia treated with risperidone or clozapine. A SPET study using the novel 5-HT2A ligand 123I-5-I-R-91150. Br. J. Psychiatry: J. Ment. Sci. 173, 236-241 (1998).
    • (1998) Br. J. Psychiatry: J. Ment. Sci. , vol.173 , pp. 236-241
    • Travis, M.J.1    Busatto, G.F.2    Pilowsky, L.S.3
  • 14
  • 15
    • 84865822927 scopus 로고    scopus 로고
    • Pharmacogenetic aspects of antipsychotic drug-induced weight gain-a critical review
    • Reynolds GP. Pharmacogenetic aspects of antipsychotic drug-induced weight gain-a critical review. Clin. Psychopharmacol. Neurosci. 10(2), 71-77 (2012).
    • (2012) Clin. Psychopharmacol. Neurosci. , vol.10 , Issue.2 , pp. 71-77
    • Reynolds, G.P.1
  • 16
    • 84862869593 scopus 로고    scopus 로고
    • Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism
    • Vauquelin G, Bostoen S, Vanderheyden P, Seeman P. Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism. Naunyn Schmiedebergs Arch. Pharmacol. 385(4), 337-372 (2012).
    • (2012) Naunyn Schmiedebergs Arch. Pharmacol. , vol.385 , Issue.4 , pp. 337-372
    • Vauquelin, G.1    Bostoen, S.2    Vanderheyden, P.3    Seeman, P.4
  • 17
    • 84858996108 scopus 로고    scopus 로고
    • Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain
    • Müller DJ, Zai CC, Sicard M et al. Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain. Pharmacogenomics 12(2), 156-164 (2012).
    • (2012) Pharmacogenomics , vol.12 , Issue.2 , pp. 156-164
    • Müller, D.J.1    Zai, C.C.2    Sicard, M.3
  • 18
    • 84872285361 scopus 로고    scopus 로고
    • Serotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: From receptor heterodimers to postsynaptic scaffolding and effector proteins
    • De Bartolomeis A, Buonaguro EF, Iasevoli F. Serotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins. Psychopharmacology 225(1), 1-19 (2013).
    • (2013) Psychopharmacology , vol.225 , Issue.1 , pp. 1-19
    • De Bartolomeis, A.1    Buonaguro, E.F.2    Iasevoli, F.3
  • 20
    • 84865743042 scopus 로고    scopus 로고
    • Pharmacogenomic associations with weight gain in olanzapine treatment of patients without schizophrenia
    • Houston JP, Kohler J, Bishop JR et al. Pharmacogenomic associations with weight gain in olanzapine treatment of patients without schizophrenia. J. Clin. Psychiatry 73(8), 1077-1086 (2012).
    • (2012) J. Clin. Psychiatry , vol.73 , Issue.8 , pp. 1077-1086
    • Houston, J.P.1    Kohler, J.2    Bishop, J.R.3
  • 21
  • 22
    • 0037320652 scopus 로고    scopus 로고
    • Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor
    • Duan J, Wainwright MS, Comeron JM et al. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum. Mol. Genet. 12(3), 205-216 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , Issue.3 , pp. 205-216
    • Duan, J.1    Wainwright, M.S.2    Comeron, J.M.3
  • 23
    • 70349102541 scopus 로고    scopus 로고
    • C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity
    • Hirvonen MM, Laakso A, Nagren K, Rinne JO, Pohjalainen T, Hietala J. C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity. Synapse 63(10), 907-912 (2009).
    • (2009) Synapse , vol.63 , Issue.10 , pp. 907-912
    • Hirvonen, M.M.1    Laakso, A.2    Nagren, K.3    Rinne, J.O.4    Pohjalainen, T.5    Hietala, J.6
  • 24
    • 78649711976 scopus 로고    scopus 로고
    • Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: An update and meta-analysis
    • Sicard MN, Zai CC, Tiwari AK et al. Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis. Pharmacogenomics 11(11), 1561-1571 (2010).
    • (2010) Pharmacogenomics , vol.11 , Issue.11 , pp. 1561-1571
    • Sicard, M.N.1    Zai, C.C.2    Tiwari, A.K.3
  • 25
    • 80053377815 scopus 로고    scopus 로고
    • Genetic predictors of antipsychotic-induced weight gain: A case-matched multi-gene study
    • Wu R, Zhao J, Shao P, Ou J, Chang M. Genetic predictors of antipsychotic-induced weight gain: a case-matched multi-gene study. Zhong Nan Da Xue Xue Bao Yi Xue Ban 36(8), 720-723 (2011).
    • (2011) Zhong Nan da Xue Xue Bao Yi Xue Ban , vol.36 , Issue.8 , pp. 720-723
    • Wu, R.1    Zhao, J.2    Shao, P.3    Ou, J.4    Chang, M.5
  • 26
    • 79959436585 scopus 로고    scopus 로고
    • Polymorphisms of the LEP LEPR and HTR2C gene: Obesity and BMI change in patients using antipsychotic medication in a naturalistic setting
    • Gregoor JG, van der Weide J, Loovers HM, van Megen HJ, Egberts TC, Heerdink ER. Polymorphisms of the LEP, LEPR and HTR2C gene: obesity and BMI change in patients using antipsychotic medication in a naturalistic setting. Pharmacogenomics 12(6), 919-923 (2011).
    • (2011) Pharmacogenomics , vol.12 , Issue.6 , pp. 919-923
    • Gregoor, J.G.1    Van Der Weide, J.2    Loovers, H.M.3    Van Megen, H.J.4    Egberts, T.C.5    Heerdink, E.R.6
  • 27
    • 80053310917 scopus 로고    scopus 로고
    • Genetic polymorphisms in the HTR2C and peroxisome proliferator-activated receptors are not associated with metabolic syndrome in patients with schizophrenia taking clozapine
    • Kang SH, Lee JI, Chang AK, Joo YH, Kim CY, Kim SY. Genetic polymorphisms in the HTR2C and peroxisome proliferator-activated receptors are not associated with metabolic syndrome in patients with schizophrenia taking clozapine. Psychiatry Investig. 8(3), 262-268 (2011).
    • (2011) Psychiatry Investig. , vol.8 , Issue.3 , pp. 262-268
    • Kang, S.H.1    Lee, J.I.2    Chang, A.K.3    Joo, Y.H.4    Kim, C.Y.5    Kim, S.Y.6
  • 28
    • 84856209453 scopus 로고    scopus 로고
    • Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: A replication study
    • Risselada AJ, Vehof J, Bruggeman R et al. Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study. Pharmacogenomics J. 12(1), 62-67 (2012).
    • (2012) Pharmacogenomics J. , vol.12 , Issue.1 , pp. 62-67
    • Risselada, A.J.1    Vehof, J.2    Bruggeman, R.3
  • 29
    • 62649090828 scopus 로고    scopus 로고
    • HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: A replication study
    • Mulder H, Cohen D, Scheffer H et al. HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study. J. Clin. Psychopharmacol. 29(1), 16-20 (2009).
    • (2009) J. Clin. Psychopharmacol. , vol.29 , Issue.1 , pp. 16-20
    • Mulder, H.1    Cohen, D.2    Scheffer, H.3
  • 30
    • 34447506214 scopus 로고    scopus 로고
    • The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia
    • Mulder H, Franke B, van der-Beek van der AA et al. The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia. J. Clin. Psychopharmacol. 27(4), 338-343 (2007).
    • (2007) J. Clin. Psychopharmacol. , vol.27 , Issue.4 , pp. 338-343
    • Mulder, H.1    Franke, B.2    Van Der-Beek Van Der, A.A.3
  • 31
    • 34247547428 scopus 로고    scopus 로고
    • 5-HT2C receptor gene polymorphisms associated with antipsychotic drug action alter promoter activity
    • Hill MJ, Reynolds GP. 5-HT2C receptor gene polymorphisms associated with antipsychotic drug action alter promoter activity. Brain Res. 1149, 14-17 (2007).
    • (2007) Brain Res. , vol.1149 , pp. 14-17
    • Hill, M.J.1    Reynolds, G.P.2
  • 32
    • 79957661982 scopus 로고    scopus 로고
    • Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain
    • Hill MJ, Reynolds GP. Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain. Pharmacogenomics 12(5), 727-734 (2011).
    • (2011) Pharmacogenomics , vol.12 , Issue.5 , pp. 727-734
    • Hill, M.J.1    Reynolds, G.P.2
  • 33
    • 84884211324 scopus 로고    scopus 로고
    • Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population
    • Almoguera B, Riveiro-Alvarez R, Lopez-Castroman J et al. Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population. Pharmacogenomics J. 13(2), 197-204 (2013).
    • (2013) Pharmacogenomics J. , vol.13 , Issue.2 , pp. 197-204
    • Almoguera, B.1    Riveiro-Alvarez, R.2    Lopez-Castroman, J.3
  • 34
    • 80052263865 scopus 로고    scopus 로고
    • Genetic interactions in the adrenergic system genes: Analysis of antipsychotic-induced weight gain
    • Luca VD, Souza RP, Viggiano E et al. Genetic interactions in the adrenergic system genes: analysis of antipsychotic-induced weight gain. Hum. Psychopharmacol. 26(6), 386-391 (2011).
    • (2011) Hum. Psychopharmacol. , vol.26 , Issue.6 , pp. 386-391
    • Luca, V.D.1    Souza, R.P.2    Viggiano, E.3
  • 35
    • 84862842896 scopus 로고    scopus 로고
    • Possible impact of ADRB3 Trp64Arg polymorphism on BMI in patients with schizophrenia
    • Sasayama D, Hori H, Teraishi T et al. Possible impact of ADRB3 Trp64Arg polymorphism on BMI in patients with schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 38(2), 341-344 (2012).
    • (2012) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.38 , Issue.2 , pp. 341-344
    • Sasayama, D.1    Hori, H.2    Teraishi, T.3
  • 36
    • 84862687967 scopus 로고    scopus 로고
    • Cardiovascular side-effects of antipsychotic drugs: The role of the autonomic nervous system
    • Leung JY, Barr AM, Procyshyn RM, Honer WG, Pang CC. Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous system. Pharmacol. Ther. 135(2), 113-122 (2012).
    • (2012) Pharmacol. Ther. , vol.135 , Issue.2 , pp. 113-122
    • Leung, J.Y.1    Barr, A.M.2    Procyshyn, R.M.3    Honer, W.G.4    Pang, C.C.5
  • 37
    • 0034785813 scopus 로고    scopus 로고
    • Genetic dissection of atypical antipsychotic-induced weight gain: Novel preliminary data on the pharmacogenetic puzzle
    • Basile VS, Masellis M, McIntyre RS, Meltzer HY, Lieberman JA, Kennedy JL. Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle. J. Clin. Psychiatry 62(Suppl. 23), S45-S66 (2001).
    • (2001) J. Clin. Psychiatry , vol.62 , Issue.SUPPL. 23
    • Basile, V.S.1    Masellis, M.2    McIntyre, R.S.3    Meltzer, H.Y.4    Lieberman, J.A.5    Kennedy, J.L.6
  • 38
    • 52649105994 scopus 로고    scopus 로고
    • Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: A cohort study
    • Ujike H, Nomura A, Morita Y et al. Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. J. Clin. Psychiatry 69(9), 1416-1422 (2008).
    • (2008) J. Clin. Psychiatry , vol.69 , Issue.9 , pp. 1416-1422
    • Ujike, H.1    Nomura, A.2    Morita, Y.3
  • 39
    • 79961231465 scopus 로고    scopus 로고
    • A double blind, placebo-controlled, randomized crossover study of the acute metabolic effects of olanzapine in healthy volunteers
    • Albaugh VL, Singareddy R, Mauger D, Lynch CJ. A double blind, placebo-controlled, randomized crossover study of the acute metabolic effects of olanzapine in healthy volunteers. PLoS ONE 6(8), e22662 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.8
    • Albaugh, V.L.1    Singareddy, R.2    Mauger, D.3    Lynch, C.J.4
  • 40
    • 84856650002 scopus 로고    scopus 로고
    • Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat
    • Jassim G, Skrede S, Vazquez MJ et al. Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology (Berl.) 219(3), 783-794 (2012).
    • (2012) Psychopharmacology (Berl.) , vol.219 , Issue.3 , pp. 783-794
    • Jassim, G.1    Skrede, S.2    Vazquez, M.J.3
  • 41
    • 34248161538 scopus 로고    scopus 로고
    • Clozapine-induced alteration of glucose homeostasis in the rat: The contribution of hypothalamic-pituitary-adrenal axis activation
    • Tulipano G, Rizzetti C, Bianchi I, Fanzani A, Spano P, Cocchi D. Clozapine-induced alteration of glucose homeostasis in the rat: the contribution of hypothalamic-pituitary-adrenal axis activation. Neuroendocrinology 85(2), 61-70 (2007).
    • (2007) Neuroendocrinology , vol.85 , Issue.2 , pp. 61-70
    • Tulipano, G.1    Rizzetti, C.2    Bianchi, I.3    Fanzani, A.4    Spano, P.5    Cocchi, D.6
  • 42
    • 33947274677 scopus 로고    scopus 로고
    • Atypical antipsychotic drugs directly impair insulin action in adipocytes: Effects on glucose transport, lipogenesis, and antilipolysis
    • Vestri HS, Maianu L, Moellering DR, Garvey WT. Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis. Neuropsychopharmacology 32(4), 765-772 (2007).
    • (2007) Neuropsychopharmacology , vol.32 , Issue.4 , pp. 765-772
    • Vestri, H.S.1    Maianu, L.2    Moellering, D.R.3    Garvey, W.T.4
  • 43
    • 84873837589 scopus 로고    scopus 로고
    • The TBC1D1 gene: Structure, function, and association with obesity and related traits
    • Fontanesi L, Bertolini F. The TBC1D1 gene: structure, function, and association with obesity and related traits. Vitam. Horm. 91, 77-95 (2013).
    • (2013) Vitam. Horm. , vol.91 , pp. 77-95
    • Fontanesi, L.1    Bertolini, F.2
  • 44
    • 79959614396 scopus 로고    scopus 로고
    • Exercise increases TBC1D1 phosphorylation in human skeletal muscle
    • Jessen N, An D, Lihn AS et al. Exercise increases TBC1D1 phosphorylation in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 301(1), E164-E171 (2011).
    • (2011) Am. J. Physiol. Endocrinol. Metab. , vol.301 , Issue.1
    • Jessen, N.1    An, D.2    Lihn, A.S.3
  • 45
    • 84865152468 scopus 로고    scopus 로고
    • The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism
    • Szekeres F, Chadt A, Tom RZ et al. The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. Am. J. Physiol. Endocrinol. Metab. 303(4), E524-E533 (2012).
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.303 , Issue.4
    • Szekeres, F.1    Chadt, A.2    Tom, R.Z.3
  • 46
    • 55049131588 scopus 로고    scopus 로고
    • Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
    • Chadt A, Leicht K, Deshmukh A et al. Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity. Nat. Genet. 40(11), 1354-1359 (2008).
    • (2008) Nat. Genet. , vol.40 , Issue.11 , pp. 1354-1359
    • Chadt, A.1    Leicht, K.2    Deshmukh, A.3
  • 47
    • 44849112532 scopus 로고    scopus 로고
    • R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population
    • Meyre D, Farge M, Lecoeur C et al. R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population. Hum. Mol. Genet. 17(12), 1798-1802 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , Issue.12 , pp. 1798-1802
    • Meyre, D.1    Farge, M.2    Lecoeur, C.3
  • 48
    • 33748745768 scopus 로고    scopus 로고
    • TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition
    • Stone S, Abkevich V, Russell DL et al. TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Hum. Mol. Genet. 15(18), 2709-2720 (2006).
    • (2006) Hum. Mol. Genet. , vol.15 , Issue.18 , pp. 2709-2720
    • Stone, S.1    Abkevich, V.2    Russell, D.L.3
  • 49
    • 77953961746 scopus 로고    scopus 로고
    • Clozapine activates AMP-activated protein kinase (AMPK) in C2C12 myotube cells and stimulates glucose uptake
    • Kim JH, Lee JO, Lee SK et al. Clozapine activates AMP-activated protein kinase (AMPK) in C2C12 myotube cells and stimulates glucose uptake. Life Sci. 87(1-2), 42-48 (2010).
    • (2010) Life Sci. , vol.87 , Issue.1-2 , pp. 42-48
    • Kim, J.H.1    Lee, J.O.2    Lee, S.K.3
  • 50
    • 84875681266 scopus 로고    scopus 로고
    • Exploratory study on association of genetic variation in TBC1D1 with antipsychotic-induced weight gain
    • Brandl EJ, Tiwari AK, Lett TA et al. Exploratory study on association of genetic variation in TBC1D1 with antipsychotic-induced weight gain. Hum. Psychopharmacol. 28(2), 183-187 (2013).
    • (2013) Hum. Psychopharmacol. , vol.28 , Issue.2 , pp. 183-187
    • Brandl, E.J.1    Tiwari, A.K.2    Lett, T.A.3
  • 51
    • 84858442357 scopus 로고    scopus 로고
    • Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: A reassessment in vitro and in vivo
    • Humbert-Claude M, Davenas E, Gbahou F, Vincent L, Arrang JM. Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: a reassessment in vitro and in vivo. Psychopharmacology 220(1), 225-241 (2012).
    • (2012) Psychopharmacology , vol.220 , Issue.1 , pp. 225-241
    • Humbert-Claude, M.1    Davenas, E.2    Gbahou, F.3    Vincent, L.4    Arrang, J.M.5
  • 52
    • 79959944606 scopus 로고    scopus 로고
    • Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication
    • Vehof J, Risselada AJ, Al Hadithy AF et al. Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication. Psychopharmacology 216(2), 257-265 (2011).
    • (2011) Psychopharmacology , vol.216 , Issue.2 , pp. 257-265
    • Vehof, J.1    Risselada, A.J.2    Al Hadithy, A.F.3
  • 53
    • 84859211563 scopus 로고    scopus 로고
    • Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels
    • Weston-Green K, Huang XF, Lian J, Deng C. Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels. Eur. Neuropsychopharmacol. 22(5), 364-373 (2012).
    • (2012) Eur. Neuropsychopharmacol. , vol.22 , Issue.5 , pp. 364-373
    • Weston-Green, K.1    Huang, X.F.2    Lian, J.3    Deng, C.4
  • 54
    • 33744510095 scopus 로고    scopus 로고
    • A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo
    • Gautam D, Han SJ, Hamdan FF et al. A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab. 3(6), 449-461 (2006).
    • (2006) Cell Metab. , vol.3 , Issue.6 , pp. 449-461
    • Gautam, D.1    Han, S.J.2    Hamdan, F.F.3
  • 55
    • 84882417694 scopus 로고    scopus 로고
    • The 'golden age' of DNA methylation in neurodegenerative diseases
    • Fuso A. The 'golden age' of DNA methylation in neurodegenerative diseases. Clin. Chem. Lab. Med. 51(3), 523-534 (2012).
    • (2012) Clin. Chem. Lab. Med. , vol.51 , Issue.3 , pp. 523-534
    • Fuso, A.1
  • 56
    • 84875225571 scopus 로고    scopus 로고
    • Catechol-methyltransferase: Characteristics, polymorphisms and role in breast cancer
    • Yager JD. Catechol-methyltransferase: characteristics, polymorphisms and role in breast cancer. Drug Discov. Today Dis. Mech. 9(1-2), e41-e46 (2012).
    • (2012) Drug Discov. Today Dis. Mech. , vol.9 , Issue.1-2
    • Yager, J.D.1
  • 57
    • 77952888355 scopus 로고    scopus 로고
    • Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia
    • Garcia-Miss Mdel R, Perez-Mutul J, Lopez-Canul B et al. Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia. J. Psychiatr. Res. 44(7), 441-446 (2010).
    • (2010) J. Psychiatr. Res. , vol.44 , Issue.7 , pp. 441-446
    • Garcia-Miss Mdel, R.1    Perez-Mutul, J.2    Lopez-Canul, B.3
  • 58
    • 36849066949 scopus 로고    scopus 로고
    • Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants
    • Ellingrod VL, Miller DD, Taylor SF, Moline J, Holman T, Kerr J. Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants. Schizophr. Res. 98(1-3), 47-54 (2008).
    • (2008) Schizophr. Res. , vol.98 , Issue.1-3 , pp. 47-54
    • Ellingrod, V.L.1    Miller, D.D.2    Taylor, S.F.3    Moline, J.4    Holman, T.5    Kerr, J.6
  • 60
    • 33846442405 scopus 로고    scopus 로고
    • Polymorphisms and low plasma activity of dopamine-beta-hydroxylase in ADHD children
    • Kopeckova M, Paclt I, Goetz P. Polymorphisms and low plasma activity of dopamine-beta-hydroxylase in ADHD children. Neuro Endocrinol. Lett. 27(6), 748-754 (2006).
    • (2006) Neuro Endocrinol. Lett. , vol.27 , Issue.6 , pp. 748-754
    • Kopeckova, M.1    Paclt, I.2    Goetz, P.3
  • 61
    • 84878959543 scopus 로고    scopus 로고
    • The effects of DBH MAOA, and MAOB on attentional biases for facial expressions
    • Gong P, Xi S, Shen G et al. The effects of DBH, MAOA, and MAOB on attentional biases for facial expressions. J. Mol. Neurosci. 49(3), 606-613 (2013).
    • (2013) J. Mol. Neurosci. , vol.49 , Issue.3 , pp. 606-613
    • Gong, P.1    Xi, S.2    Shen, G.3
  • 62
    • 84874870446 scopus 로고    scopus 로고
    • The current state of play on the molecular genetics of depression
    • Cohen-Woods S, Craig IW, McGuffin P. The current state of play on the molecular genetics of depression. Psychol. Med. 43(4), 673-687 (2013).
    • (2013) Psychol. Med. , vol.43 , Issue.4 , pp. 673-687
    • Cohen-Woods, S.1    Craig, I.W.2    McGuffin, P.3
  • 63
    • 0032821677 scopus 로고    scopus 로고
    • Serotonin metabolism in rat mesangial cells: Involvement of a serotonin transporter and monoamine oxidase A
    • Pizzinat N, Girolami JP, Parini A, Pecher C, Ordener C. Serotonin metabolism in rat mesangial cells: involvement of a serotonin transporter and monoamine oxidase A. Kidney Int. 56(4), 1391-1399 (1999).
    • (1999) Kidney Int. , vol.56 , Issue.4 , pp. 1391-1399
    • Pizzinat, N.1    Girolami, J.P.2    Parini, A.3    Pecher, C.4    Ordener, C.5
  • 64
    • 0038389841 scopus 로고    scopus 로고
    • A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain
    • Bray NJ, Buckland PR, Williams NM et al. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am. J. Hum. Genet. 73(1), 152-161 (2003).
    • (2003) Am. J. Hum. Genet. , vol.73 , Issue.1 , pp. 152-161
    • Bray, N.J.1    Buckland, P.R.2    Williams, N.M.3
  • 65
    • 34247636739 scopus 로고    scopus 로고
    • Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome
    • Bassett AS, Caluseriu O, Weksberg R, Young DA, Chow EW. Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome. Biol. Psychiatry 61(10), 1135-1140 (2007).
    • (2007) Biol. Psychiatry , vol.61 , Issue.10 , pp. 1135-1140
    • Bassett, A.S.1    Caluseriu, O.2    Weksberg, R.3    Young, D.A.4    Chow, E.W.5
  • 66
    • 0027964721 scopus 로고
    • Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters
    • Tenhunen J, Salminen M, Lundstrom K, Kiviluoto T, Savolainen R, Ulmanen I. Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters. Eur. J. Biochem. FEBS 223(3), 1049-1059 (1994).
    • (1994) Eur. J. Biochem. FEBS , vol.223 , Issue.3 , pp. 1049-1059
    • Tenhunen, J.1    Salminen, M.2    Lundstrom, K.3    Kiviluoto, T.4    Savolainen, R.5    Ulmanen, I.6
  • 67
    • 84870057403 scopus 로고    scopus 로고
    • Pharmacological treatment of schizophrenia: A critical review of the pharmacology and clinical effects of current and future therapeutic agents
    • Miyamoto S, Miyake N, Jarskog LF, Fleischhacker WW, Lieberman JA. Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents. Mol. Psychiatry 17(12), 1206-1227 (2012).
    • (2012) Mol. Psychiatry , vol.17 , Issue.12 , pp. 1206-1227
    • Miyamoto, S.1    Miyake, N.2    Jarskog, L.F.3    Fleischhacker, W.W.4    Lieberman, J.A.5
  • 68
    • 84862022001 scopus 로고    scopus 로고
    • Association of the MTHFR gene with antipsychotic-induced metabolic abnormalities in patients with schizophrenia
    • Kuzman MR, Müller DJ. Association of the MTHFR gene with antipsychotic-induced metabolic abnormalities in patients with schizophrenia. Pharmacogenomics 13(8), 843-846 (2012).
    • (2012) Pharmacogenomics , vol.13 , Issue.8 , pp. 843-846
    • Kuzman, M.R.1    Müller, D.J.2
  • 69
    • 84857911892 scopus 로고    scopus 로고
    • Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: The role of folate pharmacogenetics
    • Ellingrod VL, Taylor SF, Dalack G et al. Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics. J. Clin. Psychopharmacol. 32(2), 261-265 (2012).
    • (2012) J. Clin. Psychopharmacol. , vol.32 , Issue.2 , pp. 261-265
    • Ellingrod, V.L.1    Taylor, S.F.2    Dalack, G.3
  • 70
    • 84856267575 scopus 로고    scopus 로고
    • Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics
    • Devlin AM, Ngai YF, Ronsley R, Panagiotopoulos C. Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics. Transl. Psychiatry 2, e71 (2012).
    • (2012) Transl. Psychiatry , vol.2
    • Devlin, A.M.1    Ngai, Y.F.2    Ronsley, R.3    Panagiotopoulos, C.4
  • 71
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 407(6806), 908-913 (2000).
    • (2000) Nature , vol.407 , Issue.6806 , pp. 908-913
    • Tschöp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 72
    • 84872663273 scopus 로고    scopus 로고
    • AMPK and the neuroendocrine regulation of appetite and energy expenditure
    • Stark R, Ashley SE, Andrews ZB. AMPK and the neuroendocrine regulation of appetite and energy expenditure. Mol. Cell. Endocrinol. 366(2), 215-223 (2013).
    • (2013) Mol. Cell. Endocrinol. , vol.366 , Issue.2 , pp. 215-223
    • Stark, R.1    Ashley, S.E.2    Andrews, Z.B.3
  • 73
    • 79955768338 scopus 로고    scopus 로고
    • Association of serum levels of leptin, ghrelin, and adiponectin in schizophrenic patients and healthy controls
    • Tsai MC, Chang CM, Liu CY, Chang PY, Huang TL. Association of serum levels of leptin, ghrelin, and adiponectin in schizophrenic patients and healthy controls. Int. J. Psychiatry Clin. Pract. 15(2), 106-111 (2011).
    • (2011) Int. J. Psychiatry Clin. Pract. , vol.15 , Issue.2 , pp. 106-111
    • Tsai, M.C.1    Chang, C.M.2    Liu, C.Y.3    Chang, P.Y.4    Huang, T.L.5
  • 75
    • 84887159472 scopus 로고    scopus 로고
    • Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight
    • Silver Spring doi:10.1002/oby.20382 Epub ahead of print
    • Mason BL, Lobo MK, Parada LF, Lutter M. Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight. Obesity (Silver Spring) doi:10.1002/oby.20382 (2013) (Epub ahead of print).
    • (2013) Obesity
    • Mason, B.L.1    Lobo, M.K.2    Parada, L.F.3    Lutter, M.4
  • 76
    • 84864510413 scopus 로고    scopus 로고
    • The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain
    • Zai GC, Zai CC, Chowdhury NI et al. The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain. Prog. Neuropsychopharmacol. Biol. Psychiatry 39(1), 96-101 (2012).
    • (2012) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.39 , Issue.1 , pp. 96-101
    • Zai, G.C.1    Zai, C.C.2    Chowdhury, N.I.3
  • 77
    • 84858291188 scopus 로고    scopus 로고
    • Association study between variants of AMP-activated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain
    • Souza RP, Tiwari AK, Chowdhury NI et al. Association study between variants of AMP-activated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain. J. Psychiatr. Res. 46(4), 462-468 (2012).
    • (2012) J. Psychiatr. Res. , vol.46 , Issue.4 , pp. 462-468
    • Souza, R.P.1    Tiwari, A.K.2    Chowdhury, N.I.3
  • 78
    • 33847635179 scopus 로고    scopus 로고
    • From the cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase
    • Kim SF, Huang AS, Snowman AM, Teuscher C, Snyder SH. From the cover: antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc. Natl Acad. Sci. USA 104(9), 3456-3459 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.9 , pp. 3456-3459
    • Kim, S.F.1    Huang, A.S.2    Snowman, A.M.3    Teuscher, C.4    Snyder, S.H.5
  • 79
    • 40049095675 scopus 로고    scopus 로고
    • Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin
    • Jin H, Meyer JM, Mudaliar S, Jeste DV. Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin. Schizophr. Res. 100(1-3), 70-85 (2008).
    • (2008) Schizophr. Res. , vol.100 , Issue.1-3 , pp. 70-85
    • Jin, H.1    Meyer, J.M.2    Mudaliar, S.3    Jeste, D.V.4
  • 80
    • 84862816913 scopus 로고    scopus 로고
    • Association between ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients
    • Yang Y, Li W, Zhao J et al. Association between ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients. Behav. Brain Funct. 8, 11 (2012).
    • (2012) Behav. Brain Funct. , vol.8 , pp. 11
    • Yang, Y.1    Li, W.2    Zhao, J.3
  • 81
    • 52449123919 scopus 로고    scopus 로고
    • Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity
    • Farooqi IS, O'Rahilly S. Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity. Nat. Clin. Pract. Endocrinol. Metab. 4(10), 569-577 (2008).
    • (2008) Nat. Clin. Pract. Endocrinol. Metab. , vol.4 , Issue.10 , pp. 569-577
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 82
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 372(6505), 425-432 (1994).
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 84
    • 84862895753 scopus 로고    scopus 로고
    • Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain
    • Brandl EJ, Frydrychowicz C, Tiwari AK et al. Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain. Prog. Neuropsychopharmacol. Biol. Psychiatry 38(2), 134-141 (2012).
    • (2012) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.38 , Issue.2 , pp. 134-141
    • Brandl, E.J.1    Frydrychowicz, C.2    Tiwari, A.K.3
  • 85
    • 77949266531 scopus 로고    scopus 로고
    • The Q223R polymorphism in LEPR is associated with obesity in Pacific islanders\
    • Furusawa T, Naka I, Yamauchi T et al. The Q223R polymorphism in LEPR is associated with obesity in Pacific islanders. Hum. Genet. 127(3), 287-294 (2010).
    • (2010) Hum. Genet. , vol.127 , Issue.3 , pp. 287-294
    • Furusawa, T.1    Naka, I.2    Yamauchi, T.3
  • 86
    • 84873096725 scopus 로고    scopus 로고
    • Association of a functional polymorphism in neuropeptide y with antipsychotic-induced weight gain in schizophrenia patients
    • Tiwari AK, Brandl EJ, Weber C et al. Association of a functional polymorphism in neuropeptide Y with antipsychotic-induced weight gain in schizophrenia patients. J. Clin. Psychopharmacol. 33(1), 11-17 (2013).
    • (2013) J. Clin. Psychopharmacol. , vol.33 , Issue.1 , pp. 11-17
    • Tiwari, A.K.1    Brandl, E.J.2    Weber, C.3
  • 87
    • 79951934947 scopus 로고    scopus 로고
    • Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse
    • Srisai D, Gillum MP, Panaro BL et al. Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse. Endocrinology 152(3), 890-902 (2011).
    • (2011) Endocrinology , vol.152 , Issue.3 , pp. 890-902
    • Srisai, D.1    Gillum, M.P.2    Panaro, B.L.3
  • 88
    • 84865975078 scopus 로고    scopus 로고
    • Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain
    • Malhotra AK, Correll CU, Chowdhury NI et al. Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain. Arch. Gen. Psychiatry 69(9), 904-912 (2012).
    • (2012) Arch. Gen. Psychiatry , vol.69 , Issue.9 , pp. 904-912
    • Malhotra, A.K.1    Correll, C.U.2    Chowdhury, N.I.3
  • 89
    • 84878228310 scopus 로고    scopus 로고
    • Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene
    • Chowdhury NI, Tiwari AK, Souza RP et al. Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene. Pharmacogenomics J. 13(3), 272-279 (2012).
    • (2012) Pharmacogenomics J. , vol.13 , Issue.3 , pp. 272-279
    • Chowdhury, N.I.1    Tiwari, A.K.2    Souza, R.P.3
  • 90
    • 84873083606 scopus 로고    scopus 로고
    • Association of the common MC4R rs17782313 polymorphism with antipsychotic-related weight gain
    • Czerwensky F, Leucht S, Steimer W. Association of the common MC4R rs17782313 polymorphism with antipsychotic-related weight gain. J. Clin. Psychopharmacol. 33(1), 74-79 (2013).
    • (2013) J. Clin. Psychopharmacol. , vol.33 , Issue.1 , pp. 74-79
    • Czerwensky, F.1    Leucht, S.2    Steimer, W.3
  • 92
    • 77955050185 scopus 로고    scopus 로고
    • Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells
    • Lee JG, Cho HY, Park SW, Seo MK, Kim YH. Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(6), 1001-1006 (2010).
    • (2010) Prog. Neuropsychopharmacol. Biol. Psychiatry 3 , vol.4 , Issue.6 , pp. 1001-1006
    • Lee, J.G.1    Cho, H.Y.2    Park, S.W.3    Seo, M.K.4    Kim, Y.H.5
  • 93
    • 80555145254 scopus 로고    scopus 로고
    • Pharmacogenetics of response to antipsychotics in patients with schizophrenia
    • Arranz MJ, Rivera M, Munro JC. Pharmacogenetics of response to antipsychotics in patients with schizophrenia. CNS Drugs 25(11), 933-969 (2011).
    • (2011) CNS Drugs , vol.25 , Issue.11 , pp. 933-969
    • Arranz, M.J.1    Rivera, M.2    Munro, J.C.3
  • 94
    • 84855875337 scopus 로고    scopus 로고
    • Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment
    • Tsai A, Liou YJ, Hong CJ, Wu CL, Tsai SJ, Bai YM. Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment. Neuromol. Med. 13(4), 328-333 (2011).
    • (2011) Neuromol. Med. , vol.13 , Issue.4 , pp. 328-333
    • Tsai, A.1    Liou, Y.J.2    Hong, C.J.3    Wu, C.L.4    Tsai, S.J.5    Bai, Y.M.6
  • 95
    • 65349191920 scopus 로고    scopus 로고
    • The neurodevelopmental hypothesis of schizophrenia, revisited
    • Fatemi SH, Folsom TD. The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr. Bull. 35(3), 528-548 (2009).
    • (2009) Schizophr. Bull. , vol.35 , Issue.3 , pp. 528-548
    • Fatemi, S.H.1    Folsom, T.D.2
  • 96
    • 79953065216 scopus 로고    scopus 로고
    • A theoretical molecular network for dyslexia: Integrating available genetic findings
    • Poelmans G, Buitelaar JK, Pauls DL, Franke B. A theoretical molecular network for dyslexia: integrating available genetic findings. Mol. Psychiatry 16(4), 365-382 (2011).
    • (2011) Mol. Psychiatry , vol.16 , Issue.4 , pp. 365-382
    • Poelmans, G.1    Buitelaar, J.K.2    Pauls, D.L.3    Franke, B.4
  • 97
    • 84864868683 scopus 로고    scopus 로고
    • Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: Functional and therapeutic implications
    • Ganella DE, Ryan PJ, Bathgate RA, Gundlach AL. Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: functional and therapeutic implications. Behav. Pharmacol. 23(5-6), 516-525 (2012).
    • (2012) Behav. Pharmacol. , vol.23 , Issue.5-6 , pp. 516-525
    • Ganella, D.E.1    Ryan, P.J.2    Bathgate, R.A.3    Gundlach, A.L.4
  • 98
    • 84873369266 scopus 로고    scopus 로고
    • The pharmacogenetics of antipsychotic-induced adverse events
    • Müller DJ, Chowdhury NI, Zai CC. The pharmacogenetics of antipsychotic-induced adverse events. Curr. Opin. Psychiatry 26(2), 144-150 (2013).
    • (2013) Curr. Opin. Psychiatry , vol.26 , Issue.2 , pp. 144-150
    • Müller, D.J.1    Chowdhury, N.I.2    Zai, C.C.3
  • 99
    • 0034814491 scopus 로고    scopus 로고
    • On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine-receptors
    • Pollmacher T, Schuld A, Kraus T, Haack M, Hinze-Selch D. On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine-receptors. Fortschr. Neurol. Psychiatr. 69(Suppl. 2), S65-S74 (2001).
    • (2001) Fortschr. Neurol. Psychiatr. , vol.69 , Issue.SUPPL. 2
    • Pollmacher, T.1    Schuld, A.2    Kraus, T.3    Haack, M.4    Hinze-Selch, D.5
  • 101
    • 79960362754 scopus 로고    scopus 로고
    • Association between the ROBO1 gene and body mass index in patients using antipsychotics
    • Vehof J, Al Hadithy AF, Burger H et al. Association between the ROBO1 gene and body mass index in patients using antipsychotics. Psychiatr. Genet. 21(4), 202-207 (2011).
    • (2011) Psychiatr. Genet. , vol.21 , Issue.4 , pp. 202-207
    • Vehof, J.1    Al Hadithy, A.F.2    Burger, H.3
  • 102
    • 41549126540 scopus 로고    scopus 로고
    • On the replication of genetic associations: Timing can be everything
    • Lasky-Su J, Lyon HN, Emilsson V et al. On the replication of genetic associations: timing can be everything! Am. J. Hum. Genet. 82(4), 849-858 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , Issue.4 , pp. 849-858
    • Lasky-Su, J.1    Lyon, H.N.2    Emilsson, V.3
  • 103
    • 77954617999 scopus 로고    scopus 로고
    • Relaxin family peptide systems and the central nervous system
    • Callander GE, Bathgate RA. Relaxin family peptide systems and the central nervous system. Cell. Mol. Life Sci. 67(14), 2327-2341 (2010).
    • (2010) Cell. Mol. Life Sci. , vol.67 , Issue.14 , pp. 2327-2341
    • Callander, G.E.1    Bathgate, R.A.2
  • 104
    • 84857839933 scopus 로고    scopus 로고
    • Relaxin polymorphisms associated with metabolic disturbance in patients treated with antipsychotics
    • Munro J, Skrobot O, Sanyoura M et al. Relaxin polymorphisms associated with metabolic disturbance in patients treated with antipsychotics. J. Psychopharmacol. 26(3), 374-379 (2012).
    • (2012) J. Psychopharmacol. , vol.26 , Issue.3 , pp. 374-379
    • Munro, J.1    Skrobot, O.2    Sanyoura, M.3
  • 105
    • 82455162579 scopus 로고    scopus 로고
    • TNF-alpha-308 GA polymorphism and weight gain in patients with schizophrenia under long-term clozapine, risperidone or olanzapine treatment
    • Huang HH, Wang YC, Wu CL et al. TNF-alpha-308 GA polymorphism and weight gain in patients with schizophrenia under long-term clozapine, risperidone or olanzapine treatment. Neurosci. Lett. 504(3), 277-280 (2011).
    • (2011) Neurosci. Lett. , vol.504 , Issue.3 , pp. 277-280
    • Huang, H.H.1    Wang, Y.C.2    Wu, C.L.3
  • 106
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259(5091), 87-91 (1993).
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 107
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 95(5), 2409-2415 (1995).
    • (1995) J. Clin. Invest. , vol.95 , Issue.5 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 108
    • 0034674538 scopus 로고    scopus 로고
    • Plasma levels of cytokines and soluble cytokine receptors during treatment with olanzapine
    • Schuld A, Kraus T, Haack M, Hinze-Selch D, Kuhn M, Pollmacher T. Plasma levels of cytokines and soluble cytokine receptors during treatment with olanzapine. Schizophr. Res. 43(2-3), 164-166 (2000).
    • (2000) Schizophr. Res. , vol.43 , Issue.2-3 , pp. 164-166
    • Schuld, A.1    Kraus, T.2    Haack, M.3    Hinze-Selch, D.4    Kuhn, M.5    Pollmacher, T.6
  • 109
    • 77953937453 scopus 로고    scopus 로고
    • Genetic association between TNF-alpha-308 GA polymorphism and longitudinal weight change during clozapine treatment
    • Wang YC, Bai YM, Chen JY, Lin CC, Lai IC, Liou YJ. Genetic association between TNF-alpha-308 GA polymorphism and longitudinal weight change during clozapine treatment. Hum. Psychopharmacol. 25(4), 303-309 (2010).
    • (2010) Hum. Psychopharmacol. , vol.25 , Issue.4 , pp. 303-309
    • Wang, Y.C.1    Bai, Y.M.2    Chen, J.Y.3    Lin, C.C.4    Lai, I.C.5    Liou, Y.J.6
  • 110
    • 69849098543 scopus 로고    scopus 로고
    • Evidence for an effect of clozapine on the regulation of fat-cell derived factors
    • Yang Z, Yin JY, Gong ZC et al. Evidence for an effect of clozapine on the regulation of fat-cell derived factors. Clin. Chim. Acta 408(1-2), 98-104 (2009).
    • (2009) Clin. Chim. Acta , vol.408 , Issue.1-2 , pp. 98-104
    • Yang, Z.1    Yin, J.Y.2    Gong, Z.C.3
  • 112
    • 77950612091 scopus 로고    scopus 로고
    • INSIG1 influences obesity-related hypertriglyceridemia in humans
    • Smith EM, Zhang Y, Baye TM et al. INSIG1 influences obesity-related hypertriglyceridemia in humans. J. Lipid Res. 51(4), 701-708 (2010).
    • (2010) J. Lipid Res. , vol.51 , Issue.4 , pp. 701-708
    • Smith, E.M.1    Zhang, Y.2    Baye, T.M.3
  • 113
    • 84855510314 scopus 로고    scopus 로고
    • Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8
    • Jo Y, Lee PC, Sguigna PV, Debose-Boyd RA. Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8. Proc. Natl Acad. Sci. USA 108(51), 20503-20508 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.51 , pp. 20503-20508
    • Jo, Y.1    Lee, P.C.2    Sguigna, P.V.3    Debose-Boyd, R.A.4
  • 114
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13(4), 251-262 (2012).
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , Issue.4 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 115
    • 84859791325 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala: Lack of association with weight gain in psychiatric inpatients treated with olanzapine or clozapine
    • Staeker J, Leucht S, Steimer W. Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala: lack of association with weight gain in psychiatric inpatients treated with olanzapine or clozapine. Mol. Diagn. Ther. 16(2), 93-98 (2012).
    • (2012) Mol. Diagn. Ther. , vol.16 , Issue.2 , pp. 93-98
    • Staeker, J.1    Leucht, S.2    Steimer, W.3
  • 116
    • 84860833543 scopus 로고    scopus 로고
    • Pro12Ala polymorphism of the PPAR-gamma 2 gene, metabolic syndrome and response to metformin in clozapine-treated patients
    • Fernandez E, Carrizo E, Connell L, Baptista T. Pro12Ala polymorphism of the PPAR-gamma 2 gene, metabolic syndrome and response to metformin in clozapine-treated patients. Schizophr. Res. 137(1-3), 262-263 (2012).
    • (2012) Schizophr. Res. , vol.137 , Issue.1-3 , pp. 262-263
    • Fernandez, E.1    Carrizo, E.2    Connell, L.3    Baptista, T.4
  • 117
    • 0033434025 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma C161-T polymorphism and coronary artery disease
    • Wang XL, Oosterhof J, Duarte N. Peroxisome proliferator-activated receptor gamma C161-T polymorphism and coronary artery disease. Cardiovasc. Res. 44(3), 588-594 (1999).
    • (1999) Cardiovasc. Res. , vol.44 , Issue.3 , pp. 588-594
    • Wang, X.L.1    Oosterhof, J.2    Duarte, N.3
  • 118
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7(8), 941-946 (2001).
    • (2001) Nat. Med. , vol.7 , Issue.8 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 119
    • 78951469329 scopus 로고    scopus 로고
    • Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia
    • Jassim G, Ferno J, Theisen FM et al. Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. Pharmacopsychiatry 44(1), 15-20 (2011).
    • (2011) Pharmacopsychiatry , vol.44 , Issue.1 , pp. 15-20
    • Jassim, G.1    Ferno, J.2    Theisen, F.M.3
  • 120
    • 34547625955 scopus 로고    scopus 로고
    • Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    • Scuteri A, Sanna S, Chen WM et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3(7), e115 (2007).
    • (2007) PLoS Genet. , vol.3 , Issue.7
    • Scuteri, A.1    Sanna, S.2    Chen, W.M.3
  • 121
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • Dina C, Meyre D, Gallina S et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet. 39(6), 724-726 (2007).
    • (2007) Nat. Genet. , vol.39 , Issue.6 , pp. 724-726
    • Dina, C.1    Meyre, D.2    Gallina, S.3
  • 122
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316(5826), 889-894 (2007).
    • (2007) Science , vol.316 , Issue.5826 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3
  • 123
    • 77953292057 scopus 로고    scopus 로고
    • The genetics of obesity: FTO leads the way
    • Fawcett KA, Barroso I. The genetics of obesity: FTO leads the way. Trends Genet. 26(6), 266-274 (2010).
    • (2010) Trends Genet. , vol.26 , Issue.6 , pp. 266-274
    • Fawcett, K.A.1    Barroso, I.2
  • 124
    • 84878829550 scopus 로고    scopus 로고
    • The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients
    • Reynolds GP, Yevtushenko OO, Gordon S, Arranz B, San L, Cooper SJ. The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients. Int. J. Neuropsychopharmacol. 16(6), 1421-1425 (2013).
    • (2013) Int. J. Neuropsychopharmacol , vol.16 , Issue.6 , pp. 1421-1425
    • Reynolds, G.P.1    Yevtushenko, O.O.2    Gordon, S.3    Arranz, B.4    San, L.5    Cooper, S.J.6
  • 125
    • 33645825830 scopus 로고    scopus 로고
    • A common genetic variant is associated with adult and childhood obesity
    • Herbert A, Gerry NP, McQueen MB et al. A common genetic variant is associated with adult and childhood obesity. Science 312(5771), 279-283 (2006).
    • (2006) Science , vol.312 , Issue.5771 , pp. 279-283
    • Herbert, A.1    Gerry, N.P.2    McQueen, M.B.3
  • 126
    • 60549089825 scopus 로고    scopus 로고
    • Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: Perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Mol
    • Le Hellard S, Theisen FM, Haberhausen M et al. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Mol. Psychiatry 14(3), 308-317 (2009).
    • (2009) Psychiatry , vol.14 , Issue.3 , pp. 308-317
    • Le Hellard, S.1    Theisen, F.M.2    Haberhausen, M.3
  • 127
    • 56449127168 scopus 로고    scopus 로고
    • Performance of a neuro-fuzzy model in predicting weight changes of chronic schizophrenic patients exposed to antipsychotics
    • Lan TH, Loh EW, Wu MS et al. Performance of a neuro-fuzzy model in predicting weight changes of chronic schizophrenic patients exposed to antipsychotics. Mol. Psychiatry 13(12), 1129-1137 (2008).
    • (2008) Mol. Psychiatry , vol.13 , Issue.12 , pp. 1129-1137
    • Lan, T.H.1    Loh, E.W.2    Wu, M.S.3
  • 128
    • 84879952310 scopus 로고    scopus 로고
    • Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies
    • Nurmi EL, Spilman SL, Whelan F et al. Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. Transl. Psychiatry 3, e274 (2013).
    • (2013) Transl. Psychiatry , vol.3
    • Nurmi, E.L.1    Spilman, S.L.2    Whelan, F.3
  • 129
    • 84873966738 scopus 로고    scopus 로고
    • Using a pharmacogenomic algorithm to guide the treatment of depression
    • Hall-Flavin DK, Winner JG, Allen JD et al. Using a pharmacogenomic algorithm to guide the treatment of depression. Transl. Psychiatry 2, e172 (2012).
    • (2012) Transl. Psychiatry , vol.2
    • Hall-Flavin, D.K.1    Winner, J.G.2    Allen, J.D.3
  • 130
    • 84875082538 scopus 로고    scopus 로고
    • Proteomic profiling in schizophrenia: Enabling stratification for more effective treatment
    • Guest PC, Martins-De-Souza D, Schwarz E et al. Proteomic profiling in schizophrenia: enabling stratification for more effective treatment. Genome Med. 5(3), 25 (2013).
    • (2013) Genome Med. , vol.5 , Issue.3 , pp. 25
    • Guest, P.C.1    Martins-De-Souza, D.2    Schwarz, E.3
  • 131
    • 84868282373 scopus 로고    scopus 로고
    • Interventions for the metabolic syndrome in schizophrenia: A review
    • Papanastasiou E. Interventions for the metabolic syndrome in schizophrenia: a review. Ther. Adv. Endocrinol. Metab. 3(5), 141-162 (2012).
    • (2012) Ther. Adv. Endocrinol. Metab. , vol.3 , Issue.5 , pp. 141-162
    • Papanastasiou, E.1
  • 132
    • 84865335577 scopus 로고    scopus 로고
    • Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: A meta-analytic comparison of randomized controlled trials
    • Caemmerer J, Correll CU, Maayan L. Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: a meta-analytic comparison of randomized controlled trials. Schizophr. Res. 140(1-3), 159-168 (2012).
    • (2012) Schizophr. Res. , vol.140 , Issue.1-3 , pp. 159-168
    • Caemmerer, J.1    Correll, C.U.2    Maayan, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.