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Volumn 67, Issue 14, 2010, Pages 2327-2341

Relaxin family peptide systems and the central nervous system

Author keywords

Brain; GPCR; Relaxin; Relaxin family peptides; Relaxin 3; RXFP1; RXFP3

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CYCLIC AMP; MESSENGER RNA; OXYTOCIN; RELAXIN; RELAXIN 3; RELAXIN LIKE FACTOR; VASOPRESSIN; G PROTEIN COUPLED RECEPTOR; NEUROPEPTIDE; RECEPTOR; RELAXIN RECEPTORS; RLN3 PROTEIN, HUMAN;

EID: 77954617999     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0304-z     Document Type: Review
Times cited : (32)

References (100)
  • 1
    • 0003412980 scopus 로고
    • Experimental relaxation of the pubic ligament of the guinea pig
    • Hisaw F (1926) Experimental relaxation of the pubic ligament of the guinea pig. Proc Soc Exp Biol Med 23:661-663
    • (1926) Proc Soc Exp Biol Med , vol.23 , pp. 661-663
    • Hisaw, F.1
  • 2
    • 0038676021 scopus 로고
    • The relaxative hormone of the corpus luteum: Its purification and concentration
    • Fevold HL, Hisaw FL, Meyer RK (1930) The relaxative hormone of the corpus luteum: its purification and concentration. J Am Chem Soc 52:3340-3348
    • (1930) J Am Chem Soc , vol.52 , pp. 3340-3348
    • Fevold, H.L.1    Hisaw, F.L.2    Meyer, R.K.3
  • 3
    • 0015990909 scopus 로고
    • Purification and characterization of porcine relaxin
    • Sherwood CD, ÓByrne EM (1974) Purification and characterization of porcine relaxin. Arch Biochem Biophys 160:185-196
    • (1974) Arch Biochem Biophys , vol.160 , pp. 185-196
    • Sherwood, C.D.1    ÓByrne, E.M.2
  • 4
    • 0017740846 scopus 로고
    • Primary structure of porcine relaxin: Homology with insulin and related growth factors
    • James R, Niall H, Kwok S, Bryand-Greenwood G (1977) Primary structure of porcine relaxin: homology with insulin and related growth factors. Nature 267:544-546
    • (1977) Nature , vol.267 , pp. 544-546
    • James, R.1    Niall, H.2    Kwok, S.3    Bryand-Greenwood, G.4
  • 5
    • 0034634628 scopus 로고    scopus 로고
    • The relaxin receptor-binding site geometry suggests a novel gripping mode of interaction
    • Bullesbach EE, Schwabe C (2000) The relaxin receptor-binding site geometry suggests a novel gripping mode of interaction. J Biol Chem 275:35276-35280
    • (2000) J Biol Chem , vol.275 , pp. 35276-35280
    • Bullesbach, E.E.1    Schwabe, C.2
  • 7
    • 0021514136 scopus 로고
    • Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones
    • Hudson P, John M, Crawford R, Haralambidis J, Scanlon D, Gorman J, Tregear G, Shine J, Niall H (1984) Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones. EMBO J 3:2333-2339
    • (1984) EMBO J , vol.3 , pp. 2333-2339
    • Hudson, P.1    John, M.2    Crawford, R.3    Haralambidis, J.4    Scanlon, D.5    Gorman, J.6    Tregear, G.7    Shine, J.8    Niall, H.9
  • 8
    • 77955656171 scopus 로고
    • Purification, aminoterminal sequencing and demonstration of biological activity of human relaxin from corpora lutea
    • abstract), Indianapolis
    • Drolet DW, Henzel WJ, Johnston PD (1987) Purification, aminoterminal sequencing and demonstration of biological activity of human relaxin from corpora lutea. In: Program of the 69th Annual Meeting of the Endocrine Society, p 196 (abstract), Indianapolis
    • (1987) Program of the 69th Annual Meeting of the Endocrine Society , pp. 196
    • Drolet, D.W.1    Henzel, W.J.2    Johnston, P.D.3
  • 10
    • 0027365039 scopus 로고
    • Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells
    • Adham IM, Burkhardt E, Benahmed M, Engel W (1993) Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells. J Biol Chem 268:26668-26672
    • (1993) J Biol Chem , vol.268 , pp. 26668-26672
    • Adham, I.M.1    Burkhardt, E.2    Benahmed, M.3    Engel, W.4
  • 11
    • 0029095815 scopus 로고
    • Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta
    • Chassin D, Laurent A, Janneau JL, Berger R, Bellet D (1995) Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. Genomics 29:465-470
    • (1995) Genomics , vol.29 , pp. 465-470
    • Chassin, D.1    Laurent, A.2    Janneau, J.L.3    Berger, R.4    Bellet, D.5
  • 17
    • 84884002531 scopus 로고    scopus 로고
    • Physiology and molecular biology of the relaxin peptide family
    • Neil JD (ed). Elsevier, San Diego
    • Bathgate RA, Hsueh AJ, Sherwood OD (2005) Physiology and molecular biology of the relaxin peptide family. In: Neil JD (ed) Physiology of reproduction. Elsevier, San Diego, pp 679-768
    • (2005) Physiology of reproduction , pp. 679-768
    • Bathgate, R.A.1    Hsueh, A.J.2    Sherwood, O.D.3
  • 18
    • 0042809489 scopus 로고    scopus 로고
    • Relaxin is a key mediator of prostate growth and male reproductive tract development
    • Samuel CS, Tian H, Zhao L, Amento EP (2003) Relaxin is a key mediator of prostate growth and male reproductive tract development. Lab Invest 83:1055-1067
    • (2003) Lab Invest , vol.83 , pp. 1055-1067
    • Samuel, C.S.1    Tian, H.2    Zhao, L.3    Amento, E.P.4
  • 19
    • 0024598489 scopus 로고
    • Relaxin in the male
    • Weiss G (1989) Relaxin in the male. Biol Reprod 40:197-200
    • (1989) Biol Reprod , vol.40 , pp. 197-200
    • Weiss, G.1
  • 23
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families
    • Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson R, Lagerstrom MC, Lundin LG, Schioth HB (2003) The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 63:1256-1272
    • (2003) Mol Pharmacol , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.C.2    Lundin, L.G.3    Schioth, H.B.4
  • 24
    • 17144426920 scopus 로고    scopus 로고
    • The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7
    • Bullesbach EE, Schwabe C (2005) The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7. J Biol Chem 280:14051-14056
    • (2005) J Biol Chem , vol.280 , pp. 14051-14056
    • Bullesbach, E.E.1    Schwabe, C.2
  • 25
    • 33845933437 scopus 로고    scopus 로고
    • Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules
    • Scott DJ, Layfield S, Yan Y, Sudo S, Hsueh AJW, Tregear GW, Bathgate RAD (2006) Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem 281:34942-34954
    • (2006) J Biol Chem , vol.281 , pp. 34942-34954
    • Scott, D.J.1    Layfield, S.2    Yan, Y.3    Sudo, S.4    Hsueh, A.J.W.5    Tregear, G.W.6    Bathgate, R.A.D.7
  • 26
    • 33947501041 scopus 로고    scopus 로고
    • The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation
    • Hopkins EJ, Layfield S, Ferraro T, Bathgate RAD, Gooley PR (2007) The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation. J Biol Chem 282:4172-4184
    • (2007) J Biol Chem , vol.282 , pp. 4172-4184
    • Hopkins, E.J.1    Layfield, S.2    Ferraro, T.3    Bathgate, R.A.D.4    Gooley, P.R.5
  • 28
    • 33947324489 scopus 로고    scopus 로고
    • Relaxin family peptide receptors-former orphans reunite with their parent ligands to activate multiple signalling pathways
    • Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007) Relaxin family peptide receptors-former orphans reunite with their parent ligands to activate multiple signalling pathways. Br J Pharmacol 150:677-691
    • (2007) Br J Pharmacol , vol.150 , pp. 677-691
    • Halls, M.L.1    Van Der Westhuizen, E.T.2    Bathgate, R.A.3    Summers, R.J.4
  • 29
    • 0032989104 scopus 로고    scopus 로고
    • Cryptorchidism in mice mutant for Insl3
    • Nef S, Parada LF (1999) Cryptorchidism in mice mutant for Insl3. Nat Genet 22:295-299
    • (1999) Nat Genet , vol.22 , pp. 295-299
    • Nef, S.1    Parada, L.F.2
  • 31
    • 0036200341 scopus 로고    scopus 로고
    • Dynamic changes in the expression of relaxin-like factor (INSL3), cholesterol side-chain cleavage cytochrome p450, and 3beta-hydroxysteroid dehydrogenase in bovine ovarian follicles during growth and atresia
    • Irving-Rodgers HF, Bathgate RA, Ivell R, Domagalski R, Rodgers RJ (2002) Dynamic changes in the expression of relaxin-like factor (INSL3), cholesterol side-chain cleavage cytochrome p450, and 3beta-hydroxysteroid dehydrogenase in bovine ovarian follicles during growth and atresia. Biol Reprod 66:934-943
    • (2002) Biol Reprod , vol.66 , pp. 934-943
    • Irving-Rodgers, H.F.1    Bathgate, R.A.2    Ivell, R.3    Domagalski, R.4    Rodgers, R.J.5
  • 38
    • 0034548350 scopus 로고    scopus 로고
    • Relaxin-like factor (RLF) is differentially expressed in the normal and neoplastic human mammary gland
    • Hombach-Klonisch S, Buchmann J, Sarun S, Fischer B, Klonisch T (2000) Relaxin-like factor (RLF) is differentially expressed in the normal and neoplastic human mammary gland. Cancer 89:2161-2168
    • (2000) Cancer , vol.89 , pp. 2161-2168
    • Hombach-Klonisch, S.1    Buchmann, J.2    Sarun, S.3    Fischer, B.4    Klonisch, T.5
  • 39
    • 0032894313 scopus 로고    scopus 로고
    • Differential splicing and expression of the relaxin-like factor gene in reproductive tissues of the marmoset monkey (Callithrix jacchus)
    • Zarreh-Hoshyari-Khah MR, Einspanier A, Ivell R (1999) Differential splicing and expression of the relaxin-like factor gene in reproductive tissues of the marmoset monkey (Callithrix jacchus). Biol Reprod 60:445-453
    • (1999) Biol Reprod , vol.60 , pp. 445-453
    • Zarreh-Hoshyari-Khah, M.R.1    Einspanier, A.2    Ivell, R.3
  • 40
    • 1842297539 scopus 로고    scopus 로고
    • Mouse Leydig insulin-like (Ley I-L) gene: Structure and expression during testis and ovary development
    • Zimmermann S, Schottler P, Engel W, Adham IM (1997) Mouse Leydig insulin-like (Ley I-L) gene: structure and expression during testis and ovary development. Mol Reprod Dev 47:30-38
    • (1997) Mol Reprod Dev , vol.47 , pp. 30-38
    • Zimmermann, S.1    Schottler, P.2    Engel, W.3    Adham, I.M.4
  • 41
    • 0029908314 scopus 로고    scopus 로고
    • Relaxin-like factor gene is highly expressed in the bovine ovary of the cycle and pregnancy: sequence and messenger ribonucleic acid analysis
    • Bathgate R, Balvers M, Hunt N, Ivell R (1996) Relaxin-like factor gene is highly expressed in the bovine ovary of the cycle and pregnancy: sequence and messenger ribonucleic acid analysis. Biol Reprod 55:1452-1457
    • (1996) Biol Reprod , vol.55 , pp. 1452-1457
    • Bathgate, R.1    Balvers, M.2    Hunt, N.3    Ivell, R.4
  • 42
    • 0030576630 scopus 로고    scopus 로고
    • Structure and expression of Leydig insulin-like peptide mRNA in the sheep
    • Roche PJ, Butkus A, Wintour EM, Tregear G (1996) Structure and expression of Leydig insulin-like peptide mRNA in the sheep. Mol Cell Endocrinol 121:171-177
    • (1996) Mol Cell Endocrinol , vol.121 , pp. 171-177
    • Roche, P.J.1    Butkus, A.2    Wintour, E.M.3    Tregear, G.4
  • 43
    • 0036734781 scopus 로고    scopus 로고
    • Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain
    • Burazin TC, Bathgate RA, Macris M, Layfield S, Gundlach AL, Tregear GW (2002) Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain. J Neurochem 82:1553-1557
    • (2002) J Neurochem , vol.82 , pp. 1553-1557
    • Burazin, T.C.1    Bathgate, R.A.2    Macris, M.3    Layfield, S.4    Gundlach, A.L.5    Tregear, G.W.6
  • 44
    • 0037424265 scopus 로고    scopus 로고
    • H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2
    • Sudo S, Kumagai J, Nishi S, Layfield S, Ferraro T, Bathgate RA, Hsueh AJ (2003) H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J Biol Chem 278:7855-7862
    • (2003) J Biol Chem , vol.278 , pp. 7855-7862
    • Sudo, S.1    Kumagai, J.2    Nishi, S.3    Layfield, S.4    Ferraro, T.5    Bathgate, R.A.6    Hsueh, A.J.7
  • 47
    • 11244347812 scopus 로고    scopus 로고
    • Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7
    • Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW (2005) Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. Mol Pharmacol 67:231-240
    • (2005) Mol Pharmacol , vol.67 , pp. 231-240
    • Liu, C.1    Chen, J.2    Kuei, C.3    Sutton, S.4    Nepomuceno, D.5    Bonaventure, P.6    Lovenberg, T.W.7
  • 49
    • 15544378102 scopus 로고    scopus 로고
    • Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing
    • Sutton SW, Bonaventure P, Kuei C, Roland B, Chen J, Nepomuceno D, Lovenberg TW, Liu C (2004) Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing. Neuroendocrinology 80:298-307
    • (2004) Neuroendocrinology , vol.80 , pp. 298-307
    • Sutton, S.W.1    Bonaventure, P.2    Kuei, C.3    Roland, B.4    Chen, J.5    Nepomuceno, D.6    Lovenberg, T.W.7    Liu, C.8
  • 51
    • 52949095017 scopus 로고    scopus 로고
    • Leucine-rich repeat-containing G-protein-coupled receptor 8 in the rat brain: Enrichment in thalamic neurons and their efferent projections
    • Sedaghat K, Shen PJ, Finkelstein DI, Henderson JM, Gundlach AL (2008) Leucine-rich repeat-containing G-protein-coupled receptor 8 in the rat brain: enrichment in thalamic neurons and their efferent projections. Neuroscience 156:319-333
    • (2008) Neuroscience , vol.156 , pp. 319-333
    • Sedaghat, K.1    Shen, P.J.2    Finkelstein, D.I.3    Henderson, J.M.4    Gundlach, A.L.5
  • 52
    • 0032829909 scopus 로고    scopus 로고
    • Expression and regulation of relaxin-like factor gene transcripts in the bovine ovary: Differentiationdependent expression in theca cell cultures
    • Bathgate R, Moniac N, Bartlick B, Schumacher M, Fields M, Ivell R (1999) Expression and regulation of relaxin-like factor gene transcripts in the bovine ovary: differentiationdependent expression in theca cell cultures. Biol Reprod 61:1090-1098
    • (1999) Biol Reprod , vol.61 , pp. 1090-1098
    • Bathgate, R.1    Moniac, N.2    Bartlick, B.3    Schumacher, M.4    Fields, M.5    Ivell, R.6
  • 55
    • 0027199629 scopus 로고
    • Expression of relaxin mRNA and relaxin receptors in postnatal and adult rat brains and hearts. Localization and developmental patterns
    • Osheroff PL, Ho WH (1993) Expression of relaxin mRNA and relaxin receptors in postnatal and adult rat brains and hearts. Localization and developmental patterns. J Biol Chem 268:15193-15199
    • (1993) J Biol Chem , vol.268 , pp. 15193-15199
    • Osheroff, P.L.1    Ho, W.H.2
  • 59
    • 0025311303 scopus 로고
    • Preparation of biologically active 32P-labeled human relaxin. Displaceable binding to rat uterus, cervix, and brain
    • Osheroff PL, Ling VT, Vandlen RL, Cronin MJ, Lofgren JA (1990) Preparation of biologically active 32P-labeled human relaxin. Displaceable binding to rat uterus, cervix, and brain. J Biol Chem 265:9396-9401
    • (1990) J Biol Chem , vol.265 , pp. 9396-9401
    • Osheroff, P.L.1    Ling, V.T.2    Vandlen, R.L.3    Cronin, M.J.4    Lofgren, J.A.5
  • 60
    • 0026010298 scopus 로고
    • Autoradiographic localization of relaxin binding sites in rat brain
    • Osheroff PL, Phillips HS (1991) Autoradiographic localization of relaxin binding sites in rat brain. Proc Natl Acad Sci USA 88:6413-6417
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6413-6417
    • Osheroff, P.L.1    Phillips, H.S.2
  • 61
    • 33749059602 scopus 로고    scopus 로고
    • Comparative localization of leucine-rich repeat-containing G-protein-coupled receptor-7 (RXFP1) mRNA and [(33)P]-relaxin binding sites in rat brain: Restricted somatic co-expression a clue to relaxin action?
    • Ma S, Shen PJ, Burazin TC, Tregear GW, Gundlach AL (2006) Comparative localization of leucine-rich repeat-containing G-protein-coupled receptor-7 (RXFP1) mRNA and [(33)P]-relaxin binding sites in rat brain: restricted somatic co-expression a clue to relaxin action? Neuroscience 141:329-344
    • (2006) Neuroscience , vol.141 , pp. 329-344
    • Ma, S.1    Shen, P.J.2    Burazin, T.C.3    Tregear, G.W.4    Gundlach, A.L.5
  • 62
    • 0023640417 scopus 로고
    • The subfornical organ and relaxin-induced inhibition of reflex milk ejection in lactating rats
    • Summerlee AJ, ÓByrne KT, Jones SA, Eltringham L (1987) The subfornical organ and relaxin-induced inhibition of reflex milk ejection in lactating rats. J Endocrinol 115:347-353
    • (1987) J Endocrinol , vol.115 , pp. 347-353
    • Summerlee, A.J.1    ÓByrne, K.T.2    Jones, S.A.3    Eltringham, L.4
  • 63
    • 0023102389 scopus 로고
    • Central inhibitory effects of relaxin on the milk ejection reflex of the rat depends upon the site of injection into the cerebroventricular system
    • ÓByrne KT, Eltringham L, Summerlee AJ (1987) Central inhibitory effects of relaxin on the milk ejection reflex of the rat depends upon the site of injection into the cerebroventricular system. Brain Res 405:80-83
    • (1987) Brain Res , vol.405 , pp. 80-83
    • ÓByrne, K.T.1    Eltringham, L.2    Summerlee, A.J.3
  • 64
    • 0024432107 scopus 로고
    • Lesion of the subfornical organ affects the haemotensive response to centrally administered relaxin in anaesthetized rats
    • Mumford AD, Parry LJ, Summerlee AJ (1989) Lesion of the subfornical organ affects the haemotensive response to centrally administered relaxin in anaesthetized rats. J Endocrinol 122:747-755
    • (1989) J Endocrinol , vol.122 , pp. 747-755
    • Mumford, A.D.1    Parry, L.J.2    Summerlee, A.J.3
  • 65
    • 0020645737 scopus 로고
    • Hypothalamic integration: Organization of the paraventricular and supraoptic nuclei
    • Swanson LW, Sawchenko PE (1983) Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu Rev Neurosci 6:269-324
    • (1983) Annu Rev Neurosci , vol.6 , pp. 269-324
    • Swanson, L.W.1    Sawchenko, P.E.2
  • 67
    • 0023150757 scopus 로고
    • Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis
    • Dayanithi G, Cazalis M, Nordmann JJ (1987) Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis. Nature 325:813-816
    • (1987) Nature , vol.325 , pp. 813-816
    • Dayanithi, G.1    Cazalis, M.2    Nordmann, J.J.3
  • 68
    • 0025779713 scopus 로고
    • Central angiotensin partially mediates the pressor action of relaxin in anesthetized rats
    • Parry LJ, Summerlee AJ (1991) Central angiotensin partially mediates the pressor action of relaxin in anesthetized rats. Endocrinology 129:47-52
    • (1991) Endocrinology , vol.129 , pp. 47-52
    • Parry, L.J.1    Summerlee, A.J.2
  • 69
    • 0020002090 scopus 로고
    • Changes in water and electrolyte balance, plasma volume and composition during pregnancy in the rat
    • Atherton JC, Dark JM, Garland HO, Morgan MR, Pidgeon J, Soni S (1982) Changes in water and electrolyte balance, plasma volume and composition during pregnancy in the rat. J Physiol 330:81-93
    • (1982) J Physiol , vol.330 , pp. 81-93
    • Atherton, J.C.1    Dark, J.M.2    Garland, H.O.3    Morgan, M.R.4    Pidgeon, J.5    Soni, S.6
  • 70
    • 0031790532 scopus 로고    scopus 로고
    • The dipsogenic effects of rat relaxin: The effect of photoperiod and the potential role of relaxin on drinking in pregnancy
    • Summerlee AJ, Hornsby DJ, Ramsey DG (1998) The dipsogenic effects of rat relaxin: the effect of photoperiod and the potential role of relaxin on drinking in pregnancy. Endocrinology 139:2322-2328
    • (1998) Endocrinology , vol.139 , pp. 2322-2328
    • Summerlee, A.J.1    Hornsby, D.J.2    Ramsey, D.G.3
  • 71
    • 0035036239 scopus 로고    scopus 로고
    • Identification of efferent neural pathways from the lamina terminalis activated by blood-borne relaxin
    • Sunn N, McKinley MJ, Oldfield BJ (2001) Identification of efferent neural pathways from the lamina terminalis activated by blood-borne relaxin. J Neuroendocrinol 13:432-437
    • (2001) J Neuroendocrinol , vol.13 , pp. 432-437
    • Sunn, N.1    McKinley, M.J.2    Oldfield, B.J.3
  • 73
    • 0033303539 scopus 로고    scopus 로고
    • Water drinking in rats resulting from intravenous relaxin and its modification by other dipsogenic factors
    • Sinnayah P, Burns P, Wade JD, Weisinger RS, McKinley MJ (1999) Water drinking in rats resulting from intravenous relaxin and its modification by other dipsogenic factors. Endocrinology 140:5082-5086
    • (1999) Endocrinology , vol.140 , pp. 5082-5086
    • Sinnayah, P.1    Burns, P.2    Wade, J.D.3    Weisinger, R.S.4    McKinley, M.J.5
  • 74
    • 0028197422 scopus 로고
    • Brain angiotensin-II partially mediates the effects of relaxin on vasopressin and oxytocin release in anesthetized rats
    • Geddes BJ, Parry LJ, Summerlee AJ (1994) Brain angiotensin-II partially mediates the effects of relaxin on vasopressin and oxytocin release in anesthetized rats. Endocrinology 134:1188-1192
    • (1994) Endocrinology , vol.134 , pp. 1188-1192
    • Geddes, B.J.1    Parry, L.J.2    Summerlee, A.J.3
  • 75
    • 0023723483 scopus 로고
    • Monoclonal antibodies specific for rat relaxin. II. Passive immunization with monoclonal antibodies throughout the second half of pregnancy disrupts birth in intact rats
    • Guico-Lamm ML, Sherwood OD (1988) Monoclonal antibodies specific for rat relaxin. II. Passive immunization with monoclonal antibodies throughout the second half of pregnancy disrupts birth in intact rats. Endocrinology 123:2479-2485
    • (1988) Endocrinology , vol.123 , pp. 2479-2485
    • Guico-Lamm, M.L.1    Sherwood, O.D.2
  • 76
    • 0031788013 scopus 로고    scopus 로고
    • Neutralization of relaxin within the brain affects the timing of birth in rats
    • Summerlee AJ, Ramsey DG, Poterski RS (1998) Neutralization of relaxin within the brain affects the timing of birth in rats. Endocrinology 139:479-484
    • (1998) Endocrinology , vol.139 , pp. 479-484
    • Summerlee, A.J.1    Ramsey, D.G.2    Poterski, R.S.3
  • 77
    • 3943103488 scopus 로고    scopus 로고
    • The amygdala modulates the consolidation of memories of emotionally arousing experiences
    • McGaugh JL (2004) The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annu Rev Neurosci 27:1-28
    • (2004) Annu Rev Neurosci , vol.27 , pp. 1-28
    • McGaugh, J.L.1
  • 79
    • 0000629334 scopus 로고
    • Connexions of the dorsal tegmental nucleus in rat and rabbit
    • Morest DK (1961) Connexions of the dorsal tegmental nucleus in rat and rabbit. J Anat 95:229-246
    • (1961) J Anat , vol.95 , pp. 229-246
    • Morest, D.K.1
  • 80
    • 0019964704 scopus 로고
    • Anatomical relationships of serotoninergic and noradrenalinergic projections with the GnRH system in septum and hypothalamus
    • Jennes L, Beckman WC, Stumpf WE, Grzanna R (1982) Anatomical relationships of serotoninergic and noradrenalinergic projections with the GnRH system in septum and hypothalamus. Exp Brain Res 46:331-338
    • (1982) Exp Brain Res , vol.46 , pp. 331-338
    • Jennes, L.1    Beckman, W.C.2    Stumpf, W.E.3    Grzanna, R.4
  • 82
    • 64549127362 scopus 로고    scopus 로고
    • Verification of a relaxin-3 knockout/LacZ reporter mouse as a model of relaxin-3 deficiency
    • Smith CM, Shen PJ, Ma S, Sutton SW, Gundlach AL (2009) Verification of a relaxin-3 knockout/LacZ reporter mouse as a model of relaxin-3 deficiency. Ann NY Acad Sci 1160:259-260
    • (2009) Ann NY Acad Sci , vol.1160 , pp. 259-260
    • Smith, C.M.1    Shen, P.J.2    Ma, S.3    Sutton, S.W.4    Gundlach, A.L.5
  • 83
    • 57149110037 scopus 로고    scopus 로고
    • Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: First evidence of nucleus incertus in fish
    • Donizetti A, Grossi M, Pariante P, D'Aniello E, Izzo G, Minucci S, Aniello F (2008) Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: first evidence of nucleus incertus in fish. Dev Dyn 237:3864-3869
    • (2008) Dev Dyn , vol.237 , pp. 3864-3869
    • Donizetti, A.1    Grossi, M.2    Pariante, P.3    D'Aniello, E.4    Izzo, G.5    Minucci, S.6    Aniello, F.7
  • 84
    • 70350680168 scopus 로고    scopus 로고
    • Localization of relaxin-3 in brain of Macaca fascicularis: Identification of a nucleus incertus in primate
    • Ma S, Sang Q, Lanciego JL, Gundlach AL (2009) Localization of relaxin-3 in brain of Macaca fascicularis: identification of a nucleus incertus in primate. J Comp Neurol 517:856-872
    • (2009) J Comp Neurol , vol.517 , pp. 856-872
    • Ma, S.1    Sang, Q.2    Lanciego, J.L.3    Gundlach, A.L.4
  • 87
    • 0028792245 scopus 로고
    • GABAergic neurons in the rat pontomesencephalic tegmentum: Codistribution with cholinergic and other tegmental neurons projecting to the posterior lateral hypothalamus
    • Ford B, Holmes CJ, Mainville L, Jones BE (1995) GABAergic neurons in the rat pontomesencephalic tegmentum: codistribution with cholinergic and other tegmental neurons projecting to the posterior lateral hypothalamus. J Comp Neurol 363:177-196
    • (1995) J Comp Neurol , vol.363 , pp. 177-196
    • Ford, B.1    Holmes, C.J.2    Mainville, L.3    Jones, B.E.4
  • 90
    • 0020409215 scopus 로고
    • Corticotropin releasing factor produces behavioural activation in rats
    • Sutton RE, Koob GF, Le Moal M, Rivier J, Vale W (1982) Corticotropin releasing factor produces behavioural activation in rats. Nature 297:331-333
    • (1982) Nature , vol.297 , pp. 331-333
    • Sutton, R.E.1    Koob, G.F.2    Le Moal, M.3    Rivier, J.4    Vale, W.5
  • 91
    • 71549143466 scopus 로고    scopus 로고
    • Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF(1) activation
    • Banerjee A, Shen PJ, Ma S, Bathgate RA, Gundlach AL (2009) Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF(1) activation. Neuropharmacology 58:145-155
    • (2009) Neuropharmacology , vol.58 , pp. 145-155
    • Banerjee, A.1    Shen, P.J.2    Ma, S.3    Bathgate, R.A.4    Gundlach, A.L.5
  • 96
    • 37549022670 scopus 로고    scopus 로고
    • Serotoninergic regulation of emotional and behavioural control processes
    • Cools R, Roberts AC, Robbins TW (2008) Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn Sci 12:31-40
    • (2008) Trends Cogn Sci , vol.12 , pp. 31-40
    • Cools, R.1    Roberts, A.C.2    Robbins, T.W.3
  • 97
    • 37349043000 scopus 로고    scopus 로고
    • Developmental expression and serotonergic regulation of relaxin 3/INSL7 in the nucleus incertus of rat brain
    • Miyamoto Y, Watanabe Y, Tanaka M (2008) Developmental expression and serotonergic regulation of relaxin 3/INSL7 in the nucleus incertus of rat brain. Regul Pept 145:54-59
    • (2008) Regul Pept , vol.145 , pp. 54-59
    • Miyamoto, Y.1    Watanabe, Y.2    Tanaka, M.3


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