The E295K cancer variant of human polymerase β favors the mismatch conformational pathway during nucleotide selection

Journal of Biological Chemistry

Volumn 288, Issue 48, 2013, Pages 34850-34860

  Eckenroth, Brian E ^a   Towle Weicksel, Jamie B ^b   Sweasy, Joann B ^b   Doublié, Sylvie ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASE EXCISION REPAIRS; CELLULAR TRANSFORMATION; COGNATE NUCLEOTIDES; CONFORMATIONAL PATHWAYS; DIFFERENCE-FOURIER MAP; POLYMERASE ACTIVE SITE; POLYMERASE ACTIVITIES; STRUCTURAL REARRANGEMENT;

AMINO ACIDS; DISEASES; NUCLEOTIDES; REPAIR;

POLYMERS;

DEOXYCYTIDINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE BETA; ENZYME VARIANT; GLUTAMIC ACID; LYSINE; NUCLEOTIDE; THYMIDINE TRIPHOSPHATE;

ARTICLE; BINDING AFFINITY; CELL TRANSFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; PRIORITY JOURNAL;

EID: 84889007271     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.510891     Document Type: Article

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