메뉴 건너뛰기




Volumn 19, Issue 6, 2013, Pages 490-501

Hampering immune suppressors: Therapeutic targeting of myeloid-derived suppressor cells in cancer

Author keywords

Differentiation; Immune Suppression; MDSC; Therapeutic Targeting

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; AMILORIDE; ANTINEOPLASTIC AGENT; CALCIUM BINDING PROTEIN; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; COLECALCIFEROL; CURCUMIN; CYCLOPHOSPHAMIDE; DNA VACCINE; DOCETAXEL; DOXORUBICIN; FLUOROURACIL; GLUCAN; PACLITAXEL; PAMIDRONIC ACID; PROTEOLIPOSOME; PYRIMIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RETINOIC ACID; ROSIGLITAZONE; SILDENAFIL; STAT1 PROTEIN; STAT3 PROTEIN; SUNITINIB; TRITERPENOID; UNINDEXED DRUG; VEMURAFENIB; ZOLEDRONIC ACID;

EID: 84888998996     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0000000000000006     Document Type: Review
Times cited : (54)

References (132)
  • 1
    • 84877330702 scopus 로고    scopus 로고
    • Cancer immunoediting: Antigens, mechanisms, and implications to cancer immunotherapy
    • Vesely MD, Schreiber RD. Cancer immunoediting: Antigens, mechanisms, and implications to cancer immunotherapy. Ann N Y Acad Sci. 2013;1284:1-5.
    • (2013) Ann N y Acad Sci , vol.1284 , pp. 1-5
    • Vesely, M.D.1    Schreiber, R.D.2
  • 2
    • 0030890836 scopus 로고    scopus 로고
    • Cancer vaccines based on the identification of genes encoding cancer regression antigens
    • Rosenberg SA. Cancer vaccines based on the identification of genes encoding cancer regression antigens. Immunol Today. 1997;18:175-182.
    • (1997) Immunol Today , vol.18 , pp. 175-182
    • Rosenberg, S.A.1
  • 3
    • 0024346258 scopus 로고
    • Murine natural suppressor cells in the newborn, in bone marrow, and after cyclophosphamide: Genetic variations and dependence on IFN-gamma
    • Maier T, Holda JH, Claman HN. Murine natural suppressor cells in the newborn, in bone marrow, and after cyclophosphamide: genetic variations and dependence on IFN-gamma. J Immunol. 1989;143: 491-498.
    • (1989) J Immunol , vol.143 , pp. 491-498
    • Maier, T.1    Holda, J.H.2    Claman, H.N.3
  • 4
    • 0027092060 scopus 로고
    • T-cell subsets and suppressor cells in human bone marrow
    • Schmidt-Wolf IG, Dejbakhsh-Jones S, Ginzton N, et al. T-cell subsets and suppressor cells in human bone marrow. Blood. 1992;80: 3242-3250.
    • (1992) Blood , vol.80 , pp. 3242-3250
    • Schmidt-Wolf, I.G.1    Dejbakhsh-Jones, S.2    Ginzton, N.3
  • 5
    • 0029065835 scopus 로고
    • Involvement of nitric oxide in bone marrow-derived natural suppressor activity. Its dependence on IFN-gamma
    • Angulo I, Rodriguez R, Garcia B, et al. Involvement of nitric oxide in bone marrow-derived natural suppressor activity. Its dependence on IFN-gamma. J Immunol. 1995;155:15-26.
    • (1995) J Immunol , vol.155 , pp. 15-26
    • Angulo, I.1    Rodriguez, R.2    Garcia, B.3
  • 6
    • 0034023858 scopus 로고    scopus 로고
    • Early myeloid cells are high producers of nitric oxide upon CD40 plus IFN-gamma stimulation through a mechanism dependent on endogenous TNF-alpha and IL-1alpha
    • Angulo I, Rullas J, Campillo JA, et al. Early myeloid cells are high producers of nitric oxide upon CD40 plus IFN-gamma stimulation through a mechanism dependent on endogenous TNF-alpha and IL-1alpha. Eur J Immunol. 2000;30:1263-1271.
    • (2000) Eur J Immunol , vol.30 , pp. 1263-1271
    • Angulo, I.1    Rullas, J.2    Campillo, J.A.3
  • 7
    • 0031826383 scopus 로고    scopus 로고
    • Stimulation of immune suppressive CD34+ cells from normal bone marrow by Lewis lung carcinoma tumors
    • Wright MA, Wiers K, Vellody K, et al. Stimulation of immune suppressive CD34+ cells from normal bone marrow by Lewis lung carcinoma tumors. Cancer Immunol Immunother. 1998;46:253-260.
    • (1998) Cancer Immunol Immunother , vol.46 , pp. 253-260
    • Wright, M.A.1    Wiers, K.2    Vellody, K.3
  • 8
    • 0030465813 scopus 로고    scopus 로고
    • Mechanisms of tumor-induced immunosuppression: Evidence for contact-dependent T cell suppression by monocytes
    • Jaffe ML, Arai H, Nabel GJ. Mechanisms of tumor-induced immunosuppression: evidence for contact-dependent T cell suppression by monocytes. Mol Med. 1996;2:692-701.
    • (1996) Mol Med , vol.2 , pp. 692-701
    • Jaffe, M.L.1    Arai, H.2    Nabel, G.J.3
  • 9
    • 0032533478 scopus 로고    scopus 로고
    • Apoptotic death of CD8+ T lymphocytes after immunization: Induction of a suppressive population of Mac-1+/Gr-1+ cells
    • Bronte V, Wang M, Overwijk WW, et al. Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells. J Immunol. 1998;161:5313-5320.
    • (1998) J Immunol , vol.161 , pp. 5313-5320
    • Bronte, V.1    Wang, M.2    Overwijk, W.W.3
  • 10
    • 0033562982 scopus 로고    scopus 로고
    • Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation
    • Bronte V, Chappell DB, Apolloni E, et al. Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation. J Immunol. 1999;162:5728-5737.
    • (1999) J Immunol , vol.162 , pp. 5728-5737
    • Bronte, V.1    Chappell, D.B.2    Apolloni, E.3
  • 11
    • 0034551670 scopus 로고    scopus 로고
    • Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
    • Bronte V, Apolloni E, Cabrelle A, et al. Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood. 2000;96:3838-3846.
    • (2000) Blood , vol.96 , pp. 3838-3846
    • Bronte, V.1    Apolloni, E.2    Cabrelle, A.3
  • 12
    • 0034661719 scopus 로고    scopus 로고
    • Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation
    • Kusmartsev SA, Li Y, Chen SH. Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J Immunol. 2000;165:779-785.
    • (2000) J Immunol , vol.165 , pp. 779-785
    • Kusmartsev, S.A.1    Li, Y.2    Chen, S.H.3
  • 13
    • 33846434093 scopus 로고    scopus 로고
    • The terminology issue for myeloid-derived suppressor cells
    • author reply 426
    • Gabrilovich DI, Bronte V, Chen SH, et al. The terminology issue for myeloid-derived suppressor cells. Cancer Res. 2007;67:425; author reply 426.
    • (2007) Cancer Res , vol.67 , pp. 425
    • Gabrilovich, D.I.1    Bronte, V.2    Chen, S.H.3
  • 14
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cellYsuppressive activity
    • Movahedi K, Guilliams M, van den Bossche J, et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cellYsuppressive activity. Blood. 2008;111: 4233-4244.
    • (2008) Blood , vol.111 , pp. 4233-4244
    • Movahedi, K.1    Guilliams, M.2    Van Den Bossche, J.3
  • 15
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    • Youn JI, Nagaraj S, Collazo M, et al. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol. 2008;181:5791-5802.
    • (2008) J Immunol , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3
  • 17
    • 84866910216 scopus 로고    scopus 로고
    • Myeloid cells obtained from the blood but not from the tumor can suppress T-cell proliferation in patients with melanoma
    • Gros A, Turcotte S, Wunderlich JR, et al. Myeloid cells obtained from the blood but not from the tumor can suppress T-cell proliferation in patients with melanoma. Clin Cancer Res. 2012;18:5212-5223.
    • (2012) Clin Cancer Res , vol.18 , pp. 5212-5223
    • Gros, A.1    Turcotte, S.2    Wunderlich, J.R.3
  • 18
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi K, Traver D, Miyamoto T, et al. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404: 193-197.
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3
  • 19
    • 84880838451 scopus 로고    scopus 로고
    • Origin of monocytes and macrophages in a committed progenitor
    • Hettinger J, Richards DM, Hansson J, et al. Origin of monocytes and macrophages in a committed progenitor. Nat Immunol. 2013;14: 821-830.
    • (2013) Nat Immunol , vol.14 , pp. 821-830
    • Hettinger, J.1    Richards, D.M.2    Hansson, J.3
  • 20
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, Condamine T, Lu L, et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med. 2010;207:2439-2453.
    • (2010) J Exp Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3
  • 21
    • 77953914366 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor
    • Marigo I, Bosio E, Solito S, et al. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity. 2010;32:790-802.
    • (2010) Immunity , vol.32 , pp. 790-802
    • Marigo, I.1    Bosio, E.2    Solito, S.3
  • 22
    • 79952772423 scopus 로고    scopus 로고
    • Paired immunoglobulin-like receptor-B regulates the suppressive function and fate of myeloidderived suppressor cells
    • Ma G, Pan PY, Eisenstein S, et al. Paired immunoglobulin-like receptor-B regulates the suppressive function and fate of myeloidderived suppressor cells. Immunity. 2011;34:385-395.
    • (2011) Immunity , vol.34 , pp. 385-395
    • Ma, G.1    Pan, P.Y.2    Eisenstein, S.3
  • 23
    • 33846408655 scopus 로고    scopus 로고
    • Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
    • Varol C, Landsman L, Fogg DK, et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med. 2007;204: 171-180.
    • (2007) J Exp Med , vol.204 , pp. 171-180
    • Varol, C.1    Landsman, L.2    Fogg, D.K.3
  • 24
    • 1642406217 scopus 로고    scopus 로고
    • Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response
    • Sunderkotter C, Nikolic T, Dillon MJ, et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol. 2004;172:4410-4417.
    • (2004) J Immunol , vol.172 , pp. 4410-4417
    • Sunderkotter, C.1    Nikolic, T.2    Dillon, M.J.3
  • 25
    • 70349563347 scopus 로고    scopus 로고
    • Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16j monocyte subsets
    • Ancuta P, Liu KY, Misra V, et al. Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16j monocyte subsets. BMC Genomics. 2009;10:403.
    • (2009) BMC Genomics , vol.10 , pp. 403
    • Ancuta, P.1    Liu, K.Y.2    Misra, V.3
  • 26
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • Geissmann F, Manz MG, Jung S, et al. Development of monocytes, macrophages, and dendritic cells. Science. 2010;327:656-661.
    • (2010) Science , vol.327 , pp. 656-661
    • Geissmann, F.1    Manz, M.G.2    Jung, S.3
  • 27
    • 80051959957 scopus 로고    scopus 로고
    • The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C-monocytes
    • Hanna RN, Carlin LM, Hubbeling HG, et al. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C-monocytes. Nat Immunol. 2011;12:778-785.
    • (2011) Nat Immunol , vol.12 , pp. 778-785
    • Hanna, R.N.1    Carlin, L.M.2    Hubbeling, H.G.3
  • 28
    • 84866920497 scopus 로고    scopus 로고
    • Immune tolerance to tumor antigens occurs in a specialized environment of the spleen
    • Ugel S, Peranzoni E, Desantis G, et al. Immune tolerance to tumor antigens occurs in a specialized environment of the spleen. Cell Rep. 2012;2:628-639.
    • (2012) Cell Rep , vol.2 , pp. 628-639
    • Ugel, S.1    Peranzoni, E.2    Desantis, G.3
  • 29
    • 85027923251 scopus 로고    scopus 로고
    • Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer
    • Youn JI, Kumar V, Collazo M, et al. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat Immunol. 2013;14:211-220.
    • (2013) Nat Immunol , vol.14 , pp. 211-220
    • Youn, J.I.1    Kumar, V.2    Collazo, M.3
  • 30
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of Tumor-associated Neutrophil Phenotype by TGF-beta ''N1'' versus ' 'N2'' TAN
    • Fridlender ZG, Sun J, Kim S, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: ''N1'' versus ''N2'' TAN. Cancer Cell. 2009;16:183-194.
    • (2009) Cancer Cell , vol.16 , pp. 183-194
    • Fridlender, Z.G.1    Sun, J.2    Kim, S.3
  • 31
    • 84863116466 scopus 로고    scopus 로고
    • Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils
    • Fridlender ZG, Sun J, Mishalian I, et al. Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils. PloS One. 2012;7:e31524.
    • (2012) PloS One , vol.7
    • Fridlender, Z.G.1    Sun, J.2    Mishalian, I.3
  • 32
    • 84855301911 scopus 로고    scopus 로고
    • Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice
    • Youn JI, Collazo M, Shalova IN, et al. Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol. 2012;91:167-181.
    • (2012) J Leukoc Biol , vol.91 , pp. 167-181
    • Youn, J.I.1    Collazo, M.2    Shalova, I.N.3
  • 33
    • 84884230660 scopus 로고    scopus 로고
    • The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils
    • Raccosta L, Fontana R, Maggioni D, et al. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. J Exp Med. 2013.
    • (2013) J Exp Med
    • Raccosta, L.1    Fontana, R.2    Maggioni, D.3
  • 34
    • 84874263560 scopus 로고    scopus 로고
    • Tumor-derived gammadelta regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence
    • Ye J, Ma C, Hsueh EC, et al. Tumor-derived gammadelta regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence. J Immunol. 2013;190:2403-2414.
    • (2013) J Immunol , vol.190 , pp. 2403-2414
    • Ye, J.1    Ma, C.2    Hsueh, E.C.3
  • 35
    • 34548024379 scopus 로고    scopus 로고
    • Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique Toll-like receptor signaling pathway
    • Peng G, Wang HY, Peng W, et al. Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique Toll-like receptor signaling pathway. Immunity. 2007;27:334-348.
    • (2007) Immunity , vol.27 , pp. 334-348
    • Peng, G.1    Wang, H.Y.2    Peng, W.3
  • 36
    • 78650756969 scopus 로고    scopus 로고
    • Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    • Condamine T, Gabrilovich DI. Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol. 2011;32:19-25.
    • (2011) Trends Immunol , vol.32 , pp. 19-25
    • Condamine, T.1    Gabrilovich, D.I.2
  • 37
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9:162-174.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 38
    • 4344590947 scopus 로고    scopus 로고
    • I. High-dose granulocytemacrophage colony-stimulating factorYproducing vaccines impair the immune response through the recruitment of myeloid suppressor cells
    • Serafini P, Carbley R, Noonan KA, et al. I. High-dose granulocytemacrophage colony-stimulating factorYproducing vaccines impair the immune response through the recruitment of myeloid suppressor cells. Cancer Res. 2004;64:6337-6343.
    • (2004) Cancer Res , vol.64 , pp. 6337-6343
    • Serafini, P.1    Carbley, R.2    Noonan, K.A.3
  • 39
    • 38049181485 scopus 로고    scopus 로고
    • Reversion of immune tolerance in advanced malignancy: Modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function
    • Pan PY, Wang GX, Yin B, et al. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood. 2008; 111:219-228.
    • (2008) Blood , vol.111 , pp. 219-228
    • Pan, P.Y.1    Wang, G.X.2    Yin, B.3
  • 40
    • 34249300128 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    • Sinha P, Clements VK, Fulton AM, et al. Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res. 2007;67:4507-4513.
    • (2007) Cancer Res , vol.67 , pp. 4507-4513
    • Sinha, P.1    Clements, V.K.2    Fulton, A.M.3
  • 41
    • 25844501447 scopus 로고    scopus 로고
    • Arginase i in myeloid suppressor cells is induced by COX-2 in lung carcinoma
    • Rodriguez PC, Hernandez CP, Quiceno D, et al. Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. J Exp Med. 2005;202:931-939.
    • (2005) J Exp Med , vol.202 , pp. 931-939
    • Rodriguez, P.C.1    Hernandez, C.P.2    Quiceno, D.3
  • 42
    • 0032400862 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo
    • Gabrilovich D, Ishida T, Oyama T, et al. Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood. 1998;92:4150-4166.
    • (1998) Blood , vol.92 , pp. 4150-4166
    • Gabrilovich, D.1    Ishida, T.2    Oyama, T.3
  • 43
    • 35448954376 scopus 로고    scopus 로고
    • Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    • Bunt SK, Yang L, Sinha P, et al. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res. 2007;67: 10019-10026.
    • (2007) Cancer Res , vol.67 , pp. 10019-10026
    • Bunt, S.K.1    Yang, L.2    Sinha, P.3
  • 44
    • 4143130091 scopus 로고    scopus 로고
    • Arginase i production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
    • Rodriguez PC, Quiceno DG, Zabaleta J, et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 2004;64:5839-5849.
    • (2004) Cancer Res , vol.64 , pp. 5839-5849
    • Rodriguez, P.C.1    Quiceno, D.G.2    Zabaleta, J.3
  • 45
    • 33846933459 scopus 로고    scopus 로고
    • L-Arginine availability regulates T-lymphocyte cell-cycle progression
    • Rodriguez PC, Quiceno DG, Ochoa AC. L-Arginine availability regulates T-lymphocyte cell-cycle progression. Blood. 2007;109:1568-1573.
    • (2007) Blood , vol.109 , pp. 1568-1573
    • Rodriguez, P.C.1    Quiceno, D.G.2    Ochoa, A.C.3
  • 46
    • 0033597449 scopus 로고    scopus 로고
    • Fas-induced caspase denitrosylation
    • Mannick JB, Hausladen A, Liu L, et al. Fas-induced caspase denitrosylation. Science. 1999;284:651-654.
    • (1999) Science , vol.284 , pp. 651-654
    • Mannick, J.B.1    Hausladen, A.2    Liu, L.3
  • 47
    • 0032526629 scopus 로고    scopus 로고
    • Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway
    • Bingisser RM, Tilbrook PA, Holt PG, et al. Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. J Immunol. 1998;160:5729-5734.
    • (1998) J Immunol , vol.160 , pp. 5729-5734
    • Bingisser, R.M.1    Tilbrook, P.A.2    Holt, P.G.3
  • 48
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    • Srivastava MK, Sinha P, Clements VK, et al. Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res. 2010;70:68-77.
    • (2010) Cancer Res , vol.70 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3
  • 49
    • 33845868493 scopus 로고    scopus 로고
    • S100 proteins expressed in phagocytes: A novel group of damage-associated molecular pattern molecules
    • Foell D, Wittkowski H, Vogl T, et al. S100 proteins expressed in phagocytes: A novel group of damage-associated molecular pattern molecules. J Leukoc Biol. 2007;81:28-37.
    • (2007) J Leukoc Biol , vol.81 , pp. 28-37
    • Foell, D.1    Wittkowski, H.2    Vogl, T.3
  • 50
    • 66949145484 scopus 로고    scopus 로고
    • Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells
    • Corzo CA, Cotter MJ, Cheng P, et al. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol. 2009;182:5693-5701.
    • (2009) J Immunol , vol.182 , pp. 5693-5701
    • Corzo, C.A.1    Cotter, M.J.2    Cheng, P.3
  • 51
    • 55849107422 scopus 로고    scopus 로고
    • STAT3 mediates myeloid cellYdependent tumor angiogenesis in mice
    • Kujawski M, Kortylewski M, Lee H, et al. STAT3 mediates myeloid cellYdependent tumor angiogenesis in mice. J Clin Invest. 2008; 118:3367-3377.
    • (2008) J Clin Invest , vol.118 , pp. 3367-3377
    • Kujawski, M.1    Kortylewski, M.2    Lee, H.3
  • 52
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated HSP72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin F, Ladoire S, Mignot G, et al. Membrane-associated HSP72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest. 2010;120:457-471.
    • (2010) J Clin Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3
  • 53
    • 84864744528 scopus 로고    scopus 로고
    • Tumor-induced myeloid-derived suppressor cell function is independent of IFN-gamma and IL-4Ralpha
    • Sinha P, Parker KH, Horn L, et al. Tumor-induced myeloid-derived suppressor cell function is independent of IFN-gamma and IL-4Ralpha. Eur J Immunol. 2012;42:2052-2059.
    • (2012) Eur J Immunol , vol.42 , pp. 2052-2059
    • Sinha, P.1    Parker, K.H.2    Horn, L.3
  • 54
    • 31544446571 scopus 로고    scopus 로고
    • Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    • Huang B, Pan PY, Li Q, et al. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res. 2006; 66:1123-1131.
    • (2006) Cancer Res , vol.66 , pp. 1123-1131
    • Huang, B.1    Pan, P.Y.2    Li, Q.3
  • 55
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    • Serafini P, Mgebroff S, Noonan K, et al. Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res. 2008;68:5439-5449.
    • (2008) Cancer Res , vol.68 , pp. 5439-5449
    • Serafini, P.1    Mgebroff, S.2    Noonan, K.3
  • 56
    • 34548805636 scopus 로고    scopus 로고
    • Cross-talk between myeloidderived suppressor cells and macrophages subverts tumor immunity toward a type 2 response
    • Sinha P, Clements VK, Bunt SK, et al. Cross-talk between myeloidderived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol. 2007;179:977-983.
    • (2007) J Immunol , vol.179 , pp. 977-983
    • Sinha, P.1    Clements, V.K.2    Bunt, S.K.3
  • 57
    • 84868312968 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-betaYinduced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25jFoxP3j T cells
    • Centuori SM, Trad M, LaCasse CJ, et al. Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-betaYinduced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25jFoxP3j T cells. J Leukoc Biol. 2012;92:987-997.
    • (2012) J Leukoc Biol , vol.92 , pp. 987-997
    • Centuori, S.M.1    Trad, M.2    Lacasse, C.J.3
  • 58
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta
    • Li H, Han Y, Guo Q, et al. Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta. J Immunol. 2009;182:240-249.
    • (2009) J Immunol , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3
  • 59
    • 70349240416 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor
    • Hoechst B, Voigtlaender T, Ormandy L, et al. Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor. Hepatology. 2009;50:799-807.
    • (2009) Hepatology , vol.50 , pp. 799-807
    • Hoechst, B.1    Voigtlaender, T.2    Ormandy, L.3
  • 60
    • 84884796099 scopus 로고    scopus 로고
    • Tumor microenvironmental conversion of natural killer cells into myeloid-derived suppressor cells
    • Kang CY, Park YJ, Song B, et al. Tumor microenvironmental conversion of natural killer cells into myeloid-derived suppressor cells. Cancer Res. 2013.
    • (2013) Cancer Res
    • Kang, C.Y.1    Park, Y.J.2    Song, B.3
  • 61
    • 80054694464 scopus 로고    scopus 로고
    • Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    • Molon B, Ugel S, del Pozzo F, et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med. 2011; 208:1949-1962.
    • (2011) J Exp Med , vol.208 , pp. 1949-1962
    • Molon, B.1    Ugel, S.2    Del Pozzo, F.3
  • 62
    • 20144375187 scopus 로고    scopus 로고
    • Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination
    • de Santo C, Serafini P, Marigo I, et al. Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination. Proc Natl Acad Sci U S A. 2005;102:4185-4190.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4185-4190
    • De Santo, C.1    Serafini, P.2    Marigo, I.3
  • 63
    • 0034757918 scopus 로고    scopus 로고
    • Cyclic GMPYdependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells
    • Liu L, Li H, Underwood T, et al. Cyclic GMPYdependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells. J Pharmacol Exp Ther. 2001;299:583-592.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 583-592
    • Liu, L.1    Li, H.2    Underwood, T.3
  • 64
    • 0037222292 scopus 로고    scopus 로고
    • Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells
    • Sarfati M, Mateo V, Baudet S, et al. Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells. Blood. 2003;101: 265-269.
    • (2003) Blood , vol.101 , pp. 265-269
    • Sarfati, M.1    Mateo, V.2    Baudet, S.3
  • 65
    • 33751531874 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloidderived suppressor cell function
    • Serafini P, Meckel K, Kelso M, et al. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloidderived suppressor cell function. J Exp Med. 2006;203:2691-2702.
    • (2006) J Exp Med , vol.203 , pp. 2691-2702
    • Serafini, P.1    Meckel, K.2    Kelso, M.3
  • 66
    • 80054730389 scopus 로고    scopus 로고
    • Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model
    • Meyer C, Sevko A, Ramacher M, et al. Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model. Proc Natl Acad Sci U S A. 2011;108:17111-17116.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 17111-17116
    • Meyer, C.1    Sevko, A.2    Ramacher, M.3
  • 67
    • 77949718839 scopus 로고    scopus 로고
    • Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer
    • Nagaraj S, Youn JI, Weber H, et al. Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. Clin Cancer Res. 2010;16:1812-1823.
    • (2010) Clin Cancer Res , vol.16 , pp. 1812-1823
    • Nagaraj, S.1    Youn, J.I.2    Weber, H.3
  • 68
    • 79251551682 scopus 로고    scopus 로고
    • Inhibition of tumor-induced myeloid-derived suppressor cell function by a nanoparticulated adjuvant
    • Fernandez A, Mesa C, Marigo I, et al. Inhibition of tumor-induced myeloid-derived suppressor cell function by a nanoparticulated adjuvant. J Immunol. 2011;186:264-274.
    • (2011) J Immunol , vol.186 , pp. 264-274
    • Fernandez, A.1    Mesa, C.2    Marigo, I.3
  • 69
    • 25144466458 scopus 로고    scopus 로고
    • Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • Suzuki E, Kapoor V, Jassar AS, et al. Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res. 2005;11:6713-6721.
    • (2005) Clin Cancer Res , vol.11 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3
  • 70
    • 77951086882 scopus 로고    scopus 로고
    • 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cellYdependent antitumor immunity
    • Vincent J, Mignot G, Chalmin F, et al. 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cellYdependent antitumor immunity. Cancer Res. 2010;70: 3052-3061.
    • (2010) Cancer Res , vol.70 , pp. 3052-3061
    • Vincent, J.1    Mignot, G.2    Chalmin, F.3
  • 71
    • 79960965896 scopus 로고    scopus 로고
    • Myeloidderived suppressor cell inhibition of the IFN response in tumor-bearing mice
    • Mundy-Bosse BL, Lesinski GB, Jaime-Ramirez AC, et al. Myeloidderived suppressor cell inhibition of the IFN response in tumor-bearing mice. Cancer Res. 2011;71:5101-5110.
    • (2011) Cancer Res , vol.71 , pp. 5101-5110
    • Mundy-Bosse, B.L.1    Lesinski, G.B.2    Jaime-Ramirez, A.C.3
  • 72
    • 67349133537 scopus 로고    scopus 로고
    • Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice
    • Le HK, Graham L, Cha E, et al. Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice. Int Immunopharmacol. 2009;9:900-909.
    • (2009) Int Immunopharmacol , vol.9 , pp. 900-909
    • Le Graham, H.K.L.1    Cha, E.2
  • 73
    • 84874116665 scopus 로고    scopus 로고
    • Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce antitumor T cell immunity in vivo
    • Tongu M, Harashima N, Monma H, et al. Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce antitumor T cell immunity in vivo. Cancer Immunol Immunother. 2013; 62:383-391.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 383-391
    • Tongu, M.1    Harashima, N.2    Monma, H.3
  • 74
    • 84874112910 scopus 로고    scopus 로고
    • Rosiglitazone and gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer
    • Bunt SK, Mohr AM, Bailey JM, et al. Rosiglitazone and gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer. Cancer Immunol Immunother. 2013; 62:225-236.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 225-236
    • Bunt, S.K.1    Mohr, A.M.2    Bailey, J.M.3
  • 75
    • 78049479930 scopus 로고    scopus 로고
    • Chemotherapy delivered after viral immunogene therapy augments antitumor efficacy via multiple immune-mediated mechanisms
    • Fridlender ZG, Sun J, Singhal S, et al. Chemotherapy delivered after viral immunogene therapy augments antitumor efficacy via multiple immune-mediated mechanisms. Mol Ther. 2010;18:1947-1959.
    • (2010) Mol Ther , vol.18 , pp. 1947-1959
    • Fridlender, Z.G.1    Sun, J.2    Singhal, S.3
  • 76
    • 84872086179 scopus 로고    scopus 로고
    • Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
    • Bruchard M, Mignot G, Derangere V, et al. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med. 2013; 19:57-64.
    • (2013) Nat Med , vol.19 , pp. 57-64
    • Bruchard, M.1    Mignot, G.2    Derangere, V.3
  • 77
    • 0033758412 scopus 로고    scopus 로고
    • Indomethacin inhibits the accumulation of tumor cells in mouse lungs and subsequent growth of lung metastases
    • Levin G, Kariv N, Khomiak E, et al. Indomethacin inhibits the accumulation of tumor cells in mouse lungs and subsequent growth of lung metastases. Chemotherapy. 2000;46:429-437.
    • (2000) Chemotherapy , vol.46 , pp. 429-437
    • Levin, G.1    Kariv, N.2    Khomiak, E.3
  • 78
    • 0036468287 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo
    • Leahy KM, Ornberg RL, Wang Y, et al. Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Res. 2002;62:625-631.
    • (2002) Cancer Res , vol.62 , pp. 625-631
    • Leahy, K.M.1    Ornberg, R.L.2    Wang, Y.3
  • 79
    • 0033790479 scopus 로고    scopus 로고
    • Meloxicam inhibits the growth of nonYsmall cell lung cancer
    • Tsubouchi Y, Mukai S, Kawahito Y, et al. Meloxicam inhibits the growth of nonYsmall cell lung cancer. Anticancer Res. 2000;20:2867-2872.
    • (2000) Anticancer Res , vol.20 , pp. 2867-2872
    • Tsubouchi, Y.1    Mukai, S.2    Kawahito, Y.3
  • 80
    • 79953324535 scopus 로고    scopus 로고
    • COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells
    • Fujita M, Kohanbash G, Fellows-Mayle W, et al. COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells. Cancer Res. 2011;71:2664-2674.
    • (2011) Cancer Res , vol.71 , pp. 2664-2674
    • Fujita, M.1    Kohanbash, G.2    Fellows-Mayle, W.3
  • 81
    • 77956473075 scopus 로고    scopus 로고
    • COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function
    • Veltman JD, Lambers ME, van Nimwegen M, et al. COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function. BMC Cancer. 2010;10:464.
    • (2010) BMC Cancer , vol.10 , pp. 464
    • Veltman, J.D.1    Lambers, M.E.2    Van Nimwegen, M.3
  • 82
    • 78649598159 scopus 로고    scopus 로고
    • Pivotal advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE (2) catabolism in myeloid cells
    • Eruslanov E, Daurkin I, Ortiz J, et al. Pivotal advance: tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE(2) catabolism in myeloid cells. J Leukoc Biol. 2010;88:839-848.
    • (2010) J Leukoc Biol , vol.88 , pp. 839-848
    • Eruslanov, E.1    Daurkin, I.2    Ortiz, J.3
  • 83
    • 84880062518 scopus 로고    scopus 로고
    • Generation of myeloid-derived suppressor cells using prostaglandin E2
    • Obermajer N, Kalinski P. Generation of myeloid-derived suppressor cells using prostaglandin E2. Transplan Res. 2012;1:15.
    • (2012) Transplan Res , vol.1 , pp. 15
    • Obermajer, N.1    Kalinski, P.2
  • 84
    • 84880072604 scopus 로고    scopus 로고
    • Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2Ydependent mechanisms
    • Mao Y, Poschke I, Wennerberg E, et al. Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2Ydependent mechanisms. Cancer Res. 2013;73:3877-3887.
    • (2013) Cancer Res , vol.73 , pp. 3877-3887
    • Mao, Y.1    Poschke, I.2    Wennerberg, E.3
  • 85
    • 34447260736 scopus 로고    scopus 로고
    • Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor
    • George S. Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor. Curr Oncol Rep. 2007; 9:323-327.
    • (2007) Curr Oncol Rep , vol.9 , pp. 323-327
    • George, S.1
  • 86
    • 38849193576 scopus 로고    scopus 로고
    • FLT3 kinase inhibitors in the management of acute myeloid leukemia
    • Illmer T, Ehninger G. FLT3 kinase inhibitors in the management of acute myeloid leukemia. Clin Lymph Myeloma. 2007;8(suppl 1): S24YS34.
    • (2007) Clin Lymph Myeloma , vol.8 , Issue.SUPPL. 1
    • Illmer, T.1    Ehninger, G.2
  • 87
    • 33947416658 scopus 로고    scopus 로고
    • Sunitinib: A VEGF and PDGF receptor protein kinase and angiogenesis inhibitor
    • Roskoski R Jr. Sunitinib: A VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007;356: 323-328.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 323-328
    • Roskoski Jr., R.1
  • 88
    • 84874081070 scopus 로고    scopus 로고
    • Management of gastrointestinal stromal tumors
    • Rajendra R, Pollack SM, Jones RL. Management of gastrointestinal stromal tumors. Future Oncol. 2013;9:193-206.
    • (2013) Future Oncol , vol.9 , pp. 193-206
    • Rajendra, R.1    Pollack, S.M.2    Jones, R.L.3
  • 89
    • 84858701414 scopus 로고    scopus 로고
    • Sunitinib: The first to arrive at first-line metastatic renal cell carcinoma
    • Vazquez S, Leon L, Fernandez O, et al. Sunitinib: the first to arrive at first-line metastatic renal cell carcinoma. Adv Ther. 2012;29:202-217.
    • (2012) Adv Ther , vol.29 , pp. 202-217
    • Vazquez, S.1    Leon, L.2    Fernandez, O.3
  • 90
    • 84883445852 scopus 로고    scopus 로고
    • Long-term response to sunitinib therapy for metastatic renal cell carcinoma
    • Molina AM, Jia X, Feldman DR, et al. Long-term response to sunitinib therapy for metastatic renal cell carcinoma. Clin Genitourin Cancer. 2013.
    • (2013) Clin Genitourin Cancer
    • Molina, A.M.1    Jia, X.2    Feldman, D.R.3
  • 91
    • 65549141834 scopus 로고    scopus 로고
    • The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
    • Ozao-Choy J, Ma G, Kao J, et al. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 2009;69:2514-2522.
    • (2009) Cancer Res , vol.69 , pp. 2514-2522
    • Ozao-Choy, J.1    Ma, G.2    Kao, J.3
  • 92
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • Xin H, Zhang C, Herrmann A, et al. Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res. 2009;69:2506-2513.
    • (2009) Cancer Res , vol.69 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3
  • 93
    • 73149103231 scopus 로고    scopus 로고
    • Therapeutic activity of sunitinib for Her2/neu induced mammary cancer in FVB mice
    • Abe F, Younos I, Westphal S, et al. Therapeutic activity of sunitinib for Her2/neu induced mammary cancer in FVB mice. Int Immunopharmacol. 2010;10:140-145.
    • (2010) Int Immunopharmacol , vol.10 , pp. 140-145
    • Abe, F.1    Younos, I.2    Westphal, S.3
  • 94
    • 80054098093 scopus 로고    scopus 로고
    • Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination
    • Bose A, Taylor JL, Alber S, et al. Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination. Int J Cancer. 2011;129:2158-2170.
    • (2011) Int J Cancer , vol.129 , pp. 2158-2170
    • Bose, A.1    Taylor, J.L.2    Alber, S.3
  • 95
    • 77951754469 scopus 로고    scopus 로고
    • Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained
    • Ko JS, Rayman P, Ireland J, et al. Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Res. 2010;70:3526-3536.
    • (2010) Cancer Res , vol.70 , pp. 3526-3536
    • Ko, J.S.1    Rayman, P.2    Ireland, J.3
  • 96
    • 79958052123 scopus 로고    scopus 로고
    • MDSC as amechanismof tumor escape from sunitinib mediated anti-angiogenic therapy
    • Finke J, Ko J, Rini B, et al. MDSC as amechanismof tumor escape from sunitinib mediated anti-angiogenic therapy. Int Immunopharmacol. 2011;11:856-861.
    • (2011) Int Immunopharmacol , vol.11 , pp. 856-861
    • Finke, J.1    Ko, J.2    Rini, B.3
  • 97
    • 84874456244 scopus 로고    scopus 로고
    • Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells
    • Panka DJ, Liu Q, Geissler AK, et al. Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells. Mol Cancer. 2013;12:17.
    • (2013) Mol Cancer , vol.12 , pp. 17
    • Panka, D.J.1    Liu, Q.2    Geissler, A.K.3
  • 98
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloidderived suppressor cell accumulation in renal cell carcinoma patients
    • Ko JS, Zea AH, Rini BI, et al. Sunitinib mediates reversal of myeloidderived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res. 2009;15:2148-2157.
    • (2009) Clin Cancer Res , vol.15 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.I.3
  • 99
    • 53249111806 scopus 로고    scopus 로고
    • Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival
    • van Cruijsen H, van der Veldt AA, Vroling L, et al. Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival. Clin Cancer Res. 2008;14:5884-5892.
    • (2008) Clin Cancer Res , vol.14 , pp. 5884-5892
    • Van Cruijsen, H.1    Van Der Veldt, A.A.2    Vroling, L.3
  • 100
    • 37049006066 scopus 로고    scopus 로고
    • Amino-biphosphonateY mediated MMP-9 inhibition breaks the tumorYbone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma
    • Melani C, Sangaletti S, Barazzetta FM, et al. Amino-biphosphonateY mediated MMP-9 inhibition breaks the tumorYbone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer Res. 2007;67:11438-11446.
    • (2007) Cancer Res , vol.67 , pp. 11438-11446
    • Melani, C.1    Sangaletti, S.2    Barazzetta, F.M.3
  • 101
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • Diaz-Montero CM, Salem ML, Nishimura MI, et al. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother. 2009;58:49-59.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3
  • 102
    • 84880294344 scopus 로고    scopus 로고
    • Vemurafenib reverses immunosuppression by myeloid derived suppressor cells
    • Schilling B, Sucker A, Griewank K, et al. Vemurafenib reverses immunosuppression by myeloid derived suppressor cells. Int J Cancer. 2013;133:1653-1663.
    • (2013) Int J Cancer , vol.133 , pp. 1653-1663
    • Schilling, B.1    Sucker, A.2    Griewank, K.3
  • 103
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353:2135-2147.
    • (2005) N Engl J Med , vol.353 , pp. 2135-2147
    • Curtin, J.A.1    Fridlyand, J.2    Kageshita, T.3
  • 104
    • 36849013036 scopus 로고    scopus 로고
    • Bv8 regulates myeloid-cellY dependent tumour angiogenesis
    • Shojaei F, Wu X, Zhong C, et al. Bv8 regulates myeloid-cellY dependent tumour angiogenesis. Nature. 2007;450:825-831.
    • (2007) Nature , vol.450 , pp. 825-831
    • Shojaei, F.1    Wu, X.2    Zhong, C.3
  • 105
    • 78650722060 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
    • Kowanetz M, Wu X, Lee J, et al. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A. 2010;107:21248-21255.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21248-21255
    • Kowanetz, M.1    Wu, X.2    Lee, J.3
  • 106
    • 27644436741 scopus 로고    scopus 로고
    • Inhibition of colonystimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580
    • Conway JG, McDonald B, Parham J, et al. Inhibition of colonystimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005;102: 16078-16083.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16078-16083
    • Conway, J.G.1    McDonald, B.2    Parham, J.3
  • 107
    • 77949900433 scopus 로고    scopus 로고
    • Targeting distinct tumorinfiltrating myeloid cells by inhibiting CSF-1 receptor: Combating tumor evasion of antiangiogenic therapy
    • Priceman SJ, Sung JL, Shaposhnik Z, et al. Targeting distinct tumorinfiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood. 2010;115:1461-1471.
    • (2010) Blood , vol.115 , pp. 1461-1471
    • Priceman, S.J.1    Sung, J.L.2    Shaposhnik, Z.3
  • 108
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • Qian BZ, Li J, Zhang H, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 2011;475:222-225.
    • (2011) Nature , vol.475 , pp. 222-225
    • Qian, B.Z.1    Li, J.2    Zhang, H.3
  • 109
    • 37349100945 scopus 로고    scopus 로고
    • Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    • Yang L, Huang J, Ren X, et al. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell. 2008;13:23-35.
    • (2008) Cancer Cell , vol.13 , pp. 23-35
    • Yang, L.1    Huang, J.2    Ren, X.3
  • 110
    • 0032881792 scopus 로고    scopus 로고
    • Skewed differentiation of bone marrow CD34+ cells of tumor bearers from dendritic toward monocytic cells, and the redirection of differentiation toward dendritic cells by 1alpha,25-dihydroxyvitamin D3
    • Young MR, Wright MA, Vellody K, et al. Skewed differentiation of bone marrow CD34+ cells of tumor bearers from dendritic toward monocytic cells, and the redirection of differentiation toward dendritic cells by 1alpha,25-dihydroxyvitamin D3. Int Immunopharmacol. 1999; 21:675-688.
    • (1999) Int Immunopharmacol , vol.21 , pp. 675-688
    • Young, M.R.1    Wright, M.A.2    Vellody, K.3
  • 111
    • 59249090694 scopus 로고    scopus 로고
    • 1alpha,25-Dihydroxyvitamin D (3) to skew intratumoral levels of immune inhibitory CD34(+) progenitor cells into dendritic cells
    • Kulbersh JS, Day TA, Gillespie MB, et al. 1alpha,25-Dihydroxyvitamin D(3) to skew intratumoral levels of immune inhibitory CD34(+) progenitor cells into dendritic cells. Otolaryngol Head Neck Surg. 2009;140: 235-240.
    • (2009) Otolaryngol Head Neck Surg , vol.140 , pp. 235-240
    • Kulbersh, J.S.1    Day, T.A.2    Gillespie, M.B.3
  • 112
    • 77953916257 scopus 로고    scopus 로고
    • Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma
    • Walsh JE, Clark AM, Day TA, et al. Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma. Hum Immunol. 2010;71:659-665.
    • (2010) Hum Immunol , vol.71 , pp. 659-665
    • Walsh, J.E.1    Clark, A.M.2    Day, T.A.3
  • 113
    • 84860343623 scopus 로고    scopus 로고
    • Immunological modulation by 1alpha,25-dihydroxyvitamin D3 in patients with squamous cell carcinoma of the head and neck
    • Walker DD, Reeves TD, de Costa AM, et al. Immunological modulation by 1alpha,25-dihydroxyvitamin D3 in patients with squamous cell carcinoma of the head and neck. Cytokine. 2012;58:448-454.
    • (2012) Cytokine , vol.58 , pp. 448-454
    • Walker, D.D.1    Reeves, T.D.2    De Costa, A.M.3
  • 114
    • 84871453051 scopus 로고    scopus 로고
    • Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages
    • Di Rosa M, Malaguarnera G, de Gregorio C, et al. Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages. Cell Immunol. 2012;280:36-43.
    • (2012) Cell Immunol , vol.280 , pp. 36-43
    • Di Rosa, M.1    Malaguarnera, G.2    De Gregorio, C.3
  • 115
    • 84887197816 scopus 로고    scopus 로고
    • Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer
    • Zhang H, Maric I, Diprima MJ, et al. Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer. Blood. 2013.
    • (2013) Blood
    • Zhang, H.1    Maric, I.2    Diprima, M.J.3
  • 116
    • 0036649794 scopus 로고    scopus 로고
    • Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes
    • Tsavaris N, Kosmas C, Vadiaka M, et al. Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes. Br J Cancer. 2002;87:21-27.
    • (2002) Br J Cancer , vol.87 , pp. 21-27
    • Tsavaris, N.1    Kosmas, C.2    Vadiaka, M.3
  • 117
    • 26444540659 scopus 로고    scopus 로고
    • Combination docetaxel plus vitamin D (3) as an immune therapy in animals bearing squamous cell carcinomas
    • Young MR, Lathers DM. Combination docetaxel plus vitamin D(3) as an immune therapy in animals bearing squamous cell carcinomas. Otolaryngol Head Neck Surg. 2005;133:611-618.
    • (2005) Otolaryngol Head Neck Surg , vol.133 , pp. 611-618
    • Young, M.R.1    Lathers, D.M.2
  • 118
    • 77956680680 scopus 로고    scopus 로고
    • A novel chemoimmunomodulating property of docetaxel: Suppression of myeloid-derived suppressor cells in tumor bearers
    • Kodumudi KN, Woan K, Gilvary DL, et al. A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Clin Cancer Res. 2010;16:4583-4594.
    • (2010) Clin Cancer Res , vol.16 , pp. 4583-4594
    • Kodumudi, K.N.1    Woan, K.2    Gilvary, D.L.3
  • 119
    • 84869791457 scopus 로고    scopus 로고
    • Blockade of myeloidderived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma
    • Kodumudi KN, Weber A, Sarnaik AA, et al. Blockade of myeloidderived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma. J Immunol. 2012;189:5147-5154.
    • (2012) J Immunol , vol.189 , pp. 5147-5154
    • Kodumudi, K.N.1    Weber, A.2    Sarnaik, A.A.3
  • 120
    • 84860518841 scopus 로고    scopus 로고
    • Application of paclitaxel in low noncytotoxic doses supports vaccination with melanoma antigens in normal mice
    • Sevko A, Kremer V, Falk C, et al. Application of paclitaxel in low noncytotoxic doses supports vaccination with melanoma antigens in normal mice. J Immunotoxicol. 2012;9:275-281.
    • (2012) J Immunotoxicol , vol.9 , pp. 275-281
    • Sevko, A.1    Kremer, V.2    Falk, C.3
  • 121
    • 84862120892 scopus 로고    scopus 로고
    • Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cells in vitro in a TLR4-independent manner
    • Michels T, Shurin GV, Naiditch H, et al. Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cells in vitro in a TLR4-independent manner. J Immunotoxicol. 2012;9: 292-300.
    • (2012) J Immunotoxicol , vol.9 , pp. 292-300
    • Michels, T.1    Shurin, G.V.2    Naiditch, H.3
  • 122
    • 84857916510 scopus 로고    scopus 로고
    • Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II-IIIc breast cancer
    • Montero AJ, Diaz-Montero CM, Deutsch YE, et al. Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II-IIIc breast cancer. Breast Cancer Res Treat. 2012;132:215-223.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 215-223
    • Montero, A.J.1    Diaz-Montero, C.M.2    Deutsch, Y.E.3
  • 123
    • 0019407488 scopus 로고
    • Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid
    • Breitman TR, Collins SJ, Keene BR. Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid. Blood. 1981;57:1000-1004.
    • (1981) Blood , vol.57 , pp. 1000-1004
    • Breitman, T.R.1    Collins, S.J.2    Keene, B.R.3
  • 124
    • 0042591427 scopus 로고    scopus 로고
    • All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination
    • Kusmartsev S, Cheng F, Yu B, et al. All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res. 2003;63:4441-4449.
    • (2003) Cancer Res , vol.63 , pp. 4441-4449
    • Kusmartsev, S.1    Cheng, F.2    Yu, B.3
  • 125
    • 36348989162 scopus 로고    scopus 로고
    • Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells
    • Nefedova Y, Fishman M, Sherman S, et al. Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells. Cancer Res. 2007;67:11021-11028.
    • (2007) Cancer Res , vol.67 , pp. 11021-11028
    • Nefedova, Y.1    Fishman, M.2    Sherman, S.3
  • 126
    • 84861577263 scopus 로고    scopus 로고
    • The restoration of myeloid-derived suppressor cells as functional antigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment
    • Lee JM, Seo JH, Kim YJ, et al. The restoration of myeloid-derived suppressor cells as functional antigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment. Int J Cancer. 2012;131: 741-751.
    • (2012) Int J Cancer , vol.131 , pp. 741-751
    • Lee, J.M.1    Seo, J.H.2    Kim, Y.J.3
  • 127
    • 33749461167 scopus 로고    scopus 로고
    • All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients
    • Mirza N, Fishman M, Fricke I, et al. All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients. Cancer Res. 2006;66:9299-9307.
    • (2006) Cancer Res , vol.66 , pp. 9299-9307
    • Mirza, N.1    Fishman, M.2    Fricke, I.3
  • 128
    • 84877825407 scopus 로고    scopus 로고
    • Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer
    • Iclozan C, Antonia S, Chiappori A, et al. Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer. Cancer Immunol Immunother. 2013;62:909-918.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 909-918
    • Iclozan, C.1    Antonia, S.2    Chiappori, A.3
  • 129
    • 58149332680 scopus 로고    scopus 로고
    • Reversal of myeloid cellY mediated immunosuppression in patients with metastatic renal cell carcinoma
    • Kusmartsev S, Su Z, Heiser A, et al. Reversal of myeloid cellY mediated immunosuppression in patients with metastatic renal cell carcinoma. Clin Cancer Res. 2008;14:8270-8278.
    • (2008) Clin Cancer Res , vol.14 , pp. 8270-8278
    • Kusmartsev, S.1    Su, Z.2    Heiser, A.3
  • 130
    • 79953300942 scopus 로고    scopus 로고
    • CpG blocks immunosuppression by myeloid-derived suppressor cells in tumor-bearing mice
    • Zoglmeier C, Bauer H, Norenberg D, et al. CpG blocks immunosuppression by myeloid-derived suppressor cells in tumor-bearing mice. Clin Cancer Res. 2011;17:1765-1775.
    • (2011) Clin Cancer Res , vol.17 , pp. 1765-1775
    • Zoglmeier, C.1    Bauer, H.2    Norenberg, D.3
  • 131
    • 84863248624 scopus 로고    scopus 로고
    • Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth
    • Tu SP, Jin H, Shi JD, et al. Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. Cancer Prev Res. 2012;5: 205-215.
    • (2012) Cancer Prev Res , vol.5 , pp. 205-215
    • Tu, S.P.1    Jin, H.2    Shi, J.D.3
  • 132
    • 84876819444 scopus 로고    scopus 로고
    • Beta-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloidderived suppressor cells
    • Tian J, Ma J, Ma K, et al. beta-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloidderived suppressor cells. Eur J Immunol. 2013;43:1220-1230.
    • (2013) Eur J Immunol , vol.43 , pp. 1220-1230
    • Tian, J.1    Ma, J.2    Ma, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.