메뉴 건너뛰기




Volumn 9, Issue 2, 2013, Pages 193-206

Management of gastrointestinal stromal tumors

Author keywords

GIST; imatinib; KIT; regorafenib; sunitinib; surgery; tyrosine kinase inhibitors

Indexed keywords

CRENOLANIB; EVEROLIMUS; GANETESPIB; IMATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MASITINIB; MOTESANIB; NILOTINIB; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; REGORAFENIB; RETASPIMYCIN; STEM CELL FACTOR; SU 11548; SUNITINIB; UNCLASSIFIED DRUG; VATALANIB;

EID: 84874081070     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.12.178     Document Type: Review
Times cited : (23)

References (111)
  • 1
    • 0020514752 scopus 로고
    • Gastric stromal tumors. Reappraisal of histogenesis
    • Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am. J. Surg. Pathol. 7(6), 507-519 (1983).
    • (1983) Am. J. Surg. Pathol. , vol.7 , Issue.6 , pp. 507-519
    • Mazur, M.T.1    Clark, H.B.2
  • 2
    • 0024359271 scopus 로고
    • Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide
    • Macewen EG, Kurzman ID, Rosenthal RC et al. Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide. J. Natl Cancer Inst. 81(12), 935-938 (1989).
    • (1989) J. Natl Cancer Inst. , vol.81 , Issue.12 , pp. 935-938
    • MacEwen, E.G.1    Kurzman, I.D.2    Rosenthal, R.C.3
  • 3
    • 0035142836 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
    • Miettinen M, Lasota J. Gastrointestinal stromal tumors-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch. 438(1), 1-12 (2001).
    • (2001) Virchows Arch. , vol.438 , Issue.1 , pp. 1-12
    • Miettinen, M.1    Lasota, J.2
  • 4
    • 0033793213 scopus 로고    scopus 로고
    • Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT)
    • Miettinen M, Sobin LH, Sarlomo-Rikala M. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT). Mod. Pathol. 13(10), 1134-1142 (2000).
    • (2000) Mod. Pathol. , vol.13 , Issue.10 , pp. 1134-1142
    • Miettinen, M.1    Sobin, L.H.2    Sarlomo-Rikala, M.3
  • 5
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of ckit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y et al. Gain-of-function mutations of ckit in human gastrointestinal stromal tumors. Science 279(5350), 577-580 (1998).
    • (1998) Science , vol.279 , Issue.5350 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 6
    • 84863393301 scopus 로고    scopus 로고
    • Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/ pigmented villonodular synovitis
    • Cassier PA, Gelderblom H, Stacchiotti S et al. Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/ pigmented villonodular synovitis. Cancer 118(6), 1649-1655 (2011).
    • (2011) Cancer , vol.118 , Issue.6 , pp. 1649-1655
    • Cassier, P.A.1    Gelderblom, H.2    Stacchiotti, S.3
  • 7
    • 3042722245 scopus 로고    scopus 로고
    • Assessing the prognosis of gastrointestinal stromal tumors: A growing role for molecular testing
    • Corless CL. Assessing the prognosis of gastrointestinal stromal tumors: A growing role for molecular testing. Am. J Clin. Pathol. 122(1), 11-13 (2004).
    • (2004) Am. J Clin. Pathol. , vol.122 , Issue.1 , pp. 11-13
    • Corless, C.L.1
  • 8
    • 24944529613 scopus 로고    scopus 로고
    • Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for research and treatment of cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study
    • Van Glabbeke M, Verweij J, Casali PG et al. Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for research and treatment of cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study. J. Clin. Oncol. 23(24), 5795-5804 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.24 , pp. 5795-5804
    • Van Glabbeke, M.1    Verweij, J.2    Casali, P.G.3
  • 9
    • 0033984319 scopus 로고    scopus 로고
    • Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival
    • Dematteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann. Surg. 231(1), 51-58 (2000).
    • (2000) Ann. Surg. , vol.231 , Issue.1 , pp. 51-58
    • Dematteo, R.P.1    Lewis, J.J.2    Leung, D.3    Mudan, S.S.4    Woodruff, J.M.5    Brennan, M.F.6
  • 11
    • 56749156604 scopus 로고    scopus 로고
    • Correlation of kinase genotype and clinical outcome in the North American intergroup Phase III trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 study by cancer and leukemia group B and Southwest Oncology Group
    • Heinrich MC, Owzar K, Corless CL et al. Correlation of kinase genotype and clinical outcome in the North American intergroup Phase III trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 study by cancer and leukemia group B and Southwest Oncology Group. J. Clin. Oncol. 26(33), 5360-5367 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.33 , pp. 5360-5367
    • Heinrich, M.C.1    Owzar, K.2    Corless, C.L.3
  • 12
    • 0036468004 scopus 로고    scopus 로고
    • Challenges in oncology. Case 4. Response of metastatic gastrointestinal stromal tumor including CNS involvement to imatinib mesylate STI571
    • Brooks BJ, Bani JC, Fletcher CD, Demeteri GD. Challenges in oncology. Case 4. Response of metastatic gastrointestinal stromal tumor including CNS involvement to imatinib mesylate (STI571). J Clin. Oncol. 20(3), 870-872 (2002).
    • (2002) J Clin. Oncol. , vol.20 , Issue.3 , pp. 870-872
    • Brooks, B.J.1    Bani, J.C.2    Fletcher, C.D.3    Demeteri, G.D.4
  • 13
    • 33749459756 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Review on morphology, molecular pathology, prognosis, and differential diagnosis
    • Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch. Pathol. Lab. Med. 130(10), 1466-1478 (2006).
    • (2006) Arch. Pathol. Lab. Med. , vol.130 , Issue.10 , pp. 1466-1478
    • Miettinen, M.1    Lasota, J.2
  • 15
    • 0036301722 scopus 로고    scopus 로고
    • Diagnosis of gastrointestinal stromal tumors: A consensus approach
    • Fletcher CD, Berman JJ, Corless C et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum. Pathol. 33(5), 459-465 (2002).
    • (2002) Hum. Pathol. , vol.33 , Issue.5 , pp. 459-465
    • Fletcher, C.D.1    Berman, J.J.2    Corless, C.3
  • 16
    • 84860494445 scopus 로고    scopus 로고
    • A nonrandom association of gastrointestinal stromal tumor (GIST) and desmoid tumor (deep fibromatosis): Case series of 28 patients
    • Dumont AG, Rink L, Godwin AK et al. A nonrandom association of gastrointestinal stromal tumor (GIST) and desmoid tumor (deep fibromatosis): case series of 28 patients. Ann. Oncol. 23(5), 1335-1340 (2012).
    • (2012) Ann. Oncol. , vol.23 , Issue.5 , pp. 1335-1340
    • Dumont, A.G.1    Rink, L.2    Godwin, A.K.3
  • 17
    • 0035146716 scopus 로고    scopus 로고
    • The histopathological differential diagnosis of gastrointestinal stromal tumours
    • Graadt Van Roggen JF, Van Velthuysen ML, Hogendoorn PC. The histopathological differential diagnosis of gastrointestinal stromal tumours. J. Clin. Pathol. 54(2), 96-102 (2001).
    • (2001) J. Clin. Pathol. , vol.54 , Issue.2 , pp. 96-102
    • Graadt Van Roggen, J.F.1    Van Velthuysen, M.L.2    Hogendoorn, P.C.3
  • 18
    • 0031947592 scopus 로고    scopus 로고
    • Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
    • Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am. J. Pathol. 152(5), 1259-1269 (1998).
    • (1998) Am. J. Pathol. , vol.152 , Issue.5 , pp. 1259-1269
    • Kindblom, L.G.1    Remotti, H.E.2    Aldenborg, F.3    Meis-Kindblom, J.M.4
  • 19
    • 0027505553 scopus 로고
    • Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine
    • Rumessen JJ, Mikkelsen HB, Qvortrup K, Thuneberg L. Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine. Gastroenterology 104(2), 343-350 (1993).
    • (1993) Gastroenterology , vol.104 , Issue.2 , pp. 343-350
    • Rumessen, J.J.1    Mikkelsen, H.B.2    Qvortrup, K.3    Thuneberg, L.4
  • 21
    • 0142189433 scopus 로고    scopus 로고
    • WHO; International Agency for Research on Cancer. Fletcher CDM, Unni KK, Mertens F (Eds). IARC Press, Lyon, France
    • WHO; International Agency for Research on Cancer. Pathology and Genetics: Tumours of Soft Tissue and Bone. Fletcher CDM, Unni KK, Mertens F (Eds). IARC Press, Lyon, France (2002).
    • (2002) Pathology and Genetics: Tumours of Soft Tissue and Bone
  • 22
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of cKIT receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
    • Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. Inhibition of cKIT receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96(3), 925-932 (2000).
    • (2000) Blood , vol.96 , Issue.3 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Zigler, A.J.6
  • 23
    • 0036303804 scopus 로고    scopus 로고
    • Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    • Heinrich MC, Rubin BP, Longley BJ, Fletcher JA. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum. Pathol. 33(5), 484-495 (2002).
    • (2002) Hum. Pathol. , vol.33 , Issue.5 , pp. 484-495
    • Heinrich, M.C.1    Rubin, B.P.2    Longley, B.J.3    Fletcher, J.A.4
  • 24
    • 0036319991 scopus 로고    scopus 로고
    • Immunohistochemical staining for KIT (CD 117 in soft tissue sarcomas is very limited in distribution
    • Hornick JL, Fletcher CD. Immunohistochemical staining for KIT (CD117) in soft tissue sarcomas is very limited in distribution. Am. J. Clin. Pathol. 117(2), 188-193 (2002).
    • (2002) Am. J. Clin. Pathol. , vol.117 , Issue.2 , pp. 188-193
    • Hornick, J.L.1    Fletcher, C.D.2
  • 25
    • 0242670019 scopus 로고    scopus 로고
    • PDGFRA activating mutations in gastrointestinal stromal tumors
    • Heinrich MC, Corless CL, Duensing A et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299(5607), 708-710 (2003).
    • (2003) Science , vol.299 , Issue.5607 , pp. 708-710
    • Heinrich, M.C.1    Corless, C.L.2    Duensing, A.3
  • 26
    • 33746401591 scopus 로고    scopus 로고
    • KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours
    • Debiec-Rychter M, Sciot R, Le Cesne A et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur. J. Cancer 42(8), 1093-1103 (2006).
    • (2006) Eur. J. Cancer , vol.42 , Issue.8 , pp. 1093-1103
    • Debiec-Rychter, M.1    Sciot, R.2    Le Cesne, A.3
  • 27
    • 0035890740 scopus 로고    scopus 로고
    • KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
    • Rubin BP, Singer S, Tsao C et al. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res. 61(22), 8118-8121 (2001).
    • (2001) Cancer Res. , vol.61 , Issue.22 , pp. 8118-8121
    • Rubin, B.P.1    Singer, S.2    Tsao, C.3
  • 28
    • 84867300058 scopus 로고    scopus 로고
    • Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs
    • Emile JF, Brahimi S, Coindre JM et al. Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs. Med. Oncol. 29(3), 1765-1772 (2012).
    • (2012) Med. Oncol. , vol.29 , Issue.3 , pp. 1765-1772
    • Emile, J.F.1    Brahimi, S.2    Coindre, J.M.3
  • 29
    • 73949094832 scopus 로고    scopus 로고
    • BRAF mutation status in gastrointestinal stromal tumors
    • Hostein I, Faur N, Primois C et al. BRAF mutation status in gastrointestinal stromal tumors. Am. J. Clin. Pathol. 133(1), 141-148 (2010).
    • (2010) Am. J. Clin. Pathol. , vol.133 , Issue.1 , pp. 141-148
    • Hostein, I.1    Faur, N.2    Primois, C.3
  • 30
    • 0344010982 scopus 로고    scopus 로고
    • GIST-a significantly more common tumor than earlier apprehended. New discoveries on the pathogenesis of GIST yielded new medical treatment
    • 936-938
    • Nilsson B, Andersson J, Meis-Kindblom J et al. [GIST-a significantly more common tumor than earlier apprehended. New discoveries on the pathogenesis of GIST yielded new medical treatment]. Lakartidningen 100(11), 930-934, 936-938 (2003).
    • (2003) Lakartidningen , vol.100 , Issue.11 , pp. 930-934
    • Nilsson, B.1    Andersson, J.2    Meis-Kindblom, J.3
  • 31
    • 35148813515 scopus 로고    scopus 로고
    • Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors
    • Janeway KA, Liegl B, Harlow A et al. Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors. Cancer Res. 67(19), 9084-9088 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.19 , pp. 9084-9088
    • Janeway, K.A.1    Liegl, B.2    Harlow, A.3
  • 32
    • 49649119001 scopus 로고    scopus 로고
    • Molecular characterization of pediatric gastrointestinal stromal tumors
    • Agaram NP, Laquaglia MP, Ustun B et al. Molecular characterization of pediatric gastrointestinal stromal tumors. Clin. Cancer Res. 14(10), 3204-3215 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.10 , pp. 3204-3215
    • Agaram, N.P.1    Laquaglia, M.P.2    Ustun, B.3
  • 33
    • 67650472798 scopus 로고    scopus 로고
    • Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib
    • Janeway KA, Albritton KH, Van Den Abbeele AD et al. Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib. Pediatr. Blood Cancer 52(7), 767-771 (2009).
    • (2009) Pediatr. Blood Cancer , vol.52 , Issue.7 , pp. 767-771
    • Janeway, K.A.1    Albritton, K.H.2    Van Den Abbeele, A.D.3
  • 34
    • 78049495856 scopus 로고    scopus 로고
    • Strong expression of IGF 1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification
    • Janeway KA, Zhu MJ, Barretina J, Perez-Atayde A, Demetri GD, Fletcher JA. Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification. Int. J. Cancer 127(11), 2718-2722 (2010).
    • (2010) Int. J. Cancer , vol.127 , Issue.11 , pp. 2718-2722
    • Janeway, K.A.1    Zhu, M.J.2    Barretina, J.3    Perez-Atayde, A.4    Demetri, G.D.5    Fletcher, J.A.6
  • 35
    • 66849135214 scopus 로고    scopus 로고
    • The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): Molecular genetics and clinical implications
    • Stratakis CA, Carney JA. The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications. J. Intern. Med. 266(1), 43-52 (2009).
    • (2009) J. Intern. Med. , vol.266 , Issue.1 , pp. 43-52
    • Stratakis, C.A.1    Carney, J.A.2
  • 36
    • 0030052047 scopus 로고    scopus 로고
    • Smooth muscle tumors of the gastrointestinal tract: Analysis of prognostic factors
    • Chou FF, Eng HL, Sheen-Chen SM. Smooth muscle tumors of the gastrointestinal tract: analysis of prognostic factors. Surgery 119(2), 171-177 (1996).
    • (1996) Surgery , vol.119 , Issue.2 , pp. 171-177
    • Chou, F.F.1    Eng, H.L.2    Sheen-Chen, S.M.3
  • 37
    • 0035122393 scopus 로고    scopus 로고
    • Malignant gastrointestinal stromal tumors of the small intestine. A review of 50 cases from a prospective database
    • Crosby JA, Catton CN, Davis A et al. Malignant gastrointestinal stromal tumors of the small intestine. A review of 50 cases from a prospective database. Ann. Surg. Oncol. 8(1), 50-59 (2001).
    • (2001) Ann. Surg. Oncol. , vol.8 , Issue.1 , pp. 50-59
    • Crosby, J.A.1    Catton, C.N.2    Davis, A.3
  • 38
    • 0026598711 scopus 로고
    • Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging
    • Ng EH, Pollock RE, Munsell MF, Atkinson EN, Romsdahl MM. Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging. Ann. Surg. 215(1), 68-77 (1992).
    • (1992) Ann. Surg. , vol.215 , Issue.1 , pp. 68-77
    • Ng, E.H.1    Pollock, R.E.2    Munsell, M.F.3    Atkinson, E.N.4    Romsdahl, M.M.5
  • 39
    • 0036769928 scopus 로고    scopus 로고
    • Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease
    • Roberts PJ, Eisenberg B. Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease. Eur. J. Cancer 38(Suppl. 5), S37-38 (2002).
    • (2002) Eur. J. Cancer , vol.38 , Issue.SUPPL. 5
    • Roberts, P.J.1    Eisenberg, B.2
  • 40
    • 33744795769 scopus 로고    scopus 로고
    • Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors
    • Raut CP, Posner M, Desai J et al. Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors. J. Clin.Oncol. 24(15), 2325-2331 (2006).
    • (2006) J. Clin.Oncol. , vol.24 , Issue.15 , pp. 2325-2331
    • Raut, C.P.1    Posner, M.2    Desai, J.3
  • 41
    • 0036305274 scopus 로고    scopus 로고
    • Clinical management of gastrointestinal stromal tumors: Before and after STI-571
    • Dematteo RP, Heinrich MC, El-Rifai WM, Demetri G. Clinical management of gastrointestinal stromal tumors: before and after STI-571. Hum. Pathol. 33(5), 466-477 (2002).
    • (2002) Hum. Pathol. , vol.33 , Issue.5 , pp. 466-477
    • Dematteo, R.P.1    Heinrich, M.C.2    El-Rifai, W.M.3    Demetri, G.4
  • 42
    • 78650144360 scopus 로고    scopus 로고
    • Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: Results of the Institut Gustave-Roussy Phase II trial
    • Assi H, Missenard G, Terrier P et al. Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy Phase II trial. Curr. Oncol. 17(6), 23-31 (2010).
    • (2010) Curr. Oncol. , vol.17 , Issue.6 , pp. 23-31
    • Assi, H.1    Missenard, G.2    Terrier, P.3
  • 43
    • 0025770430 scopus 로고
    • Phase III comparison of doxorubicin and dacarbazine given by bolus versus infusion in patients with soft-tissue sarcomas: A Southwest Oncology Group study
    • Zalupski M, Metch B, Balcerzak S et al. Phase III comparison of doxorubicin and dacarbazine given by bolus versus infusion in patients with soft-tissue sarcomas: A Southwest Oncology Group study. J. Natl Cancer Inst. 83(13), 926-932 (1991).
    • (1991) J. Natl Cancer Inst. , vol.83 , Issue.13 , pp. 926-932
    • Zalupski, M.1    Metch, B.2    Balcerzak, S.3
  • 44
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2phenylaminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2phenylaminopyrimidine derivative. Cancer Res. 56(1), 100-104 (1996).
    • (1996) Cancer Res. , vol.56 , Issue.1 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3
  • 45
    • 0031454003 scopus 로고    scopus 로고
    • CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCRABL, TELABL, and TELPDGFR fusion proteins
    • Carroll M, Ohno-Jones S, Tamura S et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCRABL, TELABL, and TELPDGFR fusion proteins. Blood 90(12), 4947-4952 (1997).
    • (1997) Blood , vol.90 , Issue.12 , pp. 4947-4952
    • Carroll, M.1    Ohno-Jones, S.2    Tamura, S.3
  • 46
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCRABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H et al. Activity of a specific inhibitor of the BCRABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med. 344(14), 1038-1042 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , Issue.14 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 47
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCRABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ et al. Efficacy and safety of a specific inhibitor of the BCRABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344(14), 1031-1037 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , Issue.14 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 48
    • 0035960428 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A Phase i study
    • Van Oosterom AT, Judson I, Verweij J et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A Phase I study. Lancet 358(9291), 1421-1423 (2001).
    • (2001) Lancet , vol.358 , Issue.9291 , pp. 1421-1423
    • Van Oosterom, A.T.1    Judson, I.2    Verweij, J.3
  • 49
    • 0142121411 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target Results from an EORTC Soft Tissue and Bone Sarcoma Group Phase II study
    • Verweij J, Van Oosterom A, Blay JY et al. Imatinib mesylate (STI571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group Phase II study. Eur. J. Cancer 39(14), 2006-2011 (2003).
    • (2003) Eur. J. Cancer , vol.39 , Issue.14 , pp. 2006-2011
    • Verweij, J.1    Van Oosterom, A.2    Blay, J.Y.3
  • 50
    • 39149127634 scopus 로고    scopus 로고
    • Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033
    • Blanke CD, Rankin C, Demetri GD et al. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J. Clin. Oncol. 26(4), 626-632 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.4 , pp. 626-632
    • Blanke, C.D.1    Rankin, C.2    Demetri, G.D.3
  • 51
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
    • Verweij J, Casali PG, Zalcberg J et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet 364(9440), 1127-1134 (2004).
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 52
    • 20944443259 scopus 로고    scopus 로고
    • Consensus meeting for the management of gastrointestinal stromal tumors Report of the GIST Consensus Conference of under the auspices of ESMO
    • 20-21 March 2004
    • Blay JY, Bonvalot S, Casali P et al. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Ann. Oncol. 16(4), 566-578 (2005).
    • (2005) Ann. Oncol. , vol.16 , Issue.4 , pp. 566-578
    • Blay, J.Y.1    Bonvalot, S.2    Casali, P.3
  • 53
    • 77949898532 scopus 로고    scopus 로고
    • Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: A meta-analysis of 1,640 patients
    • Gastrointestinal Stromal Tumor MetaAnalysis Group (MetaGIST)
    • Gastrointestinal Stromal Tumor MetaAnalysis Group (MetaGIST). Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: A meta-analysis of 1,640 patients. J. Clin. Oncol. 28(7), 1247-1253 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.7 , pp. 1247-1253
  • 54
    • 62849096370 scopus 로고    scopus 로고
    • Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: A randomised, double-blind, placebo-controlled trial
    • Dematteo RP, Ballman KV, Antonescu CR et al. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: A randomised, double-blind, placebo-controlled trial. Lancet 373(9669), 1097-1104 (2009).
    • (2009) Lancet , vol.373 , Issue.9669 , pp. 1097-1104
    • Dematteo, R.P.1    Ballman, K.V.2    Antonescu, C.R.3
  • 55
    • 84859187987 scopus 로고    scopus 로고
    • One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: A randomized trial
    • Joensuu H, Eriksson M, Sundby Hall K et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: A randomized trial. JAMA 307(12), 1265-1272 (2012).
    • (2012) JAMA , vol.307 , Issue.12 , pp. 1265-1272
    • Joensuu, H.1    Eriksson, M.2    Sundby Hall, K.3
  • 56
    • 58149399145 scopus 로고    scopus 로고
    • Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): Early results of RTOG 0132/ACRIN 6665
    • Eisenberg BL, Harris J, Blanke CD et al. Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665. J. Surg. Oncol. 99(1), 42-47 (2009).
    • (2009) J. Surg. Oncol. , vol.99 , Issue.1 , pp. 42-47
    • Eisenberg, B.L.1    Harris, J.2    Blanke, C.D.3
  • 57
    • 3142731936 scopus 로고    scopus 로고
    • Neoadjuvant imatinib for unresectable gastrointestinal stromal tumor
    • Katz D, Segal A, Alberton Y et al. Neoadjuvant imatinib for unresectable gastrointestinal stromal tumor. Anticancer Drugs 15(6), 599-602 (2004).
    • (2004) Anticancer Drugs , vol.15 , Issue.6 , pp. 599-602
    • Katz, D.1    Segal, A.2    Alberton, Y.3
  • 58
    • 33644831916 scopus 로고    scopus 로고
    • Diagnosis and treatment of gastrointestinal stromal tumours
    • Bonvalot S, Le Cesne A. [Diagnosis and treatment of gastrointestinal stromal tumours]. Rev. Prat. 56(4), 359-367 (2006).
    • (2006) Rev. Prat. , vol.56 , Issue.4 , pp. 359-367
    • Bonvalot, S.1    Le Cesne, A.2
  • 59
    • 33845633389 scopus 로고    scopus 로고
    • Surgical resection of gastrointestinal stromal tumors after treatment with imatinib
    • Andtbacka RH, Ng CS, Scaife CL et al. Surgical resection of gastrointestinal stromal tumors after treatment with imatinib. Ann. Surg. Oncol. 14(1), 14-24 (2007).
    • (2007) Ann. Surg. Oncol. , vol.14 , Issue.1 , pp. 14-24
    • Andtbacka, R.H.1    Ng, C.S.2    Scaife, C.L.3
  • 60
    • 34247610583 scopus 로고    scopus 로고
    • Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor
    • Dematteo RP, Maki RG, Singer S, Gonen M, Brennan MF, Antonescu CR. Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor. Ann. Surg. 245(3), 347-352 (2007).
    • (2007) Ann. Surg. , vol.245 , Issue.3 , pp. 347-352
    • Dematteo, R.P.1    Maki, R.G.2    Singer, S.3    Gonen, M.4    Brennan, M.F.5    Antonescu, C.R.6
  • 61
    • 34247615184 scopus 로고    scopus 로고
    • Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced/metastatic GIST
    • Gronchi A, Fiore M, Miselli F et al. Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced/metastatic GIST. Ann. Surg. 245(3), 341-346 (2007).
    • (2007) Ann. Surg. , vol.245 , Issue.3 , pp. 341-346
    • Gronchi, A.1    Fiore, M.2    Miselli, F.3
  • 62
    • 33644667084 scopus 로고    scopus 로고
    • Surgical treatment of patients with initially inoperable and/or metastatic gastrointestinal stromal tumors (GIST) during therapy with imatinib mesylate
    • Rutkowski P, Nowecki Z, Nyckowski P et al. Surgical treatment of patients with initially inoperable and/or metastatic gastrointestinal stromal tumors (GIST) during therapy with imatinib mesylate. J. Surg. Oncol. 93(4), 304-311 (2006).
    • (2006) J. Surg. Oncol. , vol.93 , Issue.4 , pp. 304-311
    • Rutkowski, P.1    Nowecki, Z.2    Nyckowski, P.3
  • 63
    • 67349212626 scopus 로고    scopus 로고
    • Preoperative imatinib mesylate for unresectable or locally advanced primary gastrointestinal stromal tumors (GIST)
    • Fiore M, Palassini E, Fumagalli E et al. Preoperative imatinib mesylate for unresectable or locally advanced primary gastrointestinal stromal tumors (GIST). Eur. J. Surg. Oncol. 35(7), 739-745 (2009).
    • (2009) Eur. J. Surg. Oncol. , vol.35 , Issue.7 , pp. 739-745
    • Fiore, M.1    Palassini, E.2    Fumagalli, E.3
  • 64
    • 34548757970 scopus 로고    scopus 로고
    • Sitedependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors
    • Haller F, Happel N, Schulten HJ et al. Sitedependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors. Mod. Pathol. 20(10), 1103-1111 (2007).
    • (2007) Mod. Pathol. , vol.20 , Issue.10 , pp. 1103-1111
    • Haller, F.1    Happel, N.2    Schulten, H.J.3
  • 65
    • 77951814300 scopus 로고    scopus 로고
    • Post-imatinib surgery in advanced/metastatic GIST: Is it worthwhile in all patients? Ann
    • Mussi C, Ronellenfitsch U, Jakob J et al. Post-imatinib surgery in advanced/metastatic GIST: is it worthwhile in all patients? Ann. Oncol. 21(2), 403-408 (2010).
    • (2010) Oncol. , vol.21 , Issue.2 , pp. 403-408
    • Mussi, C.1    Ronellenfitsch, U.2    Jakob, J.3
  • 66
    • 77149155973 scopus 로고    scopus 로고
    • Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate
    • Raut CP, Wang Q, Manola J et al. Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate. Ann. Surg. Oncol. 17(2), 407-415 (2010).
    • (2010) Ann. Surg. Oncol. , vol.17 , Issue.2 , pp. 407-415
    • Raut, C.P.1    Wang, Q.2    Manola, J.3
  • 67
    • 77952422485 scopus 로고    scopus 로고
    • Radiofrequency ablation is a feasible therapeutic option in the multi modality management of sarcoma
    • Jones RL, McCall J, Adam A et al. Radiofrequency ablation is a feasible therapeutic option in the multi modality management of sarcoma. Eur. J. Surg. Oncol. 36(5), 477-482 (2010).
    • (2010) Eur. J. Surg. Oncol. , vol.36 , Issue.5 , pp. 477-482
    • Jones, R.L.1    McCall, J.2    Adam, A.3
  • 68
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich MC, Corless CL, Demetri GD et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J. Clin. Oncol. 21(23), 4342-4349 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.23 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 69
    • 0037106370 scopus 로고    scopus 로고
    • Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors
    • Singer S, Rubin BP, Lux ML et al. Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors. J. Clin. Oncol. 20(18), 3898-3905 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , Issue.18 , pp. 3898-3905
    • Singer, S.1    Rubin, B.P.2    Lux, M.L.3
  • 70
    • 2142747025 scopus 로고    scopus 로고
    • KIT-negative gastrointestinal stromal tumors: Proof of concept and therapeutic implications
    • Medeiros F, Corless CL, Duensing A et al. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am. J. Surg. Pathol. 28(7), 889-894 (2004).
    • (2004) Am. J. Surg. Pathol. , vol.28 , Issue.7 , pp. 889-894
    • Medeiros, F.1    Corless, C.L.2    Duensing, A.3
  • 71
    • 10444280878 scopus 로고    scopus 로고
    • Strategies to overcome resistance to targeted protein kinase inhibitors
    • Daub H, Specht K, Ullrich A. Strategies to overcome resistance to targeted protein kinase inhibitors. Nat. Rev. Drug Discov. 3(12), 1001-1010 (2004).
    • (2004) Nat. Rev. Drug Discov. , vol.3 , Issue.12 , pp. 1001-1010
    • Daub, H.1    Specht, K.2    Ullrich, A.3
  • 72
    • 0037045583 scopus 로고    scopus 로고
    • BCRABL gene mutations in relation to clinical resistance of Philadelphiachromosome-positive leukaemia to STI571: A prospective study
    • Von Bubnoff N, Schneller F, Peschel C, Duyster J. BCRABL gene mutations in relation to clinical resistance of Philadelphiachromosome-positive Lancet 359(9305), 487-491 (2002).
    • (2002) Lancet , vol.359 , Issue.9305 , pp. 487-491
    • Von Bubnoff, N.1    Schneller, F.2    Peschel, C.3    Duyster, J.4
  • 73
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCRABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (Ploop) are associated with a poor prognosis
    • Branford S, Rudzki Z, Walsh S et al. Detection of BCRABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (Ploop) are associated with a poor prognosis. Blood 102(1), 276-283 (2003).
    • (2003) Blood , vol.102 , Issue.1 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 74
    • 20344393896 scopus 로고    scopus 로고
    • Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation
    • Antonescu CR, Besmer P, Guo T et al. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin. Cancer Res. 11(11), 4182-4190 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , Issue.11 , pp. 4182-4190
    • Antonescu, C.R.1    Besmer, P.2    Guo, T.3
  • 75
    • 33749824425 scopus 로고    scopus 로고
    • Functional analyses and molecular modeling of two cKit mutations responsible for imatinib secondary resistance in GIST patients
    • Tamborini E, Pricl S, Negri T et al. Functional analyses and molecular modeling of two cKit mutations responsible for imatinib secondary resistance in GIST patients. Oncogene 25(45), 6140-6146 (2006).
    • (2006) Oncogene , vol.25 , Issue.45 , pp. 6140-6146
    • Tamborini, E.1    Pricl, S.2    Negri, T.3
  • 76
    • 33645693156 scopus 로고    scopus 로고
    • Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate
    • Wardelmann E, Merkelbach-Bruse S, Pauls K et al. Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. Clin. Cancer Res. 12(6), 1743-1749 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.6 , pp. 1743-1749
    • Wardelmann, E.1    Merkelbach-Bruse, S.2    Pauls, K.3
  • 77
    • 67650306170 scopus 로고    scopus 로고
    • Imatinib plasma levels are correlated with clinical benefin patients with unresectable/metastatic gastrointestinal stromal tumors
    • Demetri GD, Wang Y, Wehrle E et al. Imatinib plasma levels are correlated with clinical benefin patients with unresectable/metastatic gastrointestinal stromal tumors. J. Clin. Oncol. 27(19), 3141-3147 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.19 , pp. 3141-3147
    • Demetri, G.D.1    Wang, Y.2    Wehrle, E.3
  • 78
    • 77957341199 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with advanced gastrointestinal stromal tumours after 3 years of treatment: An open-label multicentre randomised Phase 3 trial
    • Le Cesne A, Ray-Coquard I, Bui BN et al. Discontinuation of imatinib in patients with advanced gastrointestinal stromal tumours after 3 years of treatment: an open-label multicentre randomised Phase 3 trial. Lancet Oncol. 11(10), 942-949 (2010).
    • (2010) Lancet Oncol. , vol.11 , Issue.10 , pp. 942-949
    • Le Cesne, A.1    Ray-Coquard, I.2    Bui, B.N.3
  • 79
    • 34249073831 scopus 로고    scopus 로고
    • Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor
    • Norden-Zfoni A, Desai J, Manola J et al. Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor. Clin. Cancer Res. 13(9), 2643-2650 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.9 , pp. 2643-2650
    • Norden-Zfoni, A.1    Desai, J.2    Manola, J.3
  • 80
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • Demetri GD, Van Oosterom AT, Garrett CR et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial. Lancet 368(9544), 1329-1338 (2006).
    • (2006) Lancet , vol.368 , Issue.9544 , pp. 1329-1338
    • Demetri, G.D.1    Van Oosterom, A.T.2    Garrett, C.R.3
  • 81
    • 67249147869 scopus 로고    scopus 로고
    • Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure
    • George S, Blay JY, Casali PG et al. Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure. Eur. J. Cancer 45(11), 1959-1968 (2009).
    • (2009) Eur. J. Cancer , vol.45 , Issue.11 , pp. 1959-1968
    • George, S.1    Blay, J.Y.2    Casali, P.G.3
  • 82
    • 36849023013 scopus 로고    scopus 로고
    • Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
    • Chu TF, Rupnick MA, Kerkela R et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 370(9604), 2011-2019 (2007).
    • (2007) Lancet , vol.370 , Issue.9604 , pp. 2011-2019
    • Chu, T.F.1    Rupnick, M.A.2    Kerkela, R.3
  • 83
    • 34249085905 scopus 로고    scopus 로고
    • Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: Proposal of new computed tomography response criteria
    • Choi H, Charnsangavej C, Faria SC et al. Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J. Clin. Oncol. 25(13), 1753-1759 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.13 , pp. 1753-1759
    • Choi, H.1    Charnsangavej, C.2    Faria, S.C.3
  • 84
    • 84863698793 scopus 로고    scopus 로고
    • Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: A multicenter phase II trial
    • George S, Wang Q, Heinrich MC et al. Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: A multicenter phase II trial. J Clin Oncol 30(19), 2401-2407 (2012).
    • (2012) J Clin Oncol , vol.30 , Issue.19 , pp. 2401-2407
    • George, S.1    Wang, Q.2    Heinrich, M.C.3
  • 85
    • 84872892692 scopus 로고    scopus 로고
    • Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): An international, multicentre, randomised, placebo-controlled, Phase 3 trial
    • doi: 10.1016/S0140-6736 1261857-1 Epub ahead of print
    • Demetri GD, Reichardt P, Kang YK, Blay JY et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, Phase 3 trial. Lancet doi:10.1016/S0140-6736(12)61857-1 (2012) (Epub ahead of print).
    • (2012) Lancet
    • Demetri, G.D.1    Reichardt, P.2    Kang, Y.K.3    Blay, J.Y.4
  • 86
    • 29144464371 scopus 로고    scopus 로고
    • Advances in the structural biology, design and clinical development of BcrAbl kinase inhibitors for the treatment of chronic myeloid leukaemia
    • Manley PW, Cowan-Jacob SW, Mestan J. Advances in the structural biology, design and clinical development of BcrAbl kinase inhibitors for the treatment of chronic myeloid leukaemia. Biochim. Biophys. Acta 1754(1-2), 3-13 (2005).
    • (2005) Biochim. Biophys. Acta , vol.1754 , Issue.1-2 , pp. 3-13
    • Manley, P.W.1    Cowan-Jacob, S.W.2    Mestan, J.3
  • 87
    • 33646516407 scopus 로고    scopus 로고
    • Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN107 in gastrointestinal stromal tumor cell lines
    • Prenen H, Guetens G, De Boeck G et al. Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN107 in gastrointestinal stromal tumor cell lines. Pharmacology 77(1), 11-16 (2006).
    • (2006) Pharmacology , vol.77 , Issue.1 , pp. 11-16
    • Prenen, H.1    Guetens, G.2    De Boeck, G.3
  • 88
    • 33745085275 scopus 로고    scopus 로고
    • OCT1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): Reduced OCT1 activity is the cause of low in vitro sensitivity to imatinib
    • White DL, Saunders VA, Dang P et al. OCT1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT1 activity is the cause of low in vitro sensitivity to imatinib. Blood 108(2), 697-704 (2006).
    • (2006) Blood , vol.108 , Issue.2 , pp. 697-704
    • White, D.L.1    Saunders, V.A.2    Dang, P.3
  • 89
    • 55649084518 scopus 로고    scopus 로고
    • Results with AMN 107 a novel kinase inhibitor, in gastrointestinal stromal tumor GIST: Preclinical rationale and early results in a patient Pt with imatinib IM-resistant GIST
    • San Francisco, CA, USA, 26-28 January Abstract 53
    • Dileo P, Bauer S. Van Den Abbeele A et al. Results with AMN107, a novel kinase inhibitor, in gastrointestinal stromal tumor (GIST): preclinical rationale and early results in a patient (Pt) with imatinib (IM)-resistant GIST. Presented at: American Society of Clinical Oncology 2006 Gastrointestinal Cancers Symposium. San Francisco, CA, USA, 26-28 January 2006 (Abstract 53).
    • (2006) American Society of Clinical Oncology 2006 Gastrointestinal Cancers Symposium
    • Dileo, P.1    Bauer, S.2    Van Den Abbeele, A.3
  • 90
    • 70349459886 scopus 로고    scopus 로고
    • A Phase i study of single-agent nilotinib or in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors
    • Demetri GD, Casali PG, Blay JY et al. A Phase I study of single-agent nilotinib or in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors.Clin. Cancer Res. 15(18), 5910-5916 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.18 , pp. 5910-5916
    • Demetri, G.D.1    Casali, P.G.2    Blay, J.Y.3
  • 91
    • 68949174991 scopus 로고    scopus 로고
    • Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib
    • Montemurro M, Schoffski P, Reichardt P et al. Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib. Eur. J. Cancer 45(13), 2293-2297 (2009).
    • (2009) Eur. J. Cancer , vol.45 , Issue.13 , pp. 2293-2297
    • Montemurro, M.1    Schoffski, P.2    Reichardt, P.3
  • 92
    • 84864293774 scopus 로고    scopus 로고
    • Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib
    • Reichardt P, Blay JY, Gelderblom H et al. Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib. Ann. Oncol. 23(7), 1680-1687 (2012).
    • (2012) Ann. Oncol. , vol.23 , Issue.7 , pp. 1680-1687
    • Reichardt, P.1    Blay, J.Y.2    Gelderblom, H.3
  • 93
    • 70449707509 scopus 로고    scopus 로고
    • Phase i study of the safety, tolerability, and pharmacokinetics of oral CP868,596, a highly specific platelet-derived growth factor receptor tyrosine kinase inhibitor in patients with advanced cancers
    • Lewis NL, Lewis LD, Eder JP et al. Phase I study of the safety, tolerability, and pharmacokinetics of oral CP868,596, a highly specific platelet-derived growth factor receptor tyrosine kinase inhibitor in patients with advanced cancers. J. Clin. Oncol. 27(31), 5262-5269 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.31 , pp. 5262-5269
    • Lewis, N.L.1    Lewis, L.D.2    Eder, J.P.3
  • 94
    • 84857557900 scopus 로고    scopus 로고
    • The effect of crenolanib (CP868596) on phosphorylation of the imatinib-resistant D842V PDGFRA activating mutation associated with advanced gastrointestinal stromal tumors
    • Abstract 10012
    • Heinrich M, Griffith, D, Mckinley, A, Presnell A, Ramachandran A. The effect of crenolanib (CP868596) on phosphorylation of the imatinib-resistant D842V PDGFRA activating mutation associated with advanced gastrointestinal stromal tumors. J. Clin.Oncol. 29(Suppl.), Abstract 10012 (2011).
    • (2011) J. Clin.Oncol. , vol.29 , Issue.SUPPL.
    • Heinrich, M.1    Griffith, D.2    McKinley, A.3    Presnell, A.4    Ramachandran, A.5
  • 95
    • 0036969564 scopus 로고    scopus 로고
    • KIT gene mutations in gastrointestinal stromal tumors: More complex than previously recognized? Am
    • author reply 738-739
    • Fletcher JA, Fletcher CD, Rubin BP, Ashman LK, Corless CL, Heinrich MC. KIT gene mutations in gastrointestinal stromal tumors: more complex than previously recognized? Am. J. Pathol. 161(2), 737-738; author reply 738-739 (2002).
    • (2002) J. Pathol. , vol.161 , Issue.2 , pp. 737-738
    • Fletcher, J.A.1    Fletcher, C.D.2    Rubin, B.P.3    Ashman, L.K.4    Corless, C.L.5    Heinrich, M.C.6
  • 96
    • 77957171405 scopus 로고    scopus 로고
    • A Phase I-II study of everolimus (RAD001) in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors
    • Schoffski P, Reichardt P, Blay JY et al. A Phase I-II study of everolimus (RAD001) in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors. Ann. Oncol. 21(10), 1990-1998 (2010).
    • (2010) Ann. Oncol. , vol.21 , Issue.10 , pp. 1990-1998
    • Schoffski, P.1    Reichardt, P.2    Blay, J.Y.3
  • 97
    • 79959596313 scopus 로고    scopus 로고
    • Efficacy and safety of motesanib, an oral inhibitor of VEGF, PDGF, and Kit receptors, in patients with imatinib-resistant gastrointestinal stromal tumors
    • Benjamin RS, Schoffski P, Hartmann JT et al. Efficacy and safety of motesanib, an oral inhibitor of VEGF, PDGF, and Kit receptors, in patients with imatinib-resistant gastrointestinal stromal tumors. Cancer chemother. Pharmacol. 68(1), 69-77 (2011).
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , Issue.1 , pp. 69-77
    • Benjamin, R.S.1    Schoffski, P.2    Hartmann, J.T.3
  • 98
    • 51449093764 scopus 로고    scopus 로고
    • Targeting Hsp90: Small-molecule inhibitors and their clinical development
    • Taldone T, Gozman A, Maharaj R, Chiosis G. Targeting Hsp90: small-molecule inhibitors and their clinical development. Curr. Opin. Pharmacol. 8(4), 370-374 (2008).
    • (2008) Curr. Opin. Pharmacol. , vol.8 , Issue.4 , pp. 370-374
    • Taldone, T.1    Gozman, A.2    Maharaj, R.3    Chiosis, G.4
  • 99
    • 84874041489 scopus 로고    scopus 로고
    • An open-label Phase II study of the Hsp90 inhibitor ganetespib (STA9090) in patients (pts) with metastatic and/or unresectable GIST
    • Chicago IL, USA, 3-7 June Abstract 10011
    • Demetri G, Heinrich, M, Chmielowski B et al. An open-label Phase II study of the Hsp90 inhibitor ganetespib (STA9090) in patients (pts) with metastatic and/or unresectable GIST. Presented at: 2011 American Society of Clinical Onocology Annual Meeting. Chicago, IL, USA, 3-7 June 2011 (Abstract 10011).
    • (2011) 2011 American Society of Clinical Onocology Annual Meeting
    • Demetri, G.1    Heinrich, M.2    Chmielowski, B.3
  • 100
    • 68849101479 scopus 로고    scopus 로고
    • Retaspimycin hydrochloride (IPI504): A novel heat shock protein inhibitor as an anticancer agent
    • Hanson BE, Vesole DH. Retaspimycin hydrochloride (IPI504): A novel heat shock protein inhibitor as an anticancer agent. Expert Opin. Investig. Drugs 18(9), 1375-1383 (2009).
    • (2009) Expert Opin. Investig. Drugs , vol.18 , Issue.9 , pp. 1375-1383
    • Hanson, B.E.1    Vesole, D.H.2
  • 101
    • 84864408861 scopus 로고    scopus 로고
    • Sorafenib in patients with metastatic gastrointestinal stromal tumors who failed two or more prior tyrosine kinase inhibitors: A Phase II study of Korean gastrointestinal stromal tumors study group
    • Park SH, Ryu MH, Ryoo BY et al. Sorafenib in patients with metastatic gastrointestinal stromal tumors who failed two or more prior tyrosine kinase inhibitors: A Phase II study of Korean gastrointestinal stromal tumors study group. Invest. New Drugs 30(6), 2377-2383 (2012).
    • (2012) Invest. New Drugs , vol.30 , Issue.6 , pp. 2377-2383
    • Park, S.H.1    Ryu, M.H.2    Ryoo, B.Y.3
  • 102
    • 77951878436 scopus 로고    scopus 로고
    • Phase II study of oral masitinib mesilate in imatinib-naive patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST)
    • Le Cesne A, Blay JY, Bui BN et al. Phase II study of oral masitinib mesilate in imatinib-naive patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST). Eur. J. Cancer 46(8), 1344-1351 (2010).
    • (2010) Eur. J. Cancer , vol.46 , Issue.8 , pp. 1344-1351
    • Le Cesne, A.1    Blay, J.Y.2    Bui, B.N.3
  • 103
    • 37849009384 scopus 로고    scopus 로고
    • Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate
    • Joensuu H, De Braud F, Coco P et al. Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate. Ann. Oncol. 19, 173-177 (2008).
    • (2008) Ann. Oncol. , vol.19 , pp. 173-177
    • Joensuu, H.1    De Braud, F.2    Coco, P.3
  • 104
    • 78751647387 scopus 로고    scopus 로고
    • Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST
    • Richter S, Pink D, Hohenberger P et al. Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST. ASCO Meeting Abstracts 28(Suppl. 15), 10038 (2010).
    • (2010) ASCO Meeting Abstracts , vol.28 , Issue.SUPPL. 15 , pp. 10038
    • Richter, S.1    Pink, D.2    Hohenberger, P.3
  • 105
    • 77954214309 scopus 로고    scopus 로고
    • Final results from a Phase III study of IPI-504 retaspimycin hydrochloride) versus placebo in patients with gastrointestinal stromal tumors (GIST) following failure of tyrosine kinase inhibitor (TKI) therapies
    • Demetri G, Le Cesne A, von Mehren M et al. Final results from a Phase III study of IPI-504 retaspimycin hydrochloride) versus placebo in patients with gastrointestinal stromal tumors (GIST) following failure of tyrosine kinase inhibitor (TKI) therapies. ASCO Gastrointestinal Cancers Symposium Meeting Abstracts 28(Suppl. 15), 64 (2010).
    • (2010) ASCO Gastrointestinal Cancers Symposium Meeting Abstracts , vol.28 , Issue.SUPPL. 15 , pp. 64
    • Demetri, G.1    Le Cesne, A.2    Von Mehren, M.3
  • 106
    • 68849101479 scopus 로고    scopus 로고
    • Retaspimycin hydrochloride (IPI504): A novel heat shock protein inhibitor as an anticancer agent
    • Hanson BE, Vesole DH. Retaspimycin hydrochloride (IPI504): A novel heat shock protein inhibitor as an anticancer agent. Expert Opin. Investig. Drugs 18(9), 1375-1383 (2009).
    • (2009) Expert Opin. Investig. Drugs , vol.18 , Issue.9 , pp. 1375-1383
    • Hanson, B.E.1    Vesole, D.H.2
  • 107
    • 84864408861 scopus 로고    scopus 로고
    • Sorafenib in patients with metastatic gastrointestinal stromal tumors who failed two or more prior tyrosine kinase inhibitors: A Phase II study of Korean gastrointestinal stromal tumors study group
    • Park SH, Ryu MH, Ryoo BY et al. Sorafenib in patients with metastatic gastrointestinal stromal tumors who failed two or more prior tyrosine kinase inhibitors: A Phase II study of Korean gastrointestinal stromal tumors study group. Invest. New Drugs 30(6), 2377-2383 (2012).
    • (2012) Invest. New Drugs , vol.30 , Issue.6 , pp. 2377-2383
    • Park, S.H.1    Ryu, M.H.2    Ryoo, B.Y.3
  • 108
    • 77951878436 scopus 로고    scopus 로고
    • Phase II study of oral masitinib mesilate in imatinib-naive patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST)
    • Le Cesne A, Blay JY, Bui BN et al. Phase II study of oral masitinib mesilate in imatinib-naive patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST). Eur. J. Cancer 46(8), 1344-1351 (2010).
    • (2010) Eur. J. Cancer , vol.46 , Issue.8 , pp. 1344-1351
    • Le Cesne, A.1    Blay, J.Y.2    Bui, B.N.3
  • 109
    • 37849009384 scopus 로고    scopus 로고
    • Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate
    • Joensuu H, De Braud F, Coco P et al. Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate. Ann. Oncol. 19, 173-177 (2008).
    • (2008) Ann. Oncol. , vol.19 , pp. 173-177
    • Joensuu, H.1    De Braud, F.2    Coco, P.3
  • 110
    • 78751647387 scopus 로고    scopus 로고
    • Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST
    • Richter S, Pink D, Hohenberger P et al. Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST. ASCO Meeting Abstracts 28(Suppl. 15), 10038 (2010).
    • (2010) ASCO Meeting Abstracts , vol.28 , Issue.SUPPL. 15 , pp. 10038
    • Richter, S.1    Pink, D.2    Hohenberger, P.3
  • 111
    • 77954214309 scopus 로고    scopus 로고
    • Final results from a Phase III study of IPI-504 retaspimycin hydrochloride) versus placebo in patients with gastrointestinal stromal tumors (GIST) following failure of tyrosine kinase inhibitor (TKI) therapies
    • Demetri G, Le Cesne A, von Mehren M et al. Final results from a Phase III study of IPI-504 retaspimycin hydrochloride) versus placebo in patients with gastrointestinal stromal tumors (GIST) following failure of tyrosine kinase inhibitor (TKI) therapies. ASCO Gastrointestinal Cancers Symposium Meeting Abstracts 28(Suppl. 15), 64 (2010).
    • (2010) ASCO Gastrointestinal Cancers Symposium Meeting Abstracts , vol.28 , Issue.SUPPL. 15 , pp. 64
    • Demetri, G.1    Le Cesne, A.2    Von Mehren, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.