Arginine modifications by methylglyoxal: Discovery in a recombinant monoclonal antibody and contribution to acidic species

Analytical Chemistry

Volumn 85, Issue 23, 2013, Pages 11401-11409

  Chumsae, Chris ^a,c   Gifford, Kathreen ^a   Lian, Wei ^b   Liu, Hongcheng ^a   Radziejewski, Czeslaw H ^a   Zhou, Zhaohui Sunny ^c  

^a Protein Analytics   (United States)

^b ABBVIE INC   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE MODIFICATION; CHINESE HAMSTER OVARY CELLS; METABOLIC PATHWAYS; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN PHARMACEUTICALS; PROTEIN THERAPEUTICS; REACTIVE METABOLITES; RECOMBINANT MONOCLONAL ANTIBODY;

ARGININE; CHROMATOGRAPHIC ANALYSIS; MONOCLONAL ANTIBODIES; POSITIVE IONS; PROTEINS;

CELL CULTURE;

ANTIPORTER; ARGININE; METHYLGLYOXAL; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; CHEMISTRY; CHO CELL LINE; CRICETULUS; HAMSTER; MASS SPECTROMETRY; METHODOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIPORTERS; ARGININE; CHO CELLS; CRICETINAE; CRICETULUS; MASS SPECTROMETRY; PYRUVALDEHYDE; RECOMBINANT PROTEINS;

EID: 84888994823     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac402384y     Document Type: Article

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