Characterization of the glycosylation state of a recombinant monoclonal antibody using weak cation exchange chromatography and mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 862, Issue 1-2, 2008, Pages 155-160

  Gaza Bulseco, Georgeen ^a   Bulseco, Ashley ^a   Chumsae, Chris ^a   Liu, Hongcheng ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Mass spectrometry; Oligosaccharides; Recombinant monoclonal antibody; WCX 10

Indexed keywords

CATION EXCHANGE CHROMATOGRAPHY; RECOMBINANT HUMANIZED MONOCLONAL; RECOMBINANT MONOCLONAL ANTIBODY;

COLUMN CHROMATOGRAPHY; GENETIC ENGINEERING; MASS SPECTROMETRY; OLIGOSACCHARIDES;

GLYCOSYLATION;

ASPARAGINE; GALACTOSE; MONOCLONAL ANTIBODY IGG1; OLIGOSACCHARIDE; PEPTIDE; RECOMBINANT ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FUCOSYLATION; GLYCOSYLATION; HEAVY CHAIN; HUMAN; HUMAN CELL; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; CATION EXCHANGE RESINS; CELL LINE; CHROMATOGRAPHY, ION EXCHANGE; GLYCOSYLATION; HUMANS; PEPTIDE MAPPING; RECOMBINANT PROTEINS;

EID: 38649115018     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.12.001     Document Type: Article

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