Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity

Journal of Biological Chemistry

Volumn 280, Issue 7, 2005, Pages 5724-5732

  Ahmed, Naila ^a   Dobler, Darin ^a   Dean, Mark ^a   Thornalley, Paul J ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; COMPUTER SIMULATION; ELECTROSTATICS; HYDROGEN BONDS; MAPPING; MOLECULAR STRUCTURE; PROTEINS;

HUMAN SERUM; HYDROIMIDAZOLENE; METHYLGLYOXAL; STRUCTURAL DISTORTION;

POLYPEPTIDES;

ALBUMIN; ARGININE; BASE; DIMER; ESTERASE; GUANIDINE; HUMAN SERUM ALBUMIN; HYDROGEN; IMIDAZOLE DERIVATIVE; KETOPROFEN; LIGAND; LYSINE DERIVATIVE; METHYLGLYOXAL; ORNITHINE DERIVATIVE; PEPTIDE; PYRIMIDINE DERIVATIVE; TYROSINE;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL INTERACTION; CONJUGATION; DRUG BINDING SITE; ELECTRICITY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; EXPERIMENT; GLYCATION; HYDROGEN BOND; IN VIVO STUDY; INHIBITION KINETICS; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; PEPTIDE MAPPING; PH; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MODIFICATION; REACTION ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATTLE; CHROMATOGRAPHY, LIQUID; ESTERASES; HUMANS; HYDROGEN-ION CONCENTRATION; KETOPROFEN; LIGANDS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; PROTEIN CONFORMATION; PYRUVALDEHYDE; SERUM ALBUMIN; TRYPSIN;

EID: 14044251043     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410973200     Document Type: Article

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