Unveiling a glycation hot spot in a recombinant humanized monoclonal antibody

Analytical Chemistry

Volumn 80, Issue 7, 2008, Pages 2379-2390

  Zhang, Boyan ^a   Yang, Yi ^a   Yuk, Inn ^a   Pai, Roger ^a   McKay, Patrick ^a   Eigenbrot, Charles ^a   Dennis, Mark ^a   Katta, Viswanatham ^a   Francissen, Kathleen Champion ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CHROMATOGRAPHY; COMPUTER SIMULATION; HEALTH CARE; MASS SPECTROMETRY; PROTEINS; SAFETY FACTOR;

ASPARTIC ACID RESIDUE; ELECTROSPRAY MASS SPECTROMETRIC ANALYSIS; GLYCATION; PROTEIN THERAPEUTICS;

MONOCLONAL ANTIBODIES;

BORONIC ACID DERIVATIVE; LYSINE; MONOCLONAL ANTIBODY; RECOMBINANT ANTIBODY;

AFFINITY CHROMATOGRAPHY; AMADORI REARRANGEMENT; ANIMAL CELL; ARTICLE; CATALYSIS; COMPUTER MODEL; DATA BASE; DEGRADATION; ELECTROSPRAY MASS SPECTROMETRY; GLYCATION; LIGHT CHAIN; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PROTEIN SYNTHESIS; SEQUENCE ANALYSIS; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; GLYCOSYLATION; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS;

EID: 41849111333     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac701810q     Document Type: Article

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