The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component

Neurochemistry International

Volumn 64, Issue 1, 2014, Pages 73-83

  Tronel, C ^a   Page, G ^b   Bodard, S ^a   Chalon, S ^a   Antier, D ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b UNIVERSITÉ DE POITIERS   (France)

Author keywords

Caspase 3; Cytokines; Neuroinflammation; Neuroprotection; Oxindole imidazole C16; PKR

Indexed keywords

C 16; CASPASE 3; EOSIN; HEMATOXYLIN; IMIDAZOLE DERIVATIVE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; NEUROPROTECTIVE AGENT; OXINDOLE; PROTEIN KINASE R; QUINOLINIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN DAMAGE; BRAIN TISSUE; CONTROLLED STUDY; CORPUS STRIATUM; CYTOKINE PRODUCTION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; EXCITOTOXICITY; HEMISPHERE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; IN VIVO STUDY; MALE; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALIA; RATTUS;

CASPASE-3; CYTOKINES; NEUROINFLAMMATION; NEUROPROTECTION; OXINDOLE/IMIDAZOLE C16; PKR;

ACUTE DISEASE; ANIMALS; APOPTOSIS; CASPASE 3; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; EIF-2 KINASE; IMIDAZOLES; INDOLES; INFLAMMATION; INTERLEUKIN-1BETA; MALE; NEURONS; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR;

EID: 84888990020     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.10.012     Document Type: Article

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