-
2
-
-
77249147331
-
The pivotal role of the complement system in aging and age-related macu-lar degeneration: Hypothesis re-visited
-
Anderson DH, Radeke MJ, Gallo NB et al: The pivotal role of the complement system in aging and age-related macu-lar degeneration: hypothesis re-visited. Prog Retin Eye Res. 2010;29:95-112.
-
(2010)
Prog Retin Eye Res.
, vol.29
, pp. 95-112
-
-
Anderson, D.H.1
Radeke, M.J.2
Gallo, N.B.3
-
3
-
-
59849104241
-
Molecular pathology of age-related macular degeneration
-
Ding X, Patel M, Chan CC: Molecular pathology of age-related macular degeneration. Prog Retin Eye Res. 2008;28:1-18.
-
(2008)
Prog Retin Eye Res.
, vol.28
, pp. 1-18
-
-
Ding, X.1
Patel, M.2
Chan, C.C.3
-
4
-
-
42449105692
-
Immunopathological aspects of age-related macular degeneration
-
Patel M, Chan CC: Immunopathological aspects of age-related macular degeneration. Semin Immunopathol. 2008;30:97-110.
-
(2008)
Semin Immunopathol.
, vol.30
, pp. 97-110
-
-
Patel, M.1
Chan, C.C.2
-
5
-
-
11144258543
-
Drusen proteome analysis: An approach to the etiology of age-related macular degeneration
-
DOI 10.1073/pnas.222551899
-
Crabb JW, Miyagi M, Gu X et al: Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci USA. 2002;99:14682-14687. (Pubitemid 35334544)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.23
, pp. 14682-14687
-
-
Crabb, J.W.1
Miyagi, M.2
Gu, X.3
Shadrach, K.4
West, K.A.5
Sakaguchi, H.6
Kamei, M.7
Hasan, A.8
Yan, L.9
Rayborn, M.E.10
Salomon, R.G.11
Hollyfield, J.G.12
-
6
-
-
77956402099
-
Abundant lipid and protein components of drusen
-
Wang L, Clark ME, Crossman DK et al: Abundant lipid and protein components of drusen. PLoS One. 2010;5:e10329.
-
(2010)
PLoS One.
, vol.5
-
-
Wang, L.1
Clark, M.E.2
Crossman, D.K.3
-
8
-
-
0032714687
-
Human ocular drusen possess novel core domains with a distinct carbohydrate composition
-
Mullins RF, Hageman GS: Human ocular drusen possess novel core domains with a distinct carbohydrate composition. J Histochem Cytochem. 1999;47:1533-1540.
-
(1999)
J Histochem Cytochem.
, vol.47
, pp. 1533-1540
-
-
Mullins, R.F.1
Hageman, G.S.2
-
9
-
-
78049250350
-
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
-
West XZ, Malinin NL, Merkulova AA et al: Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature. 2010;467:972-976.
-
(2010)
Nature.
, vol.467
, pp. 972-976
-
-
West, X.Z.1
Malinin, N.L.2
Merkulova, A.A.3
-
10
-
-
0041886495
-
Age-related macular degeneration - A genome scan in extended families
-
DOI 10.1086/377701
-
Majewski J, Schultz DW, Weleber RG et al: Age-Related Macular Degeneration-a Genome Scan in Extended Families. Am J Hum Genet. 2003;73:540-550. (Pubitemid 37076268)
-
(2003)
American Journal of Human Genetics
, vol.73
, Issue.3
, pp. 540-550
-
-
Majewski, J.1
Schultz, D.W.2
Weleber, R.G.3
Schain, M.B.4
Edwards, A.O.5
Matise, T.C.6
Acott, T.S.7
Ott, J.8
Klein, M.L.9
-
11
-
-
0142059654
-
A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions
-
DOI 10.1086/378505
-
Seddon JM, Santangelo SL, Book K, Chong S, Cote J: A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. Am J Hum Genet. 2003;73:780-790. (Pubitemid 37271882)
-
(2003)
American Journal of Human Genetics
, vol.73
, Issue.4
, pp. 780-790
-
-
Seddon, J.M.1
Santangelo, S.L.2
Book, K.3
Chong, S.4
Cote, J.5
-
12
-
-
3242703945
-
Age-related maculopathy: A genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions
-
DOI 10.1086/422476
-
Weeks DE, Conley YP, Tsai HJ et al: Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. Am J Hum Genet. 2004;75:174-189. (Pubitemid 38943862)
-
(2004)
American Journal of Human Genetics
, vol.75
, Issue.2
, pp. 174-189
-
-
Weeks, D.E.1
Conley, Y.P.2
Tsai, H.-J.3
Mah, T.S.4
Schmidt, S.5
Postel, E.A.6
Agarwal, A.7
Haines, J.L.8
Pericak-Vance, M.A.9
Rosenfeld, P.J.10
Paul, T.O.11
Eller, A.W.12
Morse, L.S.13
Dailey, J.P.14
Ferrell, R.E.15
Gorin, M.B.16
-
13
-
-
33751011889
-
HTRA1 promoter polymorphism in wet age-related macular degeneration
-
DOI 10.1126/science.1133807
-
Dewan A, Liu M, Hartman S et al: HTRA1 promoter polymorphism in wet age-related macular degeneration. Science. 2006;314:989-992. (Pubitemid 44749943)
-
(2006)
Science
, vol.314
, Issue.5801
, pp. 989-992
-
-
DeWan, A.1
Liu, M.2
Hartman, S.3
Zhang, S.S.-M.4
Liu, D.T.L.5
Zhao, C.6
Tam, P.O.S.7
Chan, W.M.8
Lam, D.S.C.9
Snyder, M.10
Barnstable, C.11
Pang, C.P.12
Hoh, J.13
-
14
-
-
17244379811
-
Complement factor H polymorphism and age-related macular degeneration
-
DOI 10.1126/science.1110189
-
Edwards AO, Ritter IR, Abel KJ et al: Complement Factor H Polymorphism and Age-Related Macular Degeneration. Science. 2005;308:421-424. (Pubitemid 40530082)
-
(2005)
Science
, vol.308
, Issue.5720
, pp. 421-424
-
-
Edwards, A.O.1
Ritter III, R.2
Abel, K.J.3
Manning, A.4
Panhuysen, C.5
Farrer, L.A.6
-
15
-
-
21044453724
-
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
-
DOI 10.1073/pnas.0501536102
-
Hageman GS, Anderson DH, Johnson LV et al: A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA. 2005;102:7227-7232. (Pubitemid 40696361)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.20
, pp. 7227-7232
-
-
Hageman, G.S.1
Anderson, D.H.2
Johnson, L.V.3
Hancox, L.S.4
Taiber, A.J.5
Hardisty, L.I.6
Hageman, J.L.7
Stockman, H.A.8
Borchardt, J.D.9
Gehrs, K.M.10
Smith, R.J.H.11
Silvestri, G.12
Russell, S.R.13
Klaver, C.C.W.14
Barbazetto, I.15
Chang, S.16
Yannuzzi, L.A.17
Barile, G.R.18
Merriam, J.C.19
Smith, R.T.20
Olsh, A.K.21
Bergeron, J.22
Zernant, J.23
Merriam, J.E.24
Gold, B.25
Dean, M.26
Allikmets, R.27
more..
-
16
-
-
20244388812
-
Complement factor H variant increases the risk of age-related macular degeneration
-
DOI 10.1126/science.1110359
-
Haines JL, Hauser MA, Schmidt S et al: Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005;308:419-421. (Pubitemid 40530081)
-
(2005)
Science
, vol.308
, Issue.5720
, pp. 419-421
-
-
Haines, J.L.1
Hauser, M.A.2
Schmidt, S.3
Scott, W.K.4
Olson, L.M.5
Gallins, P.6
Spencer, K.L.7
Shu, Y.K.8
Noureddine, M.9
Gilbert, J.R.10
Schnetz-Boutaud, N.11
Agarwal, A.12
Postel, E.A.13
Pericak-Vance, M.A.14
-
17
-
-
20244380171
-
Complement factor H polymorphism in age-related macular degeneration
-
DOI 10.1126/science.1109557
-
Klein RJ, Zeiss C, Chew EY et al: Complement Factor H Polymorphism in Age-Related Macular Degeneration. Science. 2005;308:385-389. (Pubitemid 40530070)
-
(2005)
Science
, vol.308
, Issue.5720
, pp. 385-389
-
-
Klein, R.J.1
Zeiss, C.2
Chew, E.Y.3
Tsai, J.-Y.4
Sackler, R.S.5
Haynes, C.6
Henning, A.K.7
SanGiovanni, J.P.8
Mane, S.M.9
Mayne, S.T.10
Bracken, M.B.11
Ferris, F.L.12
Ott, J.13
Barnstable, C.14
Hoh, J.15
-
18
-
-
27744462212
-
Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk
-
DOI 10.1093/hmg/ddi353
-
Rivera A, Fisher SA, Fritsche LG et al: Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet. 2005;14:3227-3236. (Pubitemid 41631297)
-
(2005)
Human Molecular Genetics
, vol.14
, Issue.21
, pp. 3227-3236
-
-
Rivera, A.1
Fisher, S.A.2
Fritsche, L.G.3
Keilhauer, C.N.4
Lichtner, P.5
Meitinger, T.6
Weber, B.H.F.7
-
19
-
-
54849148000
-
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration
-
Yang Z, Stratton C, Francis PJ et al: Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008;359:1456-1463.
-
(2008)
N Engl J Med.
, vol.359
, pp. 1456-1463
-
-
Yang, Z.1
Stratton, C.2
Francis, P.J.3
-
20
-
-
78650796012
-
Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study
-
Ryu E, Fridley BL, Tosakulwong N, Bailey KR, Edwards AO: Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. Mol Vis. 2010;16:2811-2821.
-
(2010)
Mol Vis.
, vol.16
, pp. 2811-2821
-
-
Ryu, E.1
Fridley, B.L.2
Tosakulwong, N.3
Bailey, K.R.4
Edwards, A.O.5
-
21
-
-
79951899224
-
CCR3 and choroidal neovascular-ization
-
Li Y, Huang D, Xia X et al: CCR3 and choroidal neovascular-ization. PLoS One. 2011;6:e17106.
-
(2011)
PLoS One.
, vol.6
-
-
Li, Y.1
Huang, D.2
Xia, X.3
-
22
-
-
73349109486
-
Toll-like receptor polymorphisms and age-related macular degeneration: Replication in three case-control samples
-
Cho Y, Wang JJ, Chew EY et al: Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci. 2009.
-
(2009)
Invest Ophthalmol Vis Sci.
-
-
Cho, Y.1
Wang, J.J.2
Chew, E.Y.3
-
23
-
-
0034702032
-
A full genome scan for age-related maculopathy
-
Weeks DE, Conley YP, Mah TS et al: A full genome scan for age-related maculopathy. Hum Mol Genet. 2000;9:1329-1349. (Pubitemid 30312482)
-
(2000)
Human Molecular Genetics
, vol.9
, Issue.9
, pp. 1329-1349
-
-
Weeks, D.E.1
Conley, Y.P.2
Mah, T.S.3
Paul, T.O.4
Morse, L.5
Ngo-Chang, J.6
Dailey, J.P.7
Ferrell, R.E.8
Gorin, M.B.9
-
24
-
-
0032468842
-
Age-related macular degeneration: Clinical features in a large family and linkage to chromosome 1q
-
Klein ML, Schultz DW, Edwards A et al: Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q. Arch Ophthalmol. 1998;116:1082-1088. (Pubitemid 29101833)
-
(1998)
Archives of Ophthalmology
, vol.116
, Issue.8
, pp. 1082-1088
-
-
Klein, M.L.1
Schultz, D.W.2
Edwards, A.3
Matise, T.C.4
Rust, K.5
Berselli, C.B.6
Trzupek, K.7
Weleber, R.G.8
Ott, J.9
Wirtz, M.K.10
Acott, T.S.11
-
25
-
-
0026739091
-
Monozygotic twin brothers with age-related macular degeneration
-
Dosso AA, Bovet J: Monozygotic twin brothers with age-related macular degeneration. Ophthalmologica. 1992; 205:24-28.
-
(1992)
Ophthalmologica.
, vol.205
, pp. 24-28
-
-
Dosso, A.A.1
Bovet, J.2
-
26
-
-
0037677746
-
A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study
-
DOI 10.1086/375500
-
Schick JH, Iyengar SK, Klein BE et al: A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study. Am J Hum Genet. 2003;72:1412-1424. (Pubitemid 36628381)
-
(2003)
American Journal of Human Genetics
, vol.72
, Issue.6
, pp. 1412-1424
-
-
Schick, J.H.1
Iyengar, S.K.2
Klein, B.E.3
Klein, R.4
Reading, K.5
Liptak, R.6
Millard, C.7
Lee, K.E.8
Tomany, S.C.9
Moore, E.L.10
Fijal, B.A.11
Elston, R.C.12
-
27
-
-
9144228044
-
Dissection of Genomewide-Scan Data in Extended Families Reveals a Major Locus and Oligogenic Susceptibility for Age-Related Macular Degeneration
-
DOI 10.1086/380912
-
Iyengar SK, Song D, Klein BE et al: Dissection of genom-ewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet. 2004;74:20-39. (Pubitemid 38085235)
-
(2004)
American Journal of Human Genetics
, vol.74
, Issue.1
, pp. 20-39
-
-
Iyengar, S.K.1
Song, D.2
Klein, B.E.K.3
Klein, R.4
Schick, J.H.5
Humphrey, J.6
Millard, C.7
Liptak, R.8
Russo, K.9
Jun, G.10
Lee, K.E.11
Fijal, B.12
Elston, R.C.13
-
28
-
-
12144288320
-
Age-Related Macular Degeneration: A High-Resolution Genome Scan for Susceptibility Loci in a Population Enriched for Late-Stage Disease
-
DOI 10.1086/382786
-
Abecasis GR, Yashar BM, Zhao Y et al: Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease. Am J Hum Genet. 2004;74:482-494. (Pubitemid 38325919)
-
(2004)
American Journal of Human Genetics
, vol.74
, Issue.3
, pp. 482-494
-
-
Abecasis, G.R.1
Yashar, B.M.2
Zhao, Y.3
Ghiasvand, N.M.4
Zareparsi, S.5
Branham, K.E.H.6
Reddick, A.C.7
Trager, E.H.8
Yoshida, S.9
Bahling, J.10
Filippova, E.11
Elner, S.12
Johnson, M.W.13
Vine, A.K.14
Sieving, P.A.15
Jacobson, S.G.16
Richards, J.E.17
Swaroop, A.18
-
29
-
-
0034761296
-
Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions
-
DOI 10.1016/S0002-9394(01)01214-4, PII S0002939401012144
-
Weeks DE, Conley YP, Tsai HJ et al: Age-related macul-opathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions. Am J Ophthalmol. 2001;132:682-692. (Pubitemid 33031284)
-
(2001)
American Journal of Ophthalmology
, vol.132
, Issue.5
, pp. 682-692
-
-
Weeks, D.E.1
Conley, Y.P.2
Tsai, H.-J.3
Mah, T.S.4
Rosenfeld, P.J.5
Paul, T.O.6
Eller, A.W.7
Morse, L.S.8
Dailey, J.P.9
Ferrell, R.E.10
Gorin, M.B.11
-
30
-
-
79955958047
-
Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility
-
Spencer KL, Olson LM, Schnetz-Boutaud N et al: Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility. Invest Ophthalmol Vis Sci. 2011;52:1748-1754.
-
(2011)
Invest Ophthalmol Vis Sci.
, vol.52
, pp. 1748-1754
-
-
Spencer, K.L.1
Olson, L.M.2
Schnetz-Boutaud, N.3
-
31
-
-
78649691414
-
Genome-wide association identifes SKIV2L and MYRIP as protective factors for age-related macular degeneration
-
Kopplin LJ, Igo RP, Jr., Wang Y et al: Genome-wide association identifes SKIV2L and MYRIP as protective factors for age-related macular degeneration. Genes Immun. 2010;11:609-621.
-
(2010)
Genes Immun.
, vol.11
, pp. 609-621
-
-
Kopplin, L.J.1
Igo Jr., R.P.2
Wang, Y.3
-
32
-
-
77952147434
-
Genetic variants near TIMP3 and high-density lipoprotein-associated loci infuence susceptibility to age-related macular degeneration
-
Chen W, Stambolian D, Edwards AO et al: Genetic variants near TIMP3 and high-density lipoprotein-associated loci infuence susceptibility to age-related macular degeneration. Proc Natl Acad Sci USA. 2010;107:7401-7406.
-
(2010)
Proc Natl Acad Sci USA.
, vol.107
, pp. 7401-7406
-
-
Chen, W.1
Stambolian, D.2
Edwards, A.O.3
-
33
-
-
0028097367
-
Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy
-
DOI 10.1038/ng1294-352
-
Weber BH, Vogt G, Pruett RC, Stohr H, Felbor U: Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy. Nat Genet. 1994;8:352-356. (Pubitemid 24375600)
-
(1994)
Nature Genetics
, vol.8
, Issue.4
, pp. 352-356
-
-
Weber, B.H.F.1
Vogt, G.2
Pruett, R.C.3
Stohr, H.4
Felbor, U.5
-
34
-
-
20544471911
-
Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration
-
DOI 10.1086/431426
-
Zareparsi S, Branham KE, Li M et al: Strong Association of the Y402H Variant in Complement Factor H at 1q32 with Susceptibility to Age-Related Macular Degeneration. Am J Hum Genet. 2005;77:149-153. (Pubitemid 40848046)
-
(2005)
American Journal of Human Genetics
, vol.77
, Issue.1
, pp. 149-153
-
-
Zareparsi, S.1
Branham, K.E.H.2
Li, M.3
Shah, S.4
Klein, R.J.5
Ott, J.6
Hoh, J.7
Abecasis, G.R.8
Swaroop, A.9
-
35
-
-
79956330534
-
Dissecting a bacterial collagen domain from Streptococcus pyogenes: Sequence and length-dependent variations in triple helix stability and folding
-
Yu Z, Brodsky B, Inouye M: Dissecting a bacterial collagen domain from Streptococcus pyogenes: sequence and length-dependent variations in triple helix stability and folding. J Biol Chem. 2011;286:18960-18968.
-
(2011)
J Biol Chem.
, vol.286
, pp. 18960-18968
-
-
Yu, Z.1
Brodsky, B.2
Inouye, M.3
-
36
-
-
43549091327
-
Haplotypes in the complement factor H (CFH) gene: Associations with drusen and advanced age-related macular degeneration
-
Francis PJ, Schultz DW, Hamon S et al: Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration. PLoS One. 2007;2:e1197.
-
(2007)
PLoS One.
, vol.2
-
-
Francis, P.J.1
Schultz, D.W.2
Hamon, S.3
-
37
-
-
33748325757
-
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration
-
DOI 10.1038/ng1871, PII NG1871
-
Li M, Atmaca-Sonmez P, Othman M et al: CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet. 2006;38:1049-1054. (Pubitemid 44325931)
-
(2006)
Nature Genetics
, vol.38
, Issue.9
, pp. 1049-1054
-
-
Li, M.1
Atmaca-Sonmez, P.2
Othman, M.3
Branham, K.E.H.4
Khanna, R.5
Wade, M.S.6
Li, Y.7
Liang, L.8
Zareparsi, S.9
Swaroop, A.10
Abecasis, G.R.11
-
38
-
-
33749123246
-
A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
-
DOI 10.1038/ng1890, PII NG1890
-
Hughes AE, Orr N, Esfandiary H et al: A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Nat Genet. 2006;38:1173-1177. (Pubitemid 44470363)
-
(2006)
Nature Genetics
, vol.38
, Issue.10
, pp. 1173-1177
-
-
Hughes, A.E.1
Orr, N.2
Esfandiary, H.3
Diaz-Torres, M.4
Goodship, T.5
Chakravarthy, U.6
-
39
-
-
0034012166
-
Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
-
Mullins RF, Russell SR, Anderson DH, Hageman GS: Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 2000;14:835-846. (Pubitemid 30241660)
-
(2000)
FASEB Journal
, vol.14
, Issue.7
, pp. 835-846
-
-
Mullins, R.F.1
Russell, S.R.2
Anderson, D.H.3
Hageman, G.S.4
-
40
-
-
0345760069
-
Characterization of amyloid assemblies in drusen: The deposits associated with aging and age-related macular degeneration
-
DOI 10.1016/j.exer.2003.10.011
-
Anderson DH, Talaga KC, Rivest AJ et al: Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp Eye Res. 2004;78:243-256. (Pubitemid 38077231)
-
(2004)
Experimental Eye Research
, vol.78
, Issue.2
, pp. 243-256
-
-
Anderson, D.H.1
Talaga, K.C.2
Rivest, A.J.3
Barron, E.4
Hageman, G.S.5
Johnson, L.V.6
-
41
-
-
33144488589
-
Drusen complement components C3a and C5a promote choroidal neovascularization
-
DOI 10.1073/pnas.0408835103
-
Nozaki M, Raisler BJ, Sakurai E et al: Drusen complement components C3a and C5a promote choroidal neovasculari-zation. Proc Natl Acad Sci USA. 2006;103:2328-2333. (Pubitemid 43271669)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.7
, pp. 2328-2333
-
-
Nozaki, M.1
Raisler, B.J.2
Sakurai, E.3
Sarma, J.V.4
Barnum, S.R.5
Lambris, J.D.6
Chen, Y.7
Zhang, K.8
Ambati, B.K.9
Baffi, J.Z.10
Ambati, J.11
-
42
-
-
33645419787
-
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
-
Gold B, Merriam JE, Zernant J et al: Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. NatGenet. 2006;38: 458-462.
-
(2006)
NatGenet.
, vol.38
, pp. 458-462
-
-
Gold, B.1
Merriam, J.E.2
Zernant, J.3
-
43
-
-
33748309136
-
Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration
-
DOI 10.1038/ng1873, PII NG1873
-
Maller J, George S, Purcell S et al: Common variation in three genes, including a noncoding variant in CFH, strongly infu-ences risk of age-related macular degeneration. NatGenet. 2006;38:1055-1059. (Pubitemid 44325932)
-
(2006)
Nature Genetics
, vol.38
, Issue.9
, pp. 1055-1059
-
-
Maller, J.1
George, S.2
Purcell, S.3
Fagerness, J.4
Altshuler, D.5
Daly, M.J.6
Seddon, J.M.7
-
44
-
-
34548406001
-
Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration
-
DOI 10.1093/hmg/ddm146
-
Spencer KL, Hauser MA, Olson LM et al: Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. Hum Mol Genet. 2007;16:1986-1992. (Pubitemid 47354881)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.16
, pp. 1986-1992
-
-
Spencer, K.L.1
Hauser, M.A.2
Olson, L.M.3
Schmidt, S.4
Scott, W.K.5
Gallins, P.6
Agarwal, A.7
Postel, E.A.8
Pericak-Vance, M.A.9
Haines, J.L.10
-
45
-
-
34547764305
-
Complement C3 variant and the risk of age-related macular degeneration
-
DOI 10.1056/NEJMoa072618
-
Yates JR, Sepp T, Matharu BK et al: Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med. 2007;357:553-561. (Pubitemid 47236280)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.6
, pp. 553-561
-
-
Yates, J.R.W.1
Sepp, T.2
Matharu, B.K.3
Khan, J.C.4
Thurlby, D.A.5
Shahid, H.6
Clayton, D.G.7
Hayward, C.8
Morgan, J.9
Wright, A.F.10
Armbrecht, A.M.11
Dhillon, B.12
Deary, I.J.13
Redmond, E.14
Bird, A.C.15
Moore, A.T.16
-
46
-
-
34948898131
-
CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
-
DOI 10.1172/JCI31692
-
Combadiere C, Feumi C, Raoul W et al: CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest. 2007;117:2920-2928. (Pubitemid 47529622)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.10
, pp. 2920-2928
-
-
Combadiere, C.1
Feumi, C.2
Raoul, W.3
Keller, N.4
Rodero, M.5
Pezard, A.6
Lavalette, S.7
Houssier, M.8
Jonet, L.9
Picard, E.10
Debre, P.11
Sirinyan, M.12
Deterre, P.13
Ferroukhi, T.14
Cohen, S.-Y.15
Chauvaud, D.16
Jeanny, J.-C.17
Chemtob, S.18
Behar-Cohen, F.19
Sennlaub, F.20
more..
-
47
-
-
9444220221
-
The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration
-
DOI 10.1096/fj.04-1862fje
-
Tuo J, Smith B, Bojanowski CM et al: The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J. 2004;18:1297-1299. (Pubitemid 39561582)
-
(2004)
FASEB Journal
, vol.18
, Issue.11
, pp. 1297-1299
-
-
Tuo, J.1
Smith, B.C.2
Bojanowski, C.M.3
Meleth, A.D.4
Gery, I.5
Csaky, K.G.6
Chew, E.Y.7
Chan, C.-C.8
-
48
-
-
77956583371
-
Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese
-
Yang X, Hu J, Zhang J, Guan H: Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese. Br J Ophthalmol. 2010;94:1211-1214.
-
(2010)
Br J Ophthalmol.
, vol.94
, pp. 1211-1214
-
-
Yang, X.1
Hu, J.2
Zhang, J.3
Guan, H.4
-
49
-
-
80055035381
-
No association between the T280M polymorphism of the CX3CR1 gene and exudative AMD
-
In Press, Corrected Proof
-
Zerbib J, Puche N, Richard F et al: No association between the T280M polymorphism of the CX3CR1 gene and exudative AMD. Exp Eye Res. In Press, Corrected Proof.
-
Exp Eye Res
-
-
Zerbib, J.1
Puche, N.2
Richard, F.3
-
50
-
-
67650457597
-
CCR3 is a target for age-related macular degeneration diagnosis and therapy
-
Takeda A, Baff JZ, Kleinman ME et al: CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 2009;460:225-230.
-
(2009)
Nature.
, vol.460
, pp. 225-230
-
-
Takeda, A.1
Baff, J.Z.2
Kleinman, M.E.3
-
51
-
-
78149475685
-
Age-related macular degeneration: Genetic and environmental factors of disease
-
Chen Y, Bedell M, Zhang K: Age-related macular degeneration: genetic and environmental factors of disease. Mol Interv. 2010;10:271-281.
-
(2010)
Mol Interv.
, vol.10
, pp. 271-281
-
-
Chen, Y.1
Bedell, M.2
Zhang, K.3
-
52
-
-
57349128451
-
Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration
-
Seitsonen S P, Onkamo P, Peng G et al: Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. PLoS One. 2008;3:e3833.
-
(2008)
PLoS One.
, vol.3
-
-
Seitsonen, S.P.1
Onkamo, P.2
Peng, G.3
-
53
-
-
33646070308
-
Cigarette smoking strongly modifes the association of loc387715 and age-related macular degeneration
-
Schmidt S, Hauser MA, Scott WK et al: Cigarette Smoking Strongly Modifes the Association of LOC387715 and Age-Related Macular Degeneration. Am J Hum Genet. 2006; 78:852-864.
-
(2006)
Am J Hum Genet.
, vol.78
, pp. 852-864
-
-
Schmidt, S.1
Hauser, M.A.2
Scott, W.K.3
-
54
-
-
33846037715
-
A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors
-
DOI 10.1001/archopht.125.1.55
-
Schaumberg DA, Hankinson SE, Guo Q, Rimm E, Hunter DJ: A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifable risk factors. Arch Ophthalmol. 2007;125:55-62. (Pubitemid 46072376)
-
(2007)
Archives of Ophthalmology
, vol.125
, Issue.1
, pp. 55-62
-
-
Schaumberg, D.A.1
Hankinson, S.E.2
Guo, Q.3
Rimm, E.4
Hunter, D.J.5
-
55
-
-
65549129157
-
Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables
-
Seddon JM, Reynolds R, Maller J et al: Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci. 2009;50:2044-2053.
-
(2009)
Invest Ophthalmol Vis Sci.
, vol.50
, pp. 2044-2053
-
-
Seddon, J.M.1
Reynolds, R.2
Maller, J.3
-
56
-
-
38049086708
-
Neovascular age-related macular degeneration risk based on CFH LOC387715/HTRA1 and smoking
-
Hughes AE, Orr N, Patterson C et al: Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking. PLoS Med. 2007;4:e355.
-
(2007)
PLoS Med.
, vol.4
-
-
Hughes, A.E.1
Orr, N.2
Patterson, C.3
-
57
-
-
79955945240
-
Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy
-
Nakanishi H, Yamashiro K, Yamada R et al: Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci. 2010;51:6183-6187.
-
(2010)
Invest Ophthalmol Vis Sci.
, vol.51
, pp. 6183-6187
-
-
Nakanishi, H.1
Yamashiro, K.2
Yamada, R.3
-
58
-
-
54949101967
-
The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples
-
Tuo J, Ross RJ, Reed GF et al: The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples. Ophthalmology. 2008;115:1891-1898.
-
(2008)
Ophthalmology.
, vol.115
, pp. 1891-1898
-
-
Tuo, J.1
Ross, R.J.2
Reed, G.F.3
-
59
-
-
66249126501
-
Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss
-
Francis PJ, Hamon SC, Ott J, Weleber RG, Klein ML: Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss. J Med Genet. 2009;46:300-307.
-
(2009)
J Med Genet.
, vol.46
, pp. 300-307
-
-
Francis, P.J.1
Hamon, S.C.2
Ott, J.3
Weleber, R.G.4
Klein, M.L.5
-
60
-
-
33750201885
-
CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses
-
DOI 10.1093/hmg/ddl396
-
Conley YP, Jakobsdottir J, Mah T et al: CFH, ELOVL4, PLEKHA1, and LOC387715 genes and susceptibility to Age-Related Maculopathy: AREDS and CHS cohorts and meta-analyses. Hum Mol Genet. 2006;15:3206-3218. (Pubitemid 44605500)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.21
, pp. 3206-3218
-
-
Conley, Y.P.1
Jakobsdottir, J.2
Mah, T.3
Weeks, D.E.4
Klein, R.5
Kuller, L.6
Ferrell, R.E.7
Gorin, M.B.8
-
61
-
-
36749100977
-
PLEKHA1-LOC387715-HTRA1 polymorphisms and exudative age-related macular degeneration in the French population
-
Leveziel N, Souied EH, Richard F et al: PLEKHA1-LOC387715-HTRA1 polymorphisms and exudative age-related macular degeneration in the French population. Mol Vis. 2007;13:2153-2159. (Pubitemid 350200532)
-
(2007)
Molecular Vision
, vol.13
, pp. 2153-2159
-
-
Leveziel, N.1
Souied, E.H.2
Richard, F.3
Barbu, V.4
Zourdani, A.5
Morineau, G.6
Zerbib, J.7
Coscas, G.8
Soubrane, G.9
Benlian, P.10
-
62
-
-
44649155930
-
Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients
-
Kaur I, Katta S, Hussain A et al: Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. Invest Ophthalmol Vis Sci. 2008;49:1771-1776.
-
(2008)
Invest Ophthalmol Vis Sci.
, vol.49
, pp. 1771-1776
-
-
Kaur, I.1
Katta, S.2
Hussain, A.3
-
63
-
-
78751607191
-
Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy
-
Gotoh N, Yamashiro K, Nakanishi H et al: Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2010;54:609-614.
-
(2010)
Jpn J Ophthalmol.
, vol.54
, pp. 609-614
-
-
Gotoh, N.1
Yamashiro, K.2
Nakanishi, H.3
-
64
-
-
60649100054
-
Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population
-
Chu J, Zhou CC, Lu N, Zhang X, Dong FT: Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population. Chin Med J (Engl). 2008;121:2525-2533.
-
(2008)
Chin Med J (Engl).
, vol.121
, pp. 2525-2533
-
-
Chu, J.1
Zhou, C.C.2
Lu, N.3
Zhang, X.4
Dong, F.T.5
-
65
-
-
78149456126
-
Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascu-larization or polypoidal choroidal vasculopathy in Chinese subjects
-
Sng CC, Cackett PD, Yeo IY et al: Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascu-larization or polypoidal choroidal vasculopathy in Chinese subjects. Ophthalmic Res. 2011;45:191-196.
-
(2011)
Ophthalmic Res.
, vol.45
, pp. 191-196
-
-
Sng, C.C.1
Cackett, P.D.2
Yeo, I.Y.3
-
66
-
-
77950461601
-
Origins and functional impact of copy number variation in the human genome
-
Conrad DF, Pinto D, Redon R et al: Origins and functional impact of copy number variation in the human genome. Nature. 2010;464:704-712.
-
(2010)
Nature.
, vol.464
, pp. 704-712
-
-
Conrad, D.F.1
Pinto, D.2
Redon, R.3
-
67
-
-
33751329250
-
Global variation in copy number in the human genome
-
DOI 10.1038/nature05329, PII NATURE05329
-
Redon R, Ishikawa S, Fitch KR et al: Global variation in copy number in the human genome. Nature. 2006;444:444-454. (Pubitemid 44809057)
-
(2006)
Nature
, vol.444
, Issue.7118
, pp. 444-454
-
-
Redon, R.1
Ishikawa, S.2
Fitch, K.R.3
Feuk, L.4
Perry, G.H.5
Andrews, T.D.6
Fiegler, H.7
Shapero, M.H.8
Carson, A.R.9
Chen, W.10
Cho, E.K.11
Dallaire, S.12
Freeman, J.L.13
Gonzalez, J.R.14
Gratacos, M.15
Huang, J.16
Kalaitzopoulos, D.17
Komura, D.18
MacDonald, J.R.19
Marshall, C.R.20
Mei, R.21
Montgomery, L.22
Nishimura, K.23
Okamura, K.24
Shen, F.25
Somerville, M.J.26
Tchinda, J.27
Valsesia, A.28
Woodwark, C.29
Yang, F.30
Zhang, J.31
Zerjal, T.32
Zhang, J.33
Armengol, L.34
Conrad, D.F.35
Estivill, X.36
Tyler-Smith, C.37
Carter, N.P.38
Aburatani, H.39
Lee, C.40
Jones, K.W.41
Scherer, S.W.42
Hurles, M.E.43
more..
-
68
-
-
77954733893
-
CnvHap: An integrative population and haplotype-based multiplatform model of SNPs and CNVs
-
Coin LJ, Asher JE, Walters RG et al: cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs. Nat Methods. 2010;7:541-546.
-
(2010)
Nat Methods.
, vol.7
, pp. 541-546
-
-
Coin, L.J.1
Asher, J.E.2
Walters, R.G.3
-
69
-
-
70350221909
-
Copy number variation in human health, disease, and evolution
-
Zhang F, Gu W, Hurles ME, Lupski JR: Copy number variation in human health, disease, and evolution. Annu Rev Genomics Hum Genet. 2009;10:451-481.
-
(2009)
Annu Rev Genomics Hum Genet.
, vol.10
, pp. 451-481
-
-
Zhang, F.1
Gu, W.2
Hurles, M.E.3
Lupski, J.R.4
-
70
-
-
32844460938
-
Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
-
DOI 10.1038/nature04489, PII NATURE04489
-
Aitman TJ, Dong R, Vyse TJ et al: Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature. 2006;439:851-855. (Pubitemid 43255703)
-
(2006)
Nature
, vol.439
, Issue.7078
, pp. 851-855
-
-
Aitman, T.J.1
Dong, R.2
Vyse, T.J.3
Norsworthy, P.J.4
Johnson, M.D.5
Smith, J.6
Mangion, J.7
Roberton-Lowe, C.8
Marshall, A.J.9
Petretto, E.10
Hodges, M.D.11
Bhangal, G.12
Patel, S.G.13
Sheehan-Rooney, K.14
Duda, M.15
Cook, P.R.16
Evans, D.J.17
Domin, J.18
Flint, J.19
Boyle, J.J.20
Pusey, C.D.21
Cook, H.T.22
more..
-
71
-
-
37549033125
-
Psoriasis is associated with increased beta-defensin genomic copy number
-
Hollox EJ, Huffmeier U, Zeeuwen PL et al: Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet. 2008;40:23-25.
-
(2008)
Nat Genet.
, vol.40
, pp. 23-25
-
-
Hollox, E.J.1
Huffmeier, U.2
Zeeuwen, P.L.3
-
72
-
-
77949542167
-
Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors
-
Huffmeier U, Bergboer JG, Becker T et al: Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors. J Invest Dermatol. 2010;130:979-984.
-
(2010)
J Invest Dermatol.
, vol.130
, pp. 979-984
-
-
Huffmeier, U.1
Bergboer, J.G.2
Becker, T.3
-
73
-
-
62549101646
-
Copy number variants in genetic susceptibility and severity of systemic lupus erythematosus
-
Ptacek T, Li X, Kelley JM, Edberg JC: Copy number variants in genetic susceptibility and severity of systemic lupus erythematosus. Cytogenet Genome Res. 2008;123:142-147.
-
(2008)
Cytogenet Genome Res.
, vol.123
, pp. 142-147
-
-
Ptacek, T.1
Li, X.2
Kelley, J.M.3
Edberg, J.C.4
-
74
-
-
34250841166
-
Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): Low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans
-
DOI 10.1086/518257
-
Yang Y, Chung EK, Wu YL et al: Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. Am J Hum Genet. 2007;80:1037-1054. (Pubitemid 47579341)
-
(2007)
American Journal of Human Genetics
, vol.80
, Issue.6
, pp. 1037-1054
-
-
Yang, Y.1
Chung, E.K.2
Yee, L.W.3
Savelli, S.L.4
Nagaraja, H.N.5
Zhou, B.6
Hebert, M.7
Jones, K.N.8
Shu, Y.9
Kitzmiller, K.10
Blanchong, C.A.11
McBride, K.L.12
Higgins, G.C.13
Rennebohm, R.M.14
Rice, R.R.15
Hackshaw, K.V.16
Roubey, R.A.S.17
Grossman, J.M.18
Tsao, B.P.19
Birmingham, D.J.20
Rovin, B.H.21
Hebert, L.A.22
Yu, C.Y.23
more..
-
75
-
-
46949096094
-
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake
-
DOI 10.1084/jem.20072413
-
Willcocks LC, Lyons PA, Clatworthy MR et al: Copy number of FCGR3B, which is associated with systemic lupus erythe-matosus, correlates with protein expression and immune complex uptake. J Exp Med. 2008;205:1573-1582. (Pubitemid 351962021)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.7
, pp. 1573-1582
-
-
Willcocks, L.C.1
Lyons, P.A.2
Clatworthy, M.R.3
Robinson, J.I.4
Yang, W.5
Newland, S.A.6
Plagnol, V.7
McGovern, N.N.8
Condliffe, A.M.9
Chilvers, E.R.10
Adu, D.11
Jolly, E.C.12
Watts, R.13
Lau, Y.L.14
Morgan, A.W.15
Nash, G.16
Smith, K.G.C.17
-
76
-
-
78651239869
-
CCL3L1 copy number variation and susceptibility to HIV-1 infection: A meta-analysis
-
Liu S, Yao L, Ding D, Zhu H: CCL3L1 copy number variation and susceptibility to HIV-1 infection: a meta-analysis. PLoS One. 2010;5:e15778.
-
(2010)
PLoS One.
, vol.5
-
-
Liu, S.1
Yao, L.2
Ding, D.3
Zhu, H.4
-
77
-
-
78651247731
-
Genome-wide analysis of copy number variants in age-related macular degeneration
-
Meyer KJ, Davis LK, Schindler EI et al: Genome-wide analysis of copy number variants in age-related macular degeneration. Hum Genet. 2011;129:91-100.
-
(2011)
Hum Genet.
, vol.129
, pp. 91-100
-
-
Meyer, K.J.1
Davis, L.K.2
Schindler, E.I.3
-
78
-
-
64549163214
-
Essential role of neph-rocystin in photoreceptor intrafagellar transport in mouse
-
Jiang ST, Chiou YY, Wang E et al: Essential role of neph-rocystin in photoreceptor intrafagellar transport in mouse. Hum Mol Genet. 2009;18:1566-1577.
-
(2009)
Hum Mol Genet.
, vol.18
, pp. 1566-1577
-
-
Jiang, S.T.1
Chiou, Y.Y.2
Wang, E.3
-
79
-
-
34848894584
-
The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice
-
DOI 10.1093/hmg/ddm198
-
Fu L, Garland D, Yang Z et al: The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice. Hum Mol Genet. 2007;16:2411-2422. (Pubitemid 47500628)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.20
, pp. 2411-2422
-
-
Fu, L.1
Garland, D.2
Yang, Z.3
Shukla, D.4
Rajendran, A.5
Pearson, E.6
Stone, E.M.7
Zhang, K.8
Pierce, E.A.9
-
80
-
-
13244271990
-
Analysis of the EFEMP1 gene in individuals and families with early onset drusen
-
DOI 10.1038/sj.eye.6701435
-
Narendran N, Guymer RH, Cain M, Baird PN: Analysis of the EFEMP1 gene in individuals and families with early onset drusen. Eye (Lond). 2005;19:11-15. (Pubitemid 40192631)
-
(2005)
Eye
, vol.19
, Issue.1
, pp. 11-15
-
-
Narendran, N.1
Guymer, R.H.2
Cain, M.3
Baird, P.N.4
-
81
-
-
33847153137
-
Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: Characterization, ethnic distribution and evolutionary implications
-
DOI 10.1080/07853890601097030, PII 768564693
-
Hageman GS, Hancox LS, Taiber AJ et al: Extended haplo-types in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications. Ann Med. 2006;38:592-604. (Pubitemid 46292019)
-
(2006)
Annals of Medicine
, vol.38
, Issue.8
, pp. 592-604
-
-
Hageman, G.S.1
Hancox, L.S.2
Taiber, A.J.3
Gehrs, K.M.4
Anderson, D.H.5
Johnson, L.V.6
Radeke, M.J.7
Kavanagh, D.8
Richards, A.9
Atkinson, J.10
Meri, S.11
Bergeron, J.12
Zernant, J.13
Merriam, J.14
Gold, B.15
Allikmets, R.16
Dean, M.17
Hageman, J.18
Hoballah, J.19
Stockman, H.20
Immonen, I.21
Laine, M.22
Jarva, H.23
Jarvela, I.24
Seitsonen, S.25
Barile, G.26
Chang, S.27
Merriam, J.C.28
Smith, R.T.29
Yannuzzi, L.A.30
more..
-
82
-
-
73949086785
-
Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration
-
Schmid-Kubista KE, Tosakulwong N, Wu Y et al: Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009;50:5070-5079.
-
(2009)
Invest Ophthalmol Vis Sci.
, vol.50
, pp. 5070-5079
-
-
Schmid-Kubista, K.E.1
Tosakulwong, N.2
Wu, Y.3
-
83
-
-
78149270873
-
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H infuences risk for age-related macular degeneration (AMD)
-
Fritsche LG, Lauer N, Hartmann A et al: An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H infuences risk for age-related macular degeneration (AMD). Hum Mol Genet. 2010;19:4694-4704.
-
(2010)
Hum Mol Genet.
, vol.19
, pp. 4694-4704
-
-
Fritsche, L.G.1
Lauer, N.2
Hartmann, A.3
-
84
-
-
33644541748
-
Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis
-
Klein R, Klein BE, Knudtson MD et al: Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis. Ophthalmology 2006;113:373-380.
-
(2006)
Ophthalmology
, vol.113
, pp. 373-380
-
-
Klein, R.1
Klein, B.E.2
Knudtson, M.D.3
-
85
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
DOI 10.1126/science.276.5321.2045
-
Polymeropoulos MH, Lavedan C, Leroy E et al: Mutation in the alpha-synuclein gene identifed in families with Parkinson's disease. Science. 1997;276:2045-2047. (Pubitemid 27443610)
-
(1997)
Science
, vol.276
, Issue.5321
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
86
-
-
0242300619
-
Alpha-synuclein locus triplication causes parkinson's disease
-
DOI 10.1126/science.1090278
-
Singleton AB, Farrer M, Johnson J et al: alpha-Synuclein locus triplication causes Parkinson's disease. Science. 2003;302:841. (Pubitemid 37339619)
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
87
-
-
29444450702
-
Common deletions and SNPs are in linkage disequilibrium in the human genome
-
DOI 10.1038/ng1695
-
Hinds DA, Kloek AP, Jen M, Chen X, Frazer KA: Common deletions and SNPs are in linkage disequilibrium in the human genome. Nat Genet. 2006;38:82-85. (Pubitemid 43011886)
-
(2006)
Nature Genetics
, vol.38
, Issue.1
, pp. 82-85
-
-
Hinds, D.A.1
Kloek, A.P.2
Jen, M.3
Chen, X.4
Frazer, K.A.5
-
88
-
-
79960942836
-
Copy number variations in candidate genes in neovascular age-related macular degeneration
-
Liu MM, Agron E, Chew E et al: Copy Number Variations in Candidate Genes in Neovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2011.
-
(2011)
Invest Ophthalmol Vis Sci.
-
-
Liu, M.M.1
Agron, E.2
Chew, E.3
-
89
-
-
39049123747
-
Racial differences in the prevalence of age-related macular degeneration: The Salisbury Eye Evaluation (SEE) Project
-
DOI 10.1001/archophthalmol.2007.53
-
Bressler SB, Munoz B, Solomon SD, West SK: Racial differences in the prevalence of age-related macular degeneration: the Salisbury Eye Evaluation (SEE) Project. Arch Ophthalmol. 2008;126:241-245. (Pubitemid 351240854)
-
(2008)
Archives of Ophthalmology
, vol.126
, Issue.2
, pp. 241-245
-
-
Bressler, S.B.1
Munoz, B.2
Solomon, S.D.3
West, S.K.4
-
90
-
-
34648846532
-
Murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration
-
DOI 10.1167/iovs.07-0051
-
Tuo J, Bojanowski CM, Zhou M et al: Murine ccl2/cx3cr1 defciency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci. 2007;48:3827-3836. (Pubitemid 351261124)
-
(2007)
Investigative Ophthalmology and Visual Science
, vol.48
, Issue.8
, pp. 3827-3836
-
-
Tuo, J.1
Bojanowski, C.M.2
Zhou, M.3
Shen, D.4
Ross, R.J.5
Rosenberg, K.L.6
Cameron, D.J.7
Yin, C.8
Kowalak, J.A.9
Zhuang, Z.10
Zhang, K.11
Chan, C.-C.12
-
91
-
-
0034800655
-
Age-Related Eye Disease Study Research G: A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
-
Age-Related Eye Disease Study Research G: A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001;119:1417-1436.
-
(2001)
Arch Ophthalmol.
, vol.119
, pp. 1417-1436
-
-
-
92
-
-
34347251914
-
Age related macular degeneration-new developments in treatment
-
Smith TC, Lee L: Age related macular degeneration-new developments in treatment. Aust Fam Physician 2007; 36:359-361.
-
(2007)
Aust Fam Physician
, vol.36
, pp. 359-361
-
-
Smith, T.C.1
Lee, L.2
-
93
-
-
48249135691
-
Coagulation gene predictors of photodynamic therapy for occult choroi-dal neovascularization in age-related macular degeneration
-
Parmeggiani F, Costagliola C, Gemmati D et al: Coagulation gene predictors of photodynamic therapy for occult choroi-dal neovascularization in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:3100-3106.
-
(2008)
Invest Ophthalmol Vis Sci.
, vol.49
, pp. 3100-3106
-
-
Parmeggiani, F.1
Costagliola, C.2
Gemmati, D.3
-
94
-
-
38449100345
-
Predictive role of coagulation-balance gene polymorphisms in the efficacy of photodynamic therapy with verteporfin for classic choroidal neovascularization secondary to age-related macular degeneration
-
DOI 10.1097/FPC.0b013e3282f12a4e, PII 0121301120071200000004
-
Parmeggiani F, Costagliola C, Gemmati D et al: Predictive role of coagulation-balance gene polymorphisms in the effcacy of photodynamic therapy with verteporfn for classic choroidal neovascularization secondary to age-related macular degeneration. Pharmacogenet Genomics. 2007;17:1039-1046. (Pubitemid 351339488)
-
(2007)
Pharmacogenetics and Genomics
, vol.17
, Issue.12
, pp. 1039-1046
-
-
Parmeggiani, F.1
Costagliola, C.2
Gemmati, D.3
D'Angelo, S.4
Perri, P.5
Scapoli, G.L.6
Catozzi, L.7
Federici, F.8
Sebastiani, A.9
Incorvaia, C.10
-
95
-
-
62649151512
-
Predictive role of C677T MTHFR polymorphism in variable effcacy of photodynamic therapy for neovas-cular age-related macular degeneration
-
Parmeggiani F, Gemmati D, Costagliola C, Sebastiani A, Incorvaia C: Predictive role of C677T MTHFR polymorphism in variable effcacy of photodynamic therapy for neovas-cular age-related macular degeneration. Pharmacogenomics. 2009;10:81-95.
-
(2009)
Pharmacogenomics.
, vol.10
, pp. 81-95
-
-
Parmeggiani, F.1
Gemmati, D.2
Costagliola, C.3
Sebastiani, A.4
Incorvaia, C.5
-
96
-
-
66149089631
-
Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab
-
Lee AY, Raya AK, Kymes SM, Shiels A, Brantley MA, Jr.: Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab. Br J Ophthalmol. 2009;93:610-613.
-
(2009)
Br J Ophthalmol.
, vol.93
, pp. 610-613
-
-
Lee, A.Y.1
Raya, A.K.2
Kymes, S.M.3
Shiels, A.4
Brantley Jr., M.A.5
-
97
-
-
55449099115
-
CFH and LOC387715/ARMS2 genotypes and antioxidants and zinc therapy for age-related macular degeneration
-
Lee AY, Brantley MA, Jr.: CFH and LOC387715/ARMS2 genotypes and antioxidants and zinc therapy for age-related macular degeneration. Pharmacogenomics. 2008;9:1547-1550.
-
(2008)
Pharmacogenomics.
, vol.9
, pp. 1547-1550
-
-
Lee, A.Y.1
Brantley Jr., M.A.2
-
98
-
-
44349192752
-
CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration
-
Klein ML, Francis PJ, Rosner B et al: CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology. 2008;115:1019-1025.
-
(2008)
Ophthalmology.
, vol.115
, pp. 1019-1025
-
-
Klein, M.L.1
Francis, P.J.2
Rosner, B.3
-
99
-
-
36549016602
-
Association of Complement Factor H and LOC387715 Genotypes with Response of Exudative Age-Related Macular Degeneration to Intravitreal Bevacizumab
-
DOI 10.1016/j.ophtha.2007.09.008, PII S0161642007010263
-
Brantley MA, Jr., Fang AM, King JM et al: Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravit-real bevacizumab. Ophthalmology. 2007;114:2168-2173. (Pubitemid 350181136)
-
(2007)
Ophthalmology
, vol.114
, Issue.12
, pp. 2168-2173
-
-
Brantley Jr., M.A.1
Fang, A.M.2
King, J.M.3
Tewari, A.4
Kymes, S.M.5
Shiels, A.6
-
100
-
-
79958079300
-
Complement factor H Y402H gene polymorphism and response to intravitreal bevacizumab in exudative age-related macular degeneration
-
Nischler C, Oberkofer H, Ortner C et al: Complement factor H Y402H gene polymorphism and response to intravitreal bevacizumab in exudative age-related macular degeneration. Acta Ophthalmol. 2011;89:344-349.
-
(2011)
Acta Ophthalmol.
, vol.89
, pp. 344-349
-
-
Nischler, C.1
Oberkofer, H.2
Ortner, C.3
-
101
-
-
0141651687
-
Effects of zinc on factor I cofactor activity of C4b-binding protein and factor H
-
DOI 10.1016/j.abb.2003.08.018
-
Blom AM, Kask L, Ramesh B, Hillarp A: Effects of zinc on factor I cofactor activity of C4b-binding protein and factor H. Arch Biochem Biophys. 2003;418:108-118. (Pubitemid 37159377)
-
(2003)
Archives of Biochemistry and Biophysics
, vol.418
, Issue.2
, pp. 108-118
-
-
Blom, A.M.1
Kask, L.2
Ramesh, B.3
Hillarp, A.4
-
102
-
-
45449083465
-
An analysis of the CFH Y402H genotype in AMD patients and controls from the UK, and response to PDT treatment
-
DOI 10.1038/sj.eye.6702830, PII 6702830
-
Goverdhan SV, Hannan S, Newsom RB et al: An analysis of the CFH Y402H genotype in AMD patients and controls from the UK, and response to PDT treatment. Eye (Lond). 2008;22:849-854. (Pubitemid 351850525)
-
(2008)
Eye
, vol.22
, Issue.6
, pp. 849-854
-
-
Goverdhan, S.V.1
Hannan, S.2
Newsom, R.B.3
Luff, A.J.4
Griffiths, H.5
Lotery, A.J.6
-
103
-
-
77952120581
-
Genome-wide association study of advanced age-related macular degeneration identifes a role of the hepatic lipase gene (LIPC)
-
Neale BM, Fagerness J, Reynolds R et al: Genome-wide association study of advanced age-related macular degeneration identifes a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci USA. 2010;107:7395-7400.
-
(2010)
Proc Natl Acad Sci USA.
, vol.107
, pp. 7395-7400
-
-
Neale, B.M.1
Fagerness, J.2
Reynolds, R.3
-
104
-
-
39349087963
-
The effect of complement factor H Y402H polymorphism on the outcome of photodynamic therapy in age-related macular degeneration
-
Seitsonen SP, Jarvela IE, Meri S et al: The effect of complement factor H Y402H polymorphism on the outcome of photodynamic therapy in age-related macular degeneration. Eur J Ophthalmol. 2007;17:943-949. (Pubitemid 351262905)
-
(2007)
European Journal of Ophthalmology
, vol.17
, Issue.6
, pp. 943-949
-
-
Seitsonen, S.P.1
Jarvela, I.E.2
Meri, S.3
Tommila, P.V.4
Ranta, P.H.5
Immonen, I.J.6
-
105
-
-
62549159509
-
Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy
-
Brantley MA, Jr., Edelstein SL, King JM et al: Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy. Eye (Lond). 2009;23:626-631.
-
(2009)
Eye (Lond).
, vol.23
, pp. 626-631
-
-
Brantley Jr., M.A.1
Edelstein, S.L.2
King, J.M.3
-
106
-
-
84856851757
-
CFH, VEGF and HTRA1 promoter genotype may infuence the response to intravit-real ranibizumab therapy for neovascular age-related macu-lar degeneration
-
McKibbin M, Ali M, Bansal S et al: CFH, VEGF and HTRA1 promoter genotype may infuence the response to intravit-real ranibizumab therapy for neovascular age-related macu-lar degeneration. Br J Ophthalmol. 2011.
-
(2011)
Br J Ophthalmol.
-
-
McKibbin, M.1
Ali, M.2
Bansal, S.3
-
107
-
-
79953218107
-
Evidence for enhanced tissue factor expression in age-related macular degeneration
-
Cho Y, Cao X, Shen D et al: Evidence for enhanced tissue factor expression in age-related macular degeneration. Lab Invest. 2011;91:519-526.
-
(2011)
Lab Invest.
, vol.91
, pp. 519-526
-
-
Cho, Y.1
Cao, X.2
Shen, D.3
-
108
-
-
78651351984
-
The epigenomic interface between genome and environment in common complex diseases
-
Bell CG, Beck S: The epigenomic interface between genome and environment in common complex diseases. Brief Funct Genomics. 2010;9:477-485.
-
(2010)
Brief Funct Genomics.
, vol.9
, pp. 477-485
-
-
Bell, C.G.1
Beck, S.2
-
109
-
-
78149399654
-
Epigenetic regulation of the immune system in health and disease
-
Fernandez-Morera JL, Calvanese V, Rodriguez-Rodero S, Menendez-Torre E, Fraga MF: Epigenetic regulation of the immune system in health and disease. Tissue Antigens. 2010;76:431-439.
-
(2010)
Tissue Antigens.
, vol.76
, pp. 431-439
-
-
Fernandez-Morera, J.L.1
Calvanese, V.2
Rodriguez-Rodero, S.3
Menendez-Torre, E.4
Fraga, M.F.5
-
110
-
-
22844440427
-
Identification of hundreds of conserved and nonconserved human microRNAs
-
DOI 10.1038/ng1590
-
Bentwich I, Avniel A, Karov Y et al: Identifcation of hundreds of conserved and nonconserved human microRNAs. Nat Genet. 2005;37:766-770. (Pubitemid 41754896)
-
(2005)
Nature Genetics
, vol.37
, Issue.7
, pp. 766-770
-
-
Bentwich, I.1
Avniel, A.2
Karov, Y.3
Aharonov, R.4
Gilad, S.5
Barad, O.6
Barzilai, A.7
Einat, P.8
Einav, U.9
Meiri, E.10
Sharon, E.11
Spector, Y.12
Bentwich, Z.13
-
112
-
-
78149469351
-
Infammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway
-
Kutty RK, Nagineni CN, Samuel W et al: Infammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway. Biochem Biophys Res Commun. 2010;402: 390-395.
-
(2010)
Biochem Biophys Res Commun.
, vol.402
, pp. 390-395
-
-
Kutty, R.K.1
Nagineni, C.N.2
Samuel, W.3
-
113
-
-
79952786337
-
DICER1 defcit induces Alu RNA toxicity in age-related macular degeneration
-
Kaneko H, Dridi S, Tarallo V et al: DICER1 defcit induces Alu RNA toxicity in age-related macular degeneration. Nature 2011;471:325-330.
-
(2011)
Nature
, vol.471
, pp. 325-330
-
-
Kaneko, H.1
Dridi, S.2
Tarallo, V.3
-
114
-
-
44949139634
-
Dicer inac-tivation leads to progressive functional and structural degeneration of the mouse retina
-
Damiani D, Alexander JJ, O'Rourke JR et al: Dicer inac-tivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008;28: 4878-4887.
-
(2008)
J Neurosci.
, vol.28
, pp. 4878-4887
-
-
Damiani, D.1
Alexander, J.J.2
O'Rourke, J.R.3
-
115
-
-
79957783544
-
Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters
-
Zhou Q, Gallagher R, Ufret-Vincenty R et al: Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc Natl Acad Sci USA. 2011;108:8287-8292.
-
(2011)
Proc Natl Acad Sci USA.
, vol.108
, pp. 8287-8292
-
-
Zhou, Q.1
Gallagher, R.2
Ufret-Vincenty, R.3
-
116
-
-
77049108395
-
The complement component 5 gene and age-related macular degeneration
-
Baas DC, Ho L, Ennis S et al: The complement component 5 gene and age-related macular degeneration. Ophthalmology. 2010;117:500-511.
-
(2010)
Ophthalmology.
, vol.117
, pp. 500-511
-
-
Baas, D.C.1
Ho, L.2
Ennis, S.3
-
117
-
-
20444471500
-
Association of HLA class I and class II polymorphisms with age-related macular degeneration
-
DOI 10.1167/iovs.04-0928
-
Goverdhan SV, Howell MW, Mullins RF et al: Association of HLA class I and class II polymorphisms with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2005;46:1726-1734. (Pubitemid 44843610)
-
(2005)
Investigative Ophthalmology and Visual Science
, vol.46
, Issue.5
, pp. 1726-1734
-
-
Goverdhan, S.V.1
Howell, M.W.2
Mullins, R.F.3
Osmond, C.4
Hodgkins, P.R.5
Self, J.6
Avery, K.7
Lotery, A.J.8
-
118
-
-
39549111290
-
Comprehensive analysis of the candidate genes CCL2 CCR2 and TLR4 in age-related macular degeneration
-
Despriet DD, Bergen AA, Merriam JE et al: Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:364-371.
-
(2008)
Invest Ophthalmol Vis Sci.
, vol.49
, pp. 364-371
-
-
Despriet, D.D.1
Bergen, A.A.2
Merriam, J.E.3
-
119
-
-
33749143628
-
Analysis of CFH, TLR4, and APOE polymorphism in India suggest the Tyr402his variant of CFH to be a global marker for age-related macular degeneration
-
DOI 10.1167/iovs.05-1430
-
Kaur I, Hussain A, Hussain N et al: Analysis of CFH, TLR4, and APOE polymorphism in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006;47:3729-3735. (Pubitemid 46044283)
-
(2006)
Investigative Ophthalmology and Visual Science
, vol.47
, Issue.9
, pp. 3729-3735
-
-
Kaur, I.1
Hussain, A.2
Hussain, N.3
Das, T.4
Pathangay, A.5
Mathai, A.6
Hussain, A.7
Nutheti, R.8
Nirmalan, P.K.9
Chakrabarti, S.10
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