Observation of a single-stranded DNA/pyrrolobenzodiazepine adduct

Journal of the American Chemical Society

Volumn 133, Issue 48, 2011, Pages 19376-19385

  Rahman, Khondaker M ^a   James, Colin H ^a   Bui, Tam T T ^b   Drake, Alex F ^b   Thurston, David E ^a,c  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR AGENTS; CD SIGNALS; COMPLEMENTARY STRAND; COVALENT BOND FORMATION; DIRECT INTERACTIONS; DUPLEX DNA; HPLC/MS; MALDI TOF MS; MINOR GROOVES; PYRROLOBENZODIAZEPINE; RELATIVE STABILITIES; ROOM TEMPERATURE; SINGLE-STRANDED DNA;

BUDGET CONTROL; SPECTROSCOPIC ANALYSIS;

DNA;

COMPLEMENTARY DNA; DNA FRAGMENT; DOUBLE STRANDED DNA; DRG 16; GUANINE; GWL 78; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; SINGLE STRANDED DNA; SJG 136; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; COVALENT BOND; DISSOCIATION; DNA ADDUCT; DRUG DNA BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR STABILITY; ROOM TEMPERATURE; STORAGE TEMPERATURE; ULTRAVIOLET SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BENZODIAZEPINES; DNA ADDUCTS; DNA, SINGLE-STRANDED; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PYRROLES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 82555194637     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja205395r     Document Type: Article

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