Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 623-627

  Lachance, Nicolas ^a   Guiral, Sébastien ^a   Huang, Zheng ^a   Leclerc, Jean Philippe ^a   Li, Chun Sing ^a   Oballa, Renata M ^a   Ramtohul, Yeeman K ^a   Wang, Hao ^a   Wu, Jin ^a   Zhang, Lei ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Desaturation index; Liver selective; MK 8245; SCD inhibitors; Stearoyl CoA desaturase inhibitors

Indexed keywords

ACYL COENZYME A DESATURASE; MK 8245; OXYGENASE INHIBITOR; STEAROYL COENZYME A DESATURASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG MEGADOSE; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER; METABOLIC DISORDER; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY;

ACETIC ACIDS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; ENZYME INHIBITORS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; LIVER; MICE; MICE, INBRED C57BL; MODELS, CHEMICAL; OBESITY; STEAROYL-COA DESATURASE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

RODENTIA;

EID: 84655163806     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.070     Document Type: Article

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