Design of imperfectly amphipathic α-helical antimicrobial peptides with enhanced cell selectivity

Acta Biomaterialia

Volumn 10, Issue 1, 2014, Pages 244-257

  Zhu, Xin ^a   Dong, Na ^a   Wang, Zeyun ^a   Ma, Zhi ^a   Zhang, Licong ^a   Ma, Qingquan ^a   Shan, Anshan ^a  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

Author keywords

Amphipathicity; Antimicrobial peptides; Bactericidal mechanism; Hemolysis; Helix

Indexed keywords

AMINO ACIDS; ANTIMICROBIAL AGENTS; BACTERIA; BLOOD; CELLS; CYTOLOGY; FLUORESCENCE SPECTROSCOPY; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; HYDROGEN BONDS; PEPTIDES; SCANNING ELECTRON MICROSCOPY;

AMPHIPATHIC; AMPHIPATHICITY; ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; BACTERICIDAL MECHANISMS; CELL-SELECTIVITY; HAEMOLYSIS; MULTICELLULAR ORGANISMS; TRYPTOPHAN RESIDUES; Α-HELIX;

ARSENALS;

AMINO ACID; POLYPEPTIDE ANTIBIOTIC AGENT; TRYPTOPHAN;

ANTIMICROBIAL ACTIVITY; ARTICLE; CELL MEMBRANE; DRUG DESIGN; ERYTHROCYTE; FLOW CYTOMETRY; FLUORESCENCE SPECTROSCOPY; GRAM POSITIVE BACTERIUM; HEMOLYSIS; HYDROGEN BOND; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FOLDING; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

AMPHIPATHICITY; ANTIMICROBIAL PEPTIDES; BACTERICIDAL MECHANISM; HEMOLYSIS; Α-HELIX;

ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; DRUG DESIGN; FLOW CYTOMETRY; HEMOLYSIS; HUMANS; MEMBRANE POTENTIALS; MICROBIAL SENSITIVITY TESTS; PROTEIN STRUCTURE, SECONDARY; SODIUM CHLORIDE;

EID: 84888645761     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.08.043     Document Type: Article

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