Biochemical property and membrane-peptide interactions of de novo antimicrobial peptides designed by helix-forming units

Amino Acids

Volumn 43, Issue 6, 2012, Pages 2527-2536

  Ma, Qing Quan ^a   Dong, Na ^a   Shan, An Shan ^a   Lv, Yin Feng ^a   Li, Yu Zhi ^b   Chen, Zhi Hui ^a   Cheng, Bao Jing ^a   Li, Zhong Yu ^a  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Amino acids; Antimicrobial peptides; Cell membrane; Helix; Residue

Indexed keywords

AMPHOLYTE; ARGININE; ISOLEUCINE; ISOLEUCYLTRYPTOPHYLARGINYLISOLEUCYLPHENYLALANYLARGININE AMIDE; ISOLEUCYLTRYPTOPHYLARGINYLISOLEUCYLPHENYLALANYLARGINYLARGINYLISOLEUCYLPHENYLALANINE AMIDE; ISOLEUCYLTRYPTOPHYLARGINYLISOLEUCYLPHENYLALANYLARGINYLARGINYLISOLEUCYLPHENYLALANYLARGINYLISOLEUCYLPHENYLALANINE AMIDE; ISOLEUCYLTRYPTOPHYLARGINYLISOLEUCYLPHENYLALANYLARGINYLARGINYLISOLEUCYLPHENYLALANYLARGINYLISOLEUCYLPHENYLALANISOLEUCYLARGINYLPHENYLALANINE AMIDE; MELITTIN; MEMBRANE PROTEIN; PHENYLALANINE; PHOSPHOLIPID; POLYPEPTIDE ANTIBIOTIC AGENT; SODIUM CHLORIDE; TRIPEPTIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALPHA HELIX; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIUM; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CELL INTERACTION; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL SELECTION; CIRCULAR DICHROISM; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; ERYTHROCYTE; HEAT; HELIX FORMING UNIT; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID VESICLE; MAMMAL CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PH; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LIPID INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

ANTI-BACTERIAL AGENTS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; ERYTHROCYTES; ESCHERICHIA COLI; HEMOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; MICROBIAL SENSITIVITY TESTS; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 84872714452     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1334-7     Document Type: Article

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